{"id":"https://openalex.org/W118025980","doi":null,"title":"F-box proteins, cell cycle and cancer","display_name":"F-box proteins, cell cycle and cancer","publication_year":2015,"publication_date":"2015-01-13","ids":{"openalex":"https://openalex.org/W118025980","mag":"118025980"},"language":"en","primary_location":{"id":"pmh:knaw:oai:pure.knaw.nl:publications/84ff0906-41c0-4cd2-83b6-1ebdf3f667e2","doi":null,"is_oa":true,"landing_page_url":"https://pure.knaw.nl/portal/en/publications/84ff0906-41c0-4cd2-83b6-1ebdf3f667e2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/other"},"volume":null,"type":"other","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.knaw.nl/portal/en/publications/84ff0906-41c0-4cd2-83b6-1ebdf3f667e2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100377797","display_name":"Jihoon Kim","orcid":"https://orcid.org/0000-0002-3258-6953","observed_orcids":["https://orcid.org/0000-0002-3258-6953"]},"institutions":[{"id":"https://openalex.org/I4210115206","display_name":"Hubrecht Institute for Developmental Biology and Stem Cell Research","ror":"https://ror.org/023qc4a07","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1322597698","https://openalex.org/I4210115206"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Jihoon Kim","raw_affiliation_strings":["Hubrecht Institute for Developmental Biology and Stem Cell Research"],"raw_orcid":"https://orcid.org/0000-0002-3258-6953","affiliations":[{"raw_affiliation_string":"Hubrecht Institute for Developmental Biology and Stem Cell Research","institution_ids":["https://openalex.org/I4210115206"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100377797"],"corresponding_institution_ids":["https://openalex.org/I4210115206"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/f-box-protein","display_name":"F-box protein","score":0.9829999804496765},{"id":"https://openalex.org/keywords/scf-ubiquitin-ligase","display_name":"SCF ubiquitin ligase","score":0.9559999704360962},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.949999988079071},{"id":"https://openalex.org/keywords/dec1","display_name":"DEC1","score":0.8820000290870667},{"id":"https://openalex.org/keywords/tfap4","display_name":"TFAP4","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dna-damage-checkpoint","display_name":"DNA damage checkpoint","score":0.7429999709129333},{"id":"https://openalex.org/keywords/g2-m-transition","display_name":"G2/M transition","score":0.6320000290870667},{"id":"https://openalex.org/keywords/mitotic-entry","display_name":"mitotic entry","score":0.9369999766349792},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/bhlh-transcription-factors","display_name":"bHLH transcription factors","score":0.9649999737739563},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.6169999837875366},{"id":"https://openalex.org/keywords/tumor-gene-expression-profiling","display_name":"tumor gene expression profiling","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.840744137763977},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.7953040599822998},{"id":"https://openalex.org/C131312102","wikidata":"https://www.wikidata.org/wiki/Q5423632","display_name":"F-box protein","level":5,"score":0.6307381987571716},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.5542190670967102},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5530470609664917},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5387858152389526},{"id":"https://openalex.org/C2908868211","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin-Protein Ligases","level":5,"score":0.5361027717590332},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.49369344115257263},{"id":"https://openalex.org/C182561583","wikidata":"https://www.wikidata.org/wiki/Q7876535","display_name":"Ubiquitin-conjugating enzyme","level":5,"score":0.4699343144893646},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4687970280647278},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.46568694710731506},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.42569664120674133},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35844892263412476},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27137747406959534},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2503974437713623}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:knaw:oai:pure.knaw.nl:publications/84ff0906-41c0-4cd2-83b6-1ebdf3f667e2","doi":null,"is_oa":true,"landing_page_url":"https://pure.knaw.nl/portal/en/publications/84ff0906-41c0-4cd2-83b