{"id":"https://openalex.org/W119507408","doi":null,"title":"Effects of drug metabolism modifiers on pulegone-induced hepatotoxicity in mice.","display_name":"Effects of drug metabolism modifiers on pulegone-induced hepatotoxicity in mice.","publication_year":1987,"publication_date":"1987-10-01","ids":{"openalex":"https://openalex.org/W119507408","mag":"119507408","pmid":"https://pubmed.ncbi.nlm.nih.gov/3432735"},"language":"en","primary_location":{"id":"pmid:3432735","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3432735","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research communications in chemical pathology and pharmacology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111650697","display_name":"Tamio Mizutani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169719367","display_name":"Kyoto Prefectural University","ror":"https://ror.org/00ktqrd38","country_code":"JP","type":"education","lineage":["https://openalex.org/I169719367","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Mizutani","raw_affiliation_strings":["Department of Food Science and Nutrition, Kyoto Prefectural University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Nutrition, Kyoto Prefectural University, Japan","institution_ids":["https://openalex.org/I169719367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009995664","display_name":"HARUKO NOMURA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Nomura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108627237","display_name":"K Nakanishi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Nakanishi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088005061","display_name":"Setsuya Fujita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Fujita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.00746681,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"58","issue":"1","first_page":"75","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12756","display_name":"Plant Toxicity and Pharmacological Properties","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulegone","display_name":"pulegone","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cytochrome-p450-inhibitors","display_name":"cytochrome P450 inhibitors","score":0.972000002861023},{"id":"https://openalex.org/keywords/skf-525a","display_name":"SKF 525-A","score":0.9390000104904175},{"id":"https://openalex.org/keywords/metyrapone","display_name":"metyrapone","score":0.9959999918937683},{"id":"https://openalex.org/keywords/piperonyl-butoxide","display_name":"piperonyl butoxide","score":1.0},{"id":"https://openalex.org/keywords/carbon-disulfide","display_name":"carbon disulfide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.7139999866485596},{"id":"https://openalex.org/keywords/hepatocellular-necrosis","display_name":"liver necrosis","score":0.8130000233650208},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.8360000252723694},{"id":"https://openalex.org/keywords/drug-metabolites","display_name":"drug metabolites","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2777861070","wikidata":"https://www.wikidata.org/wiki/Q413816","display_name":"Pulegone","level":3,"score":0.9640986919403076},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6879881620407104},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6421412825584412},{"id":"https://openalex.org/C2777338454","wikidata":"https://www.wikidata.org/wiki/Q420891","display_name":"Piperonyl butoxide","level":3,"score":0.596229076385498},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5883843302726746},{"id":"https://openalex.org/C2779864607","wikidata":"https://www.wikidata.org/wiki/Q19720556","display_name":"Centrilobular necrosis","level":3,"score":0.517115592956543},{"id":"https://openalex.org/C2776514860","wikidata":"https://www.wikidata.org/wiki/Q3817359","display_name":"Hepatoprotection","level":4,"score":0.45632389187812805},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.4549503028392792},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4483274519443512},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.441169798374176},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.4340810179710388},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.41084447503089905},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.31316906213760376},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.2768440246582031},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19730907678604126},{"id":"https://openalex.org/C2777278459","wikidata":"https://www.wikidata.org/wiki/Q170885","display_name":"Essential oil","level":2,"score":0.11416029930114746},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0793379545211792},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.07347321510314941}],"mesh":[{"descriptor_ui":"D000081005","descriptor_name":"Cyclohexane Monoterpenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002246","descriptor_name":"Carbon Disulfide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008610","descriptor_name":"Menthol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008610","descriptor_name":"Menthol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008610","descriptor_name":"Menthol","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D008797","descriptor_name":"Metyrapone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010634","descriptor_name":"Phenobarbital","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010882","descriptor_name":"Piperonyl Butoxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D039821","descriptor_name":"Monoterpenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3432735","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3432735","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research communications in chemical pathology and pharmacology","raw_type":"Journal Article"},{"id":"mag:119507408","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3432735","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2024233539","https://openalex.org/W1964670176","https://openalex.org/W1993959011","https://openalex.org/W2265717666","https://openalex.org/W2101564735","https://openalex.org/W6958830358","https://openalex.org/W122268556","https://openalex.org/W2478225744","https://openalex.org/W1972164286","https://openalex.org/W2153569909"],"abstract_inverted_index":{"Intraperitoneal":[0],"injection":[1],"of":[2,8,33,36,58,70],"R-(+)-pulegone":[3],"(pulegone),":[4],"the":[5,39,56,65,75],"main":[6],"constituent":[7],"pennyroyal":[9],"oil,":[10],"to":[11],"ddY":[12],"mice":[13,37],"caused":[14],"extensive":[15],"liver":[16,76],"injury":[17,77],"as":[18],"characterized":[19],"by":[20],"an":[21],"increase":[22],"in":[23,78],"serum":[24],"glutamic":[25],"pyruvic":[26],"transaminase":[27],"(GPT)":[28],"activity":[29],"and":[30,48],"centrilobular":[31],"necrosis":[32],"hepatocytes.":[34],"Treatments":[35],"with":[38,64],"cytochrome":[40],"P-450":[41],"enzyme":[42],"inhibitors,":[43],"SKF-525A,":[44],"metyrapone,":[45],"piperonyl":[46],"butoxide,":[47],"carbon":[49],"disulfide":[50],"(CS2),":[51],"prevented":[52],"or":[53],"markedly":[54],"alleviated":[55],"hepatotoxicity":[57],"pulegone.":[59],"These":[60],"results":[61],"are":[62],"compatible":[63],"view":[66],"that":[67],"some":[68],"metabolite":[69],"pulegone":[71],"is":[72],"responsible":[73],"for":[74],"mice.":[79]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}