{"id":"https://openalex.org/W119670204","doi":"https://doi.org/10.1182/blood.v114.22.2486.2486","title":"Improved Patient Satisfaction, Adherence and Health-Related Quality of Life with Deferasirox (Exjade\u00ae) in \u03b2-Thalassemia Patients Previously Receiving Other Iron Chelation Therapies.","display_name":"Improved Patient Satisfaction, Adherence and Health-Related Quality of Life with Deferasirox (Exjade\u00ae) in \u03b2-Thalassemia Patients Previously Receiving Other Iron Chelation Therapies.","publication_year":2009,"publication_date":"2009-11-20","ids":{"openalex":"https://openalex.org/W119670204","doi":"https://doi.org/10.1182/blood.v114.22.2486.2486","mag":"119670204"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v114.22.2486.2486","doi":"https://doi.org/10.1182/blood.v114.22.2486.2486","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v114.22.2486.2486","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049244658","display_name":"John B. Porter","orcid":"https://orcid.org/0000-0003-3000-9359","observed_orcids":["https://orcid.org/0000-0003-3000-9359"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"John B. Porter","raw_affiliation_strings":["Department of Haematology, University College London, London, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, University College London, London, United Kingdom,","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042549817","display_name":"Miranda Athanasiou-Metaxa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116665","display_name":"Ippokrateio General Hospital of Thessaloniki","ror":"https://ror.org/02kpyrm37","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210116665"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Miranda Athanasiou-Metaxa","raw_affiliation_strings":["Thalassaemia Unit, Hippokration General Hospital Thessaloniki, Thessaloniki, Greece,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thalassaemia Unit, Hippokration General Hospital Thessaloniki, Thessaloniki, Greece,","institution_ids":["https://openalex.org/I4210116665"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105839375","display_name":"Donald K. Bowden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801350665","display_name":"Monash Medical Centre","ror":"https://ror.org/036s9kg65","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801350665","https://openalex.org/I4210121067"]},{"id":"https://openalex.org/I4210121067","display_name":"Monash Health","ror":"https://ror.org/02t1bej08","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210121067"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Donald K. Bowden","raw_affiliation_strings":["Monash Medical Centre, Melbourne, Australia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Monash Medical Centre, Melbourne, Australia,","institution_ids":["https://openalex.org/I2801350665","https://openalex.org/I4210121067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068217025","display_name":"Jacques Troncy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jacques Troncy","raw_affiliation_strings":["Hematology, Hopital Edouard Herriot, Lyon, France,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Hopital Edouard Herriot, Lyon, France,","institution_ids":["https://openalex.org/I4210123600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030898208","display_name":"Dany Habr","orcid":"https://orcid.org/0000-0002-3361-6309","observed_orcids":["https://orcid.org/0000-0002-3361-6309"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dany Habr","raw_affiliation_strings":["Novartis Pharmaceuticals, East Hanover, NJ, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals, East Hanover, NJ, USA,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036354175","display_name":"Gabor Domokos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Gabor Domokos","raw_affiliation_strings":["Novartis Pharma AG, Basel, Switzerland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, Basel, Switzerland,","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029678804","display_name":"Bernard Roubert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Bernard Roubert","raw_affiliation_strings":["Novartis Pharma AG, Basel, Switzerland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, Basel, Switzerland,","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103228207","display_name":"Diana Rofail","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Diana