{"id":"https://openalex.org/W118986567","doi":"https://doi.org/10.18926/amo/32904","title":"Polymorphisms in the tumor necrosis factor-alpha gene in Turkish women with pre-eclampsia and eclampsia.","display_name":"Polymorphisms in the tumor necrosis factor-alpha gene in Turkish women with pre-eclampsia and eclampsia.","publication_year":2007,"publication_date":"2007-06-01","ids":{"openalex":"https://openalex.org/W118986567","doi":"https://doi.org/10.18926/amo/32904","mag":"118986567","pmid":"https://pubmed.ncbi.nlm.nih.gov/17593951"},"language":"en","primary_location":{"id":"pmid:17593951","doi":"https://doi.org/10.18926/amo/32904","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17593951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta medica Okayama","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ousar.lib.okayama-u.ac.jp/files/public/3/32904/2016052802462096265/fulltext.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078962520","display_name":"Ayfer Pazarba\u015f\u0131","orcid":"https://orcid.org/0000-0002-5338-7531","observed_orcids":["https://orcid.org/0000-0002-5338-7531"]},"institutions":[{"id":"https://openalex.org/I55931168","display_name":"Cukurova University","ror":"https://ror.org/05wxkj555","country_code":"TR","type":"education","lineage":["https://openalex.org/I55931168"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ayfer Pazarba\u015fi","raw_affiliation_strings":["Department of Medical Biology and Genetics, University of Cukurova, Faculty of Medicine, Balcali, Adana 01330, Turkey. payfer@cu.edu.tr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology and Genetics, University of Cukurova, Faculty of Medicine, Balcali, Adana 01330, Turkey. payfer@cu.edu.tr","institution_ids":["https://openalex.org/I55931168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084110337","display_name":"M\u00fclkiye Kasap","orcid":"https://orcid.org/0000-0002-5084-6210","observed_orcids":["https://orcid.org/0000-0002-5084-6210"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M\u00fclkiye Kasap","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023074481","display_name":"Ali \u0130rfan G\u00fczel","orcid":"https://orcid.org/0000-0002-9720-5920","observed_orcids":["https://orcid.org/0000-0002-9720-5920"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ali Irfan G\u00fczel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030326115","display_name":"Halil Kasap","orcid":"https://orcid.org/0000-0003-2545-3578","observed_orcids":["https://orcid.org/0000-0003-2545-3578"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Halil Kasap","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049672050","display_name":"Meliz Onba\u015fio\u011flu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meliz Onba\u015fio\u011flu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069960755","display_name":"Burcu \u00d6zbak\u0131r","orcid":"https://orcid.org/0000-0002-0895-0487","observed_orcids":["https://orcid.org/0000-0002-0895-0487"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Burcu Ozbakir","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012839437","display_name":"Ay\u015fe Demirkaz\u0131k","orcid":"https://orcid.org/0000-0001-7224-2832","observed_orcids":["https://orcid.org/0000-0001-7224-2832"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ay\u015fe Demirkazik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056616725","display_name":"Fatma Tuncay \u00d6zg\u00fcnen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fatma Tuncay Ozg\u00fcnen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5076045537","display_name":"Evrim G\u00fcrtun\u00e7","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Evrim G\u00fcrtun\u00e7","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4991,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.82340715,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"61","issue":"3","first_page":"153","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12464","display_name":"Neurological Complications and Syndromes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.8889999985694885},{"id":"https://openalex.org/keywords/eclampsia","display_name":"eclampsia","score":1.0},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tnf-gene-polymorphism","display_name":"TNF gene polymorphism","score":0.8799999952316284},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8899999856948853},{"id":"https://openalex.org/keywords/turkish-women","display_name":"Turkish women","score":0.7200000286102295},{"id":"https://openalex.org/keywords/genotype-distribution","display_name":"genotype distribution","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C2781276381","wikidata":"https://www.wikidata.org/wiki/Q552348","display_name":"Eclampsia","level":3,"score":0.8715047836303711},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.7611794471740723},{"id":"https://openalex.org/C76252995","wikidata":"https://www.wikidata.org/wiki/Q3395645","display_name":"Gene polymorphism","level":4,"score":0.5573213696479797},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.556225597858429},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5509396195411682},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.5259088277816772},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.5199395418167114},{"id":"https://openalex.org/C2777218350","wikidata":"https://www.wikidata.org/wiki/Q61335","display_name":"Preeclampsia","level":3,"score":0.4984128475189209},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.487177312374115},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.44796258211135864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40732717514038086},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3922725021839142},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37058746814727783},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3230300545692444},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29009824991226196},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.2840511202812195},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26350685954093933}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004461","descriptor_name":"Eclampsia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004461","descriptor_name":"Eclampsia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014421","descriptor_name":"Turkey","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:17593951","doi":"https://doi.org/10.18926/amo/32904","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17593951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta medica Okayama","raw_type":"Comparative Study"},{"id":"pmh:oai:irdb.nii.ac.jp:01081:0000648316","doi":"https://doi.org/10.18926/amo/32904","is_oa":true,"landing_page_url":"https://ousar.lib.okayama-u.ac.jp/32904","pdf_url":"https://ousar.lib.okayama-u.ac.jp/files/public/3/32904/2016052802462096265/fulltext.