{"id":"https://openalex.org/W119487397","doi":null,"title":"Misoprostol and ranitidine in the prevention of NSAID-induced ulcers: a prospective, double-blind, multicenter study.","display_name":"Misoprostol and ranitidine in the prevention of NSAID-induced ulcers: a prospective, double-blind, multicenter study.","publication_year":1996,"publication_date":"1996-02-01","ids":{"openalex":"https://openalex.org/W119487397","mag":"119487397","pmid":"https://pubmed.ncbi.nlm.nih.gov/8607484"},"language":"en","primary_location":{"id":"pmid:8607484","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8607484","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Clinical Trial"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110641363","display_name":"Jeffrey B. Raskin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210164554","display_name":"Miami VA Healthcare System","ror":"https://ror.org/05myvb614","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210119004","https://openalex.org/I4210164554"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J B Raskin","raw_affiliation_strings":["Department of Veterans Affairs Medical Center, Miami, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs Medical Center, Miami, Florida, USA","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I4210164554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107094717","display_name":"Richard H. R. White","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R H White","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036184604","display_name":"Richard Jaszewski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Jaszewski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108408569","display_name":"Mark A. Korsten","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Korsten","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112152159","display_name":"T T Schubert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T T Schubert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030454392","display_name":"J G Fort","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J G Fort","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.3361,"has_fulltext":false,"cited_by_count":101,"citation_normalized_percentile":{"value":0.9678359,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"91","issue":"2","first_page":"223","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/misoprostol","display_name":"misoprostol","score":0.996999979019165},{"id":"https://openalex.org/keywords/ranitidine","display_name":"ranitidine","score":1.0},{"id":"https://openalex.org/keywords/nsaid-induced-ulcer","display_name":"NSAID-induced ulcer","score":0.925000011920929},{"id":"https://openalex.org/keywords/gastric-ulcer","display_name":"gastric ulcer","score":0.6620000004768372},{"id":"https://openalex.org/keywords/duodenal-ulcer","display_name":"duodenal ulcer","score":1.0},{"id":"https://openalex.org/keywords/ulcer-prevention","display_name":"ulcer prevention","score":0.7960000038146973},{"id":"https://openalex.org/keywords/h2-receptor-antagonists","display_name":"H2 receptor antagonists","score":0.8080000281333923},{"id":"https://openalex.org/keywords/prostaglandin-e2-analogue","display_name":"prostaglandin E2 analogue","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9733996391296387},{"id":"https://openalex.org/C2777445857","wikidata":"https://www.wikidata.org/wiki/Q423037","display_name":"Ranitidine","level":2,"score":0.9720146656036377},{"id":"https://openalex.org/C2779199973","wikidata":"https://www.wikidata.org/wiki/Q416025","display_name":"Misoprostol","level":4,"score":0.9713677167892456},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5813467502593994},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5675145983695984},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4725643992424011},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.4678678512573242},{"id":"https://openalex.org/C2991744798","wikidata":"https://www.wikidata.org/wiki/Q608510","display_name":"Double blind","level":4,"score":0.41877931356430054},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.065940260887146},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.04873621463775635},{"id":"https://openalex.org/C2778642596","wikidata":"https://www.wikidata.org/wiki/Q8452","display_name":"Abortion","level":3,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000897","descriptor_name":"Anti-Ulcer Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000897","descriptor_name":"Anti-Ulcer Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004381","descriptor_name":"Duodenal Ulcer","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D004381","descriptor_name":"Duodenal Ulcer","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011899","descriptor_name":"Ranitidine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011899","descriptor_name":"Ranitidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013276","descriptor_name":"Stomach Ulcer","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D013276","descriptor_name":"Stomach Ulcer","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016595","descriptor_name":"Misoprostol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016595","descriptor_name":"Misoprostol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8607484","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8607484","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Clinical Trial"},{"id":"mag:119487397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8607484","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4255467625","https://openalex.org/W2116912528","https://openalex.org/W2036268181","https://openalex.org/W2167378024","https://openalex.org/W1967370328","https://openalex.org/W2411049194","https://openalex.org/W1974009646","https://openalex.org/W1970531930","https://openalex.org/W2029109403","https://openalex.org/W2342975771"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"compare":[2],"ranitidine":[3,67,140,157],"to":[4,8,60],"misoprostol":[5,62,116,145,170],"with":[6,102],"respect":[7],"the":[9,56,87,139,159,172],"prevention":[10,160,173],"of":[11,48,81,89,161,174],"gastric":[12,49,91,163,186],"and":[13,36,78,117,144,187],"duodenal":[14,51,93,176,188],"ulcers":[15,107],"in":[16,55,100,110,118,158,190],"patients":[17,30,121,191],"on":[18,32,115,122,192],"chronic":[19,33,193],"NSAID":[20,34,194],"therapy.":[21,195],"METHODS:":[22],"A":[23],"multi-center,":[24],"8-wk,":[25],"randomized,":[26],"double-blind":[27],"study.":[28],"Eligible":[29],"were":[31,37,58,108,136],"therapy":[35],"experiencing":[38],"NSAID-related":[39],"upper":[40],"gastrointestinal":[41],"(UGI)":[42],"pain":[43],"without":[44],"UGI":[45,72],"endoscopic":[46],"evidence":[47],"or":[50,66,92,96,142,147],"ulcers.":[52,164,177],"Patients":[53],"enrolled":[54],"study":[57],"randomized":[59],"either":[61],"200":[63],"micrograms":[64],"q.i.d.":[65],"150":[68],"mg":[69],"b.i.d..":[70],"Follow-up":[71],"endoscopy":[73],"was":[74,85,127,166],"performed":[75],"after":[76],"4":[77],"8":[79],"wk":[80],"treatment.":[82],"Therapeutic":[83],"failure":[84],"considered":[86],"development":[88],"a":[90,124],"ulcer":[94,134],">":[95],"=":[97],"0.3":[98],"cm":[99],"diameter":[101],"perceptible":[103],"depth.":[104],"RESULTS:":[105],"Gastric":[106],"found":[109],"only":[111],"1/180":[112],"(0.56%)":[113],"patient":[114],"11/194":[119],"(5.67%)":[120],"ranitidine,":[123],"difference":[125],"that":[126],"statistically":[128],"significant":[129],"(p":[130],"<":[131],"0.01).":[132],"Duodenal":[133],"rates":[135],"similar":[137],"for":[138,171,182],"(2/185":[141],"1.08%)":[143],"(2/181":[146],"1.10%)":[148],"groups.":[149],"CONCLUSION:":[150],"Misoprostol":[151,178],"is":[152],"significantly":[153],"more":[154],"effective":[155,168],"than":[156],"NSAID-induced":[162,175],"Ranitidine":[165],"as":[167,169],"should":[179],"be":[180],"used":[181],"prophylaxis":[183],"against":[184],"both":[185],"ulceration":[189]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
