{"id":"https://openalex.org/W116246986","doi":null,"title":"Severe childhood obesity : behavioural and pharmacological treatment","display_name":"Severe childhood obesity : behavioural and pharmacological treatment","publication_year":2011,"publication_date":"2011-11-11","ids":{"openalex":"https://openalex.org/W116246986","mag":"116246986"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26896459","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Severe_childhood_obesity_behavioural_and_pharmacological_treatment/26896459","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/40799","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018737956","display_name":"Pernilla Danielsson","orcid":"https://orcid.org/0000-0002-4674-2638","observed_orcids":["https://orcid.org/0000-0002-4674-2638"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Pernilla Danielsson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4674-2638","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5018737956"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10010","display_name":"Obesity, Physical Activity, Diet","score":0.12319999933242798,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10569","display_name":"Bariatric Surgery and Outcomes","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/childhood-obesity","display_name":"childhood obesity","score":0.9869999885559082},{"id":"https://openalex.org/keywords/morbid-obesity","display_name":"morbid obesity","score":0.8970000147819519},{"id":"https://openalex.org/keywords/behavioral-interventions","display_name":"behavioral interventions","score":0.7889999747276306},{"id":"https://openalex.org/keywords/orlistat","display_name":"orlistat","score":0.7059999704360962},{"id":"https://openalex.org/keywords/sibutramine","display_name":"sibutramine","score":0.9309999942779541},{"id":"https://openalex.org/keywords/anti-obesity-drugs","display_name":"anti-obesity drugs","score":0.8849999904632568},{"id":"https://openalex.org/keywords/prepubertal-children","display_name":"prepubertal children","score":0.7670000195503235},{"id":"https://openalex.org/keywords/hypothalamic-obesity","display_name":"hypothalamic obesity","score":0.8069999814033508},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.625},{"id":"https://openalex.org/keywords/age-at-treatment-initiation","display_name":"age at treatment initiation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/obesity-severity","display_name":"obesity severity","score":0.33500000834465027},{"id":"https://openalex.org/keywords/psychological-well-being","display_name":"psychological well-being","score":0.6449999809265137},{"id":"https://openalex.org/keywords/long-term-treatment-outcomes","display_name":"long-term treatment outcomes","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C2779422640","wikidata":"https://www.wikidata.org/wiki/Q3241451","display_name":"Childhood obesity","level":4,"score":0.5718721151351929},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5678972601890564},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5017428398132324},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3801634907722473},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.35932376980781555},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2387988567352295},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.16044503450393677}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26896459","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Severe_childhood_obesity_behavioural_and_pharmacological_treatment/26896459","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/40799","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/40799","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:116246986","doi":null,"is_oa":false,"landing_page_url":"http://publications.ki.se/xmlui/handle/10616/40799","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/40799","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/40799","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":116,"referenced_works":["https://openalex.org/W261298389","https://openalex.org/W1488468067","https://openalex.org/W1535495118","https://openalex.org/W1575558149","https://openalex.