{"id":"https://openalex.org/W116490489","doi":null,"title":"A review of inpatients with adverse drug reactions to allopurinol.","display_name":"A review of inpatients with adverse drug reactions to allopurinol.","publication_year":2000,"publication_date":"2000-04-01","ids":{"openalex":"https://openalex.org/W116490489","mag":"116490489","pmid":"https://pubmed.ncbi.nlm.nih.gov/11063179"},"language":"en","primary_location":{"id":"pmid:11063179","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11063179","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Singapore medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111854863","display_name":"B P Khoo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B P Khoo","raw_affiliation_strings":["Raffles Surgicentre, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Raffles Surgicentre, Singapore","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112751776","display_name":"Y. H. Leow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y H Leow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.361,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.6394133,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"41","issue":"4","first_page":"156","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allopurinol","display_name":"allopurinol","score":1.0},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.9929999709129333},{"id":"https://openalex.org/keywords/allopurinol-hypersensitivity-syndrome","display_name":"allopurinol hypersensitivity syndrome","score":0.9210000038146973},{"id":"https://openalex.org/keywords/drug-hypersensitivity","display_name":"drug hypersensitivity","score":0.5979999899864197},{"id":"https://openalex.org/keywords/fever","display_name":"fever","score":0.6389999985694885},{"id":"https://openalex.org/keywords/skin-rash","display_name":"rash","score":0.9869999885559082},{"id":"https://openalex.org/keywords/leukocytosis","display_name":"leukocytosis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/eosinophilia","display_name":"eosinophilia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.9890000224113464},{"id":"https://openalex.org/keywords/liver-dysfunction","display_name":"liver dysfunction","score":0.953000009059906},{"id":"https://openalex.org/keywords/uric-acid-lowering","display_name":"uric acid lowering","score":0.8069999814033508},{"id":"https://openalex.org/keywords/hospitalized-patients","display_name":"hospitalized patients","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C2780261098","wikidata":"https://www.wikidata.org/wiki/Q412486","display_name":"Allopurinol","level":2,"score":0.98519366979599},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9698629379272461},{"id":"https://openalex.org/C2778923028","wikidata":"https://www.wikidata.org/wiki/Q974869","display_name":"Leukocytosis","level":2,"score":0.7966179251670837},{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.732125997543335},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5937431454658508},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5678481459617615},{"id":"https://openalex.org/C2778570526","wikidata":"https://www.wikidata.org/wiki/Q653197","display_name":"Rash","level":2,"score":0.5624551177024841},{"id":"https://openalex.org/C2780542314","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Adverse drug reaction","level":3,"score":0.518082857131958},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.5053485035896301},{"id":"https://openalex.org/C2780402116","wikidata":"https://www.wikidata.org/wiki/Q133087","display_name":"Gout","level":2,"score":0.5051830410957336},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49910616874694824},{"id":"https://openalex.org/C2993432071","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Drug reaction","level":3,"score":0.43370574712753296},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3535432815551758},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33760374784469604},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.33555155992507935},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.20550835132598877}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000493","descriptor_name":"Allopurinol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000493","descriptor_name":"Allopurinol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003875","descriptor_name":"Drug Eruptions","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003875","descriptor_name":"Drug Eruptions","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006073","descriptor_name":"Gout","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006074","descriptor_name":"Gout Suppressants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006074","descriptor_name":"Gout Suppressants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007297","descriptor_name":"Inpatients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012846","descriptor_name":"Singapore","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017677","descriptor_name":"Age Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017678","descriptor_name":"Sex Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:11063179","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11063179","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Singapore medical journal","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.554.3112","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.554.3112","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.sma.org.sg/smj/4104/articles/4104a3.pdf","raw_type":"text"},{"id":"mag:116490489","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11063179","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1564204805","https://openalex.org/W1985112312","https://openalex.org/W2013151892","https://openalex.org/W2014810381","https://openalex.org/W2057672828","https://openalex.org/W2154564423","https://openalex.org/W2154947537","https://openalex.org/W2415953886"],"related_works":["https://openalex.org/W2154564423","https://openalex.org/W39414639","https://openalex.org/W2049621329","https://openalex.org/W2473721646","https://openalex.org/W2435722905","https://openalex.org/W2745610143","https://openalex.org/W2417572461","https://openalex.org/W2271266458","https://openalex.org/W2147011517","https://openalex.org/W2407546574"],"abstract_inverted_index":{"Allopurinol":[0],"is":[1],"still":[2],"an":[3],"effective":[4],"uric-acid":[5],"lowering":[6],"drug":[7,22],"since":[8],"its":[9],"introduction":[10],"in":[11],"1963.":[12],"However":[13],"it":[14,110],"has":[15],"been":[16],"frequently":[17,95],"incriminated":[18],"for":[19,79,90],"severe":[20,101],"adverse":[21,33,102],"reactions.":[23],"From":[24],"our":[25],"retrospective":[26],"review":[27],"of":[28,52,61,99],"13":[29],"inpatients":[30],"with":[31,105],"allopurinol":[32,80,92],"reactions":[34,103],"seen":[35],"over":[36],"3":[37],"years,":[38],"fever":[39],"and":[40,68],"rash":[41],"were":[42,94],"the":[43,53,77,100],"commonest":[44],"presenting":[45],"symptoms,":[46],"occurring":[47],"several":[48],"weeks":[49],"after":[50],"initiation":[51],"drug.":[54],"Other":[55],"associated":[56],"abnormalities":[57],"included":[58],"leukocytosis":[59],"(62%":[60],"patients),":[62],"eosinophilia":[63],"(54%),":[64],"renal":[65],"impairment":[66],"(54%)":[67],"liver":[69],"dysfunction":[70],"(69%).":[71],"Although":[72],"12":[73],"patients":[74],"(92%)":[75],"met":[76],"criteria":[78],"hypersensitivity":[81],"syndrome,":[82],"there":[83],"was":[84],"no":[85],"mortality":[86],"recorded.":[87],"The":[88],"indications":[89],"initiating":[91],"therapy":[93],"unclear.":[96],"In":[97],"view":[98],"experienced":[104],"allopurinol,":[106],"we":[107],"propose":[108],"that":[109],"should":[111],"only":[112],"be":[113],"prescribed":[114],"when":[115],"truly":[116],"indicated.":[117]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
