{"id":"https://openalex.org/W1198558446","doi":null,"title":"Epigenetic modulation of insulin-like growth factor-II overexpression by hepatitis B virus X protein in hepatocellular carcinoma.","display_name":"Epigenetic modulation of insulin-like growth factor-II overexpression by hepatitis B virus X protein in hepatocellular carcinoma.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W1198558446","mag":"1198558446","pmid":"https://pubmed.ncbi.nlm.nih.gov/26045980","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4449429"},"language":"en","primary_location":{"id":"pmid:26045980","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26045980","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4449429/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070338978","display_name":"Xu You Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu You Liu","raw_affiliation_strings":["Department of Gastroenterology, The First Affiliated Hospital, Jinan University Guangzhou, 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The First Affiliated Hospital, Jinan University Guangzhou, 510632, China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025721107","display_name":"Shao Hui Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shao Hui Tang","raw_affiliation_strings":["Department of Gastroenterology, The First Affiliated Hospital, Jinan University Guangzhou, 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The First Affiliated Hospital, Jinan University Guangzhou, 510632, China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083876116","display_name":"Sheng Lan Wu","orcid":"https://orcid.org/0000-0001-6630-3600","observed_orcids":["https://orcid.org/0000-0001-6630-3600"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sheng Lan Wu","raw_affiliation_strings":["Department of Gastroenterology, The First Affiliated Hospital, Jinan University Guangzhou, 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The First Affiliated Hospital, Jinan University Guangzhou, 510632, China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101248003","display_name":"Yu Luo","orcid":"https://orcid.org/0009-0008-2652-6138","observed_orcids":["https://orcid.org/0009-0008-2652-6138"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Hong Luo","raw_affiliation_strings":["Department of General Surgery, The First Affiliated Hospital, Jinan University Guangzhou, 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The First Affiliated Hospital, Jinan University Guangzhou, 510632, China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ming Rong Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Rong Cao","raw_affiliation_strings":["Department of General Surgery, The First Affiliated Hospital, Jinan University Guangzhou, 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The First Affiliated Hospital, Jinan University Guangzhou, 510632, China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049399419","display_name":"Hong Ke Zhou","orcid":"https://orcid.org/0000-0002-9376-4637","observed_orcids":["https://orcid.org/0000-0002-9376-4637"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Ke Zhou","raw_affiliation_strings":["Department of Gastroenterology, The First Affiliated Hospital, Jinan University Guangzhou, 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The First Affiliated Hospital, Jinan University Guangzhou, 510632, China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114051744","display_name":"Xiang Wu Jiang","orcid":"https://orcid.org/0009-0002-4248-4405","observed_orcids":["https://orcid.org/0009-0002-4248-4405"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Wu Jiang","raw_affiliation_strings":["Department of Gastroenterology, The First Affiliated Hospital, Jinan University Guangzhou, 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The First Affiliated Hospital, Jinan University Guangzhou, 510632, China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108347722","display_name":"Jian Chang Shu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Chang Shu","raw_affiliation_strings":["Department of Gastroenterology, Guangzhou Red Cross Hospital Affiliated to Medical College of Jinan University Guangzhou, 510220, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Guangzhou Red Cross Hospital Affiliated to Medical College of Jinan University Guangzhou, 510220, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109304848","display_name":"Caiqun Bie","orcid":"https://orcid.org/0000-0002-4740-5123","observed_orcids":["https://orcid.org/0000-0002-4740-5123","https://orcid.org/0009-0003-0285-9871"]},"institutions":[{"id":"https://openalex.org/I4210134919","display_name":"Shenzhen Shajing Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/049epw866","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134919"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cai Qun Bie","raw_affiliation_strings":["Department