org/W1878619947","https://openalex.org/W1920527066","https://openalex.org/W1966119050","https://openalex.org/W1966774542","https://openalex.org/W1971332218","https://openalex.org/W1978677264","https://openalex.org/W1980083818","https://openalex.org/W1980775812","https://openalex.org/W1981320195","https://openalex.org/W1989148830","https://openalex.org/W1994296264","https://openalex.org/W1996856072","https://openalex.org/W1997322857","https://openalex.org/W2000737109","https://openalex.org/W2005136472","https://openalex.org/W2005975830","https://openalex.org/W2014783793","https://openalex.org/W2016296487","https://openalex.org/W2018642433","https://openalex.org/W2018857626","https://openalex.org/W2022046031","https://openalex.org/W2022590250","https://openalex.org/W2029349706","https://openalex.org/W2031200195","https://openalex.org/W2031398208","https://openalex.org/W2037648222","https://openalex.org/W2037677945","https://openalex.org/W2038726640","https://openalex.org/W2038869287","https://openalex.org/W2039163106","https://openalex.org/W2039421379","https://openalex.org/W2039976681","https://openalex.org/W2040547409","https://openalex.org/W2040781366","https://openalex.org/W2041751298","https://openalex.org/W2042892161","https://openalex.org/W2045411634","https://openalex.org/W2053889157","https://openalex.org/W2055622839","https://openalex.org/W2057587906","https://openalex.org/W2058642308","https://openalex.org/W2062756228","https://openalex.org/W2062940741","https://openalex.org/W2062974431","https://openalex.org/W2063695659","https://openalex.org/W2067741236","https://openalex.org/W2068555588","https://openalex.org/W2071476216","https://openalex.org/W2073736807","https://openalex.org/W2075104837","https://openalex.org/W2075659354","https://openalex.org/W2075675159","https://openalex.org/W2076070483","https://openalex.org/W2077492919","https://openalex.org/W2077611309","https://openalex.org/W2078776334","https://openalex.org/W2084552642","https://openalex.org/W2084613791","https://openalex.org/W2085816496","https://openalex.org/W2085975528","https://openalex.org/W2089413299","https://openalex.org/W2089587137","https://openalex.org/W2096526724","https://openalex.org/W2096935527","https://openalex.org/W2097514101","https://openalex.org/W2097660065","https://openalex.org/W2100990163","https://openalex.org/W2101348111","https://openalex.org/W2104129218","https://openalex.org/W2104183837","https://openalex.org/W2105461016","https://openalex.org/W2105645865","https://openalex.org/W2106023093","https://openalex.org/W2106694682","https://openalex.org/W2108017768","https://openalex.org/W2108492381","https://openalex.org/W2108834046","https://openalex.org/W2109872320","https://openalex.org/W2112398480","https://openalex.org/W2113250747","https://openalex.org/W2118490190","https://openalex.org/W2118891970","https://openalex.org/W2119057053","https://openalex.org/W2119779723","https://openalex.org/W2121598130","https://openalex.org/W2122199148","https://openalex.org/W2125226484","https://openalex.org/W2126545477","https://openalex.org/W2128643576","https://openalex.org/W2129448542","https://openalex.org/W2131451413","https://openalex.org/W2132937397","https://openalex.org/W2135166377","https://openalex.org/W2137571741","https://openalex.org/W2139718609","https://openalex.org/W2140165524","https://openalex.org/W2140708883","https://openalex.org/W2141674942","https://openalex.org/W2143419479","https://openalex.org/W2147315135","https://openalex.org/W2147888023","https://openalex.org/W2156431678","https://openalex.org/W2161661503","https://openalex.org/W2162801766","https://openalex.org/W2165322684","https://openalex.org/W2165957087","https://openalex.org/W2166884301","https://openalex.org/W2290920852","https://openalex.org/W2420822298","https://openalex.org/W2506435771","https://openalex.org/W3134120608","https://openalex.org/W3143687472"],"related_works":["https://openalex.org/W2093900205","https://openalex.org/W2258557212","https://openalex.org/W754513549","https://openalex.org/W2027518544","https://openalex.org/W3009763025","https://openalex.org/W2125226484","https://openalex.org/W2166842985","https://openalex.org/W6920873709","https://openalex.org/W2040457