{"id":"https://openalex.org/W11986826","doi":null,"title":"Biomarkers aiming at cancer risk estimation of polycyclic aromatic hydrocarbons","display_name":"Biomarkers aiming at cancer risk estimation of polycyclic aromatic hydrocarbons","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W11986826","mag":"11986826"},"language":"en","primary_location":{"id":"mag:11986826","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.org/smash/record.jsf?pid=diva2:492209","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012114174","display_name":"Hans Helleberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hans Helleberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5012114174"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1206,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.42721893,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.8076000213623047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.8076000213623047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.18230000138282776,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.9869999885559082},{"id":"https://openalex.org/keywords/benzo-a-pyrene","display_name":"benzo[a]pyrene","score":0.9769999980926514},{"id":"https://openalex.org/keywords/fluoranthene","display_name":"fluoranthene","score":0.753000020980835},{"id":"https://openalex.org/keywords/biomarkers-of-exposure","display_name":"biomarkers of exposure","score":0.6909999847412109},{"id":"https://openalex.org/keywords/dose-monitoring","display_name":"dose monitoring","score":0.4519999921321869},{"id":"https://openalex.org/keywords/bpde-dna-adducts","display_name":"BPDE-DNA adducts","score":0.8320000171661377},{"id":"https://openalex.org/keywords/serum-albumin","display_name":"serum albumin","score":0.9390000104904175},{"id":"https://openalex.org/keywords/hemoglobin","display_name":"hemoglobin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hydrazinolysis","display_name":"hydrazinolysis","score":0.9039999842643738},{"id":"https://openalex.org/keywords/dna-repair-deficiency","display_name":"DNA repair deficiency","score":0.6980000138282776},{"id":"https://openalex.org/keywords/cancer-risk-assessment","display_name":"cancer risk assessment","score":0.6520000100135803},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.5320000052452087},{"id":"https://openalex.org/keywords/pah-metabolites","display_name":"PAH metabolites","score":0.5389999747276306},{"id":"https://openalex.org/keywords/solid-phase-extraction","display_name":"solid-phase extraction","score":0.4970000088214874}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7986791133880615},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.7245787978172302},{"id":"https://openalex.org/C2778951431","wikidata":"https://www.wikidata.org/wiki/Q415723","display_name":"Pyrene","level":2,"score":0.6969562768936157},{"id":"https://openalex.org/C108204754","wikidata":"https://www.wikidata.org/wiki/Q353392","display_name":"Adduct","level":2,"score":0.6101470589637756},{"id":"https://openalex.org/C2780112459","wikidata":"https://www.wikidata.org/wiki/Q423462","display_name":"Fluoranthene","level":3,"score":0.597237229347229},{"id":"https://openalex.org/C2776923573","wikidata":"https://www.wikidata.org/wiki/Q2294884","display_name":"Derivatization","level":3,"score":0.4950679838657379},{"id":"https://openalex.org/C2779033964","wikidata":"https://www.wikidata.org/wiki/Q407212","display_name":"Polycyclic aromatic hydrocarbon","level":2,"score":0.4858967661857605},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4610333740711212},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4591810405254364},{"id":"https://openalex.org/C2777538855","wikidata":"https://www.wikidata.org/wiki/Q306051","display_name":"Benzo(a)pyrene","level":3,"score":0.43145832419395447},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3925408124923706},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.2977510392665863},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.28456687927246094},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.21942666172981262},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.1777602732181549},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14830923080444336},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09235996007919312}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:11986826","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.org/smash/record.jsf?pid=diva2:492209","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":96,"referenced_works":["https://openalex.org/