{"id":"https://openalex.org/W1186385","doi":null,"title":"Clinical implications of the reduced activity of the GH-IGF-I axis in older men.","display_name":"Clinical implications of the reduced activity of the GH-IGF-I axis in older men.","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W1186385","mag":"1186385","pmid":"https://pubmed.ncbi.nlm.nih.gov/16760634"},"language":"en","primary_location":{"id":"pmid:16760634","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16760634","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of endocrinological investigation","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102809955","display_name":"Gian Paolo Ceda","orcid":"https://orcid.org/0000-0002-9648-8295","observed_orcids":["https://orcid.org/0000-0002-9648-8295"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G P Ceda","raw_affiliation_strings":["Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, 43100 Parma, Italy. gpceda@unipr.it","Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, 43100 Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, 43100 Parma, Italy. gpceda@unipr.it","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, 43100 Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109872917","display_name":"Elisabetta Dall\u2019Aglio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E Dall'Aglio","raw_affiliation_strings":["University of Parma#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Parma#TAB#","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016660184","display_name":"Marcello Giuseppe Maggio","orcid":"https://orcid.org/0000-0002-1727-6797","observed_orcids":["https://orcid.org/0000-0002-1727-6797"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Maggio","raw_affiliation_strings":["University of Parma#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Parma#TAB#","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079630161","display_name":"Fulvio Lauretani","orcid":"https://orcid.org/0000-0002-5287-9972","observed_orcids":["https://orcid.org/0000-0002-5287-9972"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F Lauretani","raw_affiliation_strings":["University of Parma#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Parma#TAB#","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091741059","display_name":"Stefania Bandinelli","orcid":"https://orcid.org/0000-0002-6491-0850","observed_orcids":["https://orcid.org/0000-0002-6491-0850"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S Bandinelli","raw_affiliation_strings":["University of Parma#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Parma#TAB#","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019690236","display_name":"Chiara Falzoi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C Falzoi","raw_affiliation_strings":["University of Parma#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Parma#TAB#","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082507218","display_name":"W Grimaldi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"W Grimaldi","raw_affiliation_strings":["University of Parma#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Parma#TAB#","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064225775","display_name":"Graziano Ceresini","orcid":"https://orcid.org/0000-0003-3347-4096","observed_orcids":["https://orcid.org/0000-0003-3347-4096"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Ceresini","raw_affiliation_strings":["University of Parma#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Parma#TAB#","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026125076","display_name":"Francesco Corradi","orcid":"https://orcid.org/0000-0002-5588-2608","observed_orcids":["https://orcid.org/0000-0002-5588-2608"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F Corradi","raw_affiliation_strings":["University of Parma#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Parma#TAB#","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048196698","display_name":"Luigi Ferrucci","orcid":"https://orcid.org/0000-0002-6273-1613","observed_orcids":["https://orcid.org/0000-0002-6273-1613"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L Ferrucci","raw_affiliation_strings":["University of Parma#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Parma#TAB#","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081619945","display_name":"Giorgio Valenti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Valenti","raw_affiliation_strings":["University of Parma#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Parma#TAB#","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008024833","display_name":"Andrew R. Hoffman","orcid":"https://orcid.org/0000-0002-0145-1917","observed_orcids":["https://orcid.org/0000-0002-0145-1917"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A R Hoffman","raw_affiliation_strings":["University of Parma#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Parma#TAB#","institution_ids":["https://openalex.org/I124601658"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I124601658"],"apc_list":null,"apc_paid":null,"fwci":4.3305,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.9433479,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"28","issue":"11 Suppl Proceedings","first_page":"96","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8529999852180481},{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.8059999942779541},{"id":"https://openalex.org/keywords/gh-igf-1-axis","display_name":"somatotropic axis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9129999876022339},{"id":"https://openalex.org/keywords/older-men","display_name":"older