{"id":"https://openalex.org/W118960770","doi":"https://doi.org/10.1002/9781118309421.ch6","title":"Metabotropic Glutamate 2/3 Receptor Agonists and Positive Allosteric Modulators of Metabotropic Glutamate Receptor 2 as Novel Agents for the Treatment of Schizophrenia","display_name":"Metabotropic Glutamate 2/3 Receptor Agonists and Positive Allosteric Modulators of Metabotropic Glutamate Receptor 2 as Novel Agents for the Treatment of Schizophrenia","publication_year":2012,"publication_date":"2012-06-24","ids":{"openalex":"https://openalex.org/W118960770","doi":"https://doi.org/10.1002/9781118309421.ch6","mag":"118960770"},"language":"en","primary_location":{"id":"doi:10.1002/9781118309421.ch6","doi":"https://doi.org/10.1002/9781118309421.ch6","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9781118309421.ch6","pdf_url":null,"source":{"id":"https://openalex.org/S4306464293","display_name":"Wiley eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Targets and Emerging Therapies for Schizophrenia","raw_type":"other"},"volume":{"id":"https://openalex.org/W2504418975","display_name":"Targets and Emerging Therapies for Schizophrenia"},"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004332028","display_name":"Gerard J. Marek","orcid":"https://orcid.org/0000-0001-8103-4306","observed_orcids":["https://orcid.org/0000-0001-8103-4306"]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerard J. Marek","raw_affiliation_strings":["Abbott Laboratories, Abbott Park, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abbott Laboratories, Abbott Park, IL, USA","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010145606","display_name":"Bruce J. Kinon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce J. Kinon","raw_affiliation_strings":["Eli Lilly and Company, Lilly Corporate Center; Indianapolis IN USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eli Lilly and Company, Lilly Corporate Center; Indianapolis IN USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074035943","display_name":"David L. McKinzie","orcid":"https://orcid.org/0000-0002-4115-3316","observed_orcids":["https://orcid.org/0000-0002-4115-3316"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. McKinzie","raw_affiliation_strings":["Neuroscience Discovery, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Discovery, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030935161","display_name":"Jeffrey M. Schkeryantz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey M. Schkeryantz","raw_affiliation_strings":["Eli Lilly and Company, Lilly Corporate Center; Indianapolis IN USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eli Lilly and Company, Lilly Corporate Center; Indianapolis IN USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060626649","display_name":"James A. Monn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A. Monn","raw_affiliation_strings":["Eli Lilly and Company, Lilly Corporate Center; Indianapolis IN USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eli Lilly and Company, Lilly Corporate Center; Indianapolis IN USA","institution_ids":["https://openalex.org/I168537998"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"143","last_page":"185"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.5371000170707703,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.5371000170707703,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.42260000109672546,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mglur2","display_name":"mGluR2","score":0.8880000114440918},{"id":"https://openalex.org/keywords/positive-allosteric-modulators","display_name":"positive allosteric modulators","score":0.9279999732971191},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.7829999923706055},{"id":"https://openalex.org/keywords/antipsychotic-drugs","display_name":"antipsychotic drugs","score":0.8199999928474426},{"id":"https://openalex.org/keywords/dopamine-d2-receptor-blockade","display_name":"dopamine D2 receptor blockade","score":0.7730000019073486},{"id":"https://openalex.org/keywords/glutamate-signaling","display_name":"glutamate signaling","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C2779583389","wikidata":"https://www.wikidata.org/wiki/Q421344","display_name":"Butyrophenone","level":4,"score":0.7468628287315369},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6617047190666199},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.62872314453125},{"id":"https://openalex.org/C49051014","wikidata":"https://www.wikidata.org/wiki/Q2033959","display_name":"Metabotropic glutamate receptor","level":4,"score":0.5960432887077332},{"id":"https://openalex.org/C41653306","wikidata":"https://www.wikidata.org/wiki/Q6589190","display_name":"Metabotropic glutamate receptor 