of Gastroenterology, The Affiliated Shenzhen Shajing Hospital, Guangzhou Medical University Shenzhen, 518104, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The Affiliated Shenzhen Shajing Hospital, Guangzhou Medical University Shenzhen, 518104, China","institution_ids":["https://openalex.org/I4210134919","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102299858","display_name":"Si Min Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Si Min Huang","raw_affiliation_strings":["Department of Gastroenterology, The First Affiliated Hospital, Jinan University Guangzhou, 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The First Affiliated Hospital, Jinan University Guangzhou, 510632, China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055095882","display_name":"Zhan Hong Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhan Hong Zheng","raw_affiliation_strings":["Department of Gastroenterology, The First Affiliated Hospital, Jinan University Guangzhou, 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The First Affiliated Hospital, Jinan University Guangzhou, 510632, China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210162753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101974825","display_name":"Fei Gao","orcid":"https://orcid.org/0000-0002-2500-7212","observed_orcids":["https://orcid.org/0000-0002-2500-7212"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Gao","raw_affiliation_strings":["Department of Gastroenterology, The First Affiliated Hospital, Jinan University Guangzhou, 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The First Affiliated Hospital, Jinan University Guangzhou, 510632, China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210162753"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6922,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.64850373,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"5","issue":"3","first_page":"956","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.0892999991774559,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.024700000882148743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b-virus-x-protein","display_name":"hepatitis B virus X protein","score":0.9829999804496765},{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":0.9509999752044678},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/promoter-hypomethylation","display_name":"promoter hypomethylation","score":0.8960000276565552},{"id":"https://openalex.org/keywords/mbd2","display_name":"MBD2","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cbp-p300","display_name":"CBP/p300","score":0.9950000047683716},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/histone-demethylation","display_name":"histone demethylation","score":0.746999979019165},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C67567795","wikidata":"https://www.wikidata.org/wiki/Q5629069","display_name":"HBx","level":4,"score":0.9834257960319519},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.8714110851287842},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.736336886882782},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.574903130531311},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5441005229949951},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5376587510108948},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.5025084018707275},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49195119738578796},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.48027896881103516},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.46486979722976685},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.4138905107975006},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.38634371757507324},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36551398038864136},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3356550931930542},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18907806277275085},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.11313796043395996},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.08727052807807922},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.054162442684173584}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:26045980","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26045980","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4449429","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4449429/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"mag:1198558446","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26045980","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4449429","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4449429/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1605104953","https://openalex.org/W1690185597","https://openalex.org/W1969776963","https://openalex.org/W1971281277","https://openalex.org/W1971