{"id":"https://openalex.org/W117660896","doi":null,"title":"Synthesis of an erodible biomimetic hydrogel for drug delivery using native chemical ligation","display_name":"Synthesis of an erodible biomimetic hydrogel for drug delivery using native chemical ligation","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W117660896","mag":"117660896"},"language":"en","primary_location":{"id":"mag:117660896","doi":null,"is_oa":false,"landing_page_url":"https://eprints.qut.edu.au/59502/","pdf_url":null,"source":{"id":"https://openalex.org/S4306513467","display_name":"Institute of Health and Biomedical Innovation","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Institute of Health and Biomedical Innovation","raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080889654","display_name":"Wren Austin Fernandes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wren Austin Fernandes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5080889654"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomimetic-hydrogels","display_name":"biomimetic hydrogels","score":0.8859999775886536},{"id":"https://openalex.org/keywords/native-chemical-ligation","display_name":"native chemical ligation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.6890000104904175},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.8240000009536743},{"id":"https://openalex.org/keywords/peptide-dendrimers","display_name":"peptide dendrimers","score":0.9240000247955322},{"id":"https://openalex.org/keywords/proteolysis","display_name":"proteolysis","score":0.8709999918937683},{"id":"https://openalex.org/keywords/shear-strength","display_name":"shear strength","score":0.7910000085830688},{"id":"https://openalex.org/keywords/local-drug-delivery","display_name":"local drug delivery","score":0.7829999923706055},{"id":"https://openalex.org/keywords/peptide-and-protein-drugs","display_name":"protein and peptide drugs","score":0.5230000019073486},{"id":"https://openalex.org/keywords/hydrogel-synthesis","display_name":"hydrogel synthesis","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.8979376554489136},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.7469106316566467},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.6779924631118774},{"id":"https://openalex.org/C2775961978","wikidata":"https://www.wikidata.org/wiki/Q1549805","display_name":"Methacrylamide","level":5,"score":0.6480329632759094},{"id":"https://openalex.org/C54400483","wikidata":"https://www.wikidata.org/wiki/Q1793202","display_name":"PEG ratio","level":2,"score":0.6279393434524536},{"id":"https://openalex.org/C2776964284","wikidata":"https://www.wikidata.org/wiki/Q410083","display_name":"Polyethylene glycol","level":2,"score":0.5897768139839172},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5502616167068481},{"id":"https://openalex.org/C2779149719","wikidata":"https://www.wikidata.org/wiki/Q682252","display_name":"PEGylation","level":3,"score":0.5288965106010437},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4717840850353241},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.43949031829833984},{"id":"https://openalex.org/C163588942","wikidata":"https://www.wikidata.org/wiki/Q5165929","display_name":"Controlled release","level":2,"score":0.43864452838897705},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.42716917395591736},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.41901516914367676},{"id":"https://openalex.org/C112613896","wikidata":"https://www.wikidata.org/wiki/Q898370","display_name":"Conjugated system","level":3,"score":0.4178074896335602},{"id":"https://openalex.org/C55637122","wikidata":"https://www.wikidata.org/wiki/Q903923","display_name":"Dendrimer","level":2,"score":0.41479769349098206},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.41064897179603577},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3897372782230377},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.28931111097335815},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.19766822457313538},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.1777087152004242},{"id":"https://openalex.org/C2779402116","wikidata":"https://www.wikidata.org/wiki/Q342939","display_name":"Acrylamide","level":4,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:117660896","doi":null,"is_oa":false,"landing_page_url":"https://eprints.qut.edu.au/59502/","pdf_url":null,"source":{"id":"https://openalex.org/S4306513467","display_name":"Institute