{"id":"https://openalex.org/W120172290","doi":null,"title":"Theory of oxygen transport to tissue.","display_name":"Theory of oxygen transport to tissue.","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W120172290","mag":"120172290","pmid":"https://pubmed.ncbi.nlm.nih.gov/2673661","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5445261"},"language":"en","primary_location":{"id":"pmid:2673661","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2673661","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical reviews in biomedical engineering","raw_type":"Journal Article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5445261","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030268482","display_name":"Aleksander S. Popel","orcid":"https://orcid.org/0000-0002-6706-9235","observed_orcids":["https://orcid.org/0000-0002-6706-9235"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A S Popel","raw_affiliation_strings":["Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030268482"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":0.8751,"has_fulltext":false,"cited_by_count":398,"citation_normalized_percentile":{"value":0.64444444,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"17","issue":"3","first_page":"257","last_page":"321"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.6439999938011169,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.6439999938011169,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.18150000274181366,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12930","display_name":"Biomedical and Chemical Research","score":0.031199999153614044,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxygen-transport","display_name":"oxygen transport","score":0.7979999780654907},{"id":"https://openalex.org/keywords/tissue-oxygenation","display_name":"tissue oxygenation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/myoglobin","display_name":"myoglobin","score":0.9760000109672546},{"id":"https://openalex.org/keywords/oxygen-diffusion","display_name":"oxygen diffusion","score":0.8790000081062317},{"id":"https://openalex.org/keywords/microcirculation","display_name":"microcirculation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mathematical-modeling-of-transport","display_name":"mathematical modeling of transport","score":0.7979999780654907},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.722000002861023},{"id":"https://openalex.org/keywords/myocardium","display_name":"myocardium","score":0.9980000257492065},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.7590000033378601},{"id":"https://openalex.org/keywords/lung","display_name":"lung","score":0.7979999780654907},{"id":"https://openalex.org/keywords/arterial-wall","display_name":"arterial wall","score":0.9470000267028809},{"id":"https://openalex.org/keywords/skin","display_name":"skin","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2993864201","wikidata":"https://www.wikidata.org/wiki/Q7873","display_name":"Oxygen transport","level":3,"score":0.9171538352966309},{"id":"https://openalex.org/C2778063876","wikidata":"https://www.wikidata.org/wiki/Q192642","display_name":"Myoglobin","level":2,"score":0.585864245891571},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.5809200406074524},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.5592667460441589},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.48112502694129944},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4380342960357666},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41865211725234985},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.184024840593338},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16406407952308655},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11468356847763062},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08810359239578247},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010108","descriptor_name":"Oxyhemoglobins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:2673661","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2673661","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical reviews in biomedical engineering","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4294358","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5445261","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5445261","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5445261","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Crit Rev Biomed Eng","raw_type":"Text"},{"id":"mag:120172290","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2673661","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4294358","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5445261","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3837110135","display_name":"Vasodilation and Microvascular Oxygen Delivery","funder_award_id":"R01HL018292","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":144,"referenced_works":["https://openalex.org/W1260666","https://openalex.org/W14867385","https://openalex.org/W38903962","https://openalex.org/W85962344","https://openalex.org/W89897400","https://openalex.org/W104783132","https://openalex.org/W112013403","https://openalex.org/W128961369","https://openalex.org/W131716305","https://openalex.org/W133860762","https://openalex.org/W136394285","https://openalex.org/W163139424","https://openalex.org/W203419246","https://openalex.org/W212888942","https://openalex.org/W241462982","https://openalex.org/W368526666","https://openalex.org/W1124761425","https://openalex.org/W1484011380","https://openalex.org/W1583677937","https://openalex.org/W1584104642","https://openalex.org/W1595402887","https://openalex.org/W1627902834","https://openalex.org/W1813652805","https://openalex.org/W1829342226","https://openalex.org/W1917321184","https://openalex.org/W1926324519","https://openalex.org/W1940605585","https://openalex.org/W1943289761","https://openalex.org/W1947047050","https://openalex.org/W1952336491","https://openalex.org/W1967390649","https://openalex.org/W1968823332","https://openalex.org/W1968906874","https://openalex.org/W1972219186","