{"id":"https://openalex.org/W120099093","doi":null,"title":"Effect of long-term treatment with antiepileptic drugs on the vitamin status.","display_name":"Effect of long-term treatment with antiepileptic drugs on the vitamin status.","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W120099093","mag":"120099093","pmid":"https://pubmed.ncbi.nlm.nih.gov/3240713"},"language":"en","primary_location":{"id":"pmid:3240713","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3240713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug-nutrient interactions","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044266720","display_name":"Klaus\u2010Henning Krause","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K H Krause","raw_affiliation_strings":["Neurolog, Univ.-Klinik, Heidelberg, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurolog, Univ.-Klinik, Heidelberg, Federal Republic of Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110046620","display_name":"J.\u2010P. Bonjour","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J P Bonjour","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009245206","display_name":"Peter Berlit","orcid":"https://orcid.org/0000-0002-9544-7256","observed_orcids":["https://orcid.org/0000-0002-9544-7256"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Berlit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049661871","display_name":"Gisela Kynast","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Kynast","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111674823","display_name":"H. Schmidt-Gayk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Schmidt-Gayk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111481843","display_name":"Bernhard Schellenberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Schellenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.603,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.6438909,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"5","issue":"4","first_page":"317","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.5863999724388123,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.5863999724388123,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.3467000126838684,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.027799999341368675,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.9710000157356262},{"id":"https://openalex.org/keywords/vitamin-status","display_name":"vitamin status","score":0.9350000023841858},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.9520000219345093},{"id":"https://openalex.org/keywords/b-vitamins","display_name":"B vitamins","score":0.6510000228881836},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.9679999947547913},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.7210000157356262},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.7820000052452087},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.8450000286102295},{"id":"https://openalex.org/keywords/beta-carotene","display_name":"beta-carotene","score":0.9049999713897705},{"id":"https://openalex.org/keywords/biotin","display_name":"biotin","score":0.9779999852180481},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.753000020980835},{"id":"https://openalex.org/keywords/enzyme-inducing-drugs","display_name":"enzyme-inducing drugs","score":0.9039999842643738},{"id":"https://openalex.org/keywords/macrocytic-anemia","display_name":"macrocytic anemia","score":0.796999990940094},{"id":"https://openalex.org/keywords/gingival-overgrowth","display_name":"gingival hyperplasia","score":0.9470000267028809},{"id":"https://openalex.org/keywords/bone-mineral-content","display_name":"bone mineral content","score":0.6990000009536743},{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d3","display_name":"25-hydroxyvitamin D3","score":0.9070000052452087},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6790000200271606},{"id":"https://openalex.org/keywords/immune-status","display_name":"immune status","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.6511447429656982},{"id":"https://openalex.org/C2776155809","wikidata":"https://www.wikidata.org/wiki/Q130365","display_name":"Riboflavin","level":2,"score":0.5834328532218933},{"id":"https://openalex.org/C2779750884","wikidata":"https://www.wikidata.org/wiki/Q187706","display_name":"Vitamin B12","level":2,"score":0.5518056154251099},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5300172567367554},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5212074518203735},{"id":"https://openalex.org/C3020471959","wikidata":"https://www.wikidata.org/wiki/Q183206","display_name":"B