{"id":"https://openalex.org/W115858723","doi":"https://doi.org/10.3748/wjg.v9.i12.2791","title":"Visceral hypersensitivity and altered colonic motility after subsidence of inflammation in a rat model of colitis","display_name":"Visceral hypersensitivity and altered colonic motility after subsidence of inflammation in a rat model of colitis","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W115858723","doi":"https://doi.org/10.3748/wjg.v9.i12.2791","mag":"115858723","pmid":"https://pubmed.ncbi.nlm.nih.gov/14669335","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4612054"},"language":"en","primary_location":{"id":"doi:10.3748/wjg.v9.i12.2791","doi":"https://doi.org/10.3748/wjg.v9.i12.2791","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v9.i12.2791","pdf_url":"https://www.wjgnet.com/1007-9327/full/v9/i12/2791.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.wjgnet.com/1007-9327/full/v9/i12/2791.htm","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046120031","display_name":"Jun\u2010Ho La","orcid":"https://orcid.org/0000-0003-4306-0305","observed_orcids":["https://orcid.org/0000-0003-4306-0305"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jun-Ho La","raw_affiliation_strings":["Department of Physiology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046120031"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":null,"apc_paid":null,"fwci":1.2429,"has_fulltext":true,"cited_by_count":94,"citation_normalized_percentile":{"value":0.79829393,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"12","first_page":"2791","last_page":"2791"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13289","display_name":"Infant Health and Development","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.9419999718666077},{"id":"https://openalex.org/keywords/visceral-hypersensitivity","display_name":"visceral hypersensitivity","score":0.9950000047683716},{"id":"https://openalex.org/keywords/colonic-motility","display_name":"colonic motility","score":0.9419999718666077},{"id":"https://openalex.org/keywords/colitis","display_name":"colitis","score":0.7239999771118164},{"id":"https://openalex.org/keywords/acetic-acid-induced-colitis","display_name":"acetic acid-induced colitis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/rectal-distension","display_name":"rectal distension","score":0.8460000157356262},{"id":"https://openalex.org/keywords/restraint-stress","display_name":"restraint stress","score":0.699999988079071},{"id":"https://openalex.org/keywords/abdominal-withdrawal-reflex","display_name":"abdominal withdrawal reflex","score":0.7549999952316284},{"id":"https://openalex.org/keywords/fecal-output","display_name":"fecal output","score":0.7739999890327454},{"id":"https://openalex.org/keywords/myeloperoxidase-activity","display_name":"myeloperoxidase activity","score":0.8190000057220459},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.8092608451843262},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.7982763051986694},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7015054225921631},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6419140100479126},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.6294432282447815},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6007314920425415},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5221179723739624},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.5039765238761902},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.45863187313079834},{"id":"https://openalex.org/C2779794527","wikidata":"https://www.wikidata.org/wiki/Q4116360","display_name":"Visceral pain","level":4,"score":0.4394567310810089},{"id":"https://openalex.org/C2776280935","wikidata":"https://www.wikidata.org/wiki/Q11083","display_name":"Large intestine","level":2,"score":0.43617263436317444},{"id":"https://openalex.org/C2776625112","wikidata":"https://www.wikidata.org/wiki/Q5282934","display_name":"Distension","level":2,"score":0.4315921664237976},{"id":"https://openalex.org/C2781074409","wikidata":"https://www.wikidata.org/wiki/Q158716","display_name":"Rectum","level":2,"score":0.4251909852027893},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4180009663105011},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3913014531135559},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.2177911102771759},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11585545539855957},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11130237579345703},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06529980897903442},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019342","descriptor_name":"Acetic Acid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3748/wjg.v9.i12.2791","doi":"https://doi.org/10.3748/wjg.v9.i12.2791","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v9.i12.2791","pdf_url":"https://www.wjgnet.com/1007-9327/full/v9/i12/2791.