{"id":"https://openalex.org/W115494979","doi":null,"title":"Inhibition of BACE1 for therapeutic use in Alzheimer's disease.","display_name":"Inhibition of BACE1 for therapeutic use in Alzheimer's disease.","publication_year":2010,"publication_date":"2010-07-08","ids":{"openalex":"https://openalex.org/W115494979","mag":"115494979","pmid":"https://pubmed.ncbi.nlm.nih.gov/20661410","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2907124"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2001145","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2907124","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2907124","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106858538","display_name":"Xiaoyang Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoyang Luo","raw_affiliation_strings":["Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038360689","display_name":"Riqiang Yan","orcid":"https://orcid.org/0000-0001-7195-7617","observed_orcids":["https://orcid.org/0000-0001-7195-7617"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Riqiang Yan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5693,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.93534002,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"3","issue":"6","first_page":"618","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bace1","display_name":"BACE1","score":0.8489999771118164},{"id":"https://openalex.org/keywords/beta-secretase","display_name":"beta-secretase","score":0.7910000085830688},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9760000109672546},{"id":"https://openalex.org/keywords/bace1-inhibitors","display_name":"BACE1 inhibitors","score":0.9800000190734863},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.9110000133514404},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.722000002861023},{"id":"https://openalex.org/keywords/gamma-secretase","display_name":"gamma-secretase","score":0.9610000252723694},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.8650000095367432},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.42399999499320984},{"id":"https://openalex.org/keywords/dose-titration","display_name":"dose titration","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.6968497037887573},{"id":"https://openalex.org/C36103677","wikidata":"https://www.wikidata.org/wiki/Q4749551","display_name":"Amyloid precursor protein secretase","level":5,"score":0.6713306307792664},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5621535181999207},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5307312607765198},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.46623608469963074},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.43325257301330566},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.41089433431625366},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38847893476486206},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38797539472579956},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38106033205986023},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.343303918838501},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30340883135795593},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1260339915752411}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016282","descriptor_name":"Aspartic Acid Endopeptidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016282","descriptor_name":"Aspartic Acid Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057055","descriptor_name":"Aspartic Acid Proteases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:2001145","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2907124","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2907124","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2907124","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"pmid:20661410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20661410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"mag:115494979","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20661410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2001145","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2907124","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1299920147","display_name":"Roles of reticulon proteins in neurodegenerative