https://openalex.org/W1973280552","https://openalex.org/W1973797471","https://openalex.org/W1973994564","https://openalex.org/W1975496510","https://openalex.org/W1975964177","https://openalex.org/W1976962747","https://openalex.org/W1981306473","https://openalex.org/W1983971792","https://openalex.org/W1984742768","https://openalex.org/W1984917715","https://openalex.org/W1985442302","https://openalex.org/W1985446716","https://openalex.org/W1986303864","https://openalex.org/W1987023996","https://openalex.org/W1994684661","https://openalex.org/W1996740809","https://openalex.org/W1997177813","https://openalex.org/W1997384911","https://openalex.org/W1998728429","https://openalex.org/W2000788497","https://openalex.org/W2004450705","https://openalex.org/W2010450451","https://openalex.org/W2017233274","https://openalex.org/W2018623863","https://openalex.org/W2019736823","https://openalex.org/W2020012274","https://openalex.org/W2020466978","https://openalex.org/W2025081061","https://openalex.org/W2027254911","https://openalex.org/W2028199953","https://openalex.org/W2029578063","https://openalex.org/W2031208694","https://openalex.org/W2032372882","https://openalex.org/W2035546874","https://openalex.org/W2035838913","https://openalex.org/W2035933065","https://openalex.org/W2036433498","https://openalex.org/W2036451182","https://openalex.org/W2036959098","https://openalex.org/W2044171475","https://openalex.org/W2044564622","https://openalex.org/W2044878618","https://openalex.org/W2045552833","https://openalex.org/W2046357529","https://openalex.org/W2047889513","https://openalex.org/W2051477392","https://openalex.org/W2054669438","https://openalex.org/W2054998144","https://openalex.org/W2055255996","https://openalex.org/W2059209225","https://openalex.org/W2061185721","https://openalex.org/W2064934284","https://openalex.org/W2070781747","https://openalex.org/W2073078410","https://openalex.org/W2073151588","https://openalex.org/W2073168836","https://openalex.org/W2073286142","https://openalex.org/W2073480258","https://openalex.org/W2074397266","https://openalex.org/W2074540389","https://openalex.org/W2074923305","https://openalex.org/W2075717750","https://openalex.org/W2075848651","https://openalex.org/W2080795393","https://openalex.org/W2082319927","https://openalex.org/W2085894909","https://openalex.org/W2086824983","https://openalex.org/W2087146005","https://openalex.org/W2087270150","https://openalex.org/W2087968036","https://openalex.org/W2088173043","https://openalex.org/W2089959358","https://openalex.org/W2090944509","https://openalex.org/W2091577918","https://openalex.org/W2092349134","https://openalex.org/W2093812190","https://openalex.org/W2109393326","https://openalex.org/W2116111563","https://openalex.org/W2121767253","https://openalex.org/W2142147155","https://openalex.org/W2145644019","https://openalex.org/W2154722293","https://openalex.org/W2163351183","https://openalex.org/W2165441269","https://openalex.org/W2171279917","https://openalex.org/W2178591638","https://openalex.org/W2187048048","https://openalex.org/W2204503696","https://openalex.org/W2243882389","https://openalex.org/W2271010007","https://openalex.org/W2297488431","https://openalex.org/W2319620325","https://openalex.org/W2392667922","https://openalex.org/W2399760255","https://openalex.org/W2407658865","https://openalex.org/W2407818708","https://openalex.org/W2408900401","https://openalex.org/W2411454590","https://openalex.org/W2413488065","https://openalex.org/W2415440605","https://openalex.org/W2416196676","https://openalex.org/W2416719427","https://openalex.org/W2417831466","https://openalex.org/W2438942568","https://openalex.org/W2461826906","https://openalex.org/W2569906198","https://openalex.org/W2908980855","https://openalex.org/W3021179073","https://openalex.org/W4241474540","https://openalex.org/W4289960280"],"related_works":["https://openalex.org/W2202385063","https://openalex.org/W2089561718","https://openalex.org/W145323371","https://openalex.org/W2170032299","https://openalex.org/W1977195337","https://openalex.org/W2115146410","https://openalex.org/W142433918","https://openalex.org/W98967536","https://openalex.org/W2115395038","https://openalex.org/W2436209984"],"abstract_inverted_index":{"This":[0],"review":[1,106],"focuses":[2],"on":[3],"the":[4,13,16,27,41,52,63,74,80,85,87,93,97,105,115,122,162],"theory":[5],"of":[6,15,21,38,43,54,73,76,92,117,126,161,164],"oxygen":[7,49,60,77,130,165],"transport":[8,22,61,131,166],"to":[9,109,136],"tissue":[10],"and":[11,32,45,51,56,96,99,128,139,151,155],"presents":[12],"state":[14],"art":[17],"in":[18,35,47,59,62,104,121,158],"mathematical":[19,36],"modeling":[20,37],"phenomena.":[23],"Results":[24],"obtained":[25],"with":[26],"classic":[28],"Krogh":[29],"tissue-cylinder":[30],"model":[31],"recent":[33],"advances":[34],"hemoglobin-oxygen":[39],"kinetics,":[40],"role":[42,53],"hemoglobin":[44],"myoglobin":[46],"facilitating":[48],"diffusion,":[50],"morphologic":[55],"hemodynamic":[57],"heterogeneities":[58],"microcirculation":[64],"are":[65,132,141,167],"critically":[66],"discussed.":[67,134],"Mathematical":[68],"models":[69],"simulate":[70],"different":[71],"parts":[72],"pathway":[75],"molecules":[78],"from":[79],"red":[81],"blood":[82],"cell,":[83,89],"through":[84],"plasma,":[86],"endothelial":[88],"other":[90],"elements":[91],"vascular":[94],"wall,":[95,150],"extra-":[98],"intracellular":[100],"space.":[101],"Special":[102],"attention":[103],"is":[107],"devoted":[108],"intracapillary":[110],"transport,":[111],"which":[112],"has":[113],"been":[114],"subject":[116],"intensive":[118],"theoretical":[119],"research":[120],"last":[123],"decade.":[124],"Models":[125],"pre-":[127],"postcapillary":[129],"also":[133],"Applications":[135],"specific":[137],"organs":[138],"tissues":[140],"reviewed,":[142],"including":[143],"skeletal":[144],"muscle,":[145],"myocardium,":[146],"brain,":[147],"lungs,":[148],"arterial":[149],"skin.":[152],"Unresolved":[153],"problems":[154],"major":[156],"gaps":[157],"our":[159],"knowledge":[160],"mechanisms":[163],"identified.":[168]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