W423707044","https://openalex.org/W983021566","https://openalex.org/W1483242733","https://openalex.org/W1509148122","https://openalex.org/W1518861232","https://openalex.org/W1532356701","https://openalex.org/W1576749780","https://openalex.org/W1963634283","https://openalex.org/W1964137274","https://openalex.org/W1966035540","https://openalex.org/W1966367628","https://openalex.org/W1966432828","https://openalex.org/W1966506053","https://openalex.org/W1968745765","https://openalex.org/W1970502777","https://openalex.org/W1974648730","https://openalex.org/W1976138981","https://openalex.org/W1981029577","https://openalex.org/W1981101136","https://openalex.org/W1982386536","https://openalex.org/W1983678815","https://openalex.org/W1985541618","https://openalex.org/W1986320042","https://openalex.org/W1988462310","https://openalex.org/W1989908249","https://openalex.org/W1990260467","https://openalex.org/W1993579104","https://openalex.org/W1994824322","https://openalex.org/W1998001201","https://openalex.org/W1998055180","https://openalex.org/W1998880088","https://openalex.org/W1999058777","https://openalex.org/W1999179622","https://openalex.org/W1999603794","https://openalex.org/W2001258296","https://openalex.org/W2002112204","https://openalex.org/W2006802772","https://openalex.org/W2009323073","https://openalex.org/W2017729229","https://openalex.org/W2018381257","https://openalex.org/W2025120166","https://openalex.org/W2030434415","https://openalex.org/W2031109095","https://openalex.org/W2031200148","https://openalex.org/W2031774815","https://openalex.org/W2032630171","https://openalex.org/W2034269086","https://openalex.org/W2034581891","https://openalex.org/W2036997692","https://openalex.org/W2039249065","https://openalex.org/W2040843256","https://openalex.org/W2044437152","https://openalex.org/W2044586543","https://openalex.org/W2045461190","https://openalex.org/W2051434272","https://openalex.org/W2051730348","https://openalex.org/W2057749204","https://openalex.org/W2058981542","https://openalex.org/W2059101420","https://openalex.org/W2060656945","https://openalex.org/W2063452861","https://openalex.org/W2064116293","https://openalex.org/W2065091408","https://openalex.org/W2065255981","https://openalex.org/W2066257734","https://openalex.org/W2069758464","https://openalex.org/W2074846736","https://openalex.org/W2079531334","https://openalex.org/W2083079683","https://openalex.org/W2089415609","https://openalex.org/W2089706668","https://openalex.org/W2090467261","https://openalex.org/W2092875569","https://openalex.org/W2092941223","https://openalex.org/W2097664721","https://openalex.org/W2098178973","https://openalex.org/W2101472561","https://openalex.org/W2103253240","https://openalex.org/W2107047644","https://openalex.org/W2114629114","https://openalex.org/W2116452745","https://openalex.org/W2117636800","https://openalex.org/W2118720215","https://openalex.org/W2118894711","https://openalex.org/W2120005875","https://openalex.org/W2129876916","https://openalex.org/W2145704539","https://openalex.org/W2147292419","https://openalex.org/W2153625286","https://openalex.org/W2158263952","https://openalex.org/W2168903742","https://openalex.org/W2240627417","https://openalex.org/W2309408685","https://openalex.org/W2312753739","https://openalex.org/W2411530065","https://openalex.org/W3004475066"],"related_works":["https://openalex.org/W2154092525","https://openalex.org/W2254779436","https://openalex.org/W3031999726","https://openalex.org/W2022431809","https://openalex.org/W2344447557","https://openalex.org/W2047688433","https://openalex.org/W1984604880","https://openalex.org/W2776616511","https://openalex.org/W7097729013","https://openalex.org/W2038210948"],"abstract_inverted_index":{"Polycyclic":[0],"aromatic":[1],"hydrocarbons":[2],"(PAH),":[3],"a":[4,55,236,399],"family":[5],"of":[6,14,52,82,98,133,162,192,199,247,266,281,295,334,371,376,388,405,411,424,445,457,469,482,510],"compounds":[7],"that":[8,145,404,452,496,516],"are":[9,505],"formed":[10],"in":[11,21,47,90,129,139,148,174,201,235,269,286,288,302,343,346,352,367,382,418,475,479,507,518],"incomplete":[12],"combustion":[13],"organic":[15],"matter,":[16,57],"occur":[17],"as":[18,96,320,322],"general":[19],"pollutants":[20],"air":[22],"and":[23,80,88,167,170,194,203,221,225,251,256,272,277,305,354,378,415,448,487],"food.":[24],"Exposure":[25],"to":[26,30,44,109,153,275,397,403,421,441,454,464,526],"PAH":[27,53,61,99,429,511],"is,":[28],"according":[29],"preliminary":[31],"estimates,":[32],"associated":[33],"with":[34,71,78,117,217,223,297,501],"non-acceptable":[35],