{"id":"https://openalex.org/W120050863","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.8521","title":"A Phase I Study of Gefitinib and irinotecan (IRN) in pediatric patients with refractory solid tumors","display_name":"A Phase I Study of Gefitinib and irinotecan (IRN) in pediatric patients with refractory solid tumors","publication_year":2004,"publication_date":"2004-07-15","ids":{"openalex":"https://openalex.org/W120050863","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.8521","mag":"120050863"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2004.22.14_suppl.8521","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.8521","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.14_suppl.8521","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034374604","display_name":"Wayne Lee Furman","orcid":"https://orcid.org/0000-0001-7352-3556","observed_orcids":["https://orcid.org/0000-0001-7352-3556"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. L. Furman","raw_affiliation_strings":["St Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090167515","display_name":"Najat C. Daw","orcid":"https://orcid.org/0000-0002-6941-8005","observed_orcids":["https://orcid.org/0000-0002-6941-8005"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. C. Daw","raw_affiliation_strings":["St Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085620590","display_name":"Kristine R. Crews","orcid":"https://orcid.org/0000-0002-7558-558X","observed_orcids":["https://orcid.org/0000-0002-7558-558X"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. R. Crews","raw_affiliation_strings":["St Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043293908","display_name":"Clinton F. Stewart","orcid":"https://orcid.org/0000-0002-1546-9720","observed_orcids":["https://orcid.org/0000-0002-1546-9720"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. F. Stewart","raw_affiliation_strings":["St Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027333697","display_name":"Beth M. McCarville","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. McCarville","raw_affiliation_strings":["St Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113716990","display_name":"Victor M. Santana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. M. Santana","raw_affiliation_strings":["St Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073649942","display_name":"Dana Hawkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Hawkins","raw_affiliation_strings":["St Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053318111","display_name":"Carlos Rodriguez Galindo","orcid":"https://orcid.org/0000-0002-2360-8946","observed_orcids":["https://orcid.org/0000-0002-2360-8946"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Rodriguez-Galindo","raw_affiliation_strings":["St Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045180889","display_name":"Fariba Navid","orcid":"https://orcid.org/0000-0002-7916-6382","observed_orcids":["https://orcid.org/0000-0002-7916-6382"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Navid","raw_affiliation_strings":["St Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109173471","display_name":"Peter J. Houghton","orcid":"https://orcid.org/0000-0002-2400-8184","observed_orcids":["https://orcid.org/0000-0002-2400-8184"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. J. Houghton","raw_affiliation_strings":["St Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1313298211"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"14_suppl","first_page":"8521","last_page":"8521"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.8359000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.8359000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":0.9959999918937683},{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":1.0},{"id":"https://openalex.org/keywords/pediatric-solid-tumors","display_name":"pediatric solid tumors","score":0.8259999752044678},{"id":"https://openalex.org/keywords/refractory-cancer","display_name":"refractory cancer","score":0.7749999761581421},{"id":"https://openalex.org/keywords/egfr-inhibitors","display_name":"EGFR inhibitors","score":0.8119999766349792},{"id":"https://openalex.org/keywords/bcrp-inhibition","display_name":"BCRP inhibition","score":0.9449999928474426},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.8320000171661377},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7710000276565552},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.8700000047683716},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.9459999799728394},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.7390000224113464},{"id":"https://openalex.org/keywords/ewing-sarcoma","display_name":"Ewing sarcoma","score":0.8809999823570251},{"id":"https://openalex.org/keywords/anaplastic-wilms-tumor","display_name":"anaplastic Wilms tumor","score":0.9520000219345093},{"id":"https://openalex.org/keywords/adrenocortical-carcinoma","display_name":"adrenocortical carcinoma","score":0.9259999990463257},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":1.0},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.4790000021457672},{"id":"https://openalex.org/keywords/drug-clearance","display_name":"drug clearance","score":0.5370000004768372},{"id":"https://openalex.org/keywords/phase-i","display_name":"phase