6-1ebdf3f667e2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/other"},{"id":"pmh:oai:dspace.library.uu.nl:1874/302855","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/302855","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/302855","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/302855","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/302855","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/302855","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:118025980","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/302855","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:knaw:oai:pure.knaw.nl:publications/84ff0906-41c0-4cd2-83b6-1ebdf3f667e2","doi":null,"is_oa":true,"landing_page_url":"https://pure.knaw.nl/portal/en/publications/84ff0906-41c0-4cd2-83b6-1ebdf3f667e2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/other"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W1993263392","https://openalex.org/W2076194625","https://openalex.org/W2120590293"],"related_works":["https://openalex.org/W2288054027","https://openalex.org/W2064221650","https://openalex.org/W1869810172","https://openalex.org/W2165584910","https://openalex.org/W2004579010","https://openalex.org/W2054357354","https://openalex.org/W2020235979","https://openalex.org/W2117165624","https://openalex.org/W338483294","https://openalex.org/W1996110479"],"abstract_inverted_index":{"E3":[0,40,72],"ubiquitin":[1,41,73,86,120,133,223,277],"ligases":[2,42,74,87,121,134],"are":[3,18,23,295],"enzymes":[4],"that":[5,17,97,147,164,178,193,219,241,294],"confer":[6],"specificity":[7],"to":[8,46,136,181],"the":[9,15,31,47,63,82,104,116,124,137,153,165,171,188,197,220,229,242,264,285],"ubiquitin-proteasome":[10],"system":[11],"by":[12,25,127,187,207],"directly":[13],"binding":[14],"proteins":[16,293],"targeted":[19,204],"for":[20,36,70,150,205,228,249],"degradation.":[21],"E3s":[22],"encoded":[24],"over":[26],"650":[27],"human":[28,108,280],"genes,":[29],"exceeding":[30],"number":[32,290],"of":[33,49,56,62,68,81,85,106,118,131,141,168,231,245,263,268,275,288,291],"genes":[34],"encoding":[35],"protein":[37],"kinases.":[38],"Accordingly,":[39],"have":[43,95,114,145,162,176,216,258],"been":[44],"linked":[45],"control":[48],"virtually":[50],"all":[51],"cellular":[52],"processes.":[53],"In":[54,159,255],"spite":[55],"their":[57,98],"fundamental":[58,89],"importance,":[59],"our":[60,79],"knowledge":[61,80],"biological":[64,83,286],"function":[65,117],"and":[66,92,122,192,239,252,283],"mechanism":[67],"action":[69],"most":[71],"is":[75,88,101,185,203,226,247],"still":[76],"poor.":[77],"Increasing":[78],"role":[84,287],"because":[90],"experimental":[91],"clinical":[93],"data":[94],"shown":[96,177],"abnormal":[99],"functions":[100,130],"involved":[102],"in":[103,179,209,279,298],"pathogenesis":[105],"many":[107],"cancers.":[109],"During":[110],"my":[111],"PhD,":[112],"I":[113,144,161,175,215,257],"investigated":[115],"SCF":[119,132,222,276],"elucidated":[123],"molecular":[125],"mechanisms":[126],"which":[128],"deregulated":[129],"contribute":[135],"unchecked":[138],"proliferation":[139],"typical":[140],"cancer":[142,299],"cells.":[143,300],"demonstrated":[146,240],"SCF\u03b2TrCP":[148,208],"targets":[149],"proteasomal":[151],"degradation":[152,206,244],"basic":[154,233],"helix-loop-helix":[155,234],"transcription":[156,235],"factor":[157],"DEC1.":[158],"particular,":[160],"found":[163,218,296],"regulated":[166],"proteolysis":[167],"DEC1":[169,184,202],"controls":[170],"DNA":[172,182,199],"damage":[173,200],"checkpoint.":[174],"response":[180],"damage,":[183],"stabilized":[186],"USP17":[189],"deubiquitylating":[190],"enzyme":[191],"during":[194],"recovery":[195],"from":[196],"G2":[198,250],"checkpoint":[201],"collaboration":[210],"with":[211],"Casein":[212],"Kinase":[213],"1a.":[214],"also":[217],"same":[221],"ligase,":[224],"SCF\u03b2TrCP,":[225],"responsible":[227],"destruction":[230],"another":[232],"factor,":[236],"namely":[237],"TFAP4,":[238],"SCF\u03b2TrCP-mediated":[243],"TFAP4":[246],"required":[248],"progression":[251],"mitotic":[253],"entry.":[254],"addition,":[256],"performed":[259],"a":[260,289],"systematic":[261],"analysis":[262],"gene":[265],"expression":[266],"profile":[267],"67":[269],"F-box":[270,292],"proteins,":[271],"substrate":[272],"receptor":[273],"subunits":[274],"ligases,":[278],"primary":[281],"tumors":[282],"studied":[284],"overexpressed":[297]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2016-06-24T00:00:00"}