men","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.8970000147819519},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.8500000238418579},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":0.9819999933242798},{"id":"https://openalex.org/keywords/frailty","display_name":"frailty","score":1.0},{"id":"https://openalex.org/keywords/physical-functioning","display_name":"physical function","score":0.7139999866485596},{"id":"https://openalex.org/keywords/muscle-strength","display_name":"muscle strength","score":0.9829999804496765},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8040000200271606},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7379999756813049},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.7246900796890259},{"id":"https://openalex.org/C2776214593","wikidata":"https://www.wikidata.org/wiki/Q1787939","display_name":"Sarcopenia","level":2,"score":0.6925647854804993},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6760299205780029},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6279690265655518},{"id":"https://openalex.org/C65232495","wikidata":"https://www.wikidata.org/wiki/Q1813773","display_name":"Synaptogenesis","level":2,"score":0.5686502456665039},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5671688318252563},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5363966226577759},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5330608487129211},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.5319825410842896},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.48733624815940857},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.46544206142425537},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.4206423759460449},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.32005876302719116},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.24202468991279602}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:16760634","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16760634","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of endocrinological investigation","raw_type":"Journal Article"},{"id":"pmh:oai:arpi.unipi.it:11568/935160","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/935160","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1186385","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16760634","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1978768469","https://openalex.org/W2136833539","https://openalex.org/W4252623227","https://openalex.org/W7095192334","https://openalex.org/W1998986225","https://openalex.org/W1976606241","https://openalex.org/W2170236103","https://openalex.org/W1977037979","https://openalex.org/W4385276019","https://openalex.org/W1999233270"],"abstract_inverted_index":{"During":[0],"the":[1,124,133,167,214,263,266],"last":[2],"decade,":[3],"a":[4,16,121,163,186,208,244,253],"significant":[5],"body":[6,198],"of":[7,49,98,126,185,211,216,234],"evidence":[8,184],"has":[9,45,115,143],"accumulated,":[10],"indicating":[11],"that":[12,118,226,256],"IGF-I":[13,44,69,93,105,119,128,142,173,192,212,228,251],"might":[14],"play":[15],"role":[17,42,122,210],"in":[18,89,104,123,170,178,197,213,240,247,257],"several":[19],"pathological":[20],"conditions":[21],"commonly":[22],"seen":[23],"during":[24],"aging,":[25],"such":[26,80],"as":[27,81],"atherosclerosis":[28],"and":[29,37,59,86,113,135,145,148,155,172,175,191,194,200,219,237,242,270],"cardiovascular":[30,264],"disease":[31],"(CVD),":[32],"cognitive":[33,111,176],"decline,":[34],"dementia,":[35],"sarcopenia":[36],"frailty.":[38],"A":[39],"vascular":[40,60],"protective":[41],"for":[43,138],"been":[46,72,116],"suggested":[47,117],"because":[48],"its":[50],"ability":[51],"to":[52,243],"stimulate":[53],"nitric":[54],"oxide":[55],"production":[56],"from":[57],"endothelial":[58],"smooth":[61],"muscle":[62,235],"cells.":[63],"In":[64,249],"cross":[65],"sectional":[66],"studies,":[67,91],"low":[68],"levels":[70,85,94,106,174,193],"have":[71,206,223],"associated":[73,231],"with":[74,107,110,162,232],"unfavorable":[75],"CVD":[76],"risk":[77],"factors":[78],"profile,":[79],"atherosclerosis,":[82],"abnormal":[83],"lipoprotein":[84],"hypertension,":[87],"while":[88],"prospective":[90],"lower":[92],"predict":[95],"future":[96],"development":[97,125,215],"ischemic":[99],"heart":[100],"disease.":[101],"The":[102],"fall":[103],"aging":[108],"correlates":[109],"decline":[112,169],"it":[114],"plays":[120],"dementia.":[127],"is":[129,136,183,229,252],"highly":[130],"expressed":[131],"within":[132],"brain":[134,140],"essential":[137],"normal":[139],"development.":[141],"anti-apoptotic":[144],"neuroprotective":[146],"effects":[147],"promotes":[149],"projection":[150],"neuron":[151],"growth,":[152],"dendritic":[153],"arborization":[154],"synaptogenesis.":[156],"Collectively,":[157],"these":[158],"data":[159],"are":[160],"consistent":[161],"causal":[164],"link":[165],"between":[166,188],"age-related":[168,195],"GH":[171,190],"deficits":[177],"older":[179,258],"persons.":[180],"Finally,":[181],"there":[182],"relationship":[187],"declining":[189],"changes":[196],"composition":[199],"physical":[201,238,271],"function.":[202,272],"However,":[203],"few":[204],"studies":[205],"documented":[207,225],"precise":[209],"sarcopenia,":[217],"frailty":[218],"poor":[220],"mobility.":[221],"We":[222],"recently":[224],"serum":[227],"significantly":[230],"measures":[233],"strength":[236],"performance":[239],"men":[241],"lesser":[245],"extent":[246],"women.":[248],"conclusion,":[250],"pleiotropic":[254],"hormone":[255],"persons":[259],"may":[260],"positively":[261],"affect":[262],"system,":[265],"central":[267],"nervous":[268],"system":[269]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}