{"id":"https://openalex.org/W118478495","doi":null,"title":"Induction of apoptosis by eugenol in human breast cancer cells.","display_name":"Induction of apoptosis by eugenol in human breast cancer cells.","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W118478495","mag":"118478495","pmid":"https://pubmed.ncbi.nlm.nih.gov/22126019"},"language":"en","primary_location":{"id":"pmid:22126019","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22126019","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of experimental biology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"N Vidhya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I215927","display_name":"University of Madras","ror":"https://ror.org/04jmt9361","country_code":"IN","type":"education","lineage":["https://openalex.org/I215927"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"N Vidhya","raw_affiliation_strings":["Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India","institution_ids":["https://openalex.org/I215927"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048606167","display_name":"S Niranjali Devaraj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Niranjali Devaraj","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.4223,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.96180897,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"49","issue":"11","first_page":"871","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.23430000245571136,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.23430000245571136,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.09529999643564224,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.09009999781847,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eugenol","display_name":"eugenol","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":1.0},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.890999972820282},{"id":"https://openalex.org/keywords/glutathione-depletion","display_name":"glutathione depletion","score":0.847000002861023},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":1.0},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8309999704360962},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7289999723434448},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.9100000262260437}],"concepts":[{"id":"https://openalex.org/C2780470866","wikidata":"https://www.wikidata.org/wiki/Q423357","display_name":"Eugenol","level":2,"score":0.8663592338562012},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7453100681304932},{"id":"https://openalex.org/C2779102032","wikidata":"https://www.wikidata.org/wiki/Q342717","display_name":"Acridine orange","level":3,"score":0.7343504428863525},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5709666609764099},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5377277731895447},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5010614395141602},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49143803119659424},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4690300226211548},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.45772585272789},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.43973207473754883},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4348742365837097},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29977500438690186},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2632080912590027},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.14962223172187805},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0822814404964447},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005054","descriptor_name":"Eugenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017392","descriptor_name":"Thiobarbituric Acid Reactive Substances","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:22126019","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22126019","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of experimental biology","raw_type":"Journal Article"},{"id":"mag:118478495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22126019","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W47146608","https://openalex.org/W60153519","https://openalex.org/W1589415602","https://openalex.org/W1614601899","https://openalex.org/W1906197854","https://openalex.org/W1983310681","https://openalex.org/W1984123521","https://openalex.org/W1996567128","https://openalex.org/W1996618849","https://openalex.org/W2027619833","https://openalex.org/W2028140975","https://openalex.org/W2032674280","https://openalex.org/W2035954299","https://openalex.org/W2043197944","https://openalex.org/W2048428832","https://openalex.org/W2063119361","https://openalex.org/W2069132215","https://openalex.org/W2088827024","https://openalex.org/W2092516681","https://openalex.org/W2092932922","https://openalex.org/W2131597845","https://openalex.org/W2140927361","https://openalex.org/W2464933902","https://openalex.org/W3154367256"],"related_works":["https://openalex.org/W2049094525","https://openalex.org/W2156131378","https://openalex.org/W2902625530","https://openalex.org/W2592102861","https://openalex.org/W2340525378","https://openalex.org/W2063119361","https://openalex.org/W3195787174","https://openalex.org/W2611052723","https://openalex.org/W2988961251","https://openalex.org/W1983288937"],"abstract_inverted_index":{"In":[0],"the":[1,43,84,93,105,146,153,163,189],"present":[2],"study,":[3],"potential":[4],"anticancer":[5],"effect":[6],"of":[7,11,16,27,59,69,74,77,83,95,109,117,128,148,155,165,192],"eugenol":[8,31,78,129,142,177],"on":[9,79],"inhibition":[10],"cell":[12,28,47,118,133,179],"proliferation":[13,108],"and":[14,37,49,64,67,97,107,123,137,151,168,181],"induction":[15,73,116],"apoptosis":[17,173,182],"in":[18,162,176,188],"human":[19,85,110],"MCF-7":[20,111],"breast":[21,86,112],"cancer":[22,87,113],"cells":[23,60,88,114,131,167],"was":[24,32,89,121,174],"investigated.":[25],"Induction":[26],"death":[29,180],"by":[30,91],"evaluated":[33],"following":[34],"MTT":[35],"assay":[36],"monitoring":[38],"lactate":[39],"dehydrogenase":[40],"released":[41],"into":[42],"culture":[44],"medium":[45],"for":[46,53,72],"viability":[48],"cytotoxicity,":[50],"giemsa":[51],"staining":[52],"morphological":[54],"alterations,":[55],"fluorescence":[56],"microscopy":[57],"analysis":[58],"using":[61],"ethidium":[62],"bromide":[63],"acridine":[65],"orange":[66],"quantitation":[68],"DNA":[70,169],"fragments":[71,170],"apoptosis.":[75],"Effect":[76],"intracellular":[80,149],"redox":[81],"status":[82],"assessed":[90],"determining":[92],"level":[94,147,154],"glutathione":[96,150],"lipid":[98,156],"peroxidation":[99],"products":[100],"(TBARS).":[101],"Eugenol":[102],"treatment":[103,143],"inhibited":[104],"growth":[106],"through":[115],"death,":[119],"which":[120],"dose":[122,159],"time":[124],"dependent.":[125],"Microscopic":[126],"examination":[127],"treated":[130],"showed":[132],"shrinkage,":[134],"membrane":[135],"blebbing":[136],"apoptotic":[138,166],"body":[139],"formation.":[140],"Further,":[141],"also":[144],"depleted":[145],"increased":[152],"peroxidation.":[157],"The":[158],"dependent":[160],"increase":[161],"percentage":[164],"suggested":[171],"that":[172],"involved":[175],"induced":[178],"might":[183],"have":[184],"played":[185],"a":[186],"role":[187],"chemopreventive":[190],"action":[191],"eugenol.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