I","score":0.375}],"concepts":[{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.9505860805511475},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8681131601333618},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.52254718542099},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.5214216709136963},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4929976165294647},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.4835226535797119},{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.4796460270881653},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.4597736597061157},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4432351291179657},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.43858981132507324},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.41333723068237305},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36314719915390015},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3552841544151306},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25989407300949097},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.08718493580818176},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.2004.22.14_suppl.8521","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.8521","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.14_suppl.8521","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"doi:10.1200/jco.2004.22.90140.8521","doi":"https://doi.org/10.1200/jco.2004.22.90140.8521","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.90140.8521","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2087430060","https://openalex.org/W2595685509","https://openalex.org/W2154935592","https://openalex.org/W658475228","https://openalex.org/W2256118092","https://openalex.org/W2605112763","https://openalex.org/W2137006197","https://openalex.org/W2163729303","https://openalex.org/W2281160660","https://openalex.org/W2975663139"],"abstract_inverted_index":{"8521":[0],"Background:":[1],"Gefitinib":[2],"(Iressa),":[3],"an":[4],"oral":[5],"Epidermal":[6],"Growth":[7],"Factor":[8],"receptor":[9],"(EGFR)":[10],"inhibitor":[11],"that":[12],"has":[13,38,280],"been":[14,144],"well":[15],"tolerated":[16,73,325],"in":[17,59,86,130,174,258,318,340],"adults,":[18],"modulates":[19],"intracellular":[20],"drug":[21],"effects":[22],"through":[23],"inhibition":[24],"of":[25,33,46,56,79,102,115,133,205,214,286,289,305,316,332],"efflux":[26],"pumps":[27],"(e.g.,":[28],"BCRP).":[29],"In":[30,177],"xenograft":[31],"models":[32],"pediatric":[34],"solid":[35,63,344],"tumors":[36],"it":[37],"additive/synergistic":[39],"activity":[40],"with":[41,61,88,108,225,243,251,266,278,320,342],"IRN,":[42],"which":[43],"was":[44,172,184,208,223],"independent":[45],"EGFR":[47],"status.":[48],"We":[49],"are":[50,68,125],"conducting":[51],"a":[52,247,256,313],"Phase":[53],"I":[54],"study":[55,293,339],"this":[57],"combination":[58,87,319,336],"children":[60,341],"refractory":[62,343],"tumors.":[64,345],"Methods:":[65],"Our":[66,310],"objectives":[67],"to":[69,186,297],"estimate":[70],"the":[71,131,215,236,292,301,329],"maximum":[72],"dose":[74],"and":[75,104,109,122,165,276,326],"dose-limiting":[76],"toxicities":[77],"(DLT)":[78],"gefitinib":[80,116,161,183,221,233,299,317],"administered":[81],"daily":[82,160],"\u00d7":[83],"21":[84,128,217],"days":[85,120,129,304],"protracted":[89],"intravenous":[90],"IRN":[91,103,166,227,321],"[day":[92],"1-":[93],"5,":[94],"day":[95,210,218],"8":[96],"-":[97],"12].":[98],"Pharmacokinetic":[99],"(PK)":[100],"studies":[101,114],"metabolites":[105],"were":[106,117,190],"obtained":[107,118],"without":[110],"concurrent":[111],"gefitinib.":[112],"PK":[113],"on":[119,209],"\u20131":[121],"8.":[123],"Courses":[124],"repeated":[126],"every":[127],"absence":[132],"DLT":[134],"or":[135,212,349,352],"disease":[136,271],"progression.":[137],"Results:":[138],"At":[139],"present,":[140],"2":[141,175,179,193],"cohorts":[142],"have":[143],"evaluated":[145],"(age":[146],"3":[147],"\u201315":[148],"yrs,":[149],"median":[150],"5":[151],"yrs).":[152],"Cohort":[153],"1":[154,199],"(n":[155,180],"=":[156,181],"5)":[157],"received":[158],"continuous":[159],"at":[162,167],"150":[163],"mg/m2/d":[164],"15":[168],"mg/m2/d.":[169],"Dose-limiting":[170],"diarrhea":[171],"seen":[173],"patients.":[176],"cohort":[178],"3),":[182],"de-escalated":[185],"112.5":[187],"mg/m2/d;":[188],"DLTs":[189,207],"experienced":[191],"by":[192],"patients":[194],"(1":[195],"grade":[196,200],"4":[197,201,274],"anorexia,":[198],"transaminitis).":[202],"The":[203],"onset":[204,288],"all":[206],"10":[211],"greater":[213],"first":[216,302],"course.":[219],"Concomitant":[220],"administration":[222],"associated":[224],"decreased":[226],"lactone":[228],"systemic":[229],"clearance":[230],"(P<0.05).":[231],"Steady-state":[232],"concentrations":[234],"approximates":[235],"IC50":[237],"for":[238,273,282,300],"BCRP":[239],"inhibition.":[240],"One":[241],"patient":[242],"Ewing":[244],"sarcoma":[245],"had":[246,255,269],"partial":[248],"response,":[249],"one":[250,265,277],"anaplastic":[252],"Wilms":[253],"tumor":[254],"decrease":[257],"multiple":[259],"(<1":[260],"cm":[261],"each)":[262],"pulmonary":[263],"nodules,":[264],"adrenocortical":[267],"carcinoma":[268],"stable":[270],"(SD)":[272],"courses":[275],"neuroblastoma":[279],"SD":[281],"3+":[283],"courses.":[284],"Because":[285],"delayed":[287],"these":[290,333],"DLTs,":[291],"is":[294],"being":[295],"amended":[296],"administer":[298],"12":[303],"each":[306],"course":[307],"only.":[308],"Conclusions:":[309],"data":[311],"suggest":[312],"shorter":[314],"schedule":[315],"may":[322],"be":[323],"better":[324],"will":[327],"maintain":[328],"apparent":[330],"synergy":[331],"agents.":[334],"This":[335],"warrants":[337],"further":[338],"Author":[346],"Disclosure":[347],"Employment":[348],"Leadership":[350],"Consultant":[351],"Advisory":[353],"Stock":[354],"Ownership":[355],"Honoraria":[356],"Research":[357],"Funding":[358],"Expert":[359],"Testimony":[360],"Other":[361],"Remuneration":[362],"AstraZeneca":[363]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
