{"id":"https://openalex.org/W11898612","doi":"https://doi.org/10.1096/fasebj.21.6.lb75","title":"Differential Responses to Lipopolysaccharide between Human and Baboon Arterial Endothelial Cells","display_name":"Differential Responses to Lipopolysaccharide between Human and Baboon Arterial Endothelial Cells","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W11898612","doi":"https://doi.org/10.1096/fasebj.21.6.lb75","mag":"11898612"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.6.lb75","doi":"https://doi.org/10.1096/fasebj.21.6.lb75","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.lb75","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049481830","display_name":"Qiang Sebastian Shi","orcid":"https://orcid.org/0000-0001-6132-8876","observed_orcids":["https://orcid.org/0000-0001-6132-8876"]},"institutions":[{"id":"https://openalex.org/I1289525096","display_name":"Texas Biomedical Research Institute","ror":"https://ror.org/00wbskb04","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289525096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiang Shi","raw_affiliation_strings":["Genetics Southwest Foundation for Biomedical Research 7620 NW Loop 410 San Antonio TX 78227\u20105301"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Southwest Foundation for Biomedical Research 7620 NW Loop 410 San Antonio TX 78227\u20105301","institution_ids":["https://openalex.org/I1289525096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083082611","display_name":"Laura A. Cox","orcid":"https://orcid.org/0000-0002-8836-3783","observed_orcids":["https://orcid.org/0000-0002-8836-3783","https://orcid.org/0000-0003-0387-0039"]},"institutions":[{"id":"https://openalex.org/I1289525096","display_name":"Texas Biomedical Research Institute","ror":"https://ror.org/00wbskb04","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289525096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura A. Cox","raw_affiliation_strings":["Genetics Southwest Foundation for Biomedical Research 7620 NW Loop 410 San Antonio TX 78227\u20105301"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Southwest Foundation for Biomedical Research 7620 NW Loop 410 San Antonio TX 78227\u20105301","institution_ids":["https://openalex.org/I1289525096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012076407","display_name":"Jeremy P. Glenn","orcid":"https://orcid.org/0000-0002-1613-034X","observed_orcids":["https://orcid.org/0000-0002-1613-034X"]},"institutions":[{"id":"https://openalex.org/I1289525096","display_name":"Texas Biomedical Research Institute","ror":"https://ror.org/00wbskb04","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289525096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy Glenn Jeremy Glenn","raw_affiliation_strings":["Genetics Southwest Foundation for Biomedical Research 7620 NW Loop 410 San Antonio TX 78227\u20105301"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Southwest Foundation for Biomedical Research 7620 NW Loop 410 San Antonio TX 78227\u20105301","institution_ids":["https://openalex.org/I1289525096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016947225","display_name":"John L. VandeBerg","orcid":"https://orcid.org/0000-0002-7087-979X","observed_orcids":["https://orcid.org/0000-0002-7087-979X"]},"institutions":[{"id":"https://openalex.org/I1289525096","display_name":"Texas Biomedical Research Institute","ror":"https://ror.org/00wbskb04","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289525096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John L. VandeBerg","raw_affiliation_strings":["Genetics Southwest Foundation for Biomedical Research 7620 NW Loop 410 San Antonio TX 78227\u20105301"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Southwest Foundation for Biomedical Research 7620 NW Loop 410 San Antonio TX 78227\u20105301","institution_ids":["https://openalex.org/I1289525096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071421730","display_name":"Xing Li Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xing Li Wang","raw_affiliation_strings":["Section of Cardiothoracic Surgery Baylor College of Medicine BCM390, One Baylor Plaza Houston TX 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardiothoracic Surgery Baylor College of Medicine BCM390, One Baylor Plaza Houston TX 77030","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00077721,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.7714999914169312,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.7714999914169312,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.08860000222921371,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9850000143051147},{"id":"https://openalex.org/keywords/arterial-endothelial-cells","display_name":"arterial endothelial