{"id":"https://openalex.org/W1161852","doi":null,"title":"Vancomycin dosing in neonatal patients: the controversy continues.","display_name":"Vancomycin dosing in neonatal patients: the controversy continues.","publication_year":1994,"publication_date":"1994-04-01","ids":{"openalex":"https://openalex.org/W1161852","mag":"1161852","pmid":"https://pubmed.ncbi.nlm.nih.gov/8152409"},"language":"en","primary_location":{"id":"pmid:8152409","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8152409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neonatal network : NN","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049922571","display_name":"Todd L Wandstrat","orcid":"https://orcid.org/0000-0003-2291-4893","observed_orcids":["https://orcid.org/0000-0003-2291-4893"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T L Wandstrat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5142775684","display_name":"S J Phleps","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S J Phleps","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5408,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.63333333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"3","first_page":"33","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":0.9070000052452087},{"id":"https://openalex.org/keywords/neonatal-dosing","display_name":"neonatal dosing","score":0.8069999814033508},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.6850000023841858},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7590000033378601},{"id":"https://openalex.org/keywords/renal-clearance","display_name":"renal clearance","score":0.8220000267028809},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.949999988079071},{"id":"https://openalex.org/keywords/gestational-age","display_name":"gestational age","score":0.8700000047683716},{"id":"https://openalex.org/keywords/postconceptional-age","display_name":"postconceptional age","score":0.968999981880188},{"id":"https://openalex.org/keywords/renal-maturation","display_name":"renal maturation","score":0.703000009059906},{"id":"https://openalex.org/keywords/antibiotic-dosing-regimens","display_name":"antibiotic dosing regimens","score":0.7110000252723694},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.8366180658340454},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.8020358085632324},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7532678246498108},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.5220896601676941},{"id":"https://openalex.org/C139254425","wikidata":"https://www.wikidata.org/wiki/Q1332167","display_name":"Volume of distribution","level":3,"score":0.4895647466182709},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.46398451924324036},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4432108998298645},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4369153082370758},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.4292987585067749},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.42402249574661255},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3974733054637909},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.3849453628063202},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.32563385367393494},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31974130868911743},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2798897922039032},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.18601489067077637},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.182213693857193},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007234","descriptor_name":"Infant, Premature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8152409","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8152409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neonatal network : NN","raw_type":"Journal Article"},{"id":"mag:1161852","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8152409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2111163807","https://openalex.org/W7098083751","https://openalex.org/W2009721767","https://openalex.org/W2030620621","https://openalex.org/W4409963699","https://openalex.org/W2387465170","https://openalex.org/W2048824204","https://openalex.org/W1857882854","https://openalex.org/W3014999727","https://openalex.org/W2042179499"],"abstract_inverted_index":{"During":[0],"the":[1,16,65,77,89,123],"past":[2],"decade,":[3],"an":[4],"increasing":[5],"incidence":[6],"of":[7,18,55,64,72,91,100,134,144],"staphylococcus":[8],"organisms":[9],"resistant":[10],"to":[11],"penicillinase-resistant":[12],"penicillins":[13],"has":[14,23,47],"necessitated":[15],"use":[17],"vancomycin.":[19],"This":[20],"increased":[21],"utilization":[22],"revitalized":[24],"research":[25],"concerning":[26],"efficacious":[27,156],"vancomycin":[28,68,101,130,145,159],"dosing":[29,38,131,138,160],"regimens":[30,139,149,166],"for":[31,97,161],"premature":[32,162],"neonates,":[33],"infants,":[34,58,165],"and":[35,51,70,95,118,157,164],"children.":[36],"Vancomycin":[37],"in":[39,67,74],"neonates":[40,163],"is":[41],"variable":[42],"because":[43],"this":[44],"patient":[45],"population":[46],"decreased":[48],"renal":[49,124],"clearance":[50,69],"a":[52],"larger":[53],"volume":[54,71],"distribution":[56,73],"than":[57],"children,":[59],"or":[60],"adults.":[61],"The":[62],"observation":[63],"variability":[66],"infants":[75],"with":[76],"same":[78],"postconceptional":[79],"age":[80,85],"(PCA)":[81],"but":[82],"different":[83],"gestational":[84],"(GA)":[86],"suggests":[87],"that":[88],"rates":[90],"maturation":[92,125],"both":[93],"extrauterine":[94],"intrauterine":[96],"disposition":[98],"mechanisms":[99],"are":[102,106],"similar":[103],"when":[104],"PCAs":[105],"equal.":[107],"Conditions":[108],"such":[109],"as":[110,170,172],"patent":[111],"ductus":[112],"arteriosus,":[113],"respiratory":[114],"distress":[115],"syndrome,":[116],"sepsis,":[117],"asphyxia":[119],"may":[120],"further":[121],"complicate":[122],"process.":[126],"Few":[127],"investigations":[128],"suggest":[129],"regimens.":[132],"Most":[133],"these":[135],"studies":[136],"propose":[137],"based":[140,150],"on":[141,151],"retrospective":[142],"analysis":[143],"pharmacokinetics":[146],"obtained":[147],"from":[148],"physician":[152],"discretion.":[153],"To":[154],"ensure":[155],"rational":[158],"should":[167],"consider":[168],"PCA":[169],"well":[171],"body":[173],"weight.":[174]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
