{"id":"https://openalex.org/W116005563","doi":null,"title":"Evaluation of efficacy and safety of erdosteine in patients affected by chronic bronchitis during an infective exacerbation phase and receiving amoxycillin as basic treatment (ECOBES, European Chronic Obstructive Bronchitis Erdosteine Study).","display_name":"Evaluation of efficacy and safety of erdosteine in patients affected by chronic bronchitis during an infective exacerbation phase and receiving amoxycillin as basic treatment (ECOBES, European Chronic Obstructive Bronchitis Erdosteine Study).","publication_year":1995,"publication_date":"1995-11-01","ids":{"openalex":"https://openalex.org/W116005563","mag":"116005563","pmid":"https://pubmed.ncbi.nlm.nih.gov/8688986"},"language":"en","primary_location":{"id":"pmid:8688986","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8688986","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical pharmacology and therapeutics","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042900658","display_name":"Carlo Felice Marchioni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C F Marchioni","raw_affiliation_strings":["Institute of Diseases of Respiratory Apparatus, Universit\u00e0 di Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Diseases of Respiratory Apparatus, Universit\u00e0 di Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111521240","display_name":"J M Polu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Polu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008000850","display_name":"Andr\u00e9 Taytard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Taytard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017347328","display_name":"T Hanard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Hanard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082224564","display_name":"G Noseda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Noseda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"C Mancini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Mancini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3542,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.61122717,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"33","issue":"11","first_page":"612","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erdosteine","display_name":"erdosteine","score":0.9860000014305115},{"id":"https://openalex.org/keywords/chronic-bronchitis","display_name":"chronic bronchitis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/infective-exacerbations","display_name":"infective exacerbations","score":0.9039999842643738},{"id":"https://openalex.org/keywords/amoxicillin","display_name":"amoxicillin","score":0.9309999942779541},{"id":"https://openalex.org/keywords/combination-antibiotic-therapy","display_name":"combination antibiotic therapy","score":0.5920000076293945},{"id":"https://openalex.org/keywords/sputum-viscosity","display_name":"sputum viscosity","score":0.8429999947547913},{"id":"https://openalex.org/keywords/spirometric-parameters","display_name":"spirometric parameters","score":0.7649999856948853},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.8029999732971191},{"id":"https://openalex.org/keywords/gastrointestinal-side-effects","display_name":"gastrointestinal adverse effects","score":0.8289999961853027},{"id":"https://openalex.org/keywords/bronchodilator-therapy","display_name":"bronchodilator therapy","score":0.4659999907016754},{"id":"https://openalex.org/keywords/placebo-controlled-comparison","display_name":"placebo comparison","score":0.42399999499320984},{"id":"https://openalex.org/keywords/body-temperature","display_name":"body temperature","score":0.41600000858306885},{"id":"https://openalex.org/keywords/arterial-blood-pressure","display_name":"arterial blood pressure","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8563476800918579},{"id":"https://openalex.org/C2992694001","wikidata":"https://www.wikidata.org/wiki/Q173022","display_name":"Chronic bronchitis","level":2,"score":0.7612993717193604},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.7326258420944214},{"id":"https://openalex.org/C2779993553","wikidata":"https://www.wikidata.org/wiki/Q173022","display_name":"Bronchitis","level":2,"score":0.5215116143226624},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.5148331522941589},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5140829682350159},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5029627680778503},{"id":"https://openalex.org/C2776301714","wikidata":"https://www.wikidata.org/wiki/Q259346","display_name":"Sputum","level":3,"score":0.47817641496658325},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.44727450609207153},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4346354007720947},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.42501014471054077},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.4234580397605896},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3308173418045044},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.1478072702884674},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0596335232257843},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000658","descriptor_name":"Amoxicillin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001991","descriptor_name":"Bronchitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005100","descriptor_name":"Expectorants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005100","descriptor_name":"Expectorants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013864","descriptor_name":"Thioglycolates","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013864","descriptor_name":"Thioglycolates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8688986","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8688986","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical