{"id":"https://openalex.org/W1196485491","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.759.14","title":"Selenium and Soy Modulate Different Processes in Tumor Progression in Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Mice","display_name":"Selenium and Soy Modulate Different Processes in Tumor Progression in Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Mice","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W1196485491","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.759.14","mag":"1196485491"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.29.1_supplement.759.14","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.759.14","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.759.14","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061691639","display_name":"Lauren A. Spencer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Spencer","raw_affiliation_strings":["Nutrition, Dietetics, and Food Science, Brigham Young University, Provo, UT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition, Dietetics, and Food Science, Brigham Young University, Provo, UT, United States","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015035489","display_name":"Bret Bahme","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bret Bahme","raw_affiliation_strings":["Nutrition, Dietetics, and Food Science, Brigham Young University, Provo, UT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition, Dietetics, and Food Science, Brigham Young University, Provo, UT, United States","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037556225","display_name":"Joseph Worden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Worden","raw_affiliation_strings":["Nutrition, Dietetics, and Food Science, Brigham Young University, Provo, UT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition, Dietetics, and Food Science, Brigham Young University, Provo, UT, United States","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066755275","display_name":"Paul M. Urie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110497","display_name":"Utah Valley Regional Medical Center","ror":"https://ror.org/019n8y489","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I108785884","https://openalex.org/I4210110497"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Urie","raw_affiliation_strings":["Pathology, Utah Valley Regional Medical Center, Provo, UT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Utah Valley Regional Medical Center, Provo, UT, United States","institution_ids":["https://openalex.org/I4210110497"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102161804","display_name":"Merrill J. Christensen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Merrill Christensen","raw_affiliation_strings":["Cancer Research Center Brigham Young University, Provo, UT, United States","Nutrition, Dietetics, and Food Science, Brigham Young University, Provo, UT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center Brigham Young University, Provo, UT, United States","institution_ids":["https://openalex.org/I100005738"]},{"raw_affiliation_string":"Nutrition, Dietetics, and Food Science, Brigham Young University, Provo, UT, United States","institution_ids":["https://openalex.org/I100005738"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03653575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11931","display_name":"Organoselenium and organotellurium chemistry","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selenium","display_name":"selenium","score":0.7739999890327454},{"id":"https://openalex.org/keywords/soy-diet","display_name":"soy diet","score":0.7350000143051147},{"id":"https://openalex.org/keywords/prostate-cancer-prevention","display_name":"prostate cancer prevention","score":0.828000009059906},{"id":"https://openalex.org/keywords/tramp-mice","display_name":"TRAMP mice","score":0.9549999833106995},{"id":"https://openalex.org/keywords/methylselenocysteine","display_name":"methylselenocysteine","score":0.8629999756813049},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7200000286102295},{"id":"https://openalex.org/keywords/prostate-lobes","display_name":"prostate lobes","score":0.6669999957084656},{"id":"https://openalex.org/keywords/gleason-score","display_name":"Gleason score","score":0.9539999961853027},{"id":"https://openalex.org/keywords/epididymal-white-adipose-tissue","display_name":"epididymal adipose tissue","score":0.7879999876022339},{"id":"https://openalex.org/keywords/urogenital-tract","display_name":"urogenital