{"id":"https://openalex.org/W120216670","doi":null,"title":"Participation of pigment epithelium of iris and ciliary body in ocular immune privilege. 1. Inhibition of T-cell activation in vitro by direct cell-to-cell contact.","display_name":"Participation of pigment epithelium of iris and ciliary body in ocular immune privilege. 1. Inhibition of T-cell activation in vitro by direct cell-to-cell contact.","publication_year":2000,"publication_date":"2000-03-01","ids":{"openalex":"https://openalex.org/W120216670","mag":"120216670","pmid":"https://pubmed.ncbi.nlm.nih.gov/10711698"},"language":"en","primary_location":{"id":"pmid:10711698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10711698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015756286","display_name":"Munenori Yoshida","orcid":"https://orcid.org/0000-0001-8783-9076","observed_orcids":["https://orcid.org/0000-0001-8783-9076"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Yoshida","raw_affiliation_strings":["Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086435720","display_name":"Masaru Takeuchi","orcid":"https://orcid.org/0000-0001-9304-4667","observed_orcids":["https://orcid.org/0000-0001-9304-4667"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Takeuchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113888925","display_name":"J. Wayne Streilein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J W Streilein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1408,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.84875315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"41","issue":"3","first_page":"811","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.635699987411499,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.635699987411499,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.3257000148296356,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ocular-immune-privilege","display_name":"ocular immune privilege","score":0.8999999761581421},{"id":"https://openalex.org/keywords/iris-pigment-epithelium","display_name":"iris pigment epithelium","score":0.906000018119812},{"id":"https://openalex.org/keywords/t-cell-activation-suppression","display_name":"T cell activation suppression","score":0.7570000290870667},{"id":"https://openalex.org/keywords/fas-ligand","display_name":"Fas ligand","score":0.8349999785423279},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.7639999985694885},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9700000286102295},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.609000027179718},{"id":"https://openalex.org/keywords/t-cell-apoptosis","display_name":"T cell apoptosis","score":0.5799999833106995},{"id":"https://openalex.org/keywords/cytokine-expression","display_name":"cytokine expression","score":0.5139999985694885},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.5690000057220459},{"id":"https://openalex.org/keywords/mixed-lymphocyte-reaction","display_name":"mixed lymphocyte reaction","score":0.671999990940094},{"id":"https://openalex.org/keywords/ovalbumin","display_name":"ovalbumin","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5480390787124634},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5144875049591064},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49619895219802856},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.48716041445732117},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.44042083621025085},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3648173213005066},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3509036898612976},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.35000839829444885},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3411905765533447}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002924","descriptor_name":"Ciliary Body","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D007165","descriptor_name":"Immunosuppression Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007498","descriptor_name":"Iris","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D007959","descriptor_name":"Lymphocyte Culture Test, Mixed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010857","descriptor_name":"Pigment Epithelium of