{"id":"https://openalex.org/W1180607209","doi":null,"title":"Avalia\u00e7\u00e3o biol\u00f3gica de comp\u00f3sitos de pol\u00edmeros biodegrad\u00e1veis em uma matriz de biocer\u00e2mica com adi\u00e7\u00e3o de tetraciclina","display_name":"Avalia\u00e7\u00e3o biol\u00f3gica de comp\u00f3sitos de pol\u00edmeros biodegrad\u00e1veis em uma matriz de biocer\u00e2mica com adi\u00e7\u00e3o de tetraciclina","publication_year":2005,"publication_date":"2005-02-02","ids":{"openalex":"https://openalex.org/W1180607209","mag":"1180607209"},"language":"pt","primary_location":{"id":"pmh:oai:americanae.aecid.es:2146930","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1843/ZMRO-7GYKE7","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UFMG","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1843/ZMRO-7GYKE7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045102308","display_name":"Andr\u00e9 Luiz Pataro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Andr\u00e9 Luiz Pataro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5045102308"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biodegradable-polymer-composites","display_name":"biodegradable polymer composites","score":0.7850000262260437},{"id":"https://openalex.org/keywords/calcium-phosphate-ceramics","display_name":"calcium phosphate ceramics","score":0.9549999833106995},{"id":"https://openalex.org/keywords/tetracycline","display_name":"tetracycline","score":0.9860000014305115},{"id":"https://openalex.org/keywords/bone-tissue-engineering","display_name":"bone tissue engineering","score":0.746999979019165},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.5730000138282776},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7289999723434448},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/biodegradation","display_name":"biodegradation","score":0.6660000085830688},{"id":"https://openalex.org/keywords/surface-morphology","display_name":"surface morphology","score":0.4359999895095825},{"id":"https://openalex.org/keywords/plga","display_name":"PLGA","score":0.5509999990463257},{"id":"https://openalex.org/keywords/polylactic-acid","display_name":"polylactic acid","score":0.8420000076293945},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.5360000133514404},{"id":"https://openalex.org/keywords/osteoinduction","display_name":"osteoinduction","score":0.5509999990463257},{"id":"https://openalex.org/keywords/osteoconduction","display_name":"osteoconduction","score":0.7200000286102295},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6470282077789307},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5311065316200256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18956661224365234}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:americanae.aecid.es:2146930","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1843/ZMRO-7GYKE7","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UFMG","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"pmh:oai:repositorio.ufmg.br:1843/ZMRO-7GYKE7","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1843/ZMRO-7GYKE7","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UFMG","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:1180607209","doi":null,"is_oa":false,"landing_page_url":"https://repositorio.ufmg.br/bitstream/1843/ZMRO-7GYKE7/1/disserta__o_mestrado___andr__pataro.