vitamins","level":2,"score":0.4966962933540344},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48891058564186096},{"id":"https://openalex.org/C2780676250","wikidata":"https://www.wikidata.org/wiki/Q187706","display_name":"Cobalamin","level":3,"score":0.4790978729724884},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.47756844758987427},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4711408019065857},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.46207430958747864},{"id":"https://openalex.org/C2778204606","wikidata":"https://www.wikidata.org/wiki/Q181354","display_name":"Biotin","level":2,"score":0.4532434344291687},{"id":"https://openalex.org/C2777550742","wikidata":"https://www.wikidata.org/wiki/Q2070695","display_name":"Macrocytic anemia","level":3,"score":0.4481661021709442},{"id":"https://openalex.org/C2776203871","wikidata":"https://www.wikidata.org/wiki/Q83187","display_name":"Thiamine","level":2,"score":0.41597577929496765},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4146423637866974},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.41216689348220825},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.266221821308136},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18368154764175415},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001361","descriptor_name":"Avitaminosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014815","descriptor_name":"Vitamins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:3240713","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3240713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug-nutrient interactions","raw_type":"Journal Article"},{"id":"mag:120099093","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3240713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1715745850","https://openalex.org/W3118787320","https://openalex.org/W1991305175","https://openalex.org/W3129333073","https://openalex.org/W3010790070","https://openalex.org/W2442740109","https://openalex.org/W2076795343","https://openalex.org/W2507701231","https://openalex.org/W2015478749","https://openalex.org/W1988931516"],"abstract_inverted_index":{"The":[0,79,254],"status":[1,206],"of":[2,17,25,33,45,54,64,69,81,92,96,102,118,124,162,180,183,201,219,243,245,252,256],"vitamins":[3,46,106,120,161],"A,":[4],"B1,":[5,107],"B2,":[6,47,108],"B6,":[7,57,109],"B12,":[8,58],"C,":[9,110,221,271],"D,":[10,111,249,272],"and":[11,20,38,50,59,61,71,86,94,115,150,153,158,186,207,210,213,250,266],"E":[12,73],"as":[13,15,121,123,222,224],"well":[14,122,223],"that":[16,32],"beta-carotene,":[18,113],"biotin,":[19,48,114,265],"folate":[21,125,274],"in":[22,74,129,137,178],"the":[23,52,62,155,159,163,181,184,187],"blood":[24],"over":[26],"500":[27],"epileptics":[28,40,76],"was":[29,143],"compared":[30],"with":[31,133,175,215,226,240],"a":[34,42,99,192,216,231],"normal":[35],"population.":[36],"Male":[37],"female":[39,75],"showed":[41,230],"poorer":[43,176,217],"supply":[44,218],"folate,":[49,244],"25-hydroxycholecalciferol;":[51],"males,":[53],"only":[55,65],"vitamin":[56,66,72,84,208,220,246,270],"E,":[60,112],"women,":[63],"A.":[67],"Concentrations":[68,117],"beta-carotene":[70],"were":[77,126,199,238],"higher.":[78],"evaluation":[80],"relations":[82],"between":[83,146,154,204],"concentrations":[85,242],"mean":[87],"daily":[88],"dose,":[89],"total":[90],"dose":[91],"anticonvulsants,":[93],"duration":[95],"therapy":[97],"suggested":[98],"possible":[100],"influence":[101,170],"anticonvulsant":[103],"medication":[104],"on":[105,171],"folate.":[116],"B":[119,164],"distinctly":[127],"lower":[128,195,227,241],"patients":[130],"under":[131,139],"monotherapy":[132],"enzyme-inducing":[134],"drugs":[135],"than":[136],"those":[138],"valproate":[140],"sodium.":[141],"There":[142,198],"no":[144,169],"relationship":[145],"bone":[147],"mineral":[148],"content":[149],"25-hydroxycholecalciferol":[151],"levels":[152],"neurographic":[156],"parameters":[157],"neurotropic":[160],"group,":[165],"which":[166],"also":[167,268],"had":[168],"concentration":[172],"performance.":[173],"Patients":[174],"results":[177],"tests":[179],"function":[182],"central":[185],"peripheral":[188],"nervous":[189],"system":[190],"displayed":[191],"tendency":[193,232],"towards":[194,233],"vitamin-C":[196],"levels.":[197],"indications":[200],"potential":[202],"links":[203],"immunological":[205],"B6":[209],"biotin.":[211,253],"Males":[212],"females":[214],"males":[225],"riboflavin":[228],"levels,":[229],"macrocytic":[234],"anaemia.":[235],"Cerebellar":[236],"disturbances":[237],"associated":[239],"C":[247],"or":[248,273],"possibly":[251,267],"incidence":[255],"gingival":[257],"hyperplasia":[258],"could":[259],"be":[260],"linked":[261],"to":[262,264,269],"riboflavin,":[263],"status.":[275]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}