{"id":"https://openalex.org/W115515833","doi":null,"title":"Assessing the correlation between mutant rhodopsin stability and the severity of retinitis pigmentosa.","display_name":"Assessing the correlation between mutant rhodopsin stability and the severity of retinitis pigmentosa.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W115515833","mag":"115515833","pmid":"https://pubmed.ncbi.nlm.nih.gov/24520188","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3919671"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2904204","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3919671","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3919671","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045485034","display_name":"Richard McKeone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104628220","display_name":"Lions Eye Institute","ror":"https://ror.org/006vyay97","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I104628220"]},{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Richard McKeone","raw_affiliation_strings":["Department of Molecular Ophthalmology, Lions Eye Institute, Perth, Western Australia ; Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Ophthalmology, Lions Eye Institute, Perth, Western Australia ; Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia","institution_ids":["https://openalex.org/I104628220","https://openalex.org/I177877127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062781993","display_name":"Matthew E. Wikstr\u00f6m","orcid":"https://orcid.org/0009-0005-4545-8319","observed_orcids":["https://orcid.org/0009-0005-4545-8319"]},"institutions":[{"id":"https://openalex.org/I104628220","display_name":"Lions Eye Institute","ror":"https://ror.org/006vyay97","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I104628220"]},{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Matthew Wikstrom","raw_affiliation_strings":["Centre for Experimental Immunology, Lions Eye Institute, Perth, Western Australia ; Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Experimental Immunology, Lions Eye Institute, Perth, Western Australia ; Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia","institution_ids":["https://openalex.org/I104628220","https://openalex.org/I177877127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013287255","display_name":"Christina Kiel","orcid":"https://orcid.org/0000-0001-8454-6008","observed_orcids":["https://orcid.org/0000-0001-8454-6008"]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210097140","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/010jaxs89","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210097140","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Christina Kiel","raw_affiliation_strings":["EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain ; Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain ; Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210097140","https://openalex.org/I4210137962"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110340269","display_name":"P. Elizabeth Rakoczy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"P Elizabeth Rakoczy","raw_affiliation_strings":["Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia","institution_ids":["https://openalex.org/I177877127"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0137,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.83940234,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"20","issue":null,"first_page":"183","last_page":"99"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinitis-pigmentosa","display_name":"retinitis pigmentosa","score":0.9750000238418579},{"id":"https://openalex.org/keywords/rhodopsin","display_name":"rhodopsin","score":0.9089999794960022},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.925000011920929},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.8529999852180481},{"id":"https://openalex.org/keywords/plasma-membrane","display_name":"plasma membrane","score":0.4189999997615814},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.7429999709129333},{"id":"https://openalex.org/keywords/genotype-phenotype-correlation","display_name":"genotype-phenotype correlation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/visual-function","display_name":"visual function","score":0.5260000228881836},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C202033177","wikidata":"https://www.wikidata.org/wiki/Q423107","display_name":"Rhodopsin","level":3,"score":0.9857796430587769},{"id":"https://openalex.org/C2781114197","wikidata":"https://www.wikidata.org/wiki/Q847057","display_name":"Retinitis pigmentosa","level":3,"score":0.835423469543457},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5858836770057678},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5148705244064331},{"id":"https://openalex.org/C30028475","wikidata":"https://www.wikidata.org/wiki/Q24785022","display_name":"Opsin","level":4,"score":0.42313069105148315},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3426993489265442},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.31256505846977234},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2547600269317627},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2526921033859253}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012174","descriptor_name":"Retinitis Pigmentosa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012174","descriptor_name":"Retinitis Pigmentosa","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012243","descriptor_name":"Rhodopsin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012243","descriptor_name":"Rhodopsin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014792","descriptor_name":"Visual Acuity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:2904204","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3919671","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24520188","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24520188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3919671","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3919671/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:publications/6604f2c1-3ca6-4a18-a03f-5087ed1bcc11","doi":null,"is_oa":false,"landing_page_url":"https://research-repository.uwa.edu.au/en/publications/6604f2c1-3ca6-4a18-a03f-5087ed1bcc11","pdf_url":null,"source":{"id":"https://openalex.org/S4306402492","display_name":"UWA Profiles and Research Repository (UWA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mckeone, R, Wikstr\u00f6m, M, Kiel, C & Rakoczy, E 2014, 'Assessing the correlation between mutant rhodopsin stability and the severity of retinitis pigmentosa', Molecular Vision, vol. 20, pp. 183-199.