{"id":"https://openalex.org/W12023830","doi":"https://doi.org/","title":"The ProteinChip Biomarker System from Ciphergen Biosystems: a novel proteomics platform for rapid biomarker discovery and validation.","display_name":"The ProteinChip Biomarker System from Ciphergen Biosystems: a novel proteomics platform for rapid biomarker discovery and validation.","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W12023830","doi":"https://doi.org/","mag":"12023830","pmid":"https://pubmed.ncbi.nlm.nih.gov/12023830"},"language":"en","primary_location":{"id":"pmid:12023830","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12023830","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society transactions","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"K Chapman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"K Chapman","raw_affiliation_strings":["Ciphergen Biosystems Ltd, Surrey Technology Centre, The Surrey Research Park, Guildford, Surrey GU2 7YG, U.K. kchapman@ciphergen.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ciphergen Biosystems Ltd, Surrey Technology Centre, The Surrey Research Park, Guildford, Surrey GU2 7YG, U.K. kchapman@ciphergen.com","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.00218369,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"30","issue":"2","first_page":"82","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.42750000953674316,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.42750000953674316,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.3068999946117401,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.260699987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-microarrays","display_name":"protein microarrays","score":0.6430000066757202},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"biomarker discovery","score":0.8130000233650208},{"id":"https://openalex.org/keywords/biomarker-validation","display_name":"biomarker validation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/surface-enhanced-laser-desorption-ionization","display_name":"SELDI","score":0.8809999823570251},{"id":"https://openalex.org/keywords/time-of-flight-mass-spectrometry","display_name":"time-of-flight mass spectrometry","score":0.8989999890327454},{"id":"https://openalex.org/keywords/protein-capture","display_name":"protein capture","score":0.47999998927116394},{"id":"https://openalex.org/keywords/cancer-research","display_name":"cancer research","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6187050938606262},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5985175371170044},{"id":"https://openalex.org/C2781005915","wikidata":"https://www.wikidata.org/wiki/Q417701","display_name":"Alloxan","level":3,"score":0.4985215663909912},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4359331727027893},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3920767605304718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37046825885772705},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3395450711250305}],"mesh":[{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:12023830","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12023830","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society transactions","raw_type":"Journal Article"},{"id":"mag:12023830","doi":null,"is_oa":false,"landing_page_url":"http://files.figshare.com/1877998/F0312023027.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:1994460541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12023830","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W81003976","https://openalex.org/W107825694","https://openalex.org/W1892773183","https://openalex.org/W1986384361","https://openalex.org/W2004897815","https://openalex.org/W2006370393","https://openalex.org/W2024583261","https://openalex.org/W2033898136","https://openalex.org/W2041340074","https://openalex.org/W2041534370","https://openalex.org/W2051048916","https://openalex.org/W2051989112","https://openalex.org/W2058282705","https://openalex.org/W2063576996","https://openalex.org/W2066806744","https://openalex.org/W2077801717","https://openalex.org/W2080972964","https://openalex.org/W2086327676","https://openalex.org/W2088012387","https://openalex.org/W2092787054","https://openalex.org/W2095477451","https://openalex.org/W2111132370","https://openalex.org/W2114651971","https://openalex.org/W2132826785","https://openalex.org/W2154182907","https://openalex.org/W2154635386","https://openalex.org/W2160161230","https://openalex.org/W2341337480","https://openalex.org/W2416837370","https://openalex.org/W2467356039"],"related_works":["https://openalex.org/W4236604656","https://openalex.org/W2478272179","https://openalex.org/W2089261441","https://openalex.org/W127706037","https://openalex.org/W139867963","https://openalex.org/W2069063012","https://openalex.org/W1819727153","https://openalex.org/W1504390819","https://openalex.org/W3020826750","https://openalex.org/W2547674863"],"abstract_inverted_index":{"Protein":[0],"biochips":[1],"are":[2,94],"emerging":[3],"in":[4,31],"two":[5],"distinct":[6],"formats.":[7],"The":[8,50,139],"first":[9],"involves":[10,53],"high-density":[11],"immobilized":[12],"arrays":[13],"of":[14,39,56,105,148],"recognition":[15],"molecules":[16,42],"(e.g.":[17,25,133],"antibodies),":[18],"where":[19],"target":[20],"binding":[21,41],"is":[22,30,71,141],"monitored":[23],"indirectly":[24],"via":[26],"fluorescence).":[27],"This":[28,69],"technology":[29,70,79,140],"its":[32],"infancy,":[33],"being":[34,142],"limited":[35],"by":[36,58,67],"the":[37,54,74,120],"availability":[38],"suitable":[40],"that":[43],"can":[44,126],"cope":[45],"effectively":[46],"with":[47,64],"protein":[48,124],"diversity.":[49],"second":[51],"format":[52],"capture":[55,103],"proteins":[57,87],"biochemical":[59],"or":[60,137],"intermolecular":[61],"interaction,":[62],"coupled":[63],"direct":[65],"detection":[66],"MS.":[68],"available":[72],"as":[73],"ProteinChip":[75,78,98],"Biomarker":[76],"System.":[77],"uses":[80],"surface-enhanced":[81],"laser":[82],"desorption/ionization":[83],"processes":[84],"to":[85,97,102,119,144,153],"analyse":[86],"directly":[88],"from":[89,129,150],"biological":[90,131],"samples.":[91],"Chromatographic":[92],"surfaces":[93],"placed":[95],"on":[96,108],"Arrays":[99],"and":[100,156],"used":[101],"subclasses":[104],"proteins,":[106],"dependent":[107],"their":[109],"physical":[110],"properties.":[111],"Time-of-flight":[112],"MS":[113],"then":[114],"assigns":[115],"native":[116],"molecular":[117],"masses":[118],"captured":[121],"proteins.":[122],"Reproducible":[123],"profiles":[125],"be":[127,158],"generated":[128],"crude":[130],"fluids":[132],"cell":[134],"lysates,":[135],"urine":[136],"serum).":[138],"applied":[143],"a":[145],"wide":[146],"range":[147],"disciplines,":[149],"plant":[151],"sciences":[152],"cancer":[154],"research,":[155],"will":[157],"reviewed":[159],"here.":[160]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}