{"id":"https://openalex.org/W115832370","doi":null,"title":"Pancreas cancer and the role of soluble immunoglobulin-like transcript 3 (ILT3).","display_name":"Pancreas cancer and the role of soluble immunoglobulin-like transcript 3 (ILT3).","publication_year":2007,"publication_date":"2007-11-09","ids":{"openalex":"https://openalex.org/W115832370","mag":"115832370","pmid":"https://pubmed.ncbi.nlm.nih.gov/17993722"},"language":"en","primary_location":{"id":"pmid:17993722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17993722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JOP : Journal of the pancreas","raw_type":"Editorial"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111711449","display_name":"Raffaello Cortesini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Raffaello Cortesini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111711449"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"6","first_page":"697","last_page":"703"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.47850000858306885,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.47850000858306885,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.13840000331401825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.0966000035405159,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9160000085830688},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.718999981880188},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cd68","display_name":"CD68","score":0.7839999794960022},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.7559999823570251},{"id":"https://openalex.org/keywords/tumor-rejection","display_name":"tumor rejection","score":0.4950000047683716},{"id":"https://openalex.org/keywords/t-cell-response","display_name":"T cell response","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6039539575576782},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48185738921165466},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4786342680454254},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.442277729511261},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40260472893714905},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3969478905200958},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39088767766952515},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3321559429168701},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09309333562850952}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007163","descriptor_name":"Immunosorbent Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D010956","descriptor_name":"Plasmapheresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:17993722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17993722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JOP : Journal of the pancreas","raw_type":"Editorial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.496.5891","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.496.5891","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.joplink.net/prev/200711/200711_01.pdf","raw_type":"text"},{"id":"mag:115832370","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17993722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5419018509","display_name":"REGULATORY T CELLS IN ALLORECOGNITION","funder_award_id":"R01AI025210","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7697805119","display_name":"Immunological Monitoring of Heart Allograft Recipients","funder_award_id":"R01AI055234","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W202433591","https://openalex.org/W1484140899","https://openalex.org/W1521600055","https://openalex.org/W1647776454","https://openalex.org/W1965999622","https://openalex.org/W1976089511","https://openalex.org/W1978741561","https://openalex.org/W1981557521","https://openalex.org/W1992699637","https://openalex.org/W2001717792","https://openalex.org/W2006598591","https://openalex.org/W2018249790","https://openalex.org/W2018972429","https://openalex.org/W2019214729","https://openalex.org/W2038689279","https://openalex.org/W2046790948","https://openalex.org/W2051940153","https://openalex.org/W2056290110","https://openalex.org/W2058205936","https://openalex.org/W2063586063","https://openalex.org/W2064006160","https://openalex.org/W2073310925","https://openalex.org/W2083210466","https://openalex.org/W2098020683","https://openalex.org/W2098983864","https://openalex.org/W2102689053","https://openalex.org/W2107889871","https://openalex.org/W2108104378","https://openalex.org/W2108860192","https://openalex.org/W2110836981","https://openalex.org/W2114954367","https://openalex.org/W2115728037","https://openalex.org/W2116886408","https://openalex.org/W2118943833","https://openalex.org/W2136798761","https://openalex.org/W2140885797","https://openalex.org/W2147443000","https://openalex.org/W2150678612","https://openalex.org/W2154953543","https://openalex.org/W2157569416","https://openalex.org/W2187801383","https://openalex.org/W2464349841"],"related_works":["https://openalex.org/W7097570431","https://openalex.org/W6987295273","https://openalex.org/W2834244588","https://openalex.org/W1601383153","https://openalex.org/W2996183050","https://openalex.org/W2885890243","https://openalex.org/W7214757134","https://openalex.org/W3138048760","https://openalex.org/W4200433565","https://openalex.org/W3004442071"],"abstract_inverted_index":{"Attempts":[0],"to":[1,14,19,161,179],"ameliorate":[2],"the":[3,34,84,87,93,122,129,142,152,155,162,167,180],"poor":[4],"prognosis":[5],"of":[6,72,83,95,119,126,145,154,164,182],"pancreatic":[7,186],"cancer":[8],"have":[9,21],"been":[10,22],"largely":[11,24],"unsuccessful.":[12,25],"Interventions":[13],"enhance":[15],"patients'":[16],"immune":[17],"responses":[18,104,110],"malignancies":[20],"also":[23],"We":[26],"now":[27],"describe":[28],"an":[29],"immune-escape":[30],"mechanism":[31],"mediated":[32],"by":[33,113,117],"inhibitory":[35],"receptor":[36],"immunoglobulin-like":[37],"transcript":[38],"3":[39],"(ILT3)":[40],"which":[41,91],"may":[42,159],"be":[43],"responsible":[44],"for":[45],"such":[46],"failures.":[47],"Using":[48],"a":[49],"humanized":[50],"severe":[51],"combined":[52],"immunodeficiency":[53],"(SCID)":[54],"mouse":[55],"model,":[56],"we":[57,77],"demonstrate":[58],"that":[59,79,136,172],"soluble":[60,88,146],"and":[61,69,100,131],"membrane":[62],"ILT3":[63,89,156,165,173],"induce":[64],"CD8+":[65,96],"T":[66,97,102],"suppressor":[67,98],"cells":[68,99],"prevent":[70],"rejection":[71],"allogeneic":[73],"tumor":[74,138],"transplants.":[75],"Furthermore,":[76],"found":[78],"patients":[80],"with":[81],"carcinoma":[82],"pancreas":[85],"produce":[86],"protein,":[90],"induces":[92],"differentiation":[94],"impairs":[101],"cell":[103],"in":[105,151,166,185],"mixed":[106],"lymphocyte":[107],"culture.":[108],"These":[109,169],"are":[111],"restored":[112],"anti-ILT3":[114],"mAb":[115],"or":[116,175],"depletion":[118,174],"sILT3":[120],"from":[121,128],"serum.":[123],"Immunohistochemical":[124],"staining":[125],"biopsies":[127],"tumors":[130],"metastatic":[132],"lymph":[133],"nodes":[134],"suggest":[135,171],"CD68+":[137],"associated":[139],"macrophages":[140],"represent":[141],"major":[143],"source":[144],"ILT3.":[147],"Alternative":[148],"splicing,":[149],"resulting":[150],"loss":[153],"transmembrane":[157],"domain":[158],"contribute":[160],"release":[163],"circulation.":[168],"data":[170],"blockade":[176],"is":[177],"crucial":[178],"success":[181],"immunobiotherapy,":[183],"particularly":[184],"cancer.":[187]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}