496","https://openalex.org/W2161283213"],"abstract_inverted_index":{"Background:":[0],"Childhood":[1,279],"obesity":[2,33,142,146,181,200,301,416,438,440,638,653,709,749,788],"is":[3,20,59,119,134,168,251,677,728],"a":[4,44,85,129,375,424,466,527,584,617,742,839],"chronic":[5],"disease":[6],"associated":[7,212],"with":[8,65,140,145,149,213,231,299,303,408,436,441,577,580,636,651,707,747,863,868],"increased":[9],"morbidity,":[10],"psychosocial":[11],"problems":[12],"and":[13,47,52,76,143,176,236,266,288,329,396,413,417,509,539,582,599,619,630,689,702,726,750,778,791,805,830,855,876],"reduced":[14],"life":[15,685],"expectancy,":[16],"all":[17,672],"of":[18,28,31,50,70,80,97,100,112,127,180,228,241,297,325,400,434,549,634,649,684,764,782,873],"which":[19,109],"today":[21],"very":[22,60],"common.":[23],"Despite":[24],"this,":[25],"long-term":[26,77],"studies":[27,92,160,220],"behavioural":[29,39,78,101,158,262,304,482],"treatment":[30,40,58,64,79,159,167,174,183,227,263,305,457,483,503,533,567,579,589,667,676,700,789,834],"childhood":[32],"are":[34],"currently":[35],"lacking.":[36],"In":[37,217,331,355,480,611],"addition,":[38],"has":[41],"often":[42],"only":[43,696],"modest":[45],"effect":[46,96,111,126,172,204,519,534],"the":[48,90,95,110,113,125,157,178,218,221,242,249,277,323,334,356,382,398,401,404,481,485,495,514,536,544,547,561,578,588,591,612,627,663,695],"number":[49],"children":[51,139,144,230,255,269,311,365,380,431,512,635,650,715,746,810],"adolescents":[53,815],"who":[54,256,716],"drop":[55],"out":[56],"during":[57,395,535,662],"high.":[61],"Therefore,":[62],"additional":[63],"antiobesity":[66],"drugs":[67],"may":[68],"be":[69,733,741],"importance.":[71],"This":[72],"thesis":[73],"evaluates":[74],"pharmacological":[75,219],"severely":[81,137,362,510,523,690,813],"obese":[82,138,254,363,511,524,691,809,814,836],"patients":[83],"in":[84,108,121,136,147,291,446,476,487,494,507,513,522,560,566,686,735,835,861],"hospital":[86],"setting.":[87],"It":[88],"includes":[89],"first":[91,537],"published":[93],"evaluating":[94],"three":[98,308,315,389,569],"years":[99,296,433,683],"treatment,":[102,326],"as":[103,105],"well":[104,669],"one":[106],"study":[107,190,225,402,592],"lipid":[114],"intestinal":[115],"uptake":[116],"inhibitor":[117],"orlistat":[118,226,581,718,731],"studied":[120,135],"prepubertal":[122,229,364,714,737,837],"children.":[123,673,692,738],"Finally,":[124],"sibutramine,":[128],"drug":[130,250,629],"that":[131,260,648,730],"increases":[132],"satiety,":[133],"hypothalamic":[141,437,637,748],"combination":[148],"aggravating":[150,442,751],"syndromes.":[151],"Aims:":[152],"The":[153,185,239,310,379,420,449,456,470,571,594,632,666,871],"primary":[154,471],"aims":[155,187],"for":[156,215,253,307,374,568,699,704,745,759,784],"were":[161,188,270,312,336,372,406,444,505,573,597,609,719],"to":[162,189,209,224,233,246,274,339,390,546,575,586,721,817],"investigate":[163,247],"whether":[164,177,191,248],"age":[165,198,316,321,497,516,563,761,783],"when":[166,679],"initiated":[169,680],"had":[170,202],"an":[171],"on":[173,205,319,604],"outcome":[175,206],"degree":[179],"predicts":[182],"efficacy.":[184],"secondary":[186],"gender,":[192],"socio-economic":[193],"factors,":[194],"parental":[195],"weight":[196],"or":[197,348,439,606,866],"at":[199,276,322,397,681],"onset":[201],"any":[203],"and,":[207],"furthermore,":[208],"evaluate":[210],"factors":[211],"risk":[214],"drop-out.":[216,705],"aim":[222,240],"was":[223,245,423,453,459,474,491,520,530,616,642,660,668,694,755],"regard":[232],"tolerance,":[234],"safety":[235],"psychological":[237,409,605],"well-being.":[238],"Sibutramine":[243,421,613,739,859],"Study":[244,422,614],"effective":[252],"have":[257],"other":[258],"diseases":[259],"make":[261],"ineffective.":[264],"Material":[265],"Methods:":[267],"All":[268],"treated":[271,302],"from":[272,543],"1998":[273],"2007":[275],"National":[278],"Obesity":[280,794,865,867],"Centre,":[281],"Karolinska":[282],"University":[283],"Hospital,":[284],"Huddinge.":[285],"Papers":[286],"I":[287],"II":[289,333],"include,":[290],"total,":[292],"643":[293],"patients,":[294],"6\u201316":[295],"age,":[298],"simple":[300],"therapy":[306],"years.":[309,570],"divided":