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:115515833","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24520188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2904204","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3919671","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W139102930","https://openalex.org/W168206613","https://openalex.org/W1223953337","https://openalex.org/W1530376792","https://openalex.org/W1533379189","https://openalex.org/W1562615854","https://openalex.org/W1866273988","https://openalex.org/W1923091024","https://openalex.org/W1963903360","https://openalex.org/W1964955754","https://openalex.org/W1965988669","https://openalex.org/W1967888295","https://openalex.org/W1968470164","https://openalex.org/W1970286448","https://openalex.org/W1970512473","https://openalex.org/W1973897761","https://openalex.org/W1984528496","https://openalex.org/W1989321578","https://openalex.org/W1995497500","https://openalex.org/W1996813207","https://openalex.org/W1997716435","https://openalex.org/W1997780365","https://openalex.org/W2000894287","https://openalex.org/W2009432227","https://openalex.org/W2010437085","https://openalex.org/W2011196651","https://openalex.org/W2013090583","https://openalex.org/W2016838762","https://openalex.org/W2021490495","https://openalex.org/W2023490488","https://openalex.org/W2027714126","https://openalex.org/W2027993492","https://openalex.org/W2033526738","https://openalex.org/W2035077266","https://openalex.org/W2041407283","https://openalex.org/W2046034472","https://openalex.org/W2046826342","https://openalex.org/W2047206270","https://openalex.org/W2051816231","https://openalex.org/W2052717453","https://openalex.org/W2054882425","https://openalex.org/W2059272723","https://openalex.org/W2060478537","https://openalex.org/W2064319275","https://openalex.org/W2067453249","https://openalex.org/W2068534497","https://openalex.org/W2071208926","https://openalex.org/W2077933871","https://openalex.org/W2092387745","https://openalex.org/W2094766925","https://openalex.org/W2094967199","https://openalex.org/W2097781824","https://openalex.org/W2097908332","https://openalex.org/W2100738249","https://openalex.org/W2113786559","https://openalex.org/W2114734450","https://openalex.org/W2115503115","https://openalex.org/W2130035243","https://openalex.org/W2130049582","https://openalex.org/W2137588110","https://openalex.org/W2137704807","https://openalex.org/W2141707485","https://openalex.org/W2143609676","https://openalex.org/W2147631462","https://openalex.org/W2150195578","https://openalex.org/W2152579394","https://openalex.org/W2153439292","https://openalex.org/W2155349225","https://openalex.org/W2158116492","https://openalex.org/W2160718682","https://openalex.org/W2169217477","https://openalex.org/W2172190191","https://openalex.org/W2208641794"],"related_works":["https://openalex.org/W1963903360","https://openalex.org/W3206895280","https://openalex.org/W4414822961","https://openalex.org/W4285605497","https://openalex.org/W1422822671","https://openalex.org/W7134816345","https://openalex.org/W2107322110","https://openalex.org/W949287050","https://openalex.org/W2079012788","https://openalex.org/W2071208926"],"abstract_inverted_index":{"PURPOSE:":[0],"Following":[1],"a":[2,7,29,101,120,203,281,313],"previous":[3],"study":[4],"that":[5,252],"demonstrated":[6],"correlation":[8,206,223,282],"between":[9,37,85,155,184,207,229,283],"rhodopsin":[10,50,62,86,107,140,158,185,195,235,287,299],"stability":[11,41,63,87,123,164,230,257,285],"and":[12,45,88,132,159,174,191,216,231,289,292,310],"the":[13,40,43,46,52,69,73,81,93,142,153,170,178,182,187,192,197,208,211,217,232,237,245,259,276,284,317],"severity":[14,24,188,218,291],"of":[15,23,32,42,49,60,72,76,83,95,100,122,189,194,210,213,219,234,247,275,286,294,319],"retinitis":[16],"pigmentosa":[17],"(RP),":[18],"we":[19],"investigated":[20],"whether":[21],"predictions":[22,165],"can":[25],"be":[26],"improved":[27],"with":[28,66,111,119,169,250,300],"regional":[30],"analysis":[31],"this":[33,96,156,267],"correlation.":[34],"The":[35,146],"association":[36],"changes":[38],"to":[39,79,115,138,151,180,273],"protein":[44,104],"relative":[47],"amount":[48,233],"reaching":[51],"plasma":[53,144,238],"membrane":[54],"was":[55,136,149,202,224],"assessed.":[56],"METHODS:":[57],"Crystallography-based":[58],"estimations":[59],"mutant":[61,117,214],"were":[64,109,127,166],"compared":[65,168],"descriptions":[67],"in":[68,227,254],"scientific":[70],"literature":[71],"visual":[74],"function":[75],"mutation":[77],"carriers":[78],"determine":[80],"extent":[82],"associations":[84],"clinical":[89,175],"phenotype.":[90],"To":[91],"test":[92],"findings":[94],"analysis,":[97],"three":[98],"residues":[99],"green":[102],"fluorescent":[103],"(GFP)":[105],"tagged":[106],"plasmid":[108],"targeted":[110],"site-directed":[112],"random":[113],"mutagenesis":[114],"generate":[116],"variants":[118,215,251],"range":[121],"changes.":[124],"These":[125],"plasmids":[126],"transfected":[128,249],"into":[129],"HEK-293":[130],"cells,":[131],"then":[133,167],"flow":[134,301],"cytometry":[135,302],"used":[137,150],"measure":[139,152],"on":[141,244],"cells'":[143],"membrane.":[145,239],"GFP":[147],"signal":[148],"ratio":[154],"membrane-bound":[157,295,298],"total":[160],"cellular":[161],"rhodopsin.":[162,296],"FoldX":[163],"surface":[171,246,269],"staining":[172],"data":[173,176],"from":[177,258],"database":[179],"characterize":[181],"relationship":[183],"stability,":[186],"RP,":[190],"expression":[193],"at":[196,236],"cell":[198],"surface.":[199],"RESULTS:":[200],"There":[201,279],"strong":[204],"linear":[205],"scale":[209],"destabilization":[212],"retinal":[220],"disease.":[221],"A":[222],"also":[225],"seen":[226],"vitro":[228],"Rhodopsin":[240],"is":[241,280],"drastically":[242],"reduced":[243],"cells":[248],"differ":[253],"their":[255],"inherent":[256],"wild-type":[260],"by":[261],"more":[262],"than":[263],"2":[264],"kcal/mol.":[265],"Below":[266],"threshold,":[268],"levels":[270,293],"are":[271],"closer":[272],"those":[274],"wild-type.":[277],"CONCLUSIONS:":[278],"mutations":[288,309],"disease":[290],"Measuring":[297],"could":[303,311],"improve":[304],"prognoses":[305],"for":[306,315],"poorly":[307],"characterized":[308],"provide":[312],"platform":[314],"measuring":[316],"effectiveness":[318],"treatments.":[320]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
