{"id":"https://openalex.org/W120152232","doi":null,"title":"Selective bipotential differentiation of mouse embryonic hepatoblasts in vitro.","display_name":"Selective bipotential differentiation of mouse embryonic hepatoblasts in vitro.","publication_year":1997,"publication_date":"1997-02-01","ids":{"openalex":"https://openalex.org/W120152232","mag":"120152232","pmid":"https://pubmed.ncbi.nlm.nih.gov/9033273","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1858272"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1544337","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1858272","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1858272","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080323516","display_name":"Leslie E. Rogler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"L E Rogler","raw_affiliation_strings":["Marion Bession Liver Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marion Bession Liver Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5080323516"],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":null,"apc_paid":null,"fwci":2.5599,"has_fulltext":false,"cited_by_count":117,"citation_normalized_percentile":{"value":0.88550323,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"150","issue":"2","first_page":"591","last_page":"602"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatoblasts","display_name":"hepatoblasts","score":0.9350000023841858},{"id":"https://openalex.org/keywords/hepatocyte-differentiation","display_name":"hepatocyte differentiation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.9279999732971191},{"id":"https://openalex.org/keywords/keratin-14","display_name":"keratin 14","score":0.9259999990463257},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.7229999899864197},{"id":"https://openalex.org/keywords/glucose-6-phosphatase","display_name":"glucose-6-phosphatase","score":0.9129999876022339},{"id":"https://openalex.org/keywords/dimethyl-sulfoxide","display_name":"dimethyl sulfoxide","score":0.9599999785423279},{"id":"https://openalex.org/keywords/sodium-butyrate","display_name":"sodium butyrate","score":0.9950000047683716},{"id":"https://openalex.org/keywords/matrigel","display_name":"Matrigel","score":0.7689999938011169},{"id":"https://openalex.org/keywords/gamma-glutamyl-transferase","display_name":"gamma-glutamyl transferase","score":0.9020000100135803},{"id":"https://openalex.org/keywords/ck19","display_name":"CK19","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8680219650268555},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5425652861595154},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.53718101978302},{"id":"https://openalex.org/C2777164004","wikidata":"https://www.wikidata.org/wiki/Q331858","display_name":"Endoderm","level":4,"score":0.4868883192539215},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4444969594478607},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.4275500774383545},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4112212359905243},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.4109208583831787},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39726001024246216},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3643017113208771},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32544538378715515},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2710813283920288},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1708342730998993},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000509","descriptor_name":"alpha-Fetoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002087","descriptor_name":"Butyrates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004121","descriptor_name":"Dimethyl Sulfoxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005723","descriptor_name":"gamma-Glutamyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019084","descriptor_name":"Fluorescent Antibody Technique, Indirect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020148","descriptor_name":"Butyric Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:1544337","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1858272","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1858272","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1858272","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:9033273","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9033273","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:120152232","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9033273","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1544337","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1858272","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1870224986","display_name":"Liver