Rofail","raw_affiliation_strings":["Mapi Values, Cheshire, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mapi Values, Cheshire, United Kingdom,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051940143","display_name":"Adam Gater","orcid":"https://orcid.org/0000-0001-9582-8596","observed_orcids":["https://orcid.org/0000-0001-9582-8596"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Adam Gater","raw_affiliation_strings":["Mapi Values, Cheshire, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mapi Values, Cheshire, United Kingdom,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110122066","display_name":"Jean\u2010Fran\u00e7ois Baladi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jean-Franc\u0327ois Baladi","raw_affiliation_strings":["Novartis Pharmaceuticals, East Hanover, NJ, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals, East Hanover, NJ, USA,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064506274","display_name":"Maria Domenica Cappellini","orcid":"https://orcid.org/0000-0001-8676-6864","observed_orcids":["https://orcid.org/0000-0001-8676-6864"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Domenica Cappellini","raw_affiliation_strings":["Universita\u0301 di Milano, Fondazione IRCCS Ospedale Maggiore Policlinico Mangiagalli e Regina Elena, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universita\u0301 di Milano, Fondazione IRCCS Ospedale Maggiore Policlinico Mangiagalli e Regina Elena, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5029678804","https://openalex.org/A5030898208","https://openalex.org/A5036354175","https://openalex.org/A5042549817","https://openalex.org/A5049244658","https://openalex.org/A5051940143","https://openalex.org/A5068217025","https://openalex.org/A5103228207","https://openalex.org/A5105839375","https://openalex.org/A5110122066"],"corresponding_institution_ids":["https://openalex.org/I1283582996","https://openalex.org/I2801350665","https://openalex.org/I4210116665","https://openalex.org/I4210121067","https://openalex.org/I4210123600","https://openalex.org/I45129253"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.302,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.62042235,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"114","issue":"22","first_page":"2486","last_page":"2486"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deferasirox","display_name":"deferasirox","score":0.9639999866485596},{"id":"https://openalex.org/keywords/beta-thalassemia","display_name":"beta-thalassemia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/iron-chelation-therapy","display_name":"iron chelation therapy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/deferoxamine","display_name":"deferoxamine","score":0.8939999938011169},{"id":"https://openalex.org/keywords/deferiprone","display_name":"deferiprone","score":0.9959999918937683},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.8730000257492065},{"id":"https://openalex.org/keywords/patient-satisfaction","display_name":"patient satisfaction","score":0.9829999804496765},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.9940000176429749},{"id":"https://openalex.org/keywords/epic-study","display_name":"EPIC study","score":0.5529999732971191},{"id":"https://openalex.org/keywords/sf-36","display_name":"SF-36","score":0.6890000104904175},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.47600001096725464},{"id":"https://openalex.org/keywords/treatment-burden","display_name":"treatment burden","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C2781053155","wikidata":"https://www.wikidata.org/wiki/Q5251502","display_name":"Deferasirox","level":3,"score":0.9654501080513},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7179328203201294},{"id":"https://openalex.org/C2777799968","wikidata":"https://www.wikidata.org/wiki/Q185137","display_name":"Thalassemia","level":2,"score":0.687907874584198},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.6379420757293701},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5791152119636536},{"id":"https://openalex.org/C2776517179","wikidata":"https://www.wikidata.org/wiki/Q749664","display_name":"Deferiprone","level":3,"score":0.5497720837593079},{"id":"https://openalex.org/C2776672577","wikidata":"https://www.wikidata.org/wiki/Q419618","display_name":"Deferoxamine","level":2,"score":0.44768384099006653},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.41630807518