673379","https://openalex.org/W1976118924","https://openalex.org/W1977396699","https://openalex.org/W1981259598","https://openalex.org/W1982191424","https://openalex.org/W1985563243","https://openalex.org/W1997866877","https://openalex.org/W2004272510","https://openalex.org/W2008306523","https://openalex.org/W2008837855","https://openalex.org/W2010629311","https://openalex.org/W2012141216","https://openalex.org/W2015277221","https://openalex.org/W2016339678","https://openalex.org/W2017341383","https://openalex.org/W2017530122","https://openalex.org/W2020767030","https://openalex.org/W2024395213","https://openalex.org/W2025277638","https://openalex.org/W2033050971","https://openalex.org/W2036565444","https://openalex.org/W2042515987","https://openalex.org/W2043861742","https://openalex.org/W2050637252","https://openalex.org/W2057211093","https://openalex.org/W2066960321","https://openalex.org/W2073482890","https://openalex.org/W2074647644","https://openalex.org/W2087770099","https://openalex.org/W2092668546","https://openalex.org/W2096399810","https://openalex.org/W2106844955","https://openalex.org/W2107277218","https://openalex.org/W2112206631","https://openalex.org/W2112489161","https://openalex.org/W2114360920","https://openalex.org/W2119014749","https://openalex.org/W2119389886","https://openalex.org/W2126196825","https://openalex.org/W2132313188","https://openalex.org/W2135231304","https://openalex.org/W2140301715","https://openalex.org/W2146278300","https://openalex.org/W2150515158","https://openalex.org/W2158819062","https://openalex.org/W2158997389","https://openalex.org/W2166332466","https://openalex.org/W2332411148"],"related_works":["https://openalex.org/W2395946324","https://openalex.org/W2083399849","https://openalex.org/W2366642089","https://openalex.org/W2320182093","https://openalex.org/W2392098789","https://openalex.org/W1537375311","https://openalex.org/W1976118924","https://openalex.org/W2025933947","https://openalex.org/W2036054227","https://openalex.org/W2066960321"],"abstract_inverted_index":{"Hepatitis":[0],"B":[1],"virus":[2],"X":[3],"protein":[4],"(HBx)":[5],"is":[6,32],"involved":[7],"in":[8,34,44,76,136],"the":[9,17,20,26,40,52,62,66,103,109,112,130,153,156,178,189,249,255,275,291],"pathogenesis":[10,292],"of":[11,16,25,42,54,65,98,111,132,155,188,216,254,264,279,293],"hepatocellular":[12],"carcinoma":[13],"(HCC).":[14],"Overexpression":[15],"transcripts":[18],"from":[19],"P3":[21,57,67,104,157,180],"and":[22,47,58,68,71,80,87,95,100,105,108,116,134,139,158,161,171,173,181,193,201,209,213,219,227,244,251,257,260,267,277],"P4":[23,59,69,106,159,182,258],"promoters":[24,107,183,259],"insulin-like":[27],"growth":[28],"factor-II":[29],"(IGF-II)":[30],"gene":[31],"observed":[33],"HCC.":[35,295],"The":[36],"present":[37],"study":[38,284],"investigated":[39,129],"involvement":[41],"HBx":[43,55,86,147,163,235],"IGF-II":[45,137,149,207],"overexpression":[46,138,208],"its":[48,140,228],"epigenetic":[49,141],"regulation.":[50,142],"Firstly,":[51],"effects":[53],"on":[56],"mRNA":[60],"expression,":[61,166],"methylation":[63],"status":[64],"promoters,":[70,160],"MBD2":[72,88,99,133,165,170,200,225,243],"expression":[73,150],"were":[74,118],"analyzed":[75],"human":[77],"HCC":[78,81],"cells":[79],"samples.":[82],"Next,":[83],"interaction":[84,241],"between":[85],"or":[89],"CBP/p300":[90,101,135,202,211],"was":[91],"assessed":[92],"by":[93,120],"co-immunoprecipitation,":[94],"HBx-mediated":[96,294],"binding":[97,226],"to":[102,177,248],"acetylation":[110,186,215,263],"corresponding":[113,190],"histones":[114,191,217,265],"H3":[115,192,218,266],"H4":[117,220,268],"evaluated":[119],"quantitative":[121],"chromatin":[122],"immunoprecipitation.":[123],"Finally,":[124],"using":[125],"siRNA":[126],"knockdown,":[127],"we":[128],"roles":[131],"Our":[143],"results":[144,196],"showed":[145,197],"that":[146,162,198,210,234,261],"promotes":[148],"via":[151,240],"inducing":[152],"hypomethylation":[154,250,276],"increases":[164],"directly":[167],"interacts":[168],"with":[169,184,242],"CBP/p300,":[172,245],"elevates":[174],"their":[175],"recruitment":[176],"hypomethylated":[179],"increased":[185],"levels":[187],"H4.":[194],"Further":[195],"endogenous":[199],"are":[203,221],"necessary":[204],"for":[205,224,274,289],"HBx-induced":[206],"presence":[212],"CBP/p300-mediated":[214,262],"partially":[222],"required":[223],"demethylase":[229],"activity.":[230],"These":[231],"data":[232],"suggest":[233],"induces":[236],"MBD2-HBx-CBP/p300":[237],"complex":[238],"formation":[239],"which":[246],"contributes":[247],"transcriptional":[252],"activation":[253,278],"IGF-II-P3":[256],"may":[269],"be":[270],"a":[271],"rate-limiting":[272],"step":[273],"these":[280],"two":[281],"promoters.":[282],"This":[283],"provides":[285],"an":[286],"alternative":[287],"mechanism":[288],"understanding":[290]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}