{"id":"https://openalex.org/W119790205","doi":"https://doi.org/10.1023/a:1006792007063","title":"Expression of vascular endothelial growth factor by human renal cancer cells enhances angiogenesis of primary tumors and production of ascites but not metastasis to the lungs in nude mice","display_name":"Expression of vascular endothelial growth factor by human renal cancer cells enhances angiogenesis of primary tumors and production of ascites but not metastasis to the lungs in nude mice","publication_year":1999,"publication_date":"1999-10-01","ids":{"openalex":"https://openalex.org/W119790205","doi":"https://doi.org/10.1023/a:1006792007063","mag":"119790205","pmid":"https://pubmed.ncbi.nlm.nih.gov/11089881"},"language":"en","primary_location":{"id":"doi:10.1023/a:1006792007063","doi":"https://doi.org/10.1023/a:1006792007063","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1006792007063","pdf_url":null,"source":{"id":"https://openalex.org/S100674681","display_name":"Clinical & Experimental Metastasis","issn_l":"0262-0898","issn":["0262-0898","1573-7276"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical & Experimental Metastasis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036804010","display_name":"Hiro-omi Kanayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiro-omi Kanayama","raw_affiliation_strings":["Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA","Departments of Cancer Biology, USA and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Departments of Cancer Biology, USA and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017882443","display_name":"Seiji Yano","orcid":"https://orcid.org/0000-0002-6151-2988","observed_orcids":["https://orcid.org/0000-0002-6151-2988"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seiji Yano","raw_affiliation_strings":["Departments of Cancer Biology, USA and","Surgical Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cancer Biology, USA and","institution_ids":[]},{"raw_affiliation_string":"Surgical Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113655795","display_name":"Sun Jin Kim","orcid":"https://orcid.org/0000-0002-5738-416X","observed_orcids":["https://orcid.org/0000-0002-5738-416X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sun Jin Kim","raw_affiliation_strings":["Departments of Cancer Biology, USA and","Surgical Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cancer Biology, USA and","institution_ids":[]},{"raw_affiliation_string":"Surgical Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109999491","display_name":"Shutaro Ozawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shutaro Ozawa","raw_affiliation_strings":["Departments of Cancer Biology, USA and","Surgical Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cancer Biology, USA and","institution_ids":[]},{"raw_affiliation_string":"Surgical Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042341684","display_name":"Lee M. Ellis","orcid":"https://orcid.org/0000-0001-8082-4904","observed_orcids":["https://orcid.org/0000-0001-8082-4904"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee M. Ellis","raw_affiliation_strings":["Departments of Cancer Biology, USA and","Surgical Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cancer Biology, USA and","institution_ids":[]},{"raw_affiliation_string":"Surgical Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111610330","display_name":"Isaiah J. Fidler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isaiah J. Fidler","raw_affiliation_strings":["Departments of Cancer Biology, USA and","Surgical Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cancer Biology, USA and","institution_ids":[]},{"raw_affiliation_string":"Surgical Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":5090,"currency":"USD","value_usd":5090},"apc_paid":null,"fwci":0.1915,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.38050382,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"17","issue":"10","first_page":"831","last_page":"840"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9079999923706055},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8759999871253967},{"id":"https://openalex.org/keywords/ascites","display_name":"ascites","score":0.9049999713897705},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/vegf165","display_name":"VEGF165","score":0.7870000004768372},{"id":"https://openalex.org/keywords/tumor-vascularization","display_name":"tumor vascularization","score":0.8669999837875366},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.5720000267028809},{"id":"https://openalex.org/keywords/nude-mice","display_name":"nude mice","score":0.6449999809265137},{"id":"https://openalex.org/keywords/metastasis-inhibition","display_name":"metastasis suppression","score":0.33000001311302185}],"concepts":[{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.6693570017814636},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.6620289087295532},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5795944333076477},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5105427503585815},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4666246175765991},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42518073320388794},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40599116683006287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3730372488498688},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3342962861061096},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26756739616394043},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.18460682034492493},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001201","descriptor_name":"Ascites","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013370","descriptor_name":"Subrenal Capsule Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042442","descriptor_name":"Vascular Endothelial Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1023/a:1006792007063","doi":"https://doi.org/10.1023/a:1006792007063","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1006792007063","pdf_url":null,"source":{"id":"https://openalex.org/S100674681","display_name":"Clinical & Experimental Metastasis","issn_l":"0262-0898","issn":["0262-0898","1573-7276"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical & Experimental Metastasis","raw_type":"journal-article"},{"id":"pmid:11089881","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11089881","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical & experimental metastasis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5766228526","display_name":"VEGF REGULATION IN HUMAN COLON CANCER","funder_award_id":"R01CA074821","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7276728165","display_name":"CANCER METASTASIS--BIOLOGY AND TREATMENT","funder_award_id":"R35CA042107","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W32167704","https://openalex.org/W589954173","https://openalex.org/W1044883788","https://openalex.org/W1462105164","https://openalex.org/W1532183186","https://openalex.org/W1552383593","https://openalex.org/W1559714867","https://openalex.org/W1586129343","https://openalex.org/W1589068001","https://openalex.org/W1590047393","https://openalex.org/W1658618454","https://openalex.org/W1780308454","https://openalex.org/W1784095256","https://openalex.org/W1903437307","https://openalex.org/W1977980079","https://openalex.org/W1978165300","https://openalex.org/W1981486175","https://openalex.org/W1994131389","https://openalex.org/W2005786175","https://openalex.org/W2016904444","https://openalex.org/W2018779108","https://openalex.org/W2034092827","https://openalex.org/W2045247659","https://openalex.org/W2050003881","https://openalex.org/W2058177351","https://openalex.org/W2059514438","https://openalex.org/W2062594120","https://openalex.org/W2067055586","https://openalex.org/W2077889827","https://openalex.org/W2084947524","https://openalex.org/W2087523741","https://openalex.org/W2093498435","https://openalex.org/W2098051886","https://openalex.org/W2098856542","https://openalex.org/W2099096390","https://openalex.org/W2100569171","https://openalex.org/W2114098415","https://openalex.org/W2138302361","https://openalex.org/W2138843392","https://openalex.org/W2162063105","https://openalex.org/W2163559464","https://openalex.org/W2165284248","https://openalex.org/W2273992414","https://openalex.org/W2319962899","https://openalex.org/W2320669141","https://openalex.org/W2324677651","https://openalex.org/W2422541285","https://openalex.org/W2464595280","https://openalex.org/W4241929933","https://openalex.org/W4298413103","https://openalex.org/W4388253455"],"related_works":["https://openalex.org/W186573701","https://openalex.org/W2134522340","https://openalex.org/W2047053014","https://openalex.org/W2353405706","https://openalex.org/W2356487775","https://openalex.org/W1784095256","https://openalex.org/W2036441426","https://openalex.org/W2416273057","https://openalex.org/W2049455929","https://openalex.org/W2098482284"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}