959045},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4006866216659546},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.34936362504959106},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3406657576560974},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.08235359191894531}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v114.22.2486.2486","doi":"https://doi.org/10.1182/blood.v114.22.2486.2486","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v114.22.2486.2486","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2555619027","https://openalex.org/W2553599327","https://openalex.org/W2052912554","https://openalex.org/W7057247350","https://openalex.org/W2131540408","https://openalex.org/W2040857128","https://openalex.org/W4248065583","https://openalex.org/W7095238450","https://openalex.org/W2050776171","https://openalex.org/W2801708774"],"abstract_inverted_index":{"Abstract":[0,1],"2486":[2],"Poster":[3],"Board":[4,691,707,792,805],"II-463":[5],"Introduction:":[6],"Iron":[7],"chelation":[8],"therapy":[9,604],"(ICT)":[10],"is":[11,84,100],"essential":[12],"in":[13,18,134,142,151,162,358,370,413,470,492,531,599,659,668,750,780],"removing":[14],"excess":[15],"iron":[16,751,781],"deposited":[17],"body":[19],"organs,":[20],"ultimately":[21],"preventing":[22],"organ":[23],"failure":[24],"and":[25,67,76,80,99,119,145,174,190,203,223,227,242,245,250,274,281,304,352,380,394,399,406,429,454,512,581,617,619,650,664],"extending":[26],"the":[27,117,183,191,206,210,228,255,263,272,375,474,582,632,736,766],"lives":[28],"of":[29,64,109,121,130,157,178,209,214,218,221,225,254,344,433,444,456,477,490,610,625,641,692,708,793,806],"patients":[30,153,260,363,388],"(pts)":[31],"with":[32,149,154,164,186,341,360,502,533,601,638,656,672,676],"transfusion-dependent":[33],"hematological":[34],"disorders":[35],"such":[36],"as":[37,312],"\u03b2-thalassemia.":[38],"Conventional":[39],"ICT":[40,73,82,187,310,434,445,457,478,499,517,642,653],"(deferoxamine,":[41],"Desferal\u00ae,":[42],"DFO)":[43],"requires":[44],"a":[45,52,78,97,110,487,728,758],"burdensome":[46,103],"regimen":[47,83],"(subcutaneous":[48],"delivery":[49],"5\u20137":[50],"times":[51],"week)":[53],"that":[54,733,763],"has":[55],"been":[56],"shown":[57],"to":[58,69,72,104,181,283,286,374,652,735,765],"negatively":[59],"impact":[60],"pts'":[61],"health-related":[62],"quality":[63],"life":[65],"(HRQL)":[66],"adherence":[68,144,282,651],"therapy.":[70,683],"Adherence":[71,285],"affects":[74],"survival":[75],"therefore":[77],"well-tolerated":[79],"effective":[81],"required.":[85],"The":[86],"once-daily":[87],"oral":[88],"chelator,":[89],"deferasirox":[90,122,287],"(Exjade\u00ae)":[91],"offers":[92],"24-hour":[93],"ICT,":[94,215,219,222,303,345],"7":[95],"days":[96],"week":[98,175],"potentially":[101],"less":[102],"pts.":[105],"Methods:":[106],"As":[107],"part":[108],"larger":[111],"single-arm,":[112],"multicenter,":[113],"open-label":[114],"trial":[115],"investigating":[116],"efficacy":[118],"safety":[120],"(EPIC":[123],"study),":[124],"217":[125,318],"\u03b2-thalassemia":[126,152,319,636],"pts":[127,169,295,320,340,424,491,532,600,637,669,677],">16":[128],"years":[129],"age":[131,324],"were":[132,170,257,321,385,418,480,537,605,661,665],"included":[133,369],"this":[135,371],"subanalysis.":[136],"Findings":[137],"reported":[138,419,495],"here":[139],"investigate":[140],"differences":[141,469],"satisfaction,":[143],"HRQoL":[146],"following":[147,497,654],"treatment":[148,655],"deferasirox,":[150],"prior":[155,342,349,356,365,534,602,639],"experience":[156],"DFO":[158,161,350,357,398,405,428,535,673],"monotherapy,":[159],"or":[160,645,694,710,795,808],"combination":[163,359,682],"deferiprone":[165],"(Ferriprox\u00ae,":[166],"L1).":[167],"All":[168],"asked":[171],"at":[172,266,392,420,542,631],"baseline":[173,202,393,503],"52":[176],"(end":[177],"study":[179],"[EOS])":[180],"complete":[182],"19-item":[184],"Satisfaction":[185],"questionnaire":[188],"(SICT)":[189],"36-item":[192],"Short":[193],"Form":[194],"health":[195,729,759],"survey":[196],"(SF-36).":[197],"Mean":[198,526,548,594],"change":[199,527,549,595],"scores":[200,248,270,384,417,472,530,550,598,627],"between":[201],"EOS":[204,395,421,543],"on":[205,271,387,688,704,789,802],"four":[207],"domains":[208,230,541,609],"SICT":[211,273,292,379,415],"(Perceived":[212],"Effectiveness":[213,476],"Side":[216,431],"Effects":[217,432],"Acceptance":[220,443],"Burden":[224