of Health and Biomedical Innovation","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Institute of Health and Biomedical Innovation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":126,"referenced_works":["https://openalex.org/W80378057","https://openalex.org/W636572322","https://openalex.org/W1458672946","https://openalex.org/W1486105856","https://openalex.org/W1505352099","https://openalex.org/W1531698622","https://openalex.org/W1545375707","https://openalex.org/W1556748674","https://openalex.org/W1605564201","https://openalex.org/W1671238747","https://openalex.org/W1890453646","https://openalex.org/W1966903068","https://openalex.org/W1969835568","https://openalex.org/W1971550603","https://openalex.org/W1973296785","https://openalex.org/W1976075691","https://openalex.org/W1976903082","https://openalex.org/W1980601065","https://openalex.org/W1980849720","https://openalex.org/W1981215463","https://openalex.org/W1983605015","https://openalex.org/W1985513441","https://openalex.org/W1988250258","https://openalex.org/W1988367724","https://openalex.org/W1988645530","https://openalex.org/W1990533056","https://openalex.org/W1990698585","https://openalex.org/W1991289157","https://openalex.org/W1991369368","https://openalex.org/W1991986285","https://openalex.org/W1992145783","https://openalex.org/W1996155302","https://openalex.org/W1996663951","https://openalex.org/W1999124243","https://openalex.org/W1999490106","https://openalex.org/W1999896941","https://openalex.org/W2003878542","https://openalex.org/W2004389193","https://openalex.org/W2005419066","https://openalex.org/W2005474600","https://openalex.org/W2007059562","https://openalex.org/W2008049688","https://openalex.org/W2010506651","https://openalex.org/W2011152920","https://openalex.org/W2012625044","https://openalex.org/W2017155882","https://openalex.org/W2018818236","https://openalex.org/W2019875670","https://openalex.org/W2020809165","https://openalex.org/W2026752436","https://openalex.org/W2026780757","https://openalex.org/W2029255146","https://openalex.org/W2035059218","https://openalex.org/W2039424741","https://openalex.org/W2044643145","https://openalex.org/W2045481383","https://openalex.org/W2046781330","https://openalex.org/W2048829256","https://openalex.org/W2050637949","https://openalex.org/W2052133821","https://openalex.org/W2052327379","https://openalex.org/W2052447744","https://openalex.org/W2053152764","https://openalex.org/W2054992092","https://openalex.org/W2055037957","https://openalex.org/W2055846825","https://openalex.org/W2058983924","https://openalex.org/W2060860123","https://openalex.org/W2060877214","https://openalex.org/W2063100081","https://openalex.org/W2066223803","https://openalex.org/W2066386897","https://openalex.org/W2067599444","https://openalex.org/W2068043688","https://openalex.org/W2074429563","https://openalex.org/W2074610214","https://openalex.org/W2074630757","https://openalex.org/W2075186712","https://openalex.org/W2075511023","https://openalex.org/W2075633788","https://openalex.org/W2075856192","https://openalex.org/W2076845200","https://openalex.org/W2077300098","https://openalex.org/W2082511674","https://openalex.org/W2089267023","https://openalex.org/W2090851652","https://openalex.org/W2093161248","https://openalex.org/W2094375186","https://openalex.org/W2095565216","https://openalex.org/W2097257058","https://openalex.org/W2099739435","https://openalex.org/W2114521891","https://openalex.org/W2115439624","https://openalex.org/W2116988397","https://openalex.org/W2119150093","https://openalex.org/W2125913170","https://openalex.org/W2127415189","https://openalex.org/W2144081123","https://openalex.org/W2145496621","https://openalex.org/W2146580600","https://openalex.org/W2151420684","https://openalex.org/W2154662589","https://openalex.org/W2154693046","https://openalex.org/W2155291988","https://openalex.org/W2157220384","https://openalex.org/W2158986880","https://openalex.org/W2159013900","https://openalex.org/W2159999899","https://openalex.org/W2160795810","https://openalex.org/W2162129864","https://openalex.org/W2164880987","https://openalex.org/W2165694975","https://openalex.org/W2166224995