Pathobiology and Gene Therapy Research Core Center","funder_award_id":"P30DK041296","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W143089095","https://openalex.org/W636264593","https://openalex.org/W1516012212","https://openalex.org/W1525130584","https://openalex.org/W1548038310","https://openalex.org/W1558031393","https://openalex.org/W1583618104","https://openalex.org/W1592395715","https://openalex.org/W1963507142","https://openalex.org/W1973657908","https://openalex.org/W1980544949","https://openalex.org/W1987068586","https://openalex.org/W1997100869","https://openalex.org/W2022051395","https://openalex.org/W2031521660","https://openalex.org/W2033705027","https://openalex.org/W2045899482","https://openalex.org/W2052357818","https://openalex.org/W2052497886","https://openalex.org/W2058099287","https://openalex.org/W2068764558","https://openalex.org/W2072891772","https://openalex.org/W2079263067","https://openalex.org/W2081178187","https://openalex.org/W2082539950","https://openalex.org/W2091345117","https://openalex.org/W2104428993","https://openalex.org/W2107270084","https://openalex.org/W2126246844","https://openalex.org/W2160818570","https://openalex.org/W2261330103","https://openalex.org/W2277261569","https://openalex.org/W2332521194","https://openalex.org/W2411082774","https://openalex.org/W2414175657"],"related_works":["https://openalex.org/W2039261165","https://openalex.org/W2099755414","https://openalex.org/W1975002361","https://openalex.org/W7111521640","https://openalex.org/W2365202407","https://openalex.org/W2560618330","https://openalex.org/W122380073","https://openalex.org/W2185260930","https://openalex.org/W2108029914","https://openalex.org/W1967942954"],"abstract_inverted_index":{"A":[0],"line":[1,8],"of":[2,17,23,41,166],"hepatic":[3],"endoderm":[4],"cells,":[5],"hepatoblast":[6,37,81],"cell":[7],"3":[9,101],"(HBC-3),":[10],"was":[11],"derived":[12],"from":[13],"the":[14,18,70,139,175,201],"liver":[15,72],"diverticulum":[16],"mouse":[19],"on":[20,27],"day":[21],"9.5":[22],"gestation":[24],"by":[25,69],"culture":[26,38,99,184],"a":[28,36,112,168,190],"mitomycin":[29],"C":[30],"treated":[31],"STON+":[32],"feeder":[33],"layer":[34],"in":[35,98,183,200],"medium":[39],"consisting":[40],"Dulbecco's":[42],"modified":[43],"Eagle's":[44],"medium,":[45],"nonessential":[46],"amino":[47],"acids,":[48],"fetal":[49],"calf":[50],"serum,":[51],"and":[52,62,93,122,127,156,158,160,188],"beta-mercaptoethanol.":[53],"This":[54],"line,":[55],"HBC-3,":[56],"stains":[57],"positively":[58],"for":[59,100,130,153],"alpha-fetoprotein,":[60],"albumin,":[61,167],"cytokeratin":[63],"14":[64],"(CK-14),":[65],"protein":[66],"markers":[67],"expressed":[68],"embryonic":[71],"diverticulum,":[73],"indicating":[74],"that":[75,196],"HBC-3":[76,83,144,180],"cells":[77,84,117,145,181],"retain":[78],"an":[79],"undifferentiated":[80],"phenotype.":[82],"acquire":[85],"hepatocyte-like":[86],"ultrastructural":[87],"characteristics,":[88],"including":[89],"bile":[90,176],"canaliculi,":[91],"peroxisomes,":[92],"glycogen":[94],"granules,":[95],"when":[96],"maintained":[97],"weeks":[102],"without":[103],"passage.":[104],"Treatment":[105],"with":[106,136,172],"dimethylsulfoxide":[107],"or":[108],"sodium":[109],"butyrate":[110],"induces":[111],"rapid":[113],"hepatocytic":[114],"differentiation.":[115],"The":[116],"cease":[118],"to":[119,193],"express":[120,163],"alpha-fetoprotein":[121],"CK-14,":[123],"maintain":[124],"albumin":[125],"expression,":[126],"become":[128],"positive":[129,152],"glucose-6-phosphatase":[131],"activity":[132],"(a":[133],"profile":[134],"consistent":[135,171],"differentiation":[137,173,199],"along":[138,174],"hepatocyte":[140],"lineage).":[141],"On":[142],"Matrigel,":[143],"form":[146],"elaborate":[147],"ductular":[148,177],"structures,":[149],"which":[150],"are":[151],"gamma-glutamyl":[154],"transpeptidase":[155],"CK-14":[157],"CK-19":[159],"do":[161],"not":[162],"detectable":[164],"amounts":[165],"phenotypic":[169],"change":[170],"lineage.":[178],"Thus,":[179],"behave":[182],"as":[185],"bipotential":[186,198],"hepatoblasts":[187],"provide":[189],"model":[191],"system":[192],"identify":[194],"factors":[195],"regulate":[197],"liver.":[202]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}