{"id":"https://openalex.org/W120187336","doi":null,"title":"Aromatase inhibitors and bone loss.","display_name":"Aromatase inhibitors and bone loss.","publication_year":2006,"publication_date":"2006-08-01","ids":{"openalex":"https://openalex.org/W120187336","mag":"120187336","pmid":"https://pubmed.ncbi.nlm.nih.gov/16986348","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2693896"},"language":"en","primary_location":{"id":"pmid:16986348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16986348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology (Williston Park, N.Y.)","raw_type":"Journal Article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2693896","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065306642","display_name":"Edith A. Perez","orcid":"https://orcid.org/0000-0002-5037-6677","observed_orcids":["https://orcid.org/0000-0002-5037-6677","https://orcid.org/0000-0001-7009-7467"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edith A Perez","raw_affiliation_strings":["Divison of Hematology/Oncology, Mayo Clinic, Jacksonville, Florida 32224, USA. perez.edith@mayo.edu","Divison of Hematology/Oncology, Mayo Clinic, Jacksonville, Florida 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divison of Hematology/Oncology, Mayo Clinic, Jacksonville, Florida 32224, USA. perez.edith@mayo.edu","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Divison of Hematology/Oncology, Mayo Clinic, Jacksonville, Florida 32224, USA","institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063285199","display_name":"Katherine N. Weilbaecher","orcid":"https://orcid.org/0000-0002-7137-4742","observed_orcids":["https://orcid.org/0000-0002-7137-4742"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katherine Weilbaecher","raw_affiliation_strings":["Medical Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4677,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.43041526,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"20","issue":"9","first_page":"1029","last_page":"39; discussion 1039"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.22669999301433563,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aromatase-inhibitors","display_name":"aromatase inhibitors","score":1.0},{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.9319999814033508},{"id":"https://openalex.org/keywords/anastrozole","display_name":"anastrozole","score":0.7799999713897705},{"id":"https://openalex.org/keywords/letrozole","display_name":"letrozole","score":1.0},{"id":"https://openalex.org/keywords/exemestane","display_name":"exemestane","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.9039999842643738},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.6710000038146973},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.5270000100135803},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.7599999904632568},{"id":"https://openalex.org/keywords/bone-mineral-density-monitoring","display_name":"bone mineral density monitoring","score":0.777999997138977},{"id":"https://openalex.org/keywords/osteonecrosis-of-the-jaw","display_name":"osteonecrosis of the jaw","score":0.9330000281333923},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.6869999766349792},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.5460000038146973},{"id":"https://openalex.org/keywords/calcium-and-vitamin-d-intake","display_name":"calcium and vitamin D intake","score":0.5989999771118164},{"id":"https://openalex.org/keywords/weight-bearing-exercise","display_name":"weight-bearing exercise","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9254580736160278},{"id":"https://openalex.org/C2775860665","wikidata":"https://www.wikidata.org/wiki/Q418819","display_name":"Exemestane","level":5,"score":0.7142168879508972},{"id":"https://openalex.org/C2776215463","wikidata":"https://www.wikidata.org/wiki/Q419143","display_name":"Anastrozole","level":5,"score":0.7046059370040894},{"id":"https://openalex.org/C2778812593","wikidata":"https://www.wikidata.org/wiki/Q194974","display_name":"Letrozole","level":5,"score":0.611736536026001},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5988919138908386},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.5933083295822144},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5598148703575134},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.5437116026878357},{"id":"https://openalex.org/C2776326535","wikidata":"https://www.wikidata.org/wiki/Q218507","display_name":"Zoledronic acid","level":2,"score":0.5413541197776794},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.49038147926330566},{"id":"https://openalex.org/C2777083390","wikidata":"https://www.wikidata.org/wiki/Q1367706","display_name":"Osteopenia","level":4,"score":0.4564294219017029},{"id":"https://openalex.org/C2776166826","wikidata":"https://www.wikidata.org/wiki/Q415287","display_name":"Aromatase","level":4,"score":0.45055440068244934},{"id":"https://openalex.org/C2777944059","wikidata":"https://www.wikidata.org/wiki/Q903917","display_name":"Selective estrogen receptor modulator","level":5,"score":0.44710877537727356},{"id":"https://openalex.org/C2777251235","wikidata":"https://www.wikidata.org/wiki/Q412205","display_name":"Bisphosphonate","level":3,"score":0.43986976146698},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4196700155735016},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3896583616733551},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.36517345905303955}],"mesh":[{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047072","descriptor_name":"Aromatase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:16986348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16986348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology (Williston Park, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2693896","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2693896","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Oncology (Williston Park)","raw_type":"Text"},{"id":"mag:120187336","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16986348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2693896","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2693896","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Oncology (Williston Park)","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000882434","display_name":"Retrovirus Models of Cancer","funder_award_id":"P01CA100730","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W200263122","https://openalex.org/W282464114","https://openalex.org/W370919183","https://openalex.org/W1531964529","https://openalex.org/W1761951195","https://openalex.org/W1800396987","https://openalex.org/W1928668153","https://openalex.org/W1971610058","https://openalex.org/W1980199268","https://openalex.org/W1981476886","https://openalex.org/W1997829755","https://openalex.org/W2011705265","https://openalex.org/W2013785685","https://openalex.org/W2017945794","https://openalex.org/W2022595441","https://openalex.org/W2024266959","https://openalex.org/W2048346627","https://openalex.org/W2067456063","https://openalex.org/W2069811152","https://openalex.org/W2070531118","https://openalex.org/W2074890088","https://openalex.org/W2096446019","https://openalex.org/W2100291515","https://openalex.org/W2101881391","https://openalex.org/W2102285316","https://openalex.org/W2107118598","https://openalex.org/W2114358979","https://openalex.org/W2115962082","https://openalex.org/W2121656289","https://openalex.org/W2127677509","https://openalex.org/W2128843508","https://openalex.org/W2137302084","https://openalex.org/W2138153565","https://openalex.org/W2141528524","https://openalex.org/W2141762477","https://openalex.org/W2141976681","https://openalex.org/W2142739119","https://openalex.org/W2151447010","https://openalex.org/W2159516503","https://openalex.org/W2160287478","https://openalex.org/W2161546266","https://openalex.org/W2162254379","https://openalex.org/W2163688875","https://openalex.org/W2164803063","https://openalex.org/W2168772783","https://openalex.org/W2245317228","https://openalex.org/W2275202492","https://openalex.org/W2423902634","https://openalex.org/W3172713090","https://openalex.org/W4243036122","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2943622393","https://openalex.org/W2931650913","https://openalex.org/W2077814106","https://openalex.org/W1976829674","https://openalex.org/W2001134948","https://openalex.org/W1986288974","https://openalex.org/W2528564885","https://openalex.org/W2006131871","https://openalex.org/W97567500","https://openalex.org/W2011667903"],"abstract_inverted_index":{"The":[0],"aromatase":[1],"inhibitors":[2,32],"(AIs)":[3],"anastrozole":[4],"(Arimidex),":[5],"letrozole":[6],"(Femara),":[7],"and":[8,54,63,76,101,126,146,152,168],"exemestane":[9],"(Aromasin)":[10],"are":[11,33,47],"significantly":[12,50],"more":[13,51],"effective":[14],"than":[15],"the":[16,171,180,188],"selective":[17],"estrogen-receptor":[18],"modulator":[19],"(SERM)":[20],"tamoxifen":[21],"in":[22,25,82,195],"preventing":[23,83],"recurrence":[24],"estrogen":[26],"receptor-positive":[27,200],"early":[28],"breast":[29,201],"cancer.":[30,202],"Aromatase":[31],"likely":[34],"to":[35,184],"replace":[36],"SERMs":[37],"as":[38,67],"first-line":[39],"adjuvant":[40],"therapy":[41,114],"for":[42,107,118,132],"many":[43],"patients.":[44],"However,":[45],"AIs":[46],"associated":[48,160],"with":[49,120,134,161,179,197],"osteoporotic":[52],"fractures":[53],"greater":[55],"bone":[56,88,104,193],"mineral":[57],"loss.":[58],"As":[59],"antiresorptive":[60],"agents,":[61],"oral":[62],"intravenous":[64],"bisphosphonates":[65,162,183],"such":[66],"alendronate":[68],"(Fosamax),":[69],"risedronate":[70],"(Actonel),":[71],"ibandronate":[72],"(Boniva),":[73],"pamidronate":[74],"(Aredia),":[75],"zoledronic":[77],"acid":[78],"(Zometa)":[79],"have":[80],"efficacy":[81],"postmenopausal":[84],"osteoporosis,":[85],"cancer":[86],"treatment-related":[87],"loss,":[89],"or":[90,186],"skeletal":[91],"complications":[92],"of":[93,170,182,191],"metastatic":[94],"disease.":[95],"Clinical":[96],"practice":[97],"guidelines":[98],"recommend":[99],"baseline":[100],"annual":[102],"follow-up":[103],"density":[105],"monitoring":[106],"all":[108],"patients":[109,119,196],"initiating":[110],"AI":[111],"therapy.":[112],"Bisphosphonate":[113],"should":[115,155,176],"be":[116,156,177],"prescribed":[117],"osteoporosis":[121],"(T":[122,136],"score":[123,137],"<":[124,138],"-2.5)":[125],"considered":[127],"on":[128],"an":[129],"individual":[130],"basis":[131],"those":[133],"osteopenia":[135],"-1).":[139],"Modifiable":[140],"lifestyle":[141],"behaviors":[142],"including":[143],"adequate":[144],"calcium":[145],"vitamin":[147],"D":[148],"intake,":[149],"weight-bearing":[150],"exercise,":[151],"smoking":[153],"cessation":[154],"addressed.":[157],"Adverse":[158],"events":[159],"include":[163],"gastrointestinal":[164],"toxicity,":[165,167],"renal":[166],"osteonecrosis":[169],"jaw.":[172],"These":[173],"safety":[174],"concerns":[175],"balanced":[178],"potential":[181],"minimize":[185],"prevent":[187],"debilitating":[189],"effects":[190],"AI-associated":[192],"loss":[194],"early,":[198],"hormone":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