","https://openalex.org/W2166405062","https://openalex.org/W2169457114","https://openalex.org/W2170630067","https://openalex.org/W2187627689","https://openalex.org/W2213205713","https://openalex.org/W2281931621","https://openalex.org/W2320655060","https://openalex.org/W2327263492","https://openalex.org/W2480681609","https://openalex.org/W2482531400","https://openalex.org/W2741170198","https://openalex.org/W2951602409","https://openalex.org/W2972967257"],"related_works":["https://openalex.org/W4366089454","https://openalex.org/W2766965864","https://openalex.org/W4404513684","https://openalex.org/W2342208027","https://openalex.org/W2313636171","https://openalex.org/W2140152375","https://openalex.org/W3206582840","https://openalex.org/W183328007","https://openalex.org/W7029222491","https://openalex.org/W4406567390"],"abstract_inverted_index":{"Hydrogels":[0],"are":[1,67],"hydrophilic,":[2],"three":[3],"dimensional":[4],"polymers":[5,25,198],"that":[6,77,125],"imbibe":[7],"large":[8],"quantities":[9],"of":[10,73,87,103,156,164,179,255,265,279],"water":[11,28],"while":[12],"remaining":[13],"insoluble":[14],"in":[15,27,40,122,204],"aqueous":[16,205],"solutions":[17],"due":[18],"to":[19,37,147,168,195,199,226,235,239,248,271],"chemical":[20,192],"or":[21,29,69],"physical":[22],"cross-linking.":[23],"The":[24,162],"swell":[26],"biological":[30],"fluids,":[31],"immobilizing":[32],"the":[33,46,74,80,84,90,135,262,277],"bioactive":[34],"agent,":[35],"leading":[36],"drug":[38,58,62,82,150,173],"release":[39,94,96,178,254],"a":[41,123,256,266],"well-defined":[42],"specific":[43,139],"manner.":[44],"Thus":[45],"hydrogels\u2019":[47],"elastic":[48],"properties,":[49],"swellability":[50],"and":[51,64,105,133,158,175,217,245,274],"biocompatibility":[52],"make":[53],"them":[54],"excellent":[55],"formulations":[56],"for":[57,154,171],"delivery.":[59],"Currently,":[60],"many":[61],"potencies":[63],"therapeutic":[65],"effects":[66],"limited":[68],"otherwise":[70],"reduced":[71],"because":[72],"partial":[75],"degradation":[76],"occurs":[78],"before":[79],"administered":[81,121],"reaches":[83],"desired":[85,131,136],"site":[86,137],"action.":[88],"On":[89],"other":[91],"hand,":[92],"sustained":[93,177],"medications":[95],"drugs":[97,118,180],"continually,":[98],"rather":[99],"than":[100],"providing":[101],"relief":[102],"symptoms":[104],"protection":[106],"solely":[107],"when":[108],"necessary.":[109],"In":[110],"fact,":[111],"it":[112],"would":[113],"be":[114,120,249],"much":[115],"better":[116],"if":[117],"could":[119],"manner":[124],"precisely":[126],"matches":[127],"physiological":[128],"needs":[129],"at":[130,134],"times":[132],"(site":[138],"targeting).":[140],"There":[141],"is":[142,167,261],"therefore":[143],"an":[144,185,240],"unmet":[145],"need":[146],"develop":[148],"controlled":[149],"delivery":[151,155,174],"systems":[152],"especially":[153],"peptide":[157,222,267],"protein":[159],"bound":[160],"drugs.":[161],"purpose":[163],"this":[165],"project":[166],"produce":[169,227],"hydrogels":[170,231],"structural":[172],"time-dependent":[176],"(bioactive":[181],"agents).":[182],"We":[183],"use":[184],"innovative":[186],"polymerisation":[187],"strategy":[188],"based":[189],"on":[190],"native":[191],"ligation":[193],"(NCL)":[194],"covalently":[196],"cross-link":[197],"form":[200],"hydrogels.":[201,229],"When":[202],"mixed":[203],"solution,":[206],"four":[207,218],"armed":[208],"(polyethylene":[209],"glycol)":[210],"amine":[211],"(PEG-4A)":[212],"end":[213],"functionalised":[214],"with":[215,252,284],"thioester":[216],"branched":[219],"Nterminal":[220],"cysteine":[221],"dendrimers":[223],"spontaneously":[224],"conjugated":[225],"biomimetic":[228],"These":[230],"showed":[232],"superior":[233],"resistance":[234],"shear":[236],"stress":[237],"compared":[238],"equivalent":[241],"PEG":[242],"macromonomer":[243,269],"system":[244],"were":[246],"shown":[247],"proteolytically":[250],"degradable":[251],"concomitant":[253],"model":[257],"payload":[258,286],"molecule.":[259],"This":[260],"first":[263],"report":[264],"dendrimers/PEG":[268],"approach":[270],"hydrogel":[272,281],"production":[273],"opens":[275],"up":[276],"prospect":[278],"facile":[280],"synthesis":[282],"together":[283],"tailored":[285],"release.":[287]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}