{"id":"https://openalex.org/W1190211246","doi":null,"title":"The UGT2B17 gene polymorphism and bone mineral density in puberty.","display_name":"The UGT2B17 gene polymorphism and bone mineral density in puberty.","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W1190211246","mag":"1190211246"},"language":"en","primary_location":{"id":"pmh:oai:www.duo.uio.no:10852/29481","doi":null,"is_oa":true,"landing_page_url":"http://urn.nb.no/URN:NBN:no-20783","pdf_url":"http://hdl.handle.net/10852/29481","source":{"id":"https://openalex.org/S4306401716","display_name":"Duo Research Archive (University of Oslo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184942183","host_organization_name":"University of Oslo","host_organization_lineage":["https://openalex.org/I184942183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10852/29481","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024797162","display_name":"Isma Sohail","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Isma Sohail","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5024797162"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.7886000275611877,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.7886000275611877,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.056299999356269836,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.048700001090765,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ugt2b17","display_name":"UGT2B17","score":0.8790000081062317},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.6959999799728394},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.925000011920929},{"id":"https://openalex.org/keywords/puberty","display_name":"puberty","score":0.9710000157356262},{"id":"https://openalex.org/keywords/bone-growth","display_name":"bone growth","score":0.7990000247955322},{"id":"https://openalex.org/keywords/testosterone-metabolism","display_name":"testosterone metabolism","score":0.6579999923706055},{"id":"https://openalex.org/keywords/male-hypogonadism","display_name":"male hypogonadism","score":0.9860000014305115},{"id":"https://openalex.org/keywords/postmenopausal-bone-loss","display_name":"postmenopausal bone loss","score":0.9179999828338623},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.37299999594688416},{"id":"https://openalex.org/keywords/insertion-deletion-polymorphism","display_name":"insertion/deletion polymorphism","score":0.6909999847412109},{"id":"https://openalex.org/keywords/troms-study","display_name":"Troms\u00f8 Study","score":0.5860000252723694},{"id":"https://openalex.org/keywords/adolescents","display_name":"adolescents","score":0.3970000147819519},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.34299999475479126}],"concepts":[{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.7434120178222656},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.6552129983901978},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48876023292541504},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43439310789108276},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4111316502094269},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35608839988708496},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3470660448074341},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31464889645576477},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1664520502090454},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.08059254288673401}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.duo.uio.no:10852/29481","doi":null,"is_oa":true,"landing_page_url":"http://urn.nb.no/URN:NBN:no-20783","pdf_url":"http://hdl.handle.net/10852/29481","source":{"id":"https://openalex.org/S4306401716","display_name":"Duo Research Archive (University of Oslo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184942183","host_organization_name":"University of Oslo","host_organization_lineage":["https://openalex.org/I184942183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},{"id":"mag:1190211246","doi":null,"is_oa":false,"landing_page_url":"https://www.duo.uio.no/bitstream/10852/29481/4/ProsjektxSohail.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.duo.uio.no:10852/29481","doi":null,"is_oa":true,"landing_page_url":"http://urn.nb.no/URN:NBN:no-20783","pdf_url":"http://hdl.handle.net/10852/29481","source":{"id":"https://openalex.org/S4306401716","display_name":"Duo Research Archive (University of Oslo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184942183","host_organization_name":"University of Oslo","host_organization_lineage":["https://openalex.org/I184942183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1190211246.pdf","grobid_xml":"https://content.openalex.org/works/W1190211246.