{"id":"https://openalex.org/W119154392","doi":null,"title":"Selective wavelength pupillometry to evaluate outer and inner retinal photoreception","display_name":"Selective wavelength pupillometry to evaluate outer and inner retinal photoreception","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W119154392","mag":"119154392"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:umu-79628","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79628","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79628","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002379328","display_name":"Aki Kawasaki","orcid":"https://orcid.org/0000-0003-0609-4194","observed_orcids":["https://orcid.org/0000-0003-0609-4194"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Aki Kawasaki","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0609-4194","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5002379328"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.6660000085830688,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.6660000085830688,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.31520000100135803,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10427","display_name":"Visual perception and processing mechanisms","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pupillometry","display_name":"pupillometry","score":0.8659999966621399},{"id":"https://openalex.org/keywords/iprgcs","display_name":"intrinsically photosensitive retinal ganglion cells","score":0.9440000057220459},{"id":"https://openalex.org/keywords/melanopsin","display_name":"melanopsin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/retinitis-pigmentosa","display_name":"retinitis pigmentosa","score":0.8870000243186951},{"id":"https://openalex.org/keywords/rod-photoreceptors","display_name":"rod photoreceptors","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cone-photoreceptors","display_name":"cone photoreceptors","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pupillary-light-reflex","display_name":"pupillary light reflex","score":0.9710000157356262},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.843999981880188},{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":0.9169999957084656},{"id":"https://openalex.org/keywords/blue-light","display_name":"blue light","score":0.5070000290870667},{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.9160000085830688},{"id":"https://openalex.org/keywords/mesopic-vision","display_name":"mesopic vision","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C2778711042","wikidata":"https://www.wikidata.org/wiki/Q3410891","display_name":"Pupillometry","level":3,"score":0.6234632730484009},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5563920140266418},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.5059248805046082},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.4849388897418976},{"id":"https://openalex.org/C2777394604","wikidata":"https://www.wikidata.org/wiki/Q173318","display_name":"Pupil","level":2,"score":0.389676034450531},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.38194626569747925},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.2861824631690979},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2224290370941162},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20568245649337769}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:umu-79628","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79628","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:119154392","doi":null,"is_oa":false,"landing_page_url":"http://umu.diva-portal.org/smash/get/diva2:643361/FULLTEXT02.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:umu-79628","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79628","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1438850562","https://openalex.org/W1479926654","https://openalex.org/W1488048016","https://openalex.org/W1507606229","https://openalex.org/W1517331917","https://openalex.org/W1575917801","https://openalex.org/W1967657577","https://openalex.org/W1971524741","https://openalex.org/W1974310493","https://openalex.org/W1974832413","https://openalex.org/W1982138519","https://openalex.org/W1982925398","https://openalex.org/W1983875092","https://openalex.org/W1986166528","https://openalex.org/W1986710543","https://openalex.org/W1988834086","https://openalex.org/W1991740613","https://openalex.org/W1993394538","https://openalex.org/W1994447302","https://openalex.org/W2002613349","https://openalex.org/W2006130774","https://openalex.org/W2006253735","https://openalex.org/W2009077913","https://openalex.org/W2009620624","https://openalex.org/W2011391168","https://openalex.org/W2013601182","https://openalex.org/W2014028088","https://openalex.org/W2017649517","https://openalex.org/W2018108929","https://openalex.org/W2020364712","https://openalex.org/W2022197238","https://openalex.org/W2024156701","https://openalex.org/W2030969627","https://openalex.org/W2031806606","https://openalex.org/W2031911867","https://openalex.org/W2035853180","https://openalex.org/W2039209617","https://openalex.org/W2041031046","https://openalex.org/W2042432891","https://openalex.org/W2043842765","https://openalex.org/W2043880944","https://openalex.org/W2050956534","https://openalex.org/W2051307515","https://openalex.org/W2053335306","https://openalex.org/W2058978487","https://openalex.org/W2069020255","https://openalex.org/W2069329719","https://openalex.org/W2069342665","https://openalex.org/W2069684088","https://openalex.org/W2072018453","https://openalex.org/W2077830514","https://openalex.org/W2077888073","https://openalex.org/W2078747175","https://openalex.org/W2081024860","https://openalex.org/W2085815839","https://openalex.org/W2087148598","https://openalex.org/W2089283829","https://openalex.org/W2091741662","https://openalex.org/W2092510