tract","score":0.8489999771118164},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C2780940892","wikidata":"https://www.wikidata.org/wiki/Q1965933","display_name":"Tramp","level":4,"score":0.8617643713951111},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7259801626205444},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6693820953369141},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6617109179496765},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6456410884857178},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5373363494873047},{"id":"https://openalex.org/C553756173","wikidata":"https://www.wikidata.org/wiki/Q876","display_name":"Selenium","level":2,"score":0.45054635405540466},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.4450840950012207},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.4379897117614746},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3988655209541321},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3780493438243866},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24743777513504028},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.29.1_supplement.759.14","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.759.14","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.759.14","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"},{"id":"https://metadata.un.org/sdg/2","score":0.5666999816894531,"display_name":"Zero hunger"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7300741876","display_name":"Timing of Exposure to Selenium and Isoflavones and Prostate Cancer Prevention","funder_award_id":"1r15ca141385-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2415451275","https://openalex.org/W2089898532","https://openalex.org/W3173628545","https://openalex.org/W6996294290","https://openalex.org/W784653086","https://openalex.org/W7046443622","https://openalex.org/W3174630245","https://openalex.org/W748024326","https://openalex.org/W6981175933","https://openalex.org/W7097933337"],"abstract_inverted_index":{"The":[0],"aim":[1],"of":[2,10,46,79,109,119,166,172,182,188],"this":[3,230],"study":[4],"was":[5],"to":[6,254],"determine":[7],"when":[8],"initiation":[9,152,178],"supplemental":[11,91],"selenium":[12],"(Se)":[13],"or":[14,37,42,75],"high-soy":[15,36],"diet":[16,106,185],"would":[17],"maximize":[18],"prevention":[19],"against":[20],"prostate":[21,200,215,227,244],"cancer":[22,245],"in":[23,58,197,212,225,229,242],"TRAMP":[24,30],"mice.":[25],"[C57BL/6":[26],"X":[27,61],"FVB]":[28],"F1":[29],"male":[31],"mice":[32],"were":[33,82,144,174],"fed":[34],"a":[35,44,59],"zero-soy":[38],"stock":[39],"diet,":[40],"with":[41,101,104,114],"without":[43],"supplement":[45],"Se":[47,92,99,115,173,207,236],"(4.0":[48],"mg":[49],"Se/kg":[50],"BW":[51],"as":[52],"Se-methylselenocysteine)":[53],"by":[54,147,176,247,251],"gavage":[55],"5":[56],"d/wk":[57],"2":[60,62],"factorial":[63],"design.":[64],"Mice":[65],"began":[66],"their":[67],"respective":[68],"diets":[69],"at":[70,72,76,84],"conception,":[71],"6":[73],"wk,":[74],"12":[77],"wk":[78],"age,":[80],"and":[81,107,126,138,159,179,237],"killed":[83],"18":[85],"wk.":[86],"Three-way":[87],"ANOVA":[88],"showed":[89,168],"that":[90,169,180,235],"significantly":[93,116],"(p":[94,135,141,156,162,201,216],"<":[95,131,136,142,157,163,202,217],"0.001)":[96,137,158],"increased":[97],"liver":[98],"content,":[100],"minor":[102],"interactions":[103,167],"basal":[105,184],"time":[108],"initiation.":[110],"In":[111,204],"addition,":[112],"dosing":[113],"decreased":[117],"weight":[118],"epididymal":[120],"fat":[121,154],"pads,":[122],"urogenital":[123],"tracts":[124],"(UGT)":[125],"total":[127],"body":[128,160],"(all":[129],"p":[130],"0.001).":[132],"Fat":[133],"pad":[134,155],"UGT":[139],"weights":[140,161],"0.02)":[143],"also":[145],"reduced":[146,175,209],"high":[148,206],"soy":[149,192,238],"intake.":[150],"Earlier":[151],"lowered":[153,194],"0.05).":[164,218],"Analysis":[165],"most":[170],"effects":[171,187],"later":[177],"composition":[181],"the":[183,198,213,220],"modified":[186],"added":[189],"Se.":[190],"High":[191],"intake":[193,208],"Gleason":[195,210],"scores":[196,211],"ventral":[199],"0.002).":[203],"contrast,":[205],"dorsolateral":[214],"Since":[219],"predominant":[221],"lesion":[222],"is":[223],"different":[224,226,248],"lobes":[228],"model,":[231],"these":[232],"data":[233],"suggest":[234],"may":[239],"be":[240],"efficacious":[241],"reducing":[243],"progression":[246],"mechanisms.":[249],"Supported":[250],"NIH":[252],"CA141385":[253],"MJC.":[255]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}