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:2146930","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1843/ZMRO-7GYKE7","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UFMG","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"},{"display_name":"Responsible consumption and production","score":0.5171999931335449,"id":"https://metadata.un.org/sdg/12"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W52520517","https://openalex.org/W103352892","https://openalex.org/W282771637","https://openalex.org/W560770918","https://openalex.org/W583689338","https://openalex.org/W600570182","https://openalex.org/W1524961740","https://openalex.org/W1539246514","https://openalex.org/W1864209824","https://openalex.org/W1951009826","https://openalex.org/W1965943436","https://openalex.org/W1967873365","https://openalex.org/W1971925267","https://openalex.org/W1971947452","https://openalex.org/W1974324128","https://openalex.org/W1975427965","https://openalex.org/W1979979612","https://openalex.org/W1981393311","https://openalex.org/W1983904522","https://openalex.org/W1988250258","https://openalex.org/W1993135217","https://openalex.org/W1993426619","https://openalex.org/W1995037331","https://openalex.org/W1999521902","https://openalex.org/W2000040477","https://openalex.org/W2014614753","https://openalex.org/W2015639818","https://openalex.org/W2017246690","https://openalex.org/W2019047966","https://openalex.org/W2019829171","https://openalex.org/W2022981155","https://openalex.org/W2026936676","https://openalex.org/W2034794242","https://openalex.org/W2038764145","https://openalex.org/W2039249790","https://openalex.org/W2050141506","https://openalex.org/W2050583174","https://openalex.org/W2051474403","https://openalex.org/W2057724290","https://openalex.org/W2060010511","https://openalex.org/W2060482258","https://openalex.org/W2063095947","https://openalex.org/W2065277272","https://openalex.org/W2069280511","https://openalex.org/W2070755479","https://openalex.org/W2071522072","https://openalex.org/W2072048781","https://openalex.org/W2075620782","https://openalex.org/W2077414480","https://openalex.org/W2077648724","https://openalex.org/W2078405503","https://openalex.org/W2080816384","https://openalex.org/W2085429548","https://openalex.org/W2086194573","https://openalex.org/W2087738962","https://openalex.org/W2091466037","https://openalex.org/W2092269548","https://openalex.org/W2098233696","https://openalex.org/W2099580984","https://openalex.org/W2106870893","https://openalex.org/W2107539758","https://openalex.org/W2133338994","https://openalex.org/W2141864641","https://openalex.org/W2146871645","https://openalex.org/W2153990931","https://openalex.org/W2161844839","https://openalex.org/W2169123659","https://openalex.org/W2260644551","https://openalex.org/W2285980872","https://openalex.org/W2287360211","https://openalex.org/W2411998254","https://openalex.org/W2482023145","https://openalex.org/W2485975609","https://openalex.org/W2491382289","https://openalex.org/W2495568134","https://openalex.org/W2736347115","https://openalex.org/W3135674928"],"related_works":["https://openalex.org/W2019484271","https://openalex.org/W1995985990","https://openalex.org/W2944601483","https://openalex.org/W2024946442","https://openalex.org/W2095278515","https://openalex.org/W2120740945","https://openalex.org/W2018225860","https://openalex.org/W3197317347","https://openalex.org/W2088335432","https://openalex.org/W7036189073"],"abstract_inverted_index":{"Biocer\u00e2micas":[0],"de":[1,3,22,27,29,59,65,73,96,102,104,115,133,147,153,167,199,215,239,242,247,257,277,283,289,300,311,315,331,348,359,427,433,448,463,479,488,500,504,511,543,552,573,581,609,636,650,658],"fosfato":[2,28],"c\u00e1lcio":[4,30],"(BC)":[5],"e":[6,34,43,67,87,108,117,164,225,253,271,281,309,334,337,345,398,411,420,521,550,616,654],"pol\u00edmeros":[7,50,134,175],"biodegrad\u00e1veis,":[8],"comp\u00f3sitos,":[9],"reconstru\u00e7\u00e3o":[10,92],"\u00f3ssea,":[11,93,671],"tetraciclina":[12,83,216,489],"biocer\u00e2mica":[13,197],"t\u00eam":[14,52],"se":[15,444],"mostrado":[16],"materiais":[17,234,318,351,534,601