{"id":"https://openalex.org/W12038825","doi":null,"title":"Abstract 10269: Angiotensin II Potentiates \u03b1-Adrenergic Vasoconstriction in the Elderly","display_name":"Abstract 10269: Angiotensin II Potentiates \u03b1-Adrenergic Vasoconstriction in the Elderly","publication_year":2010,"publication_date":"2010-11-23","ids":{"openalex":"https://openalex.org/W12038825","mag":"12038825"},"language":"en","primary_location":{"id":"mag:12038825","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/10.1161/circ.122.suppl_21.A10269","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null},"volume":null,"type":"conference-abstract","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088969769","display_name":"Zachary Barrett\u2010O\u2019Keefe","orcid":"https://orcid.org/0009-0004-1044-6695","observed_orcids":["https://orcid.org/0009-0004-1044-6695"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zachary Barrett\u2010O\u2019Keefe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039470309","display_name":"John McDaniel","orcid":"https://orcid.org/0000-0001-8571-881X","observed_orcids":["https://orcid.org/0000-0001-8571-881X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John McDaniel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001224689","display_name":"Anette S. Fjeldstad","orcid":"https://orcid.org/0000-0003-0055-6562","observed_orcids":["https://orcid.org/0000-0003-0055-6562"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anette S. Fjeldstad","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0055-6562","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022257261","display_name":"Melissa A. Hayman","orcid":"https://orcid.org/0000-0003-0381-1602","observed_orcids":["https://orcid.org/0000-0003-0381-1602"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melissa A. Hayman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0381-1602","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035467273","display_name":"Joel Douglas Trinity","orcid":"https://orcid.org/0000-0001-8271-6536","observed_orcids":["https://orcid.org/0000-0001-8271-6536"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joel D. Trinity","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8271-6536","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017035586","display_name":"Jamie D. Conklin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jamie D. Conklin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010705806","display_name":"Sean Runnels","orcid":"https://orcid.org/0000-0003-0375-7730","observed_orcids":["https://orcid.org/0000-0003-0375-7730"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sean Runnels","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0375-7730","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072763047","display_name":"DAVID E. MORGAN","orcid":"https://orcid.org/0000-0003-0329-2523","observed_orcids":["https://orcid.org/0000-0003-0329-2523"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Morgan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0329-2523","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086458150","display_name":"Mark A. Supiano","orcid":"https://orcid.org/0000-0002-5438-5087","observed_orcids":["https://orcid.org/0000-0002-5438-5087"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark A. Supiano","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5438-5087","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104051296","display_name":"Russell S. Richardson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Russell S. Richardson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012498864","display_name":"David Walter Wray","orcid":"https://orcid.org/0000-0002-6907-1734","observed_orcids":["https://orcid.org/0000-0002-6907-1734"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Walter Wray","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6907-1734","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"122","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":1.0},{"id":"https://openalex.org/keywords/alpha-adrenergic-vasoconstriction","display_name":"alpha-adrenergic vasoconstriction","score":0.9909999966621399},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7369999885559082},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8059999942779541},{"id":"https://openalex.org/keywords/renin-angiotensin-aldosterone-system","display_name":"renin-angiotensin-aldosterone system","score":0.9409999847412109},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.7829999923706055},{"id":"https://openalex.org/keywords/phentolamine","display_name":"phentolamine","score":0.9409999847412109},{"id":"https://openalex.org/keywords/brachial-artery","display_name":"brachial artery","score":0.7689999938011169},{"id":"https://openalex.org/keywords/peripheral-vasoconstriction","display_name":"peripheral vasoconstriction","score":0.781000018119812},{"id":"https://openalex.org/keywords/hypertension-in-the-elderly","display_name":"hypertension in the elderly","score":0.7839999794960022},{"id":"https://openalex.org/keywords/vascular-reactivity","display_name":"vascular reactivity","score":0.34700000286102295}],"concepts":[{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.8950777053833008},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8393397331237793},{"id":"https://openalex.org/C2780253649","wikidata":"https://www.wikidata.org/wiki/Q420360","display_name":"Phentolamine","level":3,"score":0.8343442678451538},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6601961255073547},{"id":"https://openalex.org/C158453852","wikidata":"https://www.wikidata.org/wiki/Q4684738","display_name":"Adrenergic","level":3,"score":0.5646775960922241},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4463995099067688},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.43347716331481934},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.42609769105911255},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.18351387977600098},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1526963710784912},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09375223517417908}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:12038825","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/10.1161/circ.122.suppl_21.A10269","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2330824445","https://openalex.org/W2903137863","https://openalex.org/W2088890943","https://openalex.org/W2289208598","https://openalex.org/W2181780681","https://openalex.org/W2284679917","https://openalex.org/W3169817635","https://openalex.org/W1977162618","https://openalex.org/W2134046854","https://openalex.org/W13376565"],"abstract_inverted_index":{"Introduction:":[0],"Aging":[1],"is":[2],"associated":[3],"with":[4,25,130],"increased":[5],"activity":[6],"of":[7,32,38,48,100,121],"both":[8],"the":[9,19,30,45,85,98],"adrenergic":[10,133],"and":[11,75,77,128],"renin-angiotensin-aldosterone":[12],"systems":[13],"(RAAS),":[14],"which":[15],"may":[16,41],"contribute":[17],"to":[18],"well-known":[20],"elevation":[21],"in":[22,60,84,88,97],"peripheral":[23],"vasoconstriction":[24,69,80],"age,":[26],"as":[27,29],"well":[28],"sequelae":[31],"geriatric":[33],"hypertension.":[34],"The":[35],"individual":[36],"contribution":[37],"each":[39],"pathway":[40],"be":[42,71,82,95],"exacerbated":[43],"by":[44],"potentiating":[46],"effects":[47],"ANG-II":[49,122,129],"on":[50],"alpha-adrenergic":[51,101],"vasoconstriction,":[52],"though":[53],"this":[54,91],"interaction":[55],"has":[56],"not":[57],"been":[58],"studied":[59],"healthy":[61],"aging.":[62],"Hypothesis:":[63],"We":[64],"hypothesized":[65],"that:":[66],"(1)":[67],"Alpha-adrenergic":[68],"would":[70,81,94],"similar":[72],"between":[73],"young":[74],"older,":[76,111],"(2)":[78],"ANG-II-mediated":[79],"greater":[83],"elderly":[86],"than":[87],"young,":[89,107],"but":[90],"age":[92],"effect":[93],"ablated":[96],"presence":[99],"antagonism.":[102],"Methods:":[103],"Eleven":[104],"subjects":[105],"(n=6":[106],"25\u00b11":[108],"yrs;":[109],"n=5":[110],"65\u00b11":[112],"yrs)":[113],"underwent":[114],"brachial":[115],"artery":[116],"catheterization":[117],"for":[118],"local":[119],"administration":[120],"(0.8\u201325":[123],"ng/dl/min),":[124],"NE":[125],"(2.5\u201380":[126],"ng/dl/min)":[127],"concomitant":[131],"alpha":[132],"antagonism":[134],"(phentolamine,":[135],"1...":[136]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
