{"id":"https://openalex.org/W118941838","doi":"https://doi.org/10.1007/978-1-60761-266-7_9","title":"Blastic Transformation of Classic Myeloproliferative Neoplasms","display_name":"Blastic Transformation of Classic Myeloproliferative Neoplasms","publication_year":2010,"publication_date":"2010-09-28","ids":{"openalex":"https://openalex.org/W118941838","doi":"https://doi.org/10.1007/978-1-60761-266-7_9","mag":"118941838"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-60761-266-7_9","doi":"https://doi.org/10.1007/978-1-60761-266-7_9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60761-266-7_9","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Myeloproliferative Neoplasms","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4238656967","display_name":"Myeloproliferative Neoplasms"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039057642","display_name":"Ruben A. Mesa","orcid":"https://orcid.org/0000-0001-5880-7972","observed_orcids":["https://orcid.org/0000-0001-5880-7972"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ruben A. Mesa","raw_affiliation_strings":["Professor of Medicine,\n        Consultant of Hematology & Oncology, Mayo Clinic, Scottsdale, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor of Medicine,\n        Consultant of Hematology & Oncology, Mayo Clinic, Scottsdale, AZ, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039057642"],"corresponding_institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07535322,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"169","last_page":"180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":0.9480000138282776},{"id":"https://openalex.org/keywords/essential-thrombocythemia","display_name":"essential thrombocythemia","score":0.847000002861023},{"id":"https://openalex.org/keywords/polycythemia-vera","display_name":"polycythemia vera","score":0.9990000128746033},{"id":"https://openalex.org/keywords/primary-myelofibrosis","display_name":"primary myelofibrosis","score":1.0},{"id":"https://openalex.org/keywords/acute-leukemia-transformation","display_name":"acute leukemia transformation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/karyotypic-abnormalities","display_name":"karyotype abnormalities","score":0.9559999704360962},{"id":"https://openalex.org/keywords/jak2-v617f-mutation","display_name":"JAK2 V617F mutation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.6069999933242798},{"id":"https://openalex.org/keywords/allogeneic-stem-cell-transplantation","display_name":"allogeneic stem cell transplantation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/induction-chemotherapy","display_name":"induction chemotherapy","score":0.675000011920929},{"id":"https://openalex.org/keywords/hypomethylating-agents","display_name":"hypomethylating agents","score":0.8980000019073486},{"id":"https://openalex.org/keywords/jak2-inhibition","display_name":"JAK2 inhibition","score":0.9319999814033508},{"id":"https://openalex.org/keywords/leukemogenesis","display_name":"leukemogenesis","score":0.5690000057220459},{"id":"https://openalex.org/keywords/alkylating-agents","display_name":"alkylating agents","score":0.5699999928474426},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C2781057849","wikidata":"https://www.wikidata.org/wiki/Q1368780","display_name":"Essential thrombocythemia","level":3,"score":0.79632169008255},{"id":"https://openalex.org/C2778837598","wikidata":"https://www.wikidata.org/wiki/Q948318","display_name":"Polycythemia vera","level":2,"score":0.7645213007926941},{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.7348793745040894},{"id":"https://openalex.org/C2781107747","wikidata":"https://www.wikidata.org/wiki/Q1898104","display_name":"Myeloproliferative neoplasm","level":4,"score":0.7298382520675659},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6555050611495972},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5588226914405823},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4812900125980377},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.46900248527526855},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46383652091026306},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3866352140903473},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.19460642337799072},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15754979848861694},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-60761-266-7_9","doi":"https://doi.org/10.1007/978-1-60761-266-7_9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60761-266-7_9","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Myeloproliferative