{"id":"https://openalex.org/W118175271","doi":null,"title":"ET-743: more than an innovative mechanism of action.","display_name":"ET-743: more than an innovative mechanism of action.","publication_year":2002,"publication_date":"2002-05-01","ids":{"openalex":"https://openalex.org/W118175271","mag":"118175271","pmid":"https://pubmed.ncbi.nlm.nih.gov/12173491"},"language":"en","primary_location":{"id":"pmid:12173491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12173491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-cancer drugs","raw_type":"Journal Article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024469590","display_name":"Kathleen W. Scotto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kathleen W Scotto","raw_affiliation_strings":["Department of Pharmacology, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA. KW_Scotto@fccc.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA. KW_Scotto@fccc.edu","institution_ids":["https://openalex.org/I1289437631"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024469590"],"corresponding_institution_ids":["https://openalex.org/I1289437631"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"13 Suppl 1","issue":null,"first_page":"S3","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.6074000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.6074000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.22939999401569366,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.030899999663233757,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.824999988079071},{"id":"https://openalex.org/keywords/ecteinascidia-turbinata","display_name":"Ecteinascidia turbinata","score":0.8500000238418579},{"id":"https://openalex.org/keywords/dna-minor-groove-binding","display_name":"DNA minor groove binding","score":0.8289999961853027},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.6060000061988831},{"id":"https://openalex.org/keywords/dna-mismatch-repair","display_name":"DNA mismatch repair","score":0.824999988079071},{"id":"https://openalex.org/keywords/dna-dependent-protein-kinase","display_name":"DNA-dependent protein kinase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nucleotide-excision-repair","display_name":"nucleotide excision repair","score":0.9390000104904175},{"id":"https://openalex.org/keywords/multidrug-resistance-genes","display_name":"multidrug resistance genes","score":0.7580000162124634},{"id":"https://openalex.org/keywords/transcriptional-inhibition","display_name":"transcriptional inhibition","score":0.5130000114440918},{"id":"https://openalex.org/keywords/rna-polymerase-ii","display_name":"RNA polymerase II","score":0.972000002861023},{"id":"https://openalex.org/keywords/soft-tissue-sarcoma","display_name":"soft tissue sarcoma","score":0.7789999842643738},{"id":"https://openalex.org/keywords/anticancer-mechanism","display_name":"anticancer mechanism","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5808274149894714},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5243128538131714},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.4982030391693115},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4891875088214874},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.48769697546958923},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4441720247268677},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4391616880893707},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.43123680353164673},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3571520745754242},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33432814478874207},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23642030358314514},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1391584575176239},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077606","descriptor_name":"Trabectedin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004149","descriptor_name":"Dioxoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004149","descriptor_name":"Dioxoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007546","descriptor_name":"Isoquinolines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D007546","descriptor_name":"Isoquinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018906","descriptor_name":"Antineoplastic Agents, Alkylating","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D018906","descriptor_name":"Antineoplastic Agents, Alkylating","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D044005","descriptor_name":"Tetrahydroisoquinolines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12173491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12173491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-cancer drugs","raw_type":"Journal Article"},{"id":"mag:118175271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12173491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2120685711","https://openalex.org/W4232084780","https://openalex.org/W2327808590","https://openalex.org/W1987646951","https://openalex.org/W2068216889","https://openalex.org/W2148085582","https://openalex.org/W2153737617","https://openalex.org/W2002227562","https://openalex.org/W598370354","https://openalex.org/W2337885479"],"abstract_inverted_index":{"Ecteinascidin-743":[0],"(ET-743),":[1],"an":[2],"anti-tumor":[3,69,106],"agent":[4,75],"derived":[5],"from":[6],"the":[7,80,84,90,93,105,155,160,171,191],"marine":[8],"tunicate,":[9],"Ecteinascidia":[10],"turbinata,":[11],"is":[12,72,177],"active":[13],"against":[14],"various":[15],"solid":[16],"tumor":[17],"cell":[18,49],"lines,":[19],"including":[20],"soft":[21],"tissue":[22],"sarcoma,":[23],"breast,":[24],"ovarian,":[25],"non-small-cell":[26],"lung":[27],"and":[28,31,33,207],"prostate":[29],"cancers":[30],"melanoma,":[32],"has":[34,58],"a":[35,59,67,73,139,215],"broad":[36],"spectrum":[37],"of":[38,62,83,108,111,120,152,170,175,190,204,219],"anti-cancer":[39],"activity":[40,107,124],"in":[41,97,129],"vivo.":[42],"For":[43],"reasons":[44],"as":[45],"yet":[46],"unclear,":[47],"sarcoma":[48],"lines":[50],"are":[51],"exquisitely":[52],"sensitive":[53],"to":[54,88,136,144,164],"ET-743.":[55,137],"The":[56],"drug":[57,156],"unique":[60],"mechanism":[61,151],"action":[63],"that":[64,76,211],"makes":[65],"it":[66],"novel":[68,173],"agent.":[70],"ET-743":[71,176,186,212],"DNA-binding":[74],"covalently":[77],"interacts":[78],"with":[79,159],"minor":[81],"groove":[82],"DNA":[85,98,140,161],"double":[86],"helix":[87],"bend":[89],"molecule":[91],"towards":[92],"major":[94],"groove.":[95],"Defects":[96],"repair":[99,113,133,141,162],"pathways":[100],"have":[101],"paradoxical":[102],"effects":[103],"on":[104,180],"ET-743:":[109],"loss":[110,119],"mismatch":[112],"does":[114],"not":[115,222],"affect":[116],"its":[117,126,178],"toxicity;":[118,127],"DNA-dependent":[121],"protein":[122],"kinase":[123],"enhances":[125],"defects":[128],"transcription-coupled":[130],"nucleotide":[131],"excision":[132],"confer":[134],"resistance":[135,193],"As":[138],"capability":[142],"appears":[143],"be":[145,214],"necessary":[146],"for":[147],"at":[148],"least":[149],"one":[150],"ET-743-mediated":[153],"cytotoxicity,":[154],"may":[157,213],"interact":[158],"machinery":[163],"induce":[165],"lethal":[166],"strand":[167],"breaks.":[168],"One":[169],"most":[172],"aspects":[174],"effect":[179],"RNA":[181],"polymerase":[182],"II-mediated":[183],"gene":[184,198],"transcription.":[185,224],"selectively":[187],"inhibits":[188],"activation":[189],"multidrug":[192],"gene,":[194],"while":[195],"leaving":[196],"constitutive":[197],"expression":[199],"relatively":[200],"unaffected.":[201],"Preliminary":[202],"studies":[203],"other":[205],"genes":[206],"transcriptional":[208],"inducers":[209],"indicate":[210],"more":[216],"general":[217],"inhibitor":[218],"activated,":[220],"but":[221],"basal,":[223]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}