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4612054","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4612054","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World J Gastroenterol","raw_type":"Text"},{"id":"pmid:14669335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14669335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of gastroenterology","raw_type":"Journal Article"},{"id":"mag:1576618885","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/84123X/200312/8921055.html","pdf_url":null,"source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e16\u754c\u80c3\u80a0\u75c5\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248\uff08\u7535\u5b50\u7248\uff09","raw_type":null}],"best_oa_location":{"id":"doi:10.3748/wjg.v9.i12.2791","doi":"https://doi.org/10.3748/wjg.v9.i12.2791","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v9.i12.2791","pdf_url":"https://www.wjgnet.com/1007-9327/full/v9/i12/2791.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321292","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542"},{"id":"https://openalex.org/F4320337008","display_name":"College of Veterinary Medicine, Seoul National University","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W115858723.pdf","grobid_xml":"https://content.openalex.org/works/W115858723.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W123840287","https://openalex.org/W1948475953","https://openalex.org/W1981220433","https://openalex.org/W1991559914","https://openalex.org/W2011072311","https://openalex.org/W2031354876","https://openalex.org/W2051724792","https://openalex.org/W2061137185","https://openalex.org/W2071265167","https://openalex.org/W2093993796","https://openalex.org/W2124821571","https://openalex.org/W2126452889","https://openalex.org/W2126974223","https://openalex.org/W2128908882","https://openalex.org/W2152595249","https://openalex.org/W2158380688"],"related_works":["https://openalex.org/W2365616332","https://openalex.org/W2358809299","https://openalex.org/W2360424657","https://openalex.org/W2748678913","https://openalex.org/W2076890770","https://openalex.org/W2365000263","https://openalex.org/W2384700375","https://openalex.org/W2369582640","https://openalex.org/W2357189155","https://openalex.org/W1987025002"],"abstract_inverted_index":{"AIM:":[0],"Irritable":[1],"bowel":[2,8,16],"syndrome":[3],"(IBS)":[4],"is":[5,19,207],"a":[6,208,216],"functional":[7],"disorder":[9],"characterized":[10],"by":[11,58,75],"visceral":[12,190],"hypersensitivity":[13,191],"and":[14,78,94,102,127,142,169,192,211],"altered":[15,193],"motility.":[17],"There":[18],"increasing":[20],"evidence":[21],"suggesting":[22,202],"the":[23,28,34,51,87,98,103,119,139,185,197],"role":[24],"of":[25,30,41,61,71,85,105,117,137,154,188,199,218],"inflammation":[26,52,72],"in":[27,65,125,130,166,196],"pathogenesis":[29],"IBS,":[31,189],"which":[32],"addresses":[33],"possibility":[35],"that":[36,203],"formerly":[37],"established":[38],"rat":[39],"model":[40,49,206,213],"colitis":[42,155],"could":[43],"be":[44],"used":[45],"as":[46],"an":[47,163],"IBS":[48],"after":[50],"subsided.":[53],"METHODS:":[54],"Colitis":[55],"was":[56,73],"induced":[57],"intracolonic":[59],"instillation":[60],"4%":[62],"acetic":[63],"acid":[64],"male":[66],"Sprague-Dawley":[67],"rats.":[68],"The":[69,148],"extent":[70],"assessed":[74],"histological":[76,140],"examination":[77],"myeloperoxidase":[79],"(MPO)":[80],"activity":[81,144],"assay.":[82],"After":[83],"subsidence":[84],"colitis,":[86,118,138],"rats":[88,149],"were":[89,109],"subjected":[90],"to":[91,146,159],"rectal":[92,160,167],"distension":[93,161],"restraint":[95],"stress,":[96],"then":[97],"abdominal":[99],"withdrawal":[100],"reflex":[101],"number":[104],"stress-induced":[106],"fecal":[107],"output":[108],"measured,":[110],"respectively.":[111],"RESULTS:":[112],"At":[113,133],"2":[114],"days":[115,135,152],"post-induction":[116,136,153],"colon":[120],"showed":[121,156],"characteristic":[122,186],"inflammatory":[123],"changes":[124],"histology":[126],"8-fold":[128],"increase":[129],"MPO":[131,143],"activity.":[132],"7":[134,151],"features":[141,187],"returned":[145],"normal.":[147],"at":[150],"hypersensitive":[157],"response":[158],"without":[162],"accompanying":[164],"change":[165],"compliance,":[168],"defecated":[170],"more":[171],"stools":[172],"than":[173],"control":[174],"animals":[175],"when":[176],"under":[177],"stress.":[178],"CONCLUSION:":[179],"These":[180],"results":[181],"concur":[182],"largely":[183],"with":[184],"defecation":[194],"pattern":[195],"absence":[198],"detectable":[200],"disease,":[201],"this":[204],"animal":[205],"methodologically":[209],"convenient":[210],"useful":[212],"for":[214],"studying":[215],"subset":[217],"IBS.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}