Neoplasms","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1421162947","https://openalex.org/W1446966563","https://openalex.org/W1581000033","https://openalex.org/W1970111821","https://openalex.org/W1977590248","https://openalex.org/W1980568348","https://openalex.org/W1989167457","https://openalex.org/W1993214853","https://openalex.org/W2008952929","https://openalex.org/W2015506962","https://openalex.org/W2015662674","https://openalex.org/W2025606645","https://openalex.org/W2025754007","https://openalex.org/W2027138297","https://openalex.org/W2028131386","https://openalex.org/W2028961479","https://openalex.org/W2035626929","https://openalex.org/W2038488698","https://openalex.org/W2039956148","https://openalex.org/W2045496640","https://openalex.org/W2047079894","https://openalex.org/W2049145190","https://openalex.org/W2054753195","https://openalex.org/W2055386534","https://openalex.org/W2056116861","https://openalex.org/W2056777053","https://openalex.org/W2057360098","https://openalex.org/W2058330063","https://openalex.org/W2070492834","https://openalex.org/W2082274795","https://openalex.org/W2091165956","https://openalex.org/W2106788103","https://openalex.org/W2107398329","https://openalex.org/W2112316414","https://openalex.org/W2116043577","https://openalex.org/W2118771330","https://openalex.org/W2127559749","https://openalex.org/W2129629467","https://openalex.org/W2131637500","https://openalex.org/W2143139581","https://openalex.org/W2144664431","https://openalex.org/W2146505525","https://openalex.org/W2147182596","https://openalex.org/W2300648760","https://openalex.org/W2312804644","https://openalex.org/W2315963229","https://openalex.org/W2336137267","https://openalex.org/W2530515023","https://openalex.org/W2549440460","https://openalex.org/W2550114143","https://openalex.org/W2561728622","https://openalex.org/W2562725367","https://openalex.org/W2571980413","https://openalex.org/W2586976950","https://openalex.org/W2978999022","https://openalex.org/W3114368461","https://openalex.org/W4241718608"],"related_works":["https://openalex.org/W85097932","https://openalex.org/W2127361094","https://openalex.org/W2000560762","https://openalex.org/W2732761160","https://openalex.org/W4381855175","https://openalex.org/W2981157458","https://openalex.org/W2468595421","https://openalex.org/W3152407136","https://openalex.org/W3008507789","https://openalex.org/W3153573305"],"abstract_inverted_index":{"The":[0,101],"BCR-ABL":[1],"negative":[2],"myeloproliferative":[3],"neoplasms":[4],"(MPNs)":[5],"of":[6,21,61,83,103,155,176,180,204,208],"essential":[7],"thrombocythemia,":[8],"polycythemia":[9],"vera,":[10],"and":[11,46,112,138,152,198],"primary":[12],"myelofibrosis":[13],"have":[14],"an":[15,69],"increasing":[16],"predisposition":[17],"over":[18],"the":[19,42,58,205],"course":[20],"a":[22,113,169,173],"patient\u2019s":[23],"illness":[24],"to":[25,27,34,68,72,79,89,144,185,218],"transform":[26],"overt":[28],"acute":[29],"leukemia":[30],"what":[31],"is":[32,105,166],"referred":[33],"as":[35,87,97,131,140,142],"MPN-Blast":[36],"Phase":[37],"(MPN-BP).":[38],"Current":[39],"therapies":[40,216],"for":[41,122],"MPNs":[43],"are":[44,74,183,210,217],"limited,":[45],"no":[47],"therapy":[48],"other":[49],"than":[50],"allogeneic":[51,162,192],"stem":[52,163,193],"cell":[53,164,194],"transplant":[54,165],"has":[55],"clearly":[56],"altered":[57],"natural":[59],"history":[60],"these":[62],"neoplasms.":[63],"Pathogenetic":[64],"mechanisms":[65],"which":[66,147],"lead":[67],"MPN":[70],"progressing":[71],"MPN-BP":[73,104,124,156,189,209],"incompletely":[75],"understood,":[76],"but":[77,168],"seem":[78],"correlate":[80],"with":[81],"accumulation":[82],"additional":[84],"karyotypic":[85,136],"abnormalities":[86],"opposed":[88],"increases":[90],"in":[91,172],"MPN-associated":[92],"molecular":[93],"lesion":[94],"burden":[95],"(such":[96,130],"JAK2":[98,199],"V617F":[99],").":[100],"development":[102],"heralded":[106],"by":[107,157,161],"worsening":[108],"cytopenias,":[109],"constitutional":[110],"symptoms,":[111],"very":[114],"poor":[115],"survival":[116],"despite":[117],"therapeutic":[118,181],"intervention.":[119],"Risk":[120],"factors":[121],"developing":[123],"include":[125],"both":[126],"features":[127],"at":[128],"diagnosis":[129],"increased":[132],"peripheral":[133],"blood":[134],"blasts,":[135],"abnormalities,":[137],"thrombocytopenia),":[139],"well":[141],"exposure":[143],"established":[145],"agents":[146],"enhance":[148],"leukemogenesis":[149],"(i.e.,":[150],"P-32":[151],"alkylators).":[153],"Salvage":[154],"induction":[158],"chemotherapy":[159],"followed":[160],"possible,":[167],"successful":[170],"option":[171],"small":[174],"minority":[175],"patients.":[177],"Multiple":[178],"avenues":[179],"investigation":[182],"ongoing":[184],"treat,":[186],"or":[187],"prevent,":[188],"including":[190],"early":[191],"transplantation,":[195],"hypomethylating":[196],"agents,":[197],"inhibition.":[200],"An":[201],"improved":[202],"understanding":[203],"pathogenetic":[206],"underpinings":[207],"necessary":[211],"if":[212],"more":[213],"effective":[214],"targeted":[215],"be":[219],"developed.":[220]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