"cancer":[36,64,113],"risks":[37],"showing":[38],"the":[39,91,111,125,137,155,171,213,230,261,270,282,287,300,310,313,335,364,467,470,497,519],"need":[40],"for":[41,84,239,413],"improved":[42],"data":[43],"be":[45,110,151,491],"used":[46,152,440],"risk":[48,65,480,508],"estimation.":[49],"Risk":[50],"assessment":[51],"is":[54,107,494,517],"complex":[56],"i.a.":[58],"because":[59],"certain":[60],"could":[62,150,490],"increase":[63],"by":[66,123,215,241],"more":[67,183],"than":[68,187,345,363],"one":[69,389],"mechanism,":[70],"different":[72,140],"dose-response.":[73],"This":[74],"study":[75],"deals":[76],"mainly":[77],"development":[79],"evaluation":[81],"biomarkers":[83,412],"dose.":[85,158],"Benzo[a]pyrene":[86],"(BaP),":[87],"fluoranthene":[89],"early":[92],"experiments,":[93],"were":[94,135,210,307,318,338,357,380,434],"chosen":[95],"indicators":[97],"exposure.":[100],"Among":[101],"BaP":[102,122,299,330,483],"metabolites,":[103],"\u00b1":[104],"(anti)r-7,t-8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene":[105],"(BPDE)":[106],"regarded":[108],"predominant":[112],"initiator.":[114],"In":[115,309],"mice":[116,296,419],"deficient":[118],"DNA":[119,306,356],"repair,":[120,179],"given":[121],"gavage,":[124],"dGuo-N2":[126,349,390],"adduct":[127,232,284,337,350,366,391],"levels":[128,333,351,423,456,524],"DNA,":[130],"reflecting":[131],"doses":[132],"BPDE,":[134],"approximately":[136],"same":[138],"tissues.":[141],"The":[142,159,245,263,332,348,373,409],"results":[143,471],"indicate":[144],"BPDE":[146,200,317,377],"markers":[147],"blood":[149,163,181],"measure":[154,442],"average":[156],"target":[157],"large":[160],"amounts":[161],"proteins":[164,182,214],"(serum-albumin":[165],"(SA)":[166],"hemoglobin":[168],"(Hb))":[169],"well":[172,321],"defined":[173],"vivo":[175],"turnover":[176],"kinetics,":[177],"without":[178],"make":[180],"suitable":[184,238],"dose":[185],"monitors":[186],"DNA.":[188],"A":[189],"new":[190,255],"way":[191],"isolating":[193],"measuring":[195],"histidine":[196],"(His)":[197],"adducts":[198,209,259,268,301,315],"SA":[202,252,271,311,344,368],"Hb":[204,250,273,304],"has":[205,484],"been":[206,485],"developed.":[207],"His":[208,231,267,314,336,365],"released":[211,253],"from":[212,260,316,329],"treatment":[216,293],"hydrazine.":[218],"After":[219],"derivatization":[220],"enrichment":[222],"C18":[224],"cation":[226],"solid":[227],"phase":[228],"extraction":[229],"was":[233,395,439,450],"obtained":[234,472],"form":[237],"analysis":[240],"liquid":[242],"chromatography/mass":[243],"spectrometry.":[244],"hydrazinolysis":[246],"BPDE-treated":[248],"human":[249],"both":[254],"earlier":[257],"known":[258],"proteins.":[262,290],"level":[264,285],"observed":[265],"corresponded":[274],"70":[276],"10":[278,340],"%,":[279],"respectively,":[280],"total":[283],"vitro-treated":[289],"Following":[291],"acute":[292],"(i.p.)":[294],"radiolabelled":[298],"SA,":[303],"determined.":[308],"samples":[312],"quantified,":[319],"two":[323],"other":[324,502],"so":[325],"far":[326],"unidentified":[327],"products":[328],"metabolites.":[331],"roughly":[339],"times":[341,361],"higher":[342,362],"Hb.":[347],"liver":[353],"lung":[355],"14":[358],"-":[359],"40":[360],"per":[369,392,430],"unit":[370],"weight.":[372],"mutagenic":[374,400],"effectiveness":[375],"g-radiation":[379],"determined":[381],"V79":[383],"cells.":[384],"An":[385],"incremental":[386],"formation":[387],"108":[393],"nucleotides":[394],"found":[396],"have":[398],"potency":[401],"corresponding":[402],"about":[406],"1":[407],"cGy.":[408],"usefulness":[410],"genotoxic":[414],"immunotoxic":[416],"effects":[417],"exposed":[420],"low":[422],"diesel":[425,458],"exhaust":[426,459],"(10":[427],"mg":[428],"kg":[431],"body":[432],"weight)":[433],"examined.":[435],"Ethoxyresorufin":[436],"O-deethylase":[437],"activity":[438],"induction":[443,528],"status":[444],"CYP1":[446],"isoenzymes":[447],"it":[449],"concluded":[451],"exposure":[453,514,523],"ambient":[455],"would":[460],"probably":[461],"not":[462],"lead":[463],"induction.":[465],"On":[466],"basis":[468],"some":[473],"gaps":[474,489],"quantitative":[476],"knowledge":[477],"necessary":[478],"estimation":[481,509],"filled":[486],"remaining":[488],"defined.":[492],"It":[493],"indicated":[495],"present":[498],"methods":[499],"together":[500],"sensitive":[503],"techniques":[504],"applicable":[506],"at":[512],"current":[513],"levels,":[515],"low-dose":[520],"range,":[521],"below":[522],"leading":[525],"enzyme":[527],"including":[529],"promotion.":[530]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
