{"id":"https://openalex.org/W1192008708","doi":"https://doi.org/10.1182/blood-2014-12-614370","title":"Chronic transfusion therapy improves but does not normalize systemic and pulmonary vasculopathy in sickle cell disease","display_name":"Chronic transfusion therapy improves but does not normalize systemic and pulmonary vasculopathy in sickle cell disease","publication_year":2015,"publication_date":"2015-06-03","ids":{"openalex":"https://openalex.org/W1192008708","doi":"https://doi.org/10.1182/blood-2014-12-614370","mag":"1192008708","pmid":"https://pubmed.ncbi.nlm.nih.gov/26036801","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4528063"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2014-12-614370","doi":"https://doi.org/10.1182/blood-2014-12-614370","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2014-12-614370","pdf_url":"https://ashpublications.org/blood/article-pdf/126/6/703/1390904/703.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/126/6/703/1390904/703.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015738891","display_name":"Jon A. Detterich","orcid":"https://orcid.org/0000-0002-2086-9569","observed_orcids":["https://orcid.org/0000-0002-2086-9569"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon A. Detterich","raw_affiliation_strings":["Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, CA;","Division of Cardiology, Children\u2019s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA;"],"raw_orcid":"https://orcid.org/0000-0002-2086-9569","affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, CA;","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Division of Cardiology, Children\u2019s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA;","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027869516","display_name":"Roberta Miyeko Kato","orcid":"https://orcid.org/0000-0002-4442-8426","observed_orcids":["https://orcid.org/0000-0002-4442-8426"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roberta M. Kato","raw_affiliation_strings":["Division of Pediatric Pulmonology, Children\u2019s Hospital Los Angeles, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Pulmonology, Children\u2019s Hospital Los Angeles, Los Angeles, CA;","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013151509","display_name":"Mikl\u00f3s R\u00e1bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79741316","display_name":"University of Pecs","ror":"https://ror.org/037b5pv06","country_code":"HU","type":"education","lineage":["https://openalex.org/I79741316"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Miklos Rabai","raw_affiliation_strings":["Department of Medicine, University of Pecs, Pecs, Hungary; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Pecs, Pecs, Hungary; and","institution_ids":["https://openalex.org/I79741316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019403591","display_name":"Herbert J. Meiselman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herbert J. Meiselman","raw_affiliation_strings":["Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, CA;","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077729374","display_name":"Thomas D. Coates","orcid":"https://orcid.org/0000-0001-9878-6029","observed_orcids":["https://orcid.org/0000-0001-9878-6029"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas D. Coates","raw_affiliation_strings":["Division of Hematology, Children\u2019s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Children\u2019s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034495408","display_name":"John C. Wood","orcid":"https://orcid.org/0000-0003-0996-3439","observed_orcids":["https://orcid.org/0000-0003-0996-3439"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Wood","raw_affiliation_strings":["Division of Cardiology, Children\u2019s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA;"],"raw_orcid":"https://orcid.org/0000-0003-0996-3439","affiliations":[{"raw_affiliation_string":"Division of Cardiology, Children\u2019s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA;","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":6.1553,"has_fulltext":true,"cited_by_count":71,"citation_normalized_percentile":{"value":0.97349942,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"126","issue":"6","first_page":"703","last_page":"710"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/chronic-transfusion-therapy","display_name":"chronic transfusion","score":0.9559999704360962},{"id":"https://openalex.org/keywords/free-hemoglobin","display_name":"free hemoglobin","score":0.9419999718666077},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8149999976158142},{"id":"https://openalex.org/keywords/flow-mediated-dilation","display_name":"flow-mediated dilation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/tricuspid-regurgitant-velocity","display_name":"tricuspid regurgitation velocity","score":0.9710000157356262},{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.953000009059906},{"id":"https://openalex.org/keywords/intravascular-hemolysis","display_name":"intravascular hemolysis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/blood-viscosity","display_name":"blood viscosity","score":0.7749999761581421},{"id":"https://openalex.org/keywords/vascular-reactivity","display_name":"vascular reactivity","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.785045862197876},{"id":"https://openalex.org/C2779817106","wikidata":"https://www.wikidata.org/wiki/Q7834210","display_name":"Transfusion therapy","level":3,"score":0.6603696346282959},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.542231559753418},{"id":"https://openalex.org/C2778620579","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Sickle cell anemia","level":3,"score":0.463928759098053},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.4397837817668915},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.42071300745010376},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3853766918182373},{"id":"https://openalex.org/C2780014101","wikidata":"https://www.wikidata.org/wiki/Q183605","display_name":"Blood transfusion","level":2,"score":0.3448072671890259},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3379662036895752}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001803","descriptor_name":"Blood Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001916","descriptor_name":"Brachial Artery","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001916","descriptor_name":"Brachial Artery","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001916","descriptor_name":"Brachial Artery","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014262","descriptor_name":"Tricuspid Valve Insufficiency","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D014262","descriptor_name":"Tricuspid Valve Insufficiency","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014262","descriptor_name":"Tricuspid Valve Insufficiency","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014783","descriptor_name":"Viscosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood-2014-12-614370","doi":"https://doi.org/10.1182/blood-2014-12-614370","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2014-12-614370","pdf_url":"https://ashpublications.org/blood/article-pdf/126/6/703/1390904/703.