,455],"ICT)":[226],"eight":[229],"(Physical":[231,249],"Functioning,":[232,240],"Role-Physical,":[233,611],"Bodily":[234,559,612],"Pain,":[235,613],"General":[236,566],"Health,":[237],"Vitality,":[238,614],"Social":[239,574],"Role-Emotional,":[241],"Mental":[243,251,615,620],"Health)":[244],"two":[246,291],"summary":[247],"Component":[252,584,621],"Scores)":[253],"SF-36":[256,275,381,528,596],"calculated":[258],"for":[259,422,473,482,539,551,608,743,747,773,777],"who":[261,389,678],"completed":[262,390],"respective":[264],"instruments":[265],"both":[267,423,493],"timepoints.":[268],"Higher":[269],"represent":[276],"greater":[277,488,667],"HRQL,":[278],"satisfaction":[279,649],"with,":[280],"treatment.":[284],"was":[288],"assessed":[289],"by":[290,314,725,755],"items":[293],"asking":[294],"how":[296,305],"often":[297,306],"they":[298,307],"thought":[299],"about":[300,515],"stopping":[301,516],"their":[302,309,315,498],"took":[308],"exactly":[311],"directed":[313],"doctor.":[316],"Results:":[317],"recruited":[322],"(mean":[323],"30.6":[325],"\u00b1":[326,437,441,448,452,460,464,555,562,570,577,587],"7.7);":[327],"42.9%":[328],"(n":[329,334],"=":[330,335],"93)":[331],"male,":[332],"57.1%":[333],"124)":[336],"female.":[337],"Of":[338],"216":[339],"history":[343,640],"62.0%":[346],"(n=134)":[347],"had":[348,355,364],"monotherapy":[351,536,644,674],"37.0%":[353],"(n=80)":[354],"L1":[361],"(2":[362],"LI":[366],"monotherapy;":[367],"not":[368],"analysis":[372],"due":[373],"small":[376],"patient":[377],"number).":[378],"mean-change":[382,414,471],"domain":[383,416,479,529,597],"based":[386],"questionnaires":[391],"(SICT:":[396],"105":[397],"46":[400],"DFO+L1":[401,408,603,681],"pts;":[402],"SF-36:":[403],"90":[404],"42":[407],"pts).":[409],"Significant":[410],"improvements":[411],"(p<0.0001)":[412],"having":[425],"previously":[426,670,679],"received":[427,680],"DFO+L1:":[430,439,450,462,508,522],"(DFO:":[435,446,458,504,518],"1.50":[436],"1.28;":[438],"1.19":[440],"1.32);":[442],"1.73":[447],"1.18;":[449],"1.49":[451,459],"1.26);":[453],"1.00;":[461],"1.04":[463],"1.06).":[465],"No":[466],"statistically":[467],"significant":[468],"Perceived":[475],"found":[481],"either":[483],"group.":[484],"At":[485],"EOS,":[486],"proportion":[489],"groups":[494],"always":[496],"regimen,":[500],"compared":[501,675],"69.2%":[505],"vs":[506,510,520,524],"36.0%;":[507],"69.5%":[509],"32.8%)":[511],"never":[513],"thinking":[514],"80.0%":[519],"44.0%;":[521],"74.6%":[523],"38.8%).":[525],"positive":[538,607],"all":[540,590],"(indicating":[544],"improvement":[545],"from":[546],"baseline).":[547],"Physical":[552,583,618],"Functioning":[553,575],"(5.60":[554],"20.08,":[556],"p":[557,564,572,579],"<0.005),":[558],"Pain":[560],"(10.13":[561],"28.81,":[563],"<0.001),":[565],"Health":[567,616],"Perceptions":[568],"(3.47":[569],"17.62,":[571],"<0.05),":[573],"(6.53":[576],"26.65,":[578],"<0.05)":[580],"score":[585],"(2.71":[586],"8.80,":[588],"p<0.005)":[589],"reached":[591,628],"statistical":[592,629],"significance.":[593],"also":[606,662],"Scores.":[622],"However,":[623],"none":[624],"these":[626],"significance":[630],"p<0.05":[633],"level.":[634],"Conclusions:":[635],"(DFO":[643],"DFO+L1)":[646],"demonstrated":[647],"improved":[648],"deferasirox.":[657],"Improvements":[658],"HRQL":[660],"observed":[663],"generally":[666],"treated":[671],"Disclosures:":[684],"Porter:":[685],"Novartis:":[686],"Membership":[687,703,788,801],"an":[689,705,790,803],"entity's":[690,706,791,804],"Directors":[693,709,794,807],"advisory":[695,711,796,809],"committees,":[696,797],"Research":[697],"Funding,":[698],"Speakers":[699,798],"Bureau;":[700,799],"Vifor":[701],"International:":[702],"committees.":[712,810],"Habr:Novartis":[713],"Pharmaceuticals:":[714,785],"Employment.":[715,719,723,786],"Domokos:Novartis":[716],"Pharma":[717,721],"AG:":[718,722],"Roubert:Novartis":[720],"Rofail:Employed":[724],"Mapi":[726,756],"Values,":[727,757],"outcomes":[730,749,760,779],"research":[731,761],"agency":[732,762],"consults":[734,764],"pharmaceutical":[737,767],"industry.":[738,768],"We":[739,769],"are":[740,770],"paid":[741,771],"consultants":[742,772],"Novartis":[744,774],"Pharmaceutical":[745,775],"Corporation":[746,776],"patient-reported":[748,778],"overload:":[752,782],"Consultancy.":[753,783],"Gater:Employed":[754],"Baladi:Novartis":[784],"Cappellini:Novartis:":[787],"Genzyme:":[800]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}