pharmacology and therapeutics","raw_type":"Clinical Trial"},{"id":"mag:116005563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8688986","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2254177617","https://openalex.org/W2161925112","https://openalex.org/W2163325356","https://openalex.org/W4205871009","https://openalex.org/W2771115831","https://openalex.org/W2383770023","https://openalex.org/W7203819103","https://openalex.org/W2781449832","https://openalex.org/W3192879257","https://openalex.org/W3096965598"],"abstract_inverted_index":{"An":[0],"international":[1],"multicentric":[2],"study":[3,48,115,143,261],"was":[4,49,85,116,144,151,187,262,290],"conducted":[5,50,117],"with":[6,55,60,70,90,159,189,209],"the":[7,14,19,29,43,83,120,123,145,163,227,238,256,260,288,295,334,341,345,351,418,431,435,441,452,459,462],"aim":[8],"of":[9,16,21,24,77,82,102,109,122,125,157,162,168,175,184,223,231,251,259,328,336,356,373,391,427,455,458,464,467],"demonstrating":[10],"that":[11,240,411,440],"erdosteine":[12,61,264,342,456],"improves":[13],"efficacy":[15,169],"amoxycillin":[17,71],"in":[18,68,106,141,226,326,340,344],"treatment":[20],"infective":[22],"exacerbation":[23,107],"chronic":[25,103,176],"bronchitis":[26],"mainly":[27],"on":[28,34,287],"clinical":[30,147,164,442],"symptomatology":[31],"(primary":[32],"objective),":[33],"spirometric":[35,179,305],"tests":[36,180,201],"and":[37,87,127,181,199,211,218,280,294,304,343,447,457],"body":[38,302],"temperature,":[39],"without":[40,461],"negatively":[41],"influencing":[42],"tolerance":[44],"(secondary":[45],"objectives).":[46],"The":[47,80,93,114,134,203,221,270],"as":[51,153,253,255,316,318,398],"a":[52,75,100,154,273,322,405],"prospective":[53],"evaluation,":[54,422,437],"2":[56,91,419],"comparative":[57],"groups":[58],"treated":[59],"(300":[62],"mg":[63],"x":[64,283,298],"2/day)":[65],"or":[66,400],"placebo":[67,346,372],"association":[69],"(1500":[72],"mg/day)":[73],"for":[74,277,292],"maximum":[76],"10":[78],"days.":[79],"design":[81],"trial":[84],"double-blind":[86],"parallel":[88],"group":[89],"subgroups.":[92],"treatments":[94,420],"have":[95,206,394],"been":[96,207,395],"assigned":[97],"randomly":[98],"to":[99,119,138,237,246,350],"population":[101],"bronchitic":[104],"patients":[105,224,242],"phase":[108],"n":[110,232],"=":[111,233],"237":[112],"subjects.":[113],"according":[118],"principles":[121],"Declaration":[124],"Helsinki":[126],"its":[128],"amendments":[129],"(Hong":[130],"Kong,":[131],"September":[132],"1989).":[133],"primary":[135,257],"end-point":[136],"used":[137],"determine":[139],"effectiveness":[140,228],"this":[142],"global":[146],"assessment":[148],"(GCA)":[149],"which":[150,438],"choosen":[152],"general":[155],"indication":[156],"activity":[158,454],"objective/subjective":[160],"evaluation":[161],"picture.":[165],"Secondary":[166],"endpoints":[167],"are":[170,413],"sputum":[171],"parameters,":[172],"functional":[173,319],"signs":[174,320],"obstructive":[177],"bronchitis,":[178],"overall":[182],"judgement":[183],"efficacy.":[185],"Safety":[186],"evaluated":[188],"adverse":[190,337],"drug":[191],"reactions":[192],"reporting,":[193],"arterial":[194],"blood":[195],"pressure,":[196],"heart":[197],"rate":[198],"laboratory":[200],"monitoring.":[202],"obtained":[204],"values":[205],"analyzed":[208],"two-way":[210],"factorial":[212],"ANOVA,":[213],"Least":[214],"Squares":[215],"Catmod-SAS,":[216],"Wilcoxon":[217],"Chi-square":[219],"tests.":[220],"number":[222],"included":[225],"analysis":[229,271],"is":[230,332,409,430,444],"226":[234],"subjects,":[235],"due":[236,245],"fact":[239],"11":[241],"were":[243,307,348,360,378],"lost":[244],"different":[247],"reasons.":[248],"In":[249,389,425],"term":[250],"results":[252],"far":[254],"objective":[258],"concerned,":[263],"resulted":[265],"more":[266],"active":[267],"than":[268],"placebo.":[269],"evidenced":[272,321],"very":[274],"significant":[275],"difference":[276,286],"treatment,":[278],"time":[279,282,325],"interaction":[281,296],"treatment.":[284,299],"No":[285],"contrary":[289],"observed":[291],"center":[293,297],"Sputum":[300],"volume,":[301],"temperature":[303],"parameters":[306],"not":[308],"significantly":[309],"influenced":[310],"by":[311,451],"both":[312,339],"treatments.":[313],"Viscosity,":[314],"appearance":[315],"well":[317],"modification":[323],"over":[324],"favour":[327],"erdosteine.":[329],"As":[330],"safety":[331],"concerned":[333],"majority":[335],"events,":[338],"group,":[347],"related":[349,375],"gastrointestinal":[352],"area.":[353],"For":[354,371],"erdosteine,":[355],"9/17":[357],"side-effects,":[358],"3":[359,362,377],"epigastralgias,":[361,379],"nauseas,":[363,381],"1":[364,366,369,384,386],"diarrhoea,":[365],"taste":[367],"loss,":[368],"hemorrhoids.":[370],"13/17":[374],"events":[376],"4":[380,382],"diarrhoeas,":[383],"pyrosis,":[385],"dry":[387],"mouth.":[388],"terms":[390],"severity":[392],"they":[393],"all":[396],"defined":[397],"mild":[399],"moderate":[401],"degree.":[402],"Also":[403],"from":[404,434],"qualitative":[406],"perspective":[407],"it":[408],"clear":[410],"there":[412],"no":[414],"relevant":[415],"differences":[416],"between":[417],"under":[421],"concerning":[423],"safety.":[424],"conclusion":[426],"particular":[428],"interest":[429],"datum":[432],"arising":[433],"efficacy/safety":[436],"indicates":[439],"picture":[443],"modified":[445],"earlier":[446],"at":[448],"deeper":[449],"degree":[450],"synergistic":[453],"antibiotic":[460],"risk":[463],"an":[465],"augmentation":[466],"side-effects":[468],"incidence.":[469]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