5","level":5,"score":0.5788453221321106},{"id":"https://openalex.org/C2778775820","wikidata":"https://www.wikidata.org/wiki/Q407972","display_name":"Chlorpromazine","level":2,"score":0.5771558284759521},{"id":"https://openalex.org/C26702167","wikidata":"https://www.wikidata.org/wiki/Q901988","display_name":"Metabotropic receptor","level":4,"score":0.520442545413971},{"id":"https://openalex.org/C44208683","wikidata":"https://www.wikidata.org/wiki/Q15335165","display_name":"Dopamine receptor D2","level":3,"score":0.5051894783973694},{"id":"https://openalex.org/C119128870","wikidata":"https://www.wikidata.org/wiki/Q4859538","display_name":"Metabotropic glutamate receptor 2","level":5,"score":0.4530789256095886},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.40738242864608765},{"id":"https://openalex.org/C2780948584","wikidata":"https://www.wikidata.org/wiki/Q251347","display_name":"Haloperidol","level":3,"score":0.38813573122024536},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3819277882575989},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37094300985336304},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.3684680461883545},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32898151874542236},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.31015706062316895},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2982468008995056},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.25664836168289185},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19438868761062622},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19262757897377014}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/9781118309421.ch6","doi":"https://doi.org/10.1002/9781118309421.ch6","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9781118309421.ch6","pdf_url":null,"source":{"id":"https://openalex.org/S4306464293","display_name":"Wiley eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Targets and Emerging Therapies for Schizophrenia","raw_type":"other"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":162,"referenced_works":["https://openalex.org/W49989104","https://openalex.org/W1487123995","https://openalex.org/W1586815491","https://openalex.org/W1600525795","https://openalex.org/W1748089690","https://openalex.org/W1820918747","https://openalex.org/W1887831240","https://openalex.org/W1914381346","https://openalex.org/W1926939570","https://openalex.org/W1934630626","https://openalex.org/W1945680072","https://openalex.org/W1963950604","https://openalex.org/W1967627800","https://openalex.org/W1970078705","https://openalex.org/W1970148130","https://openalex.org/W1970596941","https://openalex.org/W1971555218","https://openalex.org/W1972208853","https://openalex.org/W1972722155","https://openalex.org/W1979261539","https://openalex.org/W1981763442","https://openalex.org/W1983457793","https://openalex.org/W1984836583","https://openalex.org/W1986497573","https://openalex.org/W1986795023","https://openalex.org/W1990246915","https://openalex.org/W1990289691","https://openalex.org/W1990407514","https://openalex.org/W1990535802","https://openalex.org/W1995056605","https://openalex.org/W1996855868","https://openalex.org/W1997483502","https://openalex.org/W1999980758","https://openalex.org/W2000165848","https://openalex.org/W2002325876","https://openalex.org/W2004874205","https://openalex.org/W2009077347","https://openalex.org/W2009447429","https://openalex.org/W2010549626","https://openalex.org/W2011748173","https://openalex.org/W2011759845","https://openalex.org/W2013432476","https://openalex.org/W2013817125","https://openalex.org/W2015148582","https://openalex.org/W2016413308","https://openalex.org/W2017259777","https://openalex.org/W2018436424","https://openalex.org/W2018646758","https://openalex.org/W2019110706","https://openalex.org/W2019720677","https://openalex.org/W2023434269","https://openalex.org/W2023986042","https://openalex.org/W2025396999","https://openalex.org/W2025534288","https://openalex.org/W2026334669","https://openalex.org/W2027729471","https://openalex.org/W2028247865","https://openalex.org/W2028497563","https://openalex.org/W2030205241","https://openalex.org/W2032445862","https://openalex.org/W2036886962","https://openalex.org/W2038505488","https://openalex.org/W2038615690","https://openalex.org/W2038754388","https://openalex.org/W2040258322","https://openalex.org/W2040381103","https://openalex.org/W2040456704","https://openalex.org/W2042370460","https://openalex.org/W2043339467","https://openalex.org/W2045628566","https://openalex.org/W2045859529","https://openalex.org/W2045861729","https://openalex.org/W2046037125","https://openalex.org/W2048341607","https://openalex.org/W2052115812","https://openalex.org/W2054202278","https://openalex.org/W2055297542","https://openalex.org/W2055779394","