{"id":"https://openalex.org/W1186462452","doi":null,"title":"Omega-3 Long-Chain Polyunsaturated Fatty Acids (LCPUFAs) Suppress Retinal COX-2 mRNA and Retinal Neovascularization","display_name":"Omega-3 Long-Chain Polyunsaturated Fatty Acids (LCPUFAs) Suppress Retinal COX-2 mRNA and Retinal Neovascularization","publication_year":2007,"publication_date":"2007-05-10","ids":{"openalex":"https://openalex.org/W1186462452","mag":"1186462452"},"language":"en","primary_location":{"id":"mag:1186462452","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2386121","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113508308","display_name":"Akiko Higuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akiko Higuchi","raw_affiliation_strings":["Ophthalmology, Children's Hospital Boston/Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Children's Hospital Boston/Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025598941","display_name":"Kip M. Connor","orcid":"https://orcid.org/0000-0002-2048-9080","observed_orcids":["https://orcid.org/0000-0002-2048-9080"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kip M. Connor","raw_affiliation_strings":["Ophthalmology, Children's Hospital Boston/Harvard Medical School, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-2048-9080","affiliations":[{"raw_affiliation_string":"Ophthalmology, Children's Hospital Boston/Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082704992","display_name":"Christopher M. Aderman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher M. Aderman","raw_affiliation_strings":["Ophthalmology, Children's Hospital Boston/Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Children's Hospital Boston/Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jin Chen","orcid":"https://orcid.org/0000-0002-5557-2079","observed_orcids":["https://orcid.org/0000-0002-5557-2079"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin Chen","raw_affiliation_strings":["Ophthalmology, Children's Hospital Boston/Harvard Medical School, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-5557-2079","affiliations":[{"raw_affiliation_string":"Ophthalmology, Children's Hospital Boston/Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111393104","display_name":"J.P. SanGiovanni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.P. SanGiovanni","raw_affiliation_strings":["Division of Epidemiology and Clinical Research, National Eye Institute, NIH, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology and Clinical Research, National Eye Institute, NIH, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109835170","display_name":"Norman Salem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210121815","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norman Salem","raw_affiliation_strings":["Laboratory of Membrane Biochemistry and Biophysics, NIH/National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Membrane Biochemistry and Biophysics, NIH/National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090802305","display_name":"Emily Y. Chew","orcid":"https://orcid.org/0000-0003-0999-9802","observed_orcids":["https://orcid.org/0000-0003-0999-9802"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Y. Chew","raw_affiliation_strings":["Division of Epidemiology and Clinical Research, National Eye Institute, NIH, Bethesda, Maryland"],"raw_orcid":"https://orcid.org/0000-0003-0999-9802","affiliations":[{"raw_affiliation_string":"Division of Epidemiology and Clinical Research, National Eye Institute, NIH, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109222410","display_name":"Sharon F. Majchrzak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210121815","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon Majchrzak","raw_affiliation_strings":["Laboratory of Membrane Biochemistry and Biophysics, NIH/National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Membrane Biochemistry and Biophysics, NIH/National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091304323","display_name":"Lois E. H. Smith","orcid":"https://orcid.org/0000-0001-7644-6410","observed_orcids":["https://orcid.org/0000-0001-7644-6410"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lois E. H. Smith","raw_affiliation_strings":["Ophthalmology, Children's Hospital Boston/Harvard Medical School, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0001-7644-6410","affiliations":[{"raw_affiliation_string":"Ophthalmology, Children's Hospital Boston/Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14131468,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":"13","first_page":"3416","last_page":"3416"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.6689000129699707,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.6689000129699707,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.29100000858306885,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.9900000095367432},{"id":"https://openalex.org/keywords/long-chain-polyunsaturated-fatty-acids","display_name":"long-chain polyunsaturated fatty acids","score":0.996999979019165},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cox-2-mrna","display_name":"COX-2 mRNA","score":0.9359999895095825},{"id":"https://openalex.org/keywords/retinal-neovascularization","display_name":"retinal neovascularization","score":0.996999979019165},{"id":"https://openalex.org/keywords/retinal-disease","display_name":"retinal disease","score":0.49799999594688416},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.8086310029029846},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.6453624367713928},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49354588985443115},{"id":"https://openalex.org/C3020382795","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Long chain","level":2,"score":0.4830958843231201},{"id":"https://openalex.org/C2781359195","wikidata":"https://www.wikidata.org/wiki/Q5105209","display_name":"Choroidal neovascularization","level":3,"score":0.4770492911338806},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.41457849740982056},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20145675539970398},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13883456587791443},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.12786343693733215},{"id":"https://openalex.org/C126348684","wikidata":"https://www.wikidata.org/wiki/Q3456979","display_name":"Polymer science","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1186462452","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2386121","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W763789995","https://openalex.org/W1521591526","https://openalex.org/W2472210244","https://openalex.org/W946779706","https://openalex.org/W2736990454","https://openalex.org/W798978256","https://openalex.org/W1179550156","https://openalex.org/W942333376","https://openalex.org/W2076232924","https://openalex.org/W2802357345"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}