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Medica Okayama","raw_type":"journal article"},{"id":"pmh:oai:EPrintsOUDIR.lib.okayama-u.ac.jp:32904","doi":"https://doi.org/10.18926/amo/32904","is_oa":false,"landing_page_url":"https://ousar.lib.okayama-u.ac.jp/32904","pdf_url":null,"source":{"id":"https://openalex.org/S4377196325","display_name":"Okayama University Scientific Achievement Repository (Okayama University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I163770644","host_organization_name":"Okayama University","host_organization_lineage":["https://openalex.org/I163770644"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Medica Okayama","raw_type":"Journal Article"},{"id":"mag:118986567","doi":"https://doi.org/10.18926/amo/32904","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17593951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:01081:0000648316","doi":"https://doi.org/10.18926/amo/32904","is_oa":true,"landing_page_url":"https://ousar.lib.okayama-u.ac.jp/32904","pdf_url":"https://ousar.lib.okayama-u.ac.jp/files/public/3/32904/2016052802462096265/fulltext.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Medica Okayama","raw_type":"journal article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W118986567.pdf","grobid_xml":"https://content.openalex.org/works/W118986567.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W92735085","https://openalex.org/W1682212455","https://openalex.org/W1969025572","https://openalex.org/W1969892023","https://openalex.org/W1980247868","https://openalex.org/W2001046375","https://openalex.org/W2008256216","https://openalex.org/W2009282890","https://openalex.org/W2013784872","https://openalex.org/W2035801210","https://openalex.org/W2036345510","https://openalex.org/W2036763081","https://openalex.org/W2043135188","https://openalex.org/W2045082082","https://openalex.org/W2045260257","https://openalex.org/W2056382301","https://openalex.org/W2058450394","https://openalex.org/W2061542205","https://openalex.org/W2090533697","https://openalex.org/W2092212521","https://openalex.org/W2092416896","https://openalex.org/W2103467021","https://openalex.org/W2104468961","https://openalex.org/W2105463007","https://openalex.org/W2108587366","https://openalex.org/W2118094114","https://openalex.org/W2120210536","https://openalex.org/W2120330190","https://openalex.org/W2133614172","https://openalex.org/W2303691248","https://openalex.org/W2334044617","https://openalex.org/W2336184170","https://openalex.org/W2395197513","https://openalex.org/W2418050054","https://openalex.org/W3142218095"],"related_works":["https://openalex.org/W1970546215","https://openalex.org/W2347873855","https://openalex.org/W2067398109","https://openalex.org/W2105463007","https://openalex.org/W2892166817","https://openalex.org/W2594658561","https://openalex.org/W1271495618","https://openalex.org/W1682212455","https://openalex.org/W2118387070","https://openalex.org/W4295236153"],"abstract_inverted_index":{"The":[0,12],"genetic":[1],"background":[2],"predisposing":[3],"pregnant":[4],"women":[5],"to":[6,19,188,198],"pre-eclampsia/eclampsia":[7],"(PE/E)":[8],"is":[9,23,168],"still":[10],"unknown.":[11],"aim":[13],"of":[14,41,45,65,83,116,130,201],"the":[15,27,55,63,79,84,98,122,128,131,139,151,179,194,209],"current":[16],"study":[17],"was":[18,69,94,119,185],"investigate":[20],"whether":[21,171,190],"there":[22],"an":[24,158],"association":[25,159],"between":[26,78,121,160,206],"TNF-alpha-308":[28],"and":[29,32,47,57,87,100,124,163,208],"850":[30],"polymorphisms":[31,162],"PE":[33,46,105,197],"or":[34],"eclampsia.":[35],"In":[36,182],"this":[37,191],"study,":[38],"40":[39],"cases":[40,44,51],"eclampsia,":[42],"113":[43],"80":[48],"normotensive":[49,88],"control":[50,125,152],"were":[52],"genotyped":[53],"for":[54],"TNF-alpha-G-308A":[56],"C-850":[58],"polymorphisms.":[59],"At":[60],"position":[61],"308,":[62],"replacement":[64],"Guanine":[66],"with":[67,127,150],"Adenosine":[68],"denoted":[70],"as":[71],"TNF2.":[72],"We":[73,155],"found":[74],"a":[75,175],"significant":[76,204],"difference":[77,205],"TNF2":[80,90],"allele":[81],"frequencies":[82],"eclamptic,":[85],"pre-eclamptic":[86],"controls.":[89,210],"(AA)":[91],"polymorphism":[92,118,173,192],"frequency":[93,129],"significantly":[95,112,136],"higher":[96],"among":[97],"eclamptics":[99],"pre-eclamptics":[101],"(control":[102],":":[103,106,109,142,146],"5%,":[104],"13.3%,":[107],"E":[108,145],"12.9%).":[110],"A":[111],"different":[113],"genotype":[114,134],"distribution":[115],"C-850T":[117,172],"observed":[120],"PE/E":[123],"groups,":[126],"variant":[132],"TT":[133],"being":[135],"reduced":[137],"in":[138],"preeclamptics":[140],"(PE":[141],"17%":[143],";":[144],"17.5%)":[147],"when":[148],"compared":[149],"group":[153],"(24.3%).":[154],"have":[156],"demonstrated":[157],"TNF-alpha":[161,180],"pre-eclampsia":[164],"susceptibility.":[165],"However,":[166],"it":[167,184],"not":[169,186],"known":[170],"has":[174],"functional":[176],"effect":[177],"on":[178],"gene.":[181],"addition,":[183],"possible":[187],"determine":[189],"promotes":[193],"progression":[195],"from":[196],"eclampsia":[199,207],"because":[200],"no":[202],"statistically":[203]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