],"interessantes":[18],"para":[19,90,111,220,228,611,669,677],"a":[20,71,77,82,91,113,129,313,399,416,429,440,446,492,506,525,570,624,640,678],"engenharia":[21,58],"tecidos":[23],"\u00f3ssea.":[24],"As":[25,531,560,656],"biocer\u00e2micas":[26],"apresentam":[31],"caracter\u00edsticas":[32,159],"f\u00edsico-qu\u00edmicas":[33],"arquitet\u00f4nicas":[35],"importantes":[36],"que":[37,386,395,524,638],"possibilitam":[38,639],"respostas":[39],"biol\u00f3gicas":[40,88],"como":[41,55,94,324,514,646,667],"osteocondutividade":[42],"osteoindutividade":[44],"intr\u00ednseca.":[45],"Por":[46],"outro":[47],"lado,":[48],"os":[49,174,221,229,260,472,541,558,612,633],"biodegrad\u00e1veis":[51,135,176],"sido":[53],"utilizados":[54],"andaimes":[56],"na":[57,206],"tecidos,":[60],"principalmente":[61,564],"pela":[62],"cin\u00e9tica":[63],"previs\u00edvel":[64],"biodegrada\u00e7\u00e3o":[66],"plasticidade.":[68],"No":[69],"entanto,":[70],"forma\u00e7\u00e3o":[72],"comp\u00f3sitos":[74,170,380,419,593],"parece":[75],"otimizar":[76],"resposta":[78,154,326,393,454,493,618],"biol\u00f3gica":[79,327,494],"reparadora.":[80],"Todavia,":[81],"apresenta":[84],"propriedades":[85,657],"farmacol\u00f3gicas":[86],"favor\u00e1veis":[89],"antibi\u00f3tico":[95],"amplo":[97],"espectro,":[98],"atividade":[99],"anticolagen\u00e1sica,":[100],"inibi\u00e7\u00e3o":[101],"reabsor\u00e7\u00e3o":[103],"osso,":[105],"a\u00e7\u00e3o":[106],"antiinflamat\u00f3ria":[107],"uma":[109,137,194,537,547,617],"habilidade":[110],"promover":[112],"adsor\u00e7\u00e3o":[114,503],"fibroblastos":[116],"tecido":[118,276,282],"conectivo":[119],"em":[120,136,193,237,361,554,596,647],"superf\u00edcies":[121,532],"radiculares.":[122],"Os":[123,169,233,372,600,628],"objetivos":[124],"desse":[125],"trabalho":[126],"foram":[127,171,235,516],"avaliar":[128],"influ\u00eancia":[130],"da":[131,160,196,364,484,577,642,644],"associa\u00e7\u00e3o":[132],"matriz":[138,195],"biocer\u00e2mica,":[139,582],"adicionando-se":[140,211],"ou":[141,183,212],"n\u00e3o":[142,213],"tetraciclina,":[143],"mediante:":[144],"(1)":[145,287],"graus":[146,608],"citotoxicidade":[148,290,376,610],"in":[149,156,223,231,291,328,377,614,622,630,634],"vitro;":[150],"(2)":[151,325],"padr\u00f5es":[152,166],"inflamat\u00f3ria":[155,619],"vivo;":[157],"(3)":[158],"superf\u00edcie":[161],"dos":[162,296,317,350,379,418,421,495,533,592],"biomateriais;":[163],"(4)":[165],"degrada\u00e7\u00e3o.":[168],"preparados":[172],"utilizando-se":[173],"D,L":[177,184],"Poli":[178,185],"(\u00c1cido":[179,186],"L\u00e1tico-Glic\u00f3lico)":[180],"(PLGA)":[181],"50:50":[182],"L\u00e1tico)":[187],"(PLA)":[188],"(Birminghan":[189],"Polymers,":[190],"Inc.)":[191],"dispersos":[192],"Osteosynt\u00ae":[198],"granulometria":[200],"80x60":[201],"Mesh":[202],"(Einco":[203],"Biomaterial":[204],"Ltda.),":[205],"propor\u00e7\u00e3o":[207],"1:3":[208],"p/p":[209,219,227],"respectivamente,":[210],"cloridrato":[214],"(Merck)":[217],"0,01%":[218],"testes":[222,230,288,310,613,674],"vitro":[224,292,378,615],"0,1%":[226],"vivo.":[232],"conformados":[236],"pastilhas":[238,561],"aproximadamente":[240],"7mm":[241],"di\u00e2metro":[243],"sob":[244],"press\u00e3o":[245],"constante":[246],"250":[248],"kg/m2":[249],"por":[250,255,467,519,546,567],"5":[251],"minutos":[252],"esterilizados":[254],"\u00f3xido":[256],"etileno.":[258],"Estabeleceram-se":[259],"grupos":[261],"teste:":[262],"PLGA:BC,":[263],"PLGA:BC":[264,404,458],"+":[265,269],"TCN,":[266],"PLA:BC,":[267],"PLA:BC":[268,389],"TCN":[270],"controle:":[272],"BC,":[273],"PLA,":[274],"PLGA,":[275,568],"animal":[278,284],"apenas":[279],"incisionado":[280],"h\u00edgido.":[285],"Realizaram-se:":[286],"pelo":[293,357],"contato":[294,556],"direto":[295],"mesmos":[297],"com