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4528063","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4528063","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Text"},{"id":"pmid:26036801","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26036801","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1182/blood-2014-12-614370","doi":"https://doi.org/10.1182/blood-2014-12-614370","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2014-12-614370","pdf_url":"https://ashpublications.org/blood/article-pdf/126/6/703/1390904/703.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1999843896","display_name":null,"funder_award_id":"1U54 HL117718","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2098862387","display_name":null,"funder_award_id":"2 K12 HD 52954-6 A1","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4132288098","display_name":"Erythrocyte Nitric Oxide Links Rheology and Vasculopathy in Sickle Cell Disease","funder_award_id":"K23HL119627","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4758887890","display_name":null,"funder_award_id":"U54-HL090511","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5092304127","display_name":"Multimodal biophysical markers of vascular disease in hemoglobinopathies","funder_award_id":"U01HL117718","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5399073165","display_name":null,"funder_award_id":"1 U54 HL090511-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5900184332","display_name":"General Clinical Research Center","funder_award_id":"M01RR000043","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5919997565","display_name":null,"funder_award_id":"R01\u2010DK097115","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5973715474","display_name":"Childrens Hospital Los Angeles Child Health Research Development Award","funder_award_id":"K12HD052954","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6305008868","display_name":"Iron-mediated vascular disease in sickle cell disease.","funder_award_id":"RC1HL099412","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7537374094","display_name":null,"funder_award_id":"RR00043-43","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8444074154","display_name":null,"funder_award_id":"HL117718","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8700108846","display_name":"Basic and Translational Research Program","funder_award_id":"5u54hl090511-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309100","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1192008708.pdf","grobid_xml":"https://content.openalex.org/works/W1192008708.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W63494502","https://openalex.org/W155985806","https://openalex.org/W1555489744","https://openalex.org/W1948831045","https://openalex.org/W1956337241","https://openalex.org/W1968799061","https://openalex.org/W1984048336","https://openalex.org/W1999948518","https://openalex.org/W2006754069","https://openalex.org/W2025593289","https://openalex.org/W2025936915","https://openalex.org/W2027816595","https://openalex.org/W2030806407","https://openalex.org/W2040024980","https://openalex.org/W2040323431","https://openalex.org/W2049519896","https://openalex.org/W2056556235","https://openalex.org/W2069447459","https://openalex.org/W2073869392","https://openalex.org/W2078057998","https://openalex.org/W2078356687","https://openalex.org/W2081305693","https://openalex.org/W2086096535","https://openalex.org/W2091181219","https://openalex.org/W2093841568","https://openalex.org/W2108607846","https://openalex.org/W2111103033","https://openalex.org/W2112789217","https://openalex.org/W2117136049","https://openalex.org/W2117154557","https://openalex.org/W2124406409","https://openalex.org/W2130410599","https://openalex.org/W2136356633","https://openalex.org/W2139654614","https://openalex.org/W2148547093","https://openalex.org/W2150027863","https://openalex.org/W2155545690","https://openalex.org/W2159506302","https://openalex.org/W2161770560","https://openalex.org/W2165932923","https://openalex.org/W2234332752","https://openalex.org/W2284118245","https://openalex.org/W2322074970","https://openalex.org/W4241694836"],"related_works":["https://openalex.org/W2555266981","https://openalex.org/W2914085299","https://openalex.org/W2105262812","https://openalex.org/W2746746526","https://openalex.org/W1975656141","https://openalex.org/W2557804606","https://openalex.org/W2565987868","https://openalex.org/W2930677652","https://openalex.org/W2577432845","https://openalex.org/W2500833210"],"abstract_inverted_index":{"Tricuspid":[0],"regurgitant":[1],"(TR)":[2],"jet":[3,61,104,120,140,159],"velocity":[4,105,121,141,160],"and":[5,27,46,59,72,81,92,106,137,142,161,171,177,186],"its":[6],"relationship":[7,132],"to":[8],"pulmonary":[9,47],"hypertension":[10],"has":[11],"been":[12],"controversial":[13],"in":[14,24,76,86,93,109,147],"sickle":[15],"cell":[16],"disease":[17],"(SCD).":[18],"Plasma":[19],"free":[20,37,68,135,169],"hemoglobin":[21,38,136,170],"is":[22],"elevated":[23],"SCD":[25,79,88,111],"patients":[26,112],"acutely":[28],"impairs":[29],"systemic":[30,45],"vascular":[31,191],"reactivity.":[32],"We":[33,100],"postulated":[34],"that":[35,183],"plasma":[36,67,134,168],"would":[39],"be":[40],"negatively":[41],"associated":[42,166],"with":[43,114,125,167,180],"both":[44,138],"endothelial":[48],"function,":[49],"assessed":[50],"by":[51],"flow-mediated":[52],"dilation":[53],"(FMD)":[54],"of":[55],"the":[56,115,148,181],"brachial":[57],"artery":[58],"TR":[60,70,103,119,139,158],"velocity,":[62],"respectively.":[63],"Whole":[64],"blood":[65],"viscosity,":[66],"hemoglobin,":[69],"jet,":[71],"FMD":[73,108,162],"were":[74,163],"measured":[75],"chronically":[77,149],"transfused":[78,150],"pre-":[80],"posttransfusion":[82],"(N":[83,89,97],"=":[84,90,98],"25),":[85],"nontransfused":[87,110],"26),":[91],"ethnicity-matched":[94],"control":[95],"subjects":[96],"10).":[99],"found":[101],"increased":[102,187],"decreased":[107],"compared":[113],"other":[116],"2":[117],"groups.":[118],"was":[122,128],"inversely":[123],"correlated":[124],"FMD.":[126,143,153],"There":[127],"a":[129],"striking":[130],"nonlinear":[131],"between":[133],"A":[144],"single":[145],"transfusion":[146,172],"cohort":[151],"improved":[152],"In":[154],"our":[155],"patient":[156],"sample,":[157],"most":[164],"strongly":[165],"status":[173],"(transfusions":[174],"being":[175],"protective),":[176],"thus":[178],"consistent":[179],"hypothesis":[182],"intravascular":[184],"hemolysis":[185],"endogenous":[188],"erythropoiesis":[189],"damage":[190],"endothelia.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
