{"id":"https://openalex.org/W120426452","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.1046.7","title":"Modelling the negative regulation of muscle protein degradation by attachment complexes using C. elegans","display_name":"Modelling the negative regulation of muscle protein degradation by attachment complexes using C. elegans","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W120426452","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.1046.7","mag":"120426452"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.24.1_supplement.1046.7","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.1046.7","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.1046.7","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038506453","display_name":"Timothy Etheridge","orcid":"https://orcid.org/0000-0002-3588-8711","observed_orcids":["https://orcid.org/0000-0002-3588-8711"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Timothy Etheridge","raw_affiliation_strings":["Clinical Physiology University of Nottingham Derby United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Physiology University of Nottingham Derby United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059648760","display_name":"Nathaniel J. Szewczyk","orcid":"https://orcid.org/0000-0003-4425-9746","observed_orcids":["https://orcid.org/0000-0003-4425-9746"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nathaniel J Szewczyk","raw_affiliation_strings":["Clinical Physiology University of Nottingham Derby United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Physiology University of Nottingham Derby United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I142263535"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01030141,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muscle-protein-degradation","display_name":"muscle protein degradation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.9440000057220459},{"id":"https://openalex.org/keywords/dense-bodies","display_name":"dense bodies","score":0.9390000104904175},{"id":"https://openalex.org/keywords/dystrophy","display_name":"dystrophy","score":0.5440000295639038},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6891096830368042},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6833299398422241},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.670783281326294},{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.6013324856758118},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.6009860634803772},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.5667174458503723},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5594792366027832},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.5403422117233276},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5066867470741272},{"id":"https://openalex.org/C2779030066","wikidata":"https://www.wikidata.org/wiki/Q1137767","display_name":"Muscular dystrophy","level":2,"score":0.46374639868736267},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.4298558831214905},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.4242042005062103},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4166612923145294},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.35454633831977844},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29737091064453125},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24727153778076172},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2076038420200348},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12003615498542786},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.10685938596725464}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.24.1_supplement.1046.7","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.1046.7","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.1046.7","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1990478935","https://openalex.org/W7098664996","https://openalex.org/W2050956010","https://openalex.org/W2171092871","https://openalex.org/W1974684339","https://openalex.org/W6991830045","https://openalex.org/W2147893071","https://openalex.org/W2511994955","https://openalex.org/W2167275854","https://openalex.org/W2019817816"],"abstract_inverted_index":{"Focal":[0],"adhesions":[1,40,77],"are":[2],"present":[3],"in":[4,49,52,81,95,103,105,129,134,142,166,171],"both":[5,33],"human":[6,194],"and":[7,35,88,137,139,144],"C.":[8,97],"elegans":[9,98],"muscle,":[10],"with":[11],"many":[12],"of":[13,18,22,38,46,57,66,70,112,115,122,131,146,156,159],"the":[14,29,64,73,109,147,160,177],"constituent":[15],"proteins":[16],"(~115":[17],"at":[19],"least":[20],"150)":[21],"these":[23,100],"complexes":[24],"having":[25],"putative":[26],"orthology":[27],"between":[28],"two":[30],"systems.":[31],"In":[32],"worms":[34],"humans,":[36],"components":[37],"focal":[39,76],"have":[41],"been":[42],"suggested":[43],"as":[44],"regulators":[45],"(mal)adaptive":[47],"changes":[48],"muscle":[50,75,125,135,168,197],"size":[51],"response":[53],"to":[54,62,107],"a":[55,67],"range":[56],"pathological/environmental":[58],"conditions.":[59],"We":[60],"aimed":[61],"examine":[63],"involvement":[65],"known":[68],"subset":[69],"genes":[71,101,127],"comprising":[72],"worm":[74],"(termed":[78],"dense":[79,116,161],"bodies)":[80],"regulating":[82,179],"three":[83],"sub\u2010cellular":[84,173],"compartments:":[85],"cytosol,":[86,136],"mitochondria":[87],"myofibres.":[89],"RNAi":[90,120],"experiments":[91],"were":[92],"conducted":[93],"acutely":[94],"adult":[96],"against":[99],"(25":[102],"total)":[104],"order":[106],"assess":[108],"physiologic":[110],"significance":[111],"acute":[113],"loss":[114],"body":[117,162],"constituents.":[118],"Acute":[119],"treatment":[121],"all":[123,172],"25":[124],"attachment\u2010related":[126],"resulted":[128],"degradation":[130,181],"reporter":[132],"protein":[133,180],"mitochondrial":[138],"myofibrillar":[140],"dystrophies":[141],"18":[143],"19":[145],"target":[148],"genes,":[149],"respectively.":[150],"It":[151],"thus":[152],"appears":[153],"that":[154],"maintenance":[155],"this":[157],"set":[158],"complex":[163],"is":[164,199],"crucial":[165],"maintaining":[167],"cell":[169],"integrity":[170],"compartments":[174],"tested.":[175],"Uncovering":[176],"mechanism(s)":[178],"and/or":[182],"dystrophy":[183],"may":[184],"provide":[185],"novel":[186],"therapeutic":[187],"targets":[188],"for":[189],"understanding,":[190],"treating":[191],"or":[192],"preventing":[193],"diseases":[195],"where":[196],"atrophy":[198],"characteristic.":[200],"Support:":[201],"MRC":[202],"(G0801271)":[203]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}