003","https://openalex.org/W2093996130","https://openalex.org/W2107550000","https://openalex.org/W2110209988","https://openalex.org/W2113150385","https://openalex.org/W2117649297","https://openalex.org/W2118108368","https://openalex.org/W2123311935","https://openalex.org/W2126201948","https://openalex.org/W2132499434","https://openalex.org/W2132842186","https://openalex.org/W2135393774","https://openalex.org/W2137222303","https://openalex.org/W2138643959","https://openalex.org/W2151809142","https://openalex.org/W2160214073","https://openalex.org/W2165727733","https://openalex.org/W2170538407"],"related_works":["https://openalex.org/W2076077724","https://openalex.org/W2398225596","https://openalex.org/W2072439670","https://openalex.org/W2911973810","https://openalex.org/W7120855110","https://openalex.org/W2341071302","https://openalex.org/W1988738248","https://openalex.org/W2117649297","https://openalex.org/W1982138519","https://openalex.org/W4384695460"],"abstract_inverted_index":{"Purpose":[0],"Intrinsically":[1],"photosensitive":[2],"retinal":[3,48,71,80,107,299,403],"ganglion":[4],"cells":[5],"(ipRGCs)":[6],"express":[7],"a":[8,56,116,123,138,161,189,211,287,353,382,450],"unique":[9],"photopigment":[10],"called":[11],"melanopsin.":[12],"Capable":[13],"of":[14,67,125,129,177,191,290,315,334,339,368,374,385,396,402,417,435,453],"direct":[15,192],"phototransduction,":[16],"the":[17,30,34,64,86,90,96,167,227,252,261,279,293,316,331,348,357,436],"ipRGCs":[18,91],"are":[19],"also":[20,324],"influenced":[21],"by":[22,266],"rods":[23,335],"and":[24,43,45,69,76,118,132,153,160,169,173,200,214,268,278,330,343,365,379,419],"cones":[25],"via":[26],"synaptic":[27],"inputs.":[28],"Thus,":[29],"photoinput":[31],"that":[32,59,303],"mediates":[33],"pupil":[35,87,171,181,196,232,242,262,301,321,350,359,438,455],"light":[36,88,93,121,184,202,229,442],"reflex":[37],"derives":[38],"from":[39,166,306],"both":[40],"outer":[41,68],"(rods":[42],"cones)":[44],"inner":[46,70,106],"(melanopsin-mediated)":[47],"photoreception.":[49],"This":[50],"thesis":[51],"has":[52],"aimed":[53],"to":[54,84,105,115,175,183,198,216,235,275,388,440],"develop":[55],"pupillometric":[57],"test":[58],"provides":[60],"quantitative":[61],"information":[62,94],"about":[63],"functional":[65],"status":[66],"photoreception":[72,108],"in":[73,77,220,282,286,328,371,444],"healthy":[74,221,346],"eyes":[75,78],"with":[79,150,251,258,337,446],"degeneration.":[81],"In":[82,224,256,345,399,423],"addition":[83],"regulating":[85],"reflex,":[89],"signal":[92],"for":[95,146,413],"circadian":[97,354,451],"rhythm,":[98],"thus,":[99],"these":[100],"two":[101,147],"non-visual":[102,430],"physiologic":[103],"responses":[104,114,172,197,233,263,302],"were":[109,135,144,207,271,310],"examined":[110],"simultaneously.":[111],"Methods":[112],"Pupil":[113],"long":[117],"short":[119],"wavelength":[120,426],"over":[122],"range":[124],"intensities":[126],"(under":[127],"conditions":[128,395],"light,":[130],"mesopic":[131],"dark":[133,397],"adaptation)":[134],"recorded":[136,208],"using":[137],"customized":[139],"infrared":[140],"computerized":[141],"pupillometer.":[142],"Results":[143,223],"compared":[145,234,274],"groups:":[148],"patients":[149,257,329],"retinitis":[151,259,375],"pigmentosa":[152,376],"controls.":[154],"The":[155,180,312,433],"response":[156,182,322,351,360,439],"function":[157,370],"threshold":[158,313],"intensity":[159,163,314,333],"half-max":[162],"was":[164,186,248,323],"determined":[165],"rod-weighted":[168],"cone-weighted":[170],"correlated":[174,215,336],"extent":[176],"visual":[178,340],"loss.":[179],"offset":[185],"assessed":[187],"as":[188,381],"measure":[190],"melanopsin":[193,291],"activation.":[194],"Lastly,":[195],"red":[199,237],"blue":[201,228,254,391,441],"at":[203,297],"equal":[204],"photo":[205],"flux":[206],"hourly":[209],"during":[210],"24-hour":[212],"period":[213],"salivary":[217],"melatonin":[218,447],"concentrations":[219],"subjects.":[222],"normal":[225],"eyes,":[226],"evoked":[230],"greater":[231,288],"equiluminant":[236],"light.":[238,255],"With":[239],"increasing":[240],"intensity,":[241],"contraction":[243],"became":[244],"more":[245,408],"sustained":[246],"which":[247],"most":[249],"apparent":[250],"brightest":[253],"pigmentosa,":[260],"mediated":[264],"predominantly":[265,305],"rod":[267,369,418],"cone":[269,308,421],"activation":[270],"significantly":[272,325],"reduced":[273,326],"controls,":[276,347],"(p<0.001)":[277],"relative":[280],"decrease":[281],"their":[283],"contribution":[284],"resulted":[285],"influence":[289],"on":[292],"post-stimulus":[294,437],"response.":[295],"Even":[296],"endstage":[298],"degeneration,":[300,404],"derived":[304],"residual":[307,415],"activity":[309],"detectable.":[311],"rod-mediated,":[317],"but":[318],"not":[319],"cone-mediated,":[320],"(p=0.006)":[327],"half-maximal":[332],"severity":[338],"loss":[341,367,384],"(r2=0.7":[342],"p=0.02).":[344],"melanopsin-mediated":[349],"demonstrated":[352],"modulation":[355],"whereas":[356],"cone-mediated":[358],"did":[361],"not.":[362],"Conclusion":[363],"Early":[364],"progressive":[366,383],"mild-moderate":[372],"stages":[373,401],"is":[377,407,443],"detectable":[378],"quantifiable":[380],"pupillary":[386],"sensitivity":[387],"extremely":[389],"dim":[390],"lights":[392],"obtained":[393],"under":[394],"adaptation.":[398],"advanced":[400],"chromatic":[405],"pupillometry":[406,427],"sensitive":[409],"than":[410],"standard":[411],"electroretinography":[412],"detecting":[414],"levels":[416],"especially":[420],"activity.":[422],"addition,":[424],"selective":[425],"can":[428],"assess":[429],"light-dependent":[431],"functions.":[432],"timing":[434],"phase":[445],"secretion,":[448],"suggesting":[449],"regulation":[452],"this":[454],"parameter.":[456]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}