[313],"into":[314],"groups":[317],"based":[318],"their":[320,723],"start":[324,545],"6\u20139,":[327],"10\u201313":[328],"14\u201316.":[330],"Paper":[332,359],"subjects":[335],"further":[337],"assigned":[338],"two":[340],"groups:":[341],"moderate":[342],"obesity,":[343,350],"<":[344,556,624],"3.5":[345,352],"BMI":[346,353,369,477,489,540],"SDS,":[347],"severe":[349,708],">":[351],"SDS.":[354,478],"Orlistat":[357,833],"Study,":[358],"III,":[360],"11":[361],"(age":[366],"8.3\u201312.3":[367],"yrs),":[368],"SDS":[370,490,541],"5.3\u20139.2)":[371],"recruited":[373],"12-week":[376],"open":[377,468,664],"treatment.":[378,819],"received":[381],"standard":[383],"adult":[384],"dose,":[385],"i.e.":[386],"120":[387],"mg":[388],"four":[391],"times":[392],"daily.":[393],"Before,":[394],"end":[399,548],"period":[403,458],"participants":[405,572],"investigated":[407],"evaluation,":[410],"blood":[411],"chemistry":[412],"parameters":[414],"reflecting":[415],"fat":[418,724],"mass.":[419],"double-blind,":[425],"placebo-controlled,":[426],"cross":[427],"-over":[428],"study.":[429,841],"50":[430],"(7\u201320":[432],"age)":[435],"syndromes":[443,752],"randomised":[445],"diagnostic":[447],"pairs.":[448],"initial":[450],"sibutramine/placebo":[451],"dose":[452],"10":[454],"mg.":[455],"20":[460,462],"+":[461],"weeks,":[463],"followed":[464],"by":[465,671,757],"6-month":[467],"phase.":[469,665],"efficacy":[472],"variable":[473],"change":[475,542],"Results:":[479],"studies,":[484],"decline":[486],"mean":[488],"most":[492],"pronounced":[493,646],"youngest":[496],"group":[498,564],"(P":[499,555,623,639,654],"=":[500,553,640,655],"0.001).":[501,557,656],"Pronounced":[502],"effects":[504,596,603],"found":[506,531],"moderately":[508,688],"younger":[515],"groups.":[517],"No":[518,601],"observed":[521,661],"adolescents.":[525],"Only":[526,558],"weak":[528],"correlation":[529],"between":[532,626],"year":[538,550],"three,":[551],"r":[552],"0.51":[554],"30%":[559],"oldest":[562],"remained":[565],"able":[574,720],"comply":[576],"expressed":[583],"desire":[585],"continue":[587],"after":[590],"period.":[593],"side":[595],"mild":[598],"tolerable.":[600],"negative":[602],"physical":[607],"well-being":[608],"detected.":[610],"there":[615],"clinically":[618],"statistically":[620],"significant":[621,643],"difference":[622],"0.001)":[625],"active":[628],"placebo.":[631],"response":[633],"0.005)":[641],"but":[644,811],"less":[645],"than":[647],"non-hypothalamic":[652],"A":[657],"continued":[658],"reduction":[659],"tolerated":[670],"Conclusions:":[674],"Behavioural":[675],"successful":[678],"6\u20139":[682],"both":[687],"Age":[693],"dependent":[697],"factor":[698],"success":[701,790],"predictor":[703],"Adolescents":[706],"need":[710],"special":[711],"attention.":[712],"Obese":[713],"used":[717,734],"reduce":[722],"intake":[725],"it":[727],"possible":[729],"could":[732],"motivated":[736],"might":[740],"suitable":[743],"aid":[744],"if":[753],"sibutramine":[754],"approved":[756],"EMEA":[758],"this":[760],"group.":[762],"List":[763],"scientific":[765],"papers":[766],"I.":[767],"Danielsson":[768,799,824,849],"P,":[769,800,825,850],"Svensson":[770],"V,":[771],"Kowalski":[772],"J,":[773,802],"Nyberg":[774],"G,":[775],"Ekblom":[776,803],"\u00d6":[777,804],"Marcus":[779,806,831,856],"C.":[780,807,832,857],"Importance":[781],"three-year":[785],"continuous":[786],"behavioral":[787,818],"dropout":[792],"rate.":[793],"Facts.":[795],"[Accepted]":[796],"https://pubmed.ncbi.nlm.nih.gov/22433615":[797],"II.":[798],"Kowlaski":[801],"Severely":[808],"not":[812],"respond":[816],"[Submitted]":[820],"III.":[821],"Norgren":[822,853],"S,":[823],"Jurold":[826],"R,":[827],"L\u00f6tborn":[828],"M":[829],"children:":[838],"pilot":[840],"Acta":[842],"Paediatrica.":[843],"2003;":[844],"92:":[845],"666-670.":[846],"https://doi.org/10.1080/08035250310002353":[847],"IV.":[848],"Janson":[851],"A,":[852],"S":[854],"Impact":[858],"Therapy":[860],"Children":[862],"Hypothalamic":[864],"Aggravting":[869],"Syndromes.":[870],"Journal":[872],"Clinical":[874],"Endocrinology":[875],"Metabolism.":[877],"2007;":[878],"92(11):4101-4106.":[879],"https://doi.org/10.1210/jc.2007-0826":[880]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}