{"id":"https://openalex.org/W1162238802","doi":null,"title":"Formation and repair of complex DNA damage induced by ionizing radiation","display_name":"Formation and repair of complex DNA damage induced by ionizing radiation","publication_year":2013,"publication_date":"2013-04-23","ids":{"openalex":"https://openalex.org/W1162238802","mag":"1162238802"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/32008","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/32008","pdf_url":"http://hdl.handle.net/2077/32008","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2077/32008","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049643598","display_name":"Karin Magnander","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Karin Magnander","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5049643598"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.6830999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.6830999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.2930000126361847,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.7210000157356262},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.7289999723434448},{"id":"https://openalex.org/keywords/clustered-dna-damage","display_name":"clustered DNA damage","score":0.8420000076293945},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.7070000171661377},{"id":"https://openalex.org/keywords/chromatin","display_name":"chromatin","score":0.9549999833106995},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/indirect-effects","display_name":"indirect effects","score":0.4129999876022339},{"id":"https://openalex.org/keywords/alpha-particles","display_name":"alpha particles","score":0.7039999961853027},{"id":"https://openalex.org/keywords/cell-cycle-dependence","display_name":"cell cycle dependence","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.7590000033378601},{"id":"https://openalex.org/keywords/antioxidant-scavengers","display_name":"antioxidant scavengers","score":0.5299999713897705},{"id":"https://openalex.org/keywords/normal-human-cells","display_name":"normal human cells","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.8178380727767944},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.43751347064971924},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3685288727283478},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.20958232879638672},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.205576092004776},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1956973373889923},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17142337560653687},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.1201418936252594}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/32008","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/32008","pdf_url":"http://hdl.handle.net/2077/32008","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:1162238802","doi":null,"is_oa":false,"landing_page_url":"https://gupea.ub.gu.se/bitstream/2077/32008/4/gupea_2077_32008_4.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/32008","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/32008","pdf_url":"http://hdl.handle.net/2077/32008","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323421","display_name":"G\u00f6teborgs Universitet","ror":"https://ror.org/01tm6cn81"},{"id":"https://openalex.org/F4320335013","display_name":"Socialstyrelsen","ror":"https://ror.org/01v4pc162"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1162238802.pdf","grobid_xml":"https://content.openalex.org/works/W1162238802.grobid-xml"},"referenced_works_count":128,"referenced_works":["https://openalex.org/W167480922","https://openalex.org/W1484882395","https://openalex.org/W1531598193","https://openalex.org/W1562498242","https://openalex.org/W1831033366","https://openalex.org/W1917341586","https://openalex.org/W1967251446","https://openalex.org/W1967985689","https://openalex.org/W1968241360","https://openalex.org/W1968260561","https://openalex.org/W1969107888","https://openalex.org/W1975660840","https://openalex.org/W1979268921","