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W1963592766","https://openalex.org/W1976746229","https://openalex.org/W2079700993","https://openalex.org/W2107163673","https://openalex.org/W2124900263","https://openalex.org/W2143013163"],"related_works":["https://openalex.org/W2049635932","https://openalex.org/W2073428316","https://openalex.org/W3210871267","https://openalex.org/W2790456354","https://openalex.org/W1984522168","https://openalex.org/W2041225207","https://openalex.org/W1970821796","https://openalex.org/W2104218121","https://openalex.org/W2105348001","https://openalex.org/W2247615543"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,111,202,240,293,340,414,431],"uridine":[2],"diphosphate-glucuronosyltransferase":[3],"B17":[4],"is":[5,16,38,102,418,434],"important":[6,17],"for":[7,18,67,132,196,230,249,258,289,301,325,354,368],"the":[8,19,42,56,59,68,71,89,100,156,160,197,221,233,236,250,259,273,283,290,302,309,318,326,333,348,355,369,376,393,409,424,429,451],"excretion":[9],"and":[10,45,63,92,108,129,147,168,170,189,199,211,235,263,276,282,313,337,347,380,392,406,408],"thereby":[11],"inactivation":[12],"of":[13,26,58,127,134,152,159,174,278,285,295,317,344],"testosterone.":[14],"Testosterone":[15],"bone":[20,46,75,106,135,176,224,404,425,447],"growth":[21,47,136],"in":[22,48,74,115,155,223,232,242,246,422,428,450],"puberty.":[23,49,430],"Low":[24],"values":[25,300,324],"this":[27,116],"hormone":[28],"can":[29],"cause":[30],"male":[31,93,153,390],"hypogonadism.":[32,94],"Here":[33],"we":[34,78,97],"determine":[35],"if":[36,55,83,99],"there":[37,84],"any":[39,86],"relationship":[40,87,269],"between":[41,88,220,272,342,389,402],"UGT2B17":[43,90,237,251,274,303,327,349,370,394,410,415],"polymorphism":[44,91,101,238,253,261,275,350,417,433],"Our":[50],"agenda":[51],"was":[52,85,192,217,244,270,351,361,386,399],"to":[53,80,444],"find":[54,81],"distribution":[57],"genotypes":[60],"(insertion/insertion,":[61],"insertion/deletion":[62],"deletion/deletion)":[64],"were":[65,118,204],"different":[66,122],"groups":[69,123],"with":[70,104,256,308,332,375,436],"highest":[72],"increase":[73],"mass.":[76],"Also":[77],"wanted":[79],"out":[82],"At":[95],"last":[96],"studied":[98],"associated":[103,435],"postmenopausal":[105,175,403],"mass":[107,405],"loss.":[109],"METHODS:":[110],"DNA":[112],"samples":[113],"used":[114],"study":[117,162,173],"selected":[119],"from":[120],"three":[121],"1)":[124],"a":[125,150,172,218,363,420,437,445],"cohort":[126],"children":[128],"adolescents":[130],"recruited":[131],"studies":[133],"by":[137,163,179],"Prof.":[138,164,180],"Jens":[139],"P":[140],"Berg,":[141],"Hormone":[142],"Laboratory,":[143],"Aker":[144,186],"university":[145,187],"hospital":[146,188],"UiO,":[148],"2)":[149],"substudy":[151],"hypogonadism":[154,391],"fourth":[157],"survey":[158],"Troms\u00f8":[161],"Johan":[165],"Svartberg,":[166],"UNN":[167],"UiT\u00f8,":[169],"3)":[171],"loss":[177,407],"(BUS-study)":[178],"Jan":[181],"A.":[182],"Falch,":[183],"Endocrine":[184],"Clinic,":[185],"UiO.":[190],"Genotyping":[191],"performed":[193],"using":[194,206],"primers":[195],"insertion":[198,260],"deletion":[200,252],"gene.":[201],"products":[203],"amplified":[205],"polymerase":[207],"chain":[208],"reaction":[209],"(PCR)":[210],"separated":[212],"on":[213],"gel.":[214],"RESULTS:":[215],"There":[216,360,385,398],"correlation":[219],"gain":[222,241],"mineral":[225,426,448],"density":[226,427,449],"ultradistal":[227],"forearm":[228],"(BMDud)":[229],"boys":[231,247,356],"puberty":[234],"(p=0,009).":[239],"BMDud":[243],"higher":[245,299,323,366,438,446],"homozygous":[248],"(0.100\u00b10.037)":[254],"compared":[255,307,331,374],"homozygotes":[257],"(0.060\u00b10.040)":[262],"heterozygotes":[264,314,338,381],"(0.071\u00b10.041).":[265],"A":[266],"statistically":[267,364],"significant":[268,365],"found":[271,353],"BMD":[277,284,294,316,343],"trochanter":[279,296,345],"major":[280,297,346],"(p=0.017)":[281],"total":[286,319],"hip":[287,320],"(p=0.016)":[288],"whole":[291],"group.":[292],"showed":[298,322],"deletion/deletion":[304,328,371,432],"genotype":[305,311,329,335,372,378],"(0.845\u00b10.147)":[306],"insertion/insertion":[310,334,377],"(0.786\u00b10.115)":[312],"(0.767\u00b10.119).Additionally,":[315],"also":[321,352,362],"(1.05\u00b10.155)":[330],"(0.992\u00b10.131)":[336],"(0.962\u00b10.138).":[339],"association":[341,388,401],"analysed":[357],"separately":[358],"(p=0.02).":[359],"value":[367,441],"(0.904\u00b10.157)":[373],"(0.791\u00b10.129)":[379],"(0.788\u00b10.129).":[382],"Substudy":[383,396],"2:":[384],"no":[387,400],"polymorphism.":[395,412],"3:":[397],"gene":[411,416],"DISCUSSION:":[413],"playing":[419],"role":[421],"determining":[423],"serum":[439],"IGF-1":[440],"again":[442],"stimulates":[443],"puberty\".":[452]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}