https://openalex.org/W2057623734","https://openalex.org/W2058101809","https://openalex.org/W2058787575","https://openalex.org/W2059282203","https://openalex.org/W2059780497","https://openalex.org/W2060765599","https://openalex.org/W2060974385","https://openalex.org/W2061369817","https://openalex.org/W2061506085","https://openalex.org/W2061965299","https://openalex.org/W2062489616","https://openalex.org/W2063468076","https://openalex.org/W2063490887","https://openalex.org/W2064453282","https://openalex.org/W2064825212","https://openalex.org/W2066536490","https://openalex.org/W2067090030","https://openalex.org/W2067874558","https://openalex.org/W2068761941","https://openalex.org/W2069005613","https://openalex.org/W2069140039","https://openalex.org/W2072471087","https://openalex.org/W2072998985","https://openalex.org/W2074483296","https://openalex.org/W2074744435","https://openalex.org/W2074873783","https://openalex.org/W2077609442","https://openalex.org/W2077685932","https://openalex.org/W2078977508","https://openalex.org/W2080529726","https://openalex.org/W2081792830","https://openalex.org/W2082406942","https://openalex.org/W2084989539","https://openalex.org/W2085477113","https://openalex.org/W2085574409","https://openalex.org/W2086593869","https://openalex.org/W2087100144","https://openalex.org/W2087370791","https://openalex.org/W2089299823","https://openalex.org/W2090006256","https://openalex.org/W2092204227","https://openalex.org/W2092416470","https://openalex.org/W2092485817","https://openalex.org/W2092809358","https://openalex.org/W2093805519","https://openalex.org/W2094099092","https://openalex.org/W2100173530","https://openalex.org/W2100194652","https://openalex.org/W2100877613","https://openalex.org/W2103903531","https://openalex.org/W2105962778","https://openalex.org/W2106042714","https://openalex.org/W2107985334","https://openalex.org/W2110315049","https://openalex.org/W2113113845","https://openalex.org/W2116386279","https://openalex.org/W2116896173","https://openalex.org/W2118900648","https://openalex.org/W2128412582","https://openalex.org/W2129733697","https://openalex.org/W2132259245","https://openalex.org/W2133176999","https://openalex.org/W2137924108","https://openalex.org/W2138368199","https://openalex.org/W2147197593","https://openalex.org/W2149201522","https://openalex.org/W2152027982","https://openalex.org/W2152550910","https://openalex.org/W2153645092","https://openalex.org/W2159996636","https://openalex.org/W2162327153","https://openalex.org/W2165050824","https://openalex.org/W2165843693","https://openalex.org/W2166826909","https://openalex.org/W2167480327","https://openalex.org/W2170029299","https://openalex.org/W2180195230","https://openalex.org/W2277185635","https://openalex.org/W2312770619","https://openalex.org/W2318283658","https://openalex.org/W2321928394","https://openalex.org/W2950192423","https://openalex.org/W2951621448","https://openalex.org/W3025891904"],"related_works":["https://openalex.org/W2137394433","https://openalex.org/W4393011620","https://openalex.org/W1789415031","https://openalex.org/W2032249286","https://openalex.org/W2339885506","https://openalex.org/W2318903872","https://openalex.org/W2116265043","https://openalex.org/W2033584117","https://openalex.org/W2130872919","https://openalex.org/W2192915718"],"abstract_inverted_index":{"The":[0],"origin":[1],"of":[2,11,29,55,70,80,112],"modern":[3],"psychopharmacology":[4],"can":[5],"be":[6],"traced":[7],"to":[8,66,110],"the":[9,12,30,41,53,64,72],"discovery":[10],"first":[13,65],"clinically":[14],"efficacious":[15],"antipsychotic":[16,27,98,113],"drug,":[17],"chlorpromazine,":[18],"in":[19,52,108],"1952.":[20],"Following":[21],"this":[22],"watershed":[23],"advance,":[24],"several":[25],"additional":[26],"agents":[28],"same":[31],"(i.e.,":[32],"phenothiazine)":[33],"class,":[34],"as":[35,37],"well":[36],"others":[38],"derived":[39],"from":[40],"butyrophenone":[42,75],"scaffold":[43],"(e.g.,":[44],"haloperidol,":[45],"1958),":[46],"were":[47,63],"discovered":[48],"and":[49,60,74],"widely":[50],"utilized":[51],"treatment":[54],"schizophrenia":[56],"patients.":[57],"Arvid":[58],"Carlsson":[59],"his":[61],"colleagues":[62],"show":[67],"that":[68,96],"antipsychotics":[69],"both":[71],"phenothiazine":[73],"classes":[76],"acted":[77],"via":[78],"blockade":[79],"dopamine":[81,102,117],"(DA)":[82],"receptors":[83,104],"[1].":[84],"This":[85],"hypothesis":[86],"was":[87],"further":[88],"refined":[89],"over":[90],"a":[91],"decade":[92],"later":[93],"by":[94],"observations":[95],"all":[97],"drugs":[99],"potently":[100],"block":[101],"D2-like":[103],"[2,":[105],"3].":[106],"Interest":[107],"moving":[109],"mechanisms":[111],"action":[114],"other":[115],"than":[116],"D2":[118]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