https://openalex.org/W1980947442","https://openalex.org/W1983626749","https://openalex.org/W1983715980","https://openalex.org/W1984356120","https://openalex.org/W1985594788","https://openalex.org/W1986865088","https://openalex.org/W1988876801","https://openalex.org/W1988988225","https://openalex.org/W1989998334","https://openalex.org/W1990491149","https://openalex.org/W1990942802","https://openalex.org/W1994197132","https://openalex.org/W1997534905","https://openalex.org/W1999346813","https://openalex.org/W2000149072","https://openalex.org/W2000725303","https://openalex.org/W2001382956","https://openalex.org/W2010339813","https://openalex.org/W2012018845","https://openalex.org/W2015009560","https://openalex.org/W2017313933","https://openalex.org/W2018965969","https://openalex.org/W2019963243","https://openalex.org/W2024339581","https://openalex.org/W2028668473","https://openalex.org/W2029016424","https://openalex.org/W2029065442","https://openalex.org/W2034269086","https://openalex.org/W2035134384","https://openalex.org/W2035535455","https://openalex.org/W2036742887","https://openalex.org/W2038889579","https://openalex.org/W2039073527","https://openalex.org/W2039251341","https://openalex.org/W2039655187","https://openalex.org/W2044161724","https://openalex.org/W2045526190","https://openalex.org/W2048147004","https://openalex.org/W2049521368","https://openalex.org/W2053320691","https://openalex.org/W2054127210","https://openalex.org/W2061060103","https://openalex.org/W2061137324","https://openalex.org/W2069021242","https://openalex.org/W2071761375","https://openalex.org/W2071889409","https://openalex.org/W2072325705","https://openalex.org/W2072850662","https://openalex.org/W2072854810","https://openalex.org/W2074483662","https://openalex.org/W2078293698","https://openalex.org/W2079643669","https://openalex.org/W2079904287","https://openalex.org/W2080392363","https://openalex.org/W2086702526","https://openalex.org/W2087239831","https://openalex.org/W2091010656","https://openalex.org/W2092255361","https://openalex.org/W2093857326","https://openalex.org/W2094116995","https://openalex.org/W2094499979","https://openalex.org/W2095840620","https://openalex.org/W2095938938","https://openalex.org/W2096083625","https://openalex.org/W2099077495","https://openalex.org/W2099689808","https://openalex.org/W2100598040","https://openalex.org/W2104191744","https://openalex.org/W2105648889","https://openalex.org/W2106664352","https://openalex.org/W2107325904","https://openalex.org/W2111313313","https://openalex.org/W2111727001","https://openalex.org/W2112585587","https://openalex.org/W2113777563","https://openalex.org/W2115391316","https://openalex.org/W2116478273","https://openalex.org/W2119346494","https://openalex.org/W2119562750","https://openalex.org/W2120943086","https://openalex.org/W2123422722","https://openalex.org/W2123431188","https://openalex.org/W2125641208","https://openalex.org/W2129176270","https://openalex.org/W2132396299","https://openalex.org/W2134807701","https://openalex.org/W2135417045","https://openalex.org/W2135904268","https://openalex.org/W2136647418","https://openalex.org/W2139777089","https://openalex.org/W2140210955","https://openalex.org/W2141991853","https://openalex.org/W2145049401","https://openalex.org/W2145454870","https://openalex.org/W2148781180","https://openalex.org/W2149171028","https://openalex.org/W2154026141","https://openalex.org/W2155869612","https://openalex.org/W2157040042","https://openalex.org/W2157910372","https://openalex.org/W2160755617","https://openalex.org/W2161489869","https://openalex.org/W2165339852","https://openalex.org/W2166189554","https://openalex.org/W2170433351","https://openalex.org/W2178225883","https://openalex.org/W2178785249","https://openalex.org/W2187346948","https://openalex.org/W2212997336","https://openalex.org/W2215141092","https://openalex.org/W2255315609","https://openalex.org/W2327569416","https://openalex.org/W2419017482","https://openalex.org/W4294108862","https://openalex.org/W4302614508"],"related_works":["https://openalex.org/W2001382956","https