cells","score":0.9409999847412109},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8209999799728394},{"id":"https://openalex.org/keywords/e-selectin","display_name":"E-selectin","score":0.7860000133514404},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.7350000143051147},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7829999923706055},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.734468936920166},{"id":"https://openalex.org/C2779594886","wikidata":"https://www.wikidata.org/wiki/Q159429","display_name":"Baboon","level":2,"score":0.691825807094574},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.6418679356575012},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5636739730834961},{"id":"https://openalex.org/C2776246508","wikidata":"https://www.wikidata.org/wiki/Q5376428","display_name":"Endothelial activation","level":3,"score":0.48762765526771545},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4861716628074646},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48572713136672974},{"id":"https://openalex.org/C199616788","wikidata":"https://www.wikidata.org/wiki/Q4037752","display_name":"E-selectin","level":4,"score":0.4427397847175598},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4301391839981079},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.42750105261802673},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.42718902230262756},{"id":"https://openalex.org/C185946421","wikidata":"https://www.wikidata.org/wiki/Q3146527","display_name":"ICAM-1","level":3,"score":0.42681872844696045},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.415658175945282},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3935989737510681},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3596632480621338},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.29165542125701904},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.24029481410980225},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.22662830352783203},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1881677508354187},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18491291999816895}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.6.lb75","doi":"https://doi.org/10.1096/fasebj.21.6.lb75","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.lb75","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6899999976158142,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2031689924","https://openalex.org/W1966545845","https://openalex.org/W2040403011","https://openalex.org/W2140746373","https://openalex.org/W2200684646","https://openalex.org/W2016685400","https://openalex.org/W2089753337","https://openalex.org/W2061035318","https://openalex.org/W1987787892","https://openalex.org/W3035981052"],"abstract_inverted_index":{"Since":[0],"inflammation":[1],"plays":[2],"a":[3,95,102],"critical":[4],"role":[5],"in":[6,98,105,108,115,122,134,141,145,151,186,227],"atherosclerotic":[7],"initiation,":[8],"we":[9,39,178],"want":[10],"to":[11,21,43,70,83,94,193,208,218,229],"know":[12],"if":[13],"endothelial":[14,30,36,216],"cells":[15,31,37],"from":[16],"arterial":[17,29,35,215],"vessels":[18],"respond":[19],"differently":[20],"proinflammatory":[22,219],"stimuli":[23,220],"among":[24],"primates.":[25],"Using":[26],"cultured":[27],"human":[28],"(HAECs)":[32],"and":[33,48,57,66,101,120,147,153,184,188,225],"baboon":[34],"(BAECs),":[38],"compared":[40],"their":[41,173],"responses":[42,217],"tumor":[44],"necrosis":[45],"factor\u2010a":[46],"(TNF\u2010a)":[47],"LPS":[49,84,92,128,143],"by":[50],"measuring":[51],"expression":[52,100,107,157,167],"of":[53,59,73,81,88,91,118,165,182],"cellular":[54],"adhesion":[55],"molecules":[56],"release":[58,131],"cytokines.":[60],"We":[61],"found":[62,179],"that":[63,202,214],"both":[64],"HAECs":[65,76,152,187],"BAECs":[67,123,203],"responded":[68],"similarly":[69],"10.0":[71],"ng/mL":[72],"TNF\u2010a.":[74],"However,":[75],"showed":[77],"significantly":[78],"higher":[79],"degree":[80],"response":[82,228],"than":[85],"BAECs.":[86,142,189],"Treatment":[87],"1.0":[89],"ug/mL":[90],"led":[93],"3.7\u2010fold":[96],"increase":[97,104],"E\u2010selectin":[99,119],"2.5\u2010fold":[103],"ICAM\u20101":[106],"HAECs,":[109,135],"but":[110,136],"there":[111],"was":[112,138],"no":[113],"change":[114],"the":[116,125,163],"expressions":[117],"ICAM":[121],"under":[124],"same":[126],"conditions.":[127],"increased":[129],"IL\u20108":[130],"approximately":[132],"20.5\u2010fold":[133],"it":[137],"only":[139],"2.9\u2010fold":[140],"resulted":[144],"7.8\u2010fold":[146],"4.9\u2010fold":[148],"MCP\u20101":[149],"increases":[150],"BAECs,":[154],"respectively.":[155],"These":[156],"differences":[158],"were":[159,197,221],"also":[160,198],"confirmed":[161],"at":[162],"level":[164],"mRNA":[166],"using":[168],"gene":[169],"arrays.":[170],"By":[171],"determining":[172],"transcription":[174],"factor":[175],"activation":[176,181],"levels,":[177],"differential":[180],"p50":[183],"p65":[185],"Some":[190],"components":[191],"related":[192],"LPS\u2010mediated":[194],"signal":[195],"pathway":[196],"differentially":[199],"expressed,":[200],"indicating":[201],"have":[204],"instinct":[205],"hyporesponsive":[206],"nature":[207],"LPS.":[209],"Our":[210],"current":[211],"data":[212],"suggest":[213],"different":[222,230],"between":[223],"humans":[224],"baboons":[226],"stimuli.":[231]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}