disorders","funder_award_id":"R01AG025493","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W84124737","https://openalex.org/W200948446","https://openalex.org/W1502820594","https://openalex.org/W1507460091","https://openalex.org/W1517918086","https://openalex.org/W1541961513","https://openalex.org/W1596984737","https://openalex.org/W1611407165","https://openalex.org/W1644122431","https://openalex.org/W1655404681","https://openalex.org/W1854324009","https://openalex.org/W1929269608","https://openalex.org/W1945588738","https://openalex.org/W1958181441","https://openalex.org/W1971077103","https://openalex.org/W1972089545","https://openalex.org/W1975448620","https://openalex.org/W1977688919","https://openalex.org/W1983187084","https://openalex.org/W1983751614","https://openalex.org/W1987452659","https://openalex.org/W1989453114","https://openalex.org/W1993168711","https://openalex.org/W1995805296","https://openalex.org/W1999660763","https://openalex.org/W2002551374","https://openalex.org/W2003283600","https://openalex.org/W2003659505","https://openalex.org/W2003932771","https://openalex.org/W2004883429","https://openalex.org/W2010416572","https://openalex.org/W2011385800","https://openalex.org/W2015587575","https://openalex.org/W2016250935","https://openalex.org/W2016717347","https://openalex.org/W2017917068","https://openalex.org/W2023274935","https://openalex.org/W2026031997","https://openalex.org/W2026053103","https://openalex.org/W2029214965","https://openalex.org/W2031231593","https://openalex.org/W2034355601","https://openalex.org/W2034504333","https://openalex.org/W2036028081","https://openalex.org/W2040252771","https://openalex.org/W2041520260","https://openalex.org/W2042600422","https://openalex.org/W2042926301","https://openalex.org/W2047198245","https://openalex.org/W2052931631","https://openalex.org/W2053378951","https://openalex.org/W2055187389","https://openalex.org/W2057031451","https://openalex.org/W2059552870","https://openalex.org/W2062283435","https://openalex.org/W2063978545","https://openalex.org/W2068042361","https://openalex.org/W2070596032","https://openalex.org/W2070977076","https://openalex.org/W2073024446","https://openalex.org/W2073155435","https://openalex.org/W2079651671","https://openalex.org/W2082700144","https://openalex.org/W2086951287","https://openalex.org/W2087524018","https://openalex.org/W2090904095","https://openalex.org/W2096883126","https://openalex.org/W2105815637","https://openalex.org/W2113404473","https://openalex.org/W2114808687","https://openalex.org/W2123448028","https://openalex.org/W2129955844","https://openalex.org/W2131819352","https://openalex.org/W2132590291","https://openalex.org/W2133019124","https://openalex.org/W2136903466","https://openalex.org/W2150703360","https://openalex.org/W2154375856","https://openalex.org/W2155237226","https://openalex.org/W2160524771","https://openalex.org/W2162815565","https://openalex.org/W2166888773","https://openalex.org/W2167474523","https://openalex.org/W2171436731","https://openalex.org/W2179551254","https://openalex.org/W2205982756","https://openalex.org/W2912432751"],"related_works":["https://openalex.org/W4240174594","https://openalex.org/W2183569487","https://openalex.org/W2047186114","https://openalex.org/W2918727416","https://openalex.org/W3148754788","https://openalex.org/W1971678374","https://openalex.org/W1995839193","https://openalex.org/W2473342350","https://openalex.org/W3118966991","https://openalex.org/W1993469127"],"abstract_inverted_index":{"Since":[0],"BACE1":[1,33,76,96,106],"was":[2],"reported":[3],"as":[4],"the":[5,22,43,51,69,88,93],"beta-secretase":[6,44],"in":[7,68,113,125],"Alzheimer's":[8],"disease":[9],"(AD)":[10],"over":[11],"ten":[12],"years":[13],"ago,":[14],"encouraging":[15],"progress":[16],"has":[17],"been":[18,79],"made":[19],"toward":[20],"understanding":[21],"cellular":[23],"functions":[24],"of":[25,75,95,102,117],"BACE1.":[26],"Genetic":[27],"studies":[28],"have":[29,78],"further":[30],"confirmed":[31],"that":[32],"is":[34,129],"essential":[35],"for":[36,81],"processing":[37],"amyloid":[38],"precursor":[39],"protein":[40],"(APP)":[41],"at":[42],"site.":[45],"Only":[46],"after":[47],"this":[48],"cleavage":[49],"can":[50],"membrane-bound":[52],"APP":[53],"C-terminal":[54],"fragment":[55],"be":[56,111],"subsequently":[57],"cleaved":[58],"by":[59],"gamma-secretase":[60],"to":[61,110,120],"release":[62],"so-called":[63],"AD-causing":[64],"Abeta":[65],"peptides.":[66],"Hence,":[67],"past":[70],"decade,":[71],"a":[72],"wide":[73],"variety":[74],"inhibitors":[77,97,107],"developed":[80],"AD":[82,127],"therapy.":[83],"This":[84],"review":[85],"will":[86],"summarize":[87],"major":[89],"historical":[90],"events":[91],"during":[92],"evolution":[94],"designed":[98],"through":[99],"different":[100],"strategies":[101],"drug":[103,118],"discovery.":[104],"Although":[105],"are":[108],"expected":[109],"safe":[112],"general,":[114],"careful":[115],"titration":[116],"dosage":[119],"avoid":[121],"undesirable":[122],"side":[123],"effects":[124],"BACE1-directed":[126],"therapy":[128],"also":[130],"emphasized.":[131]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