Eye","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10711698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10711698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:120216670","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10711698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W30866796","https://openalex.org/W53283566","https://openalex.org/W124676984","https://openalex.org/W149481866","https://openalex.org/W1486085957","https://openalex.org/W1510532059","https://openalex.org/W1531951330","https://openalex.org/W1549449626","https://openalex.org/W1558813989","https://openalex.org/W1568998401","https://openalex.org/W1599245394","https://openalex.org/W1600044145","https://openalex.org/W1610376024","https://openalex.org/W1709882622","https://openalex.org/W1947544645","https://openalex.org/W1978018492","https://openalex.org/W1986725618","https://openalex.org/W1989400519","https://openalex.org/W2002503549","https://openalex.org/W2002726220","https://openalex.org/W2005198041","https://openalex.org/W2008965380","https://openalex.org/W2027342157","https://openalex.org/W2032118018","https://openalex.org/W2043060387","https://openalex.org/W2046397066","https://openalex.org/W2059846081","https://openalex.org/W2060820237","https://openalex.org/W2062755596","https://openalex.org/W2069758360","https://openalex.org/W2069809638","https://openalex.org/W2073271975","https://openalex.org/W2074968169","https://openalex.org/W2083708523","https://openalex.org/W2124459550","https://openalex.org/W2127475758","https://openalex.org/W2130476194","https://openalex.org/W2139309876","https://openalex.org/W2236375555","https://openalex.org/W2409551497","https://openalex.org/W2413645590"],"related_works":["https://openalex.org/W2155216707","https://openalex.org/W2157635590","https://openalex.org/W2013828165","https://openalex.org/W113953514","https://openalex.org/W7096342842","https://openalex.org/W2084731262","https://openalex.org/W1990121620","https://openalex.org/W2089927477","https://openalex.org/W1541199699","https://openalex.org/W149481866"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"determine":[2],"by":[3,64,75,114,120,274,311],"what":[4],"mechanism(s)":[5],"iris":[6],"and":[7,32,37,68,79,88,133,136,165,170,176,197,203,251,259,267,301],"ciliary":[8],"body":[9],"(I/CB)":[10],"pigment":[11],"epithelial":[12],"(PE)":[13],"cells":[14,25,62,102,132,183,220,231,235,243,298],"inhibit":[15],"T-cell":[16,44,49,95,151,195],"activation":[17,45,152],"in":[18,46,205,209,227],"vitro.":[19],"METHODS:":[20],"Pure":[21],"cultured":[22,123,217],"I/CB":[23,100,115,124,130,147,181,218,229,241,275,289],"PE":[24,101,116,125,131,182,219,230,242,276,290],"were":[26,90,103,188,237],"obtained":[27],"from":[28,299],"eyes":[29],"of":[30,58,70,81,94,99,108,122,138,150,156,173,199,216],"normal":[31],"CD95":[33,318],"ligand":[34,52,213],"(CD95L)deficient":[35],"mice":[36],"tested":[38],"for":[39,246,309],"their":[40],"capacity":[41],"to":[42,145,159,264,270],"suppress":[43],"three":[47,211],"different":[48],"receptor":[50],"(Tcr)":[51],"systems:":[53],"mixed":[54],"lymphocyte":[55],"reactions,":[56],"stimulation":[57],"Tcr":[59,212,308],"transgenic":[60],"T":[61,134,142,234,297],"(D011.10)":[63],"specific":[65],"antigen":[66,310],"(ovalbumin),":[67],"ligation":[69],"the":[71,106,154,171,285,307],"Tcr-associated":[72],"CD3":[73],"molecule":[74],"anti-CD3":[76],"antibodies.":[77],"Proliferation":[78],"secretion":[80,198],"cytokines":[82,303],"(interferon":[83],"[IFN]-gamma,":[84],"interleukin":[85],"[IL]-2,":[86],"IL-4,":[87,202,255],"IL-10)":[89],"assessed":[91],"as":[92],"measures":[93],"activation.":[96],"Suppressive":[97],"influences":[98],"determined":[104],"on":[105],"basis":[107],"RT-PCR-":[109],"detected":[110],"cytokine":[111],"genes":[112],"expressed":[113,244],"cells,":[117,126,291],"immunosuppression":[118],"mediated":[119,273],"supernatants":[121],"direct":[127,293],"contact":[128],"between":[129],"lymphocytes,":[135],"promotion":[137],"apoptosis":[139],"among":[140],"responding":[141,233],"cells.":[143,277],"Attempts":[144],"reverse":[146,271],"PE-dependent":[148],"suppression":[149,223,272],"included":[153],"use":[155],"neutralizing":[157],"antibodies":[158],"IL-10,":[160,250,266],"tumor":[161],"necrosis":[162],"factor":[163,168],"(TNF)-alpha":[164],"transforming":[166],"growth":[167],"(TGF)-beta,":[169],"addition":[172],"exogenous":[174,280],"IL-2":[175,281],"IL-12.":[177],"RESULTS:":[178],"Cultured":[179,240,288],"mouse":[180],"(including":[184],"CD95L-deficient":[185],"cells),":[186],"which":[187,228],"more":[189],"than":[190],"95%":[191],"keratin":[192],"positive,":[193],"suppressed":[194],"proliferation":[196],"IFN-gamma,":[200,256],"IL-2,":[201],"IL-10":[204],"a":[206,312],"dose-dependent":[207],"fashion":[208],"all":[210],"systems.":[214],"Supernatants":[215],"displayed":[221],"little":[222],"activity,":[224],"whereas":[225],"cultures":[226],"contacted":[232],"directly":[236],"profoundly":[238],"immunosuppressive.":[239],"mRNA":[245],"TGF-beta1,":[247],"TGF-beta2,":[248],"IL-6,":[249],"TNF-alpha,":[252],"but":[253],"not":[254,316],"proopiomelanocortin":[257],"(POMC),":[258],"CD95L":[260],"(Fas":[261],"L).":[262],"Antibodies":[263],"TGF-beta,":[265],"TNF-alpha":[268],"failed":[269],"Moreover,":[278],"neither":[279],"or":[282,319],"IL-12":[283],"relieved":[284],"suppression.":[286],"CONCLUSIONS:":[287],"through":[292,306],"cell-to-cell":[294],"contact,":[295],"prevent":[296],"proliferating":[300],"secreting":[302],"when":[304],"stimulated":[305],"mechanism":[313],"that":[314],"does":[315],"involve":[317],"apoptosis.":[320]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}