://openalex.org/W3033139341","https://openalex.org/W2138090189","https://openalex.org/W255240917","https://openalex.org/W1996315957","https://openalex.org/W2327569416","https://openalex.org/W2114121641","https://openalex.org/W7146988710","https://openalex.org/W2215141092","https://openalex.org/W2560742319"],"abstract_inverted_index":{"DNA":[0,20,28,175,240],"is":[1,35,261],"the":[2,24,45,126,137,155,166,294,321,332,342],"critical":[3],"target":[4],"when":[5],"cells":[6,179],"are":[7,87,318,327],"exposed":[8],"to":[9,17,70,194,219,271,320,348,356],"ionizing":[10,40,71,110,267,279,316],"radiation,":[11,268,280,317],"a":[12,92,133,202,288],"potent":[13],"stressor":[14],"with":[15,121,180,210,277],"capacity":[16],"produce":[18],"complex":[19,50,169,355],"damages,":[21],"thereby":[22],"increasing":[23],"risk":[25],"of":[26,49,73,84,95,99,136,140,149,154,168,197,207,213,227,234,246,256,296,336],"cancer.":[27],"and":[29,47,57,101,104,152,204,258,285,311],"associated":[30],"histones":[31],"form":[32],"chromatin,":[33],"which":[34],"an":[36],"effective":[37],"protection":[38],"against":[39],"radiation.":[41],"We":[42,200,222,252],"have":[43],"investigated":[44,165],"formation":[46,217],"repair":[48,167,206,245,295,350],"lesions,":[51],"including":[52],"double":[53],"strand":[54],"breaks":[55],"(DSB)":[56],"clustered":[58,85,208,312],"damages":[59],"(two":[60],"or":[61,182,185,189,351],"more":[62,115,160,283],"lesions":[63,86,170],"within":[64],"10-20":[65],"base":[66],"pairs)":[67],"after":[68],"exposure":[69],"radiation":[72,111,141],"different":[74],"beam":[75],"qualities,":[76],"in":[77,117,178,187,269,287,290,324,338,359],"normal":[78,339],"human":[79],"cells.":[80,123,325],"The":[81],"biological":[82],"consequences":[83],"not":[88,243],"fully":[89],"understood.\\nWe":[90],"present":[91,201,253],"major":[93,232],"influence":[94,135,158,226,233,244],"chromatin":[96,184,235],"on":[97,142],"induction":[98,255],"DSB":[100,216,250,257,284,297,310],"oxidized":[102],"purine-":[103],"pyrimidine":[105],"clusters.":[106],"For":[107,124],"example,":[108],"sparsely":[109,278],"induces":[112],"170":[113],"times":[114],"clusters":[116,159,247,301,337,353],"naked":[118],"DNA,":[119],"compared":[120],"intact":[122],"DSB,":[125],"same":[127],"factor":[128],"was":[129,237,273,298],"120.":[130],"This":[131],"reflects":[132],"pronounced":[134],"indirect":[138,156],"effect":[139],"clusters,":[143],"supporting":[144],"our":[145,360],"finding":[146],"that":[147,254],"abolishment":[148],"radical":[150],"scavengers,":[151],"suppression":[153],"effect,":[157],"than":[161],"DSB.":[162],"Also,":[163,293],"we":[164],"(i)":[171],"formed":[172,314],"from":[173],"direct":[174],"hits,":[176],"(ii)":[177],"hypo-":[181],"hyperacetylated":[183],"(iii)":[186],"cycling":[188],"non-proliferating":[190],"cultures,":[191],"conditions":[192],"assumed":[193],"compromise":[195],"removal":[196,335],"these":[198],"lesions.":[199],"fast":[203],"efficient":[205,334,349],"damage":[209],"no":[211,224,231],"evidence":[212],"de":[214],"novo":[215],"due":[218,347],"attempted":[220],"repair.":[221],"observe":[223],"large":[225],"proliferation":[228],"status.":[229],"Surprisingly,":[230,300],"acetylation":[236],"found.":[238],"Direct":[239],"hits":[241],"did":[242],"but":[248],"compromised":[249],"processing.":[251],"cell":[259,262,291],"survival":[260],"cycle":[263],"dependent":[264],"for":[265,331],"densely":[266],"contrast":[270],"what":[272],"previously":[274],"reported.":[275],"Compared":[276],"\u03b1-particles":[281,304],"induce":[282],"result":[286],"decrease":[289,344],"survival.":[292],"compromised.":[299],"induced":[302],"by":[303,315],"were":[305],"rapidly":[306],"repaired.\\nIn":[307],"conclusion,":[308],"both":[309],"damage,":[313],"sensitive":[319],"antioxidant":[322],"level":[323],"There":[326],"two":[328],"possible":[329],"explanations":[330],"observed":[333],"cells,":[340],"either":[341],"rapid":[343],"could":[345],"be":[346,357],"represent":[352],"too":[354],"assessed":[358],"method.":[361]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}