{"id":"https://openalex.org/W118999907","doi":null,"title":"Lineage relationship analysis of lymphoid progenitor subsets in the bone marrow of na\u00efve mice and during inflammation","display_name":"Lineage relationship analysis of lymphoid progenitor subsets in the bone marrow of na\u00efve mice and during inflammation","publication_year":2011,"publication_date":"2011-07-28","ids":{"openalex":"https://openalex.org/W118999907","mag":"118999907"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1322960","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1322960/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051502902","display_name":"Rebecca Leyland","orcid":"https://orcid.org/0000-0002-0310-381X","observed_orcids":["https://orcid.org/0000-0002-0310-381X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rebecca Leyland","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5051502902"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.025800000876188278,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lymphoid-progenitor-cells","display_name":"lymphoid progenitor cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/lineage-relationships","display_name":"lineage relationships","score":0.5059999823570251},{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.7160000205039978},{"id":"https://openalex.org/keywords/b-cell-development","display_name":"B cell development","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.5730000138282776},{"id":"https://openalex.org/keywords/acute-inflammation","display_name":"acute inflammation","score":0.621999979019165},{"id":"https://openalex.org/keywords/common-lymphoid-progenitors","display_name":"common lymphoid progenitors","score":0.8730000257492065},{"id":"https://openalex.org/keywords/myeloid-progenitor-cells","display_name":"myeloid progenitor cells","score":0.7720000147819519},{"id":"https://openalex.org/keywords/sca-1","display_name":"Sca-1","score":0.9120000004768372},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.6819999814033508},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9200000166893005},{"id":"https://openalex.org/keywords/lps","display_name":"LPS","score":0.6169999837875366},{"id":"https://openalex.org/keywords/lymphopoiesis","display_name":"lymphocyte development","score":0.7730000019073486},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8460000157356262},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":1.0}],"concepts":[{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.7321171760559082},{"id":"https://openalex.org/C79904392","wikidata":"https://www.wikidata.org/wiki/Q5976738","display_name":"Lymphopoiesis","level":4,"score":0.7230366468429565},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6915597915649414},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6691454648971558},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.629128634929657},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5732645988464355},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5202635526657104},{"id":"https://openalex.org/C113646796","wikidata":"https://www.wikidata.org/wiki/Q50263283","display_name":"Recombination-activating gene","level":4,"score":0.4650871157646179},{"id":"https://openalex.org/C125929170","wikidata":"https://www.wikidata.org/wiki/Q908966","display_name":"Cre recombinase","level":5,"score":0.43949219584465027},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.41169652342796326},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4001334607601166},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35355615615844727},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.19534435868263245},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.14258643984794617},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11942505836486816},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07611039280891418},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1322960","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1322960/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:118999907","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1322960","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":211,"referenced_works":["https://openalex.org/W39168122","https://openalex.org/W58922472","https://openalex.org/W65051584","https://openalex.org/W163125452","https://openalex.org/W171208246","https://openalex.org/W335876340","https://openalex.org/W1488010611","https://openalex.org/W1504158565","https://openalex.org/W1508065027","https://openalex.org/W1515187929","https://openalex.org/W1524365680","https://openalex.org/W1531742112","https://openalex.org/W1534220439","https://openalex.org/W1535510845","https://openalex.org/W1553577256","https://openalex.org/W1559018455","https://openalex.org/W1570302914","https://openalex.org/W1574400868","https://openalex.org/W1575237114","https://openalex.org/W1586539673","https://openalex.org/W1587877789","https://openalex.org/W1602164070","https://openalex.org/W1611133889","https://openalex.org/W1617267715","https://openalex.org/W1649547160","https://openalex.org/W1684886834","https://openalex.org/W1748108826","https://openalex.org/W1776790137","https://openalex.org/W1776803469","https://openalex.org/W1836932878","https://openalex.org/W1846959033","https://openalex.org/W1848816727","https://openalex.org/W1897184448","https://openalex.org/W1906130994","https://openalex.org/W1918973414","https://openalex.org/W1962949679","https://openalex.org/W1963975982","https://openalex.org/W1965953554","https://openalex.org/W1965989057","https://openalex.org/W1966177375","https://openalex.org/W1966969776","https://openalex.org/W1969134886","https://openalex.org/W1970209679","https://openalex.org/W1970718401","https://openalex.org/W1972518526","https://openalex.org/W1973035870","https://openalex.org/W1973054937","https://openalex.org/W1973099013","https://openalex.org/W1973319726","https://openalex.org/W1974659776","https://openalex.org/W1976756827","https://openalex.org/W1978529593","https://openalex.org/W1978611085","https://openalex.org/W1978926805","https://openalex.org/W1979496181","https://openalex.org/W1980509634","https://openalex.org/W1981817625","https://openalex.org/W1982130774","https://openalex.org/W1984407446","https://openalex.org/W1985192507","https://openalex.org/W1986568472","https://openalex.org/W1987320897","https://openalex.org/W1988447004","https://openalex.org/W1991601117","https://openalex.org/W1992621257","https://openalex.org/W1993648538","https://openalex.org/W1994367842","https://openalex.org/W1994987603","https://openalex.org/W1995344823","https://openalex.org/W1995530329","https://openalex.org/W1995549977","https://openalex.org/W1995946399","https://openalex.org/W1996120614","https://openalex.org/W1996418577","https://openalex.org/W1997936907","https://openalex.org/W1999246265","https://openalex.org/W1999582446","https://openalex.org/W2000844825","https://openalex.org/W2002817805","https://openalex.org/W2003371248","https://openalex.org/W2003919985","https://openalex.org/W2005226810","https://openalex.org/W2005273809","https://openalex.org/W2011059916","https://openalex.org/W2011328327","https://openalex.org/W2014983427","https://openalex.org/W2016857233","https://openalex.org/W2019676172","https://openalex.org/W2021312689","https://openalex.org/W2021483351","https://openalex.org/W2021821241","https://openalex.org/W2024336287","https://openalex.org/W2024746633","https://openalex.org/W2025077961","https://openalex.org/W2026246891","https://openalex.org/W2027509917","https://openalex.org/W2027706002","https://openalex.org/W2029619625","https://openalex.org/W2030298463","https://openalex.org/W2033563723","https://openalex.org/W2034863468","https://openalex.org/W2038078421","https://openalex.org/W2039903578","https://openalex.org/W2042108397","https://openalex.org/W2042456644","https://openalex.org/W2044135934","https://openalex.org/W2045899482","https://openalex.org/W2047137615","https://openalex.org/W2048793063","https://openalex.org/W2049470832","https://openalex.org/W2051728885","https://openalex.org/W2052904272","https://openalex.org/W2053388918","https://openalex.org/W2053522317","https://openalex.org/W2055050130","https://openalex.org/W2055568103","https://openalex.org/W2057159461","https://openalex.org/W2058781233","https://openalex.org/W2059260080","https://openalex.org/W2061307900","https://openalex.org/W2062618476","https://openalex.org/W2062835892","https://openalex.org/W2067131315","https://openalex.org/W2067859886","https://openalex.org/W2068871282","https://openalex.org/W2069615428","https://openalex.org/W2070856478","https://openalex.org/W2072411272","https://openalex.org/W2074291164","https://openalex.org/W2075524647","https://openalex.org/W2077099756","https://openalex.org/W2077330278","https://openalex.org/W2078374748","https://openalex.org/W2080006310","https://openalex.org/W2080801585","https://openalex.org/W2080961105","https://openalex.org/W2081255800","https://openalex.org/W2081617617","https://openalex.org/W2082746204","https://openalex.org/W2084080535","https://openalex.org/W2084407030","https://openalex.org/W2084429794","https://openalex.org/W2084652820","https://openalex.org/W2086943348","https://openalex.org/W2087143957","https://openalex.org/W2089031335","https://openalex.org/W2089500151","https://openalex.org/W2090439142","https://openalex.org/W2090786449","https://openalex.org/W2093264415","https://openalex.org/W2095016279","https://openalex.org/W2095833996","https://openalex.org/W2100378064","https://openalex.org/W2100820895","https://openalex.org/W2101526959","https://openalex.org/W2102782482","https://openalex.org/W2103917924","https://openalex.org/W2104025073","https://openalex.org/W2106761197","https://openalex.org/W2106915396","https://openalex.org/W2108513916","https://openalex.org/W2109553674","https://openalex.org/W2109627278","https://openalex.org/W2111382822","https://openalex.org/W2112721427","https://openalex.org/W2113260405","https://openalex.org/W2115993724","https://openalex.org/W2119709204","https://openalex.org/W2122879998","https://openalex.org/W2123410322","https://openalex.org/W2123884323","https://openalex.org/W2125453374","https://openalex.org/W2126464081","https://openalex.org/W2127559729","https://openalex.org/W2127704036","https://openalex.org/W2129270330","https://openalex.org/W2129319296","https://openalex.org/W2129971199","https://openalex.org/W2131263031","https://openalex.org/W2131579749","https://openalex.org/W2132364074","https://openalex.org/W2132965191","https://openalex.org/W2133562017","https://openalex.org/W2133794305","https://openalex.org/W2134421457","https://openalex.org/W2135123996","https://openalex.org/W2135703618","https://openalex.org/W2138596251","https://openalex.org/W2139532093","https://openalex.org/W2139715266","https://openalex.org/W2139867627","https://openalex.org/W2143576638","https://openalex.org/W2146499290","https://openalex.org/W2149939821","https://openalex.org/W2150149896","https://openalex.org/W2152414109","https://openalex.org/W2154577970","https://openalex.org/W2154861644","https://openalex.org/W2156150500","https://openalex.org/W2156423848","https://openalex.org/W2168742658","https://openalex.org/W2170963974","https://openalex.org/W2172033467","https://openalex.org/W2241378836","https://openalex.org/W2255354048","https://openalex.org/W2394549358","https://openalex.org/W2397960289","https://openalex.org/W2397969091","https://openalex.org/W2413209306","https://openalex.org/W4298843628","https://openalex.org/W4313347834"],"related_works":["https://openalex.org/W3135289584","https://openalex.org/W2152414109","https://openalex.org/W2443609694","https://openalex.org/W2330291931","https://openalex.org/W2241283341","https://openalex.org/W2586792923","https://openalex.org/W1937582563","https://openalex.org/W1913056497","https://openalex.org/W614526450","https://openalex.org/W7223057144"],"abstract_inverted_index":{"During":[0],"haematopoiesis":[1],"multipotent":[2],"stem":[3],"cells":[4,83],"generate":[5],"all":[6,82,125],"cellular":[7],"components":[8],"of":[9,20,28,40,56,65,114,119,134,146,153,158,164,207,217,222,237,249,255,291],"the":[10,18,24,36,62,103,120,143,156,196,205,213,247,288],"\\nblood":[11],"including":[12],"lymphocytes.":[13],"Despite":[14],"great":[15],"progress":[16],"in":[17,45,69,95,112,124,130,167,178,192,230,233,246],"isolation":[19],"lineage":[21],"\\nrestricted":[22],"progenitors,":[23],"exact":[25,37],"precursor-product":[26],"relationship":[27,64],"these":[29,165,282],"subsets":[30,68,152,166],"remains":[31],"\\npoorly":[32],"understood.":[33],"In":[34,241],"particular":[35],"branch":[38],"point":[39],"T-":[41,126],"and":[42,106,127,129,136,150,215,273],"B-cell":[43,197],"development":[44],"\\nthe":[46],"bone":[47,238],"marrow":[48,239],"has":[49],"not":[50],"been":[51],"unequivocally":[52],"mapped.":[53],"The":[54],"aim":[55],"my":[57],"project":[58],"was":[59,100,122,260],"to":[60,79,195,228,267,274],"\\ninvestigate":[61],"developmental":[63],"various":[66],"progenitor":[67],"normal":[70],"mice":[71,229],"\\nand":[72],"during":[73],"an":[74,115,147,208],"acute":[75,209],"inflammation.":[76],"\\nIn":[77],"order":[78],"permanently":[80],"identify":[81],"which":[84,96],"emanated":[85],"from":[86],"early":[87,218],"lymphoid":[88],"\\ncompartments":[89],"we":[90],"generated":[91],"a":[92,97,131,234,243,275],"mouse":[93],"model":[94,141],"Cre":[98,108],"recombinase":[99],"inserted":[101],"\\ninto":[102],"Rag1":[104],"locus":[105],"functional":[107],"activity":[109],"would":[110],"result":[111],"activation":[113],"eYFP":[116],"\\nreporter.":[117],"Expression":[118],"reporter":[121,160],"found":[123,266],"B-cells":[128],"significant":[132],"\\nsubset":[133],"NK-cells":[135],"dendritic":[137],"cells.":[138],"Furthermore":[139],"this":[140],"allowed":[142],"prospective":[144],"\\nisolation":[145],"\u2018ELP":[148],"analogue\u2019":[149],"two":[151],"CLPs":[154,187],"on":[155,257],"basis":[157],"their":[159,193],"\\nexpression.":[161],"Functional":[162],"analysis":[163,180],"vivo":[168,231],"demonstrated":[169],"comparable":[170],"\\ndevelopmental":[171],"properties":[172],"with":[173],"slightly":[174],"different":[175],"kinetics.":[176],"Furthermore,":[177],"vitro":[179],"\\nof":[181],"isolated":[182],"progenitors":[183,251,259],"established":[184],"that":[185],"reporter-positive":[186],"were":[188,265],"significantly":[189],"more":[190],"\\nadvanced":[191],"commitment":[194],"lineage.":[198],"\\nWe":[199],"extended":[200],"our":[201],"studies":[202],"by":[203,253,271,278],"investigating":[204],"impact":[206],"systemic":[210],"inflammation":[211],"\\non":[212],"size":[214],"composition":[216],"haemato-lymphoid":[219],"subsets.":[220],"Administration":[221],"LPS":[223],"\\nor":[224],"heat-inactivated":[225],"E.":[226],"coli":[227],"resulted":[232],"complete":[235],"halt":[236],"\\nlymphopoiesis.":[240],"addition,":[242],"marked":[244],"decrease":[245],"number":[248],"myeloid":[250],"\\naccompanied":[252],"upregulation":[254],"Sca-1":[256],"haematopoietic":[258],"observed.":[261],"\\nThese":[262],"inflammation-induced":[263],"changes":[264],"be":[268],"mainly":[269],"caused":[270],"IFN\u03b3":[272],"lesser":[276],"extend":[277],"TNF\u03b1,":[279],"thus":[280],"identifying":[281],"cytokines":[283],"as":[284],"key":[285],"mediators":[286],"for":[287],"\\ninfection-induced":[289],"regulation":[290],"haematopoiesis.":[292]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