":[298,431,540,557,575,586],"c\u00e9lulas":[299,464,505],"camundongo":[301],"(fibroblastos":[302],"tumorig\u00eanicos":[303],"L-929)":[304],"(ASTM":[305],"F-813;":[306],"ISO":[307,321],"10993-5)":[308],"elui\u00e7\u00e3o":[312],"partir":[314,441,507],"extratos":[316],"(USP":[319],"XXIII;":[320],"10.993-5)":[322],"assim":[323,513],"vivo":[329,631],"atrav\u00e9s":[330],"an\u00e1lises":[332],"macro":[333],"microsc\u00f3picas":[335],"(MO":[336],"MEV)":[338],"ap\u00f3s":[339],"1,":[340],"7,":[341],"13,":[342],"21,":[343],"28":[344],"56":[346],"dias":[347],"implanta\u00e7\u00e3o":[349],"nos":[352],"camundongos":[353],"machos":[354],"Swiss":[355],"(aprovado":[356],"Comit\u00ea":[358],"\u00c9tica":[360],"Experimenta\u00e7\u00e3o":[362],"Animal":[363],"UFMG,":[365],"parecer":[366],"014/04)":[367],"(ISO":[368],"10993-6;":[369],"MHW":[370],"1995).":[371],"resultados":[373,629],"mostram":[374],"baixa":[375,406],"quando":[381],"comparados":[382],"aos":[383],"controles,":[384],"sendo":[385,523],"o":[387,396,477,663],"comp\u00f3sito":[388,403,457,661],"apresentou":[390,405,423],"um":[391,424,449,460],"\u00edndice":[392],"melhor":[394],"PLA":[397],"BC":[400,544],"isoladamente.":[401],"O":[402],"citotoxicidade,":[407],"semelhantemente":[408],"ao":[409,437,456,474,598],"PLGA":[410],"\u00e0":[412],"BC.":[413],"In":[414],"vivo,":[415,623],"maioria":[417],"controles":[422],"infiltrado":[425,450],"inflamat\u00f3rio":[426,451],"leve":[428],"moderado":[430,462],"predom\u00ednio":[432],"PMNs":[434],"do":[435,442,508,660],"1o":[436,509],"7o":[438],",":[439],"qual":[443,625],"observou":[445],"presen\u00e7a":[447],"mononuclear.":[452],"A":[453,486,502,590],"tecidual":[455,481],"exibiu":[459],"ac\u00famulo":[461],"inflamat\u00f3rias":[465],"mononucleares":[466],"mais":[468,588],"tempo.":[469,599],"Em":[470],"todos":[471],"grupos,":[473],"21o":[475],"dia,":[476],"padr\u00e3o":[478],"organiza\u00e7\u00e3o":[480],"demonstrou-se":[482],"pr\u00f3ximo":[483],"normalidade.":[485],"adi\u00e7\u00e3o":[487],"influenciou":[490],"favoravelmente":[491],"materiais,":[496],"apresentando":[497],"menor":[498],"grau":[499],"inflama\u00e7\u00e3o.":[501],"dia":[510],"implanta\u00e7\u00e3o,":[512],"angiog\u00eanese,":[515],"verificadas":[517],"microscopicamente":[518],"MEV":[520],"MO,":[522],"angiog\u00eanese":[526],"foi":[527,594],"observada":[528],"tamb\u00e9m":[529],"macroscopicamente.":[530],"implantados":[535],"apresentaram":[536,603],"microestrutura":[538],"semicristalina,":[539],"gr\u00e2nulos":[542],"recobertos":[545],"fase":[548],"cont\u00ednua":[549],"pl\u00e1stica":[551],"pol\u00edmero":[553,574],"\u00edntimo":[555],"mesmos.":[559],"sofreram":[562],"eros\u00e3o,":[563],"as":[565,583],"formadas":[566],"diminuindo":[569],"por\u00e7\u00e3o":[571],"superficial":[572],"aumento":[576],"exposi\u00e7\u00e3o":[578],"das":[579],"part\u00edculas":[580],"quais":[584],"apresentaram-se":[585],"formato":[587],"arredondado.":[589],"porosidade":[591],"aumentando":[595],"rela\u00e7\u00e3o":[597],"testados":[602],"biocompatibilidade":[604],"aceit\u00e1vel,":[605],"demonstrando":[606],"baixos":[607],"aguda":[620],"inicial":[621],"diminuiu":[626],"progressivamente.":[627],"corroboram":[632],"vitro,":[635],"forma":[637],"continua\u00e7\u00e3o":[641],"avalia\u00e7\u00e3o":[643],"biocompatibilidade,":[645],"s\u00edtios":[648],"ortotr\u00f3picos":[649],"outros":[651],"modelos":[652],"animais":[653],"humanos.":[655],"modelagem":[659],"sugerem":[662],"seu":[664],"poss\u00edvel":[665],"uso":[666],"material":[668],"reposi\u00e7\u00e3o":[670],"embora":[672],"maiores":[673],"sejam":[675],"necess\u00e1rios":[676],"comprova\u00e7\u00e3o":[679],"desses":[680],"usos.":[681]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2016-06-24T00:00:00"}