{"id":"https://openalex.org/W115488122","doi":null,"title":"Modulation of cellular functions in retroorbital fibroblasts using antisense oligonucleotides targeting the c-myc protooncogene.","display_name":"Modulation of cellular functions in retroorbital fibroblasts using antisense oligonucleotides targeting the c-myc protooncogene.","publication_year":1995,"publication_date":"1995-06-01","ids":{"openalex":"https://openalex.org/W115488122","mag":"115488122","pmid":"https://pubmed.ncbi.nlm.nih.gov/7775120"},"language":"en","primary_location":{"id":"pmid:7775120","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7775120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108468053","display_name":"Armin E. Heufelder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A E Heufelder","raw_affiliation_strings":["Molecular Thyroid Research Laboratory, Ludwig-Maximilians Universit\u00e4t, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Thyroid Research Laboratory, Ludwig-Maximilians Universit\u00e4t, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039851000","display_name":"Rebecca S. Bahn","orcid":"https://orcid.org/0000-0003-1692-3064","observed_orcids":["https://orcid.org/0000-0003-1692-3064"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R S Bahn","raw_affiliation_strings":["Molecular Thyroid Research Laboratory, Ludwig-Maximilians-Universit\u00e4t, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Thyroid Research Laboratory, Ludwig-Maximilians-Universit\u00e4t, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I8204097"],"apc_list":null,"apc_paid":null,"fwci":1.3795,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.78852393,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"7","first_page":"1420","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11538","display_name":"Ophthalmology and Eye Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11538","display_name":"Ophthalmology and Eye Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-myc-proto-oncogene","display_name":"c-myc proto-oncogene","score":0.9610000252723694},{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.9020000100135803},{"id":"https://openalex.org/keywords/phosphorothioate-oligodeoxynucleotides","display_name":"phosphorothioate oligodeoxynucleotides","score":0.9210000038146973},{"id":"https://openalex.org/keywords/orbital-fibroblasts","display_name":"orbital fibroblasts","score":0.9760000109672546},{"id":"https://openalex.org/keywords/graves-ophthalmopathy","display_name":"Graves' ophthalmopathy","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/glycosaminoglycan-biosynthesis","display_name":"glycosaminoglycan synthesis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.8429999947547913},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.906000018119812},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.5199999809265137},{"id":"https://openalex.org/keywords/serum-stimulation","display_name":"serum stimulation","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.709031343460083},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.5937031507492065},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5318037867546082},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4813712239265442},{"id":"https://openalex.org/C35866371","wikidata":"https://www.wikidata.org/wiki/Q6005502","display_name":"Immunocytochemistry","level":2,"score":0.455333411693573},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4380958080291748},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.43498694896698},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4125257730484009},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.40063416957855225},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3272356688976288},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20485937595367432},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1888788640499115},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1830119788646698},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1195635199546814},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006111","descriptor_name":"Graves Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006111","descriptor_name":"Graves Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006111","descriptor_name":"Graves Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009915","descriptor_name":"Orbit","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009915","descriptor_name":"Orbit","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009915","descriptor_name":"Orbit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7775120","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7775120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:115488122","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7775120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1681053427","https://openalex.org/W1886269763","https://openalex.org/W2092680933","https://openalex.org/W1605711455","https://openalex.org/W2371327551","https://openalex.org/W2328424358","https://openalex.org/W2010221283","https://openalex.org/W1999444785","https://openalex.org/W1955818313","https://openalex.org/W1992451469"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1,24],"examine":[2],"the":[3,9,18,30,118,133,165,206,229,261],"signal":[4],"transduction":[5],"pathways":[6],"involved":[7,34,227],"in":[8,35,42,185,198,228,241,265],"activation":[10],"of":[11,20,50,66,97,132,161,234,250],"orbital":[12,44,63,262],"fibroblast":[13],"effector":[14],"functions":[15],"relevant":[16],"to":[17,94,175,237,245,258,260],"pathogenesis":[19],"Graves'":[21],"ophthalmopathy":[22],"(GO).":[23],"determine,":[25],"using":[26,149],"antisense":[27,54,100,135,172,208],"technology,":[28],"whether":[29],"c-myc":[31,53,99,134,141,162,166,171,207,220],"protooncogene":[32,221],"is":[33],"cell":[36,112,180],"proliferation":[37,107,181],"and":[38,74,91,102,114,137,143,155,164,182,192,202,222,231],"glycosaminoglycan":[39],"(GAG)":[40],"synthesis":[41,123,184],"cultured":[43],"fibroblasts":[45],"(OF).":[46],"METHODS:":[47],"The":[48,130,219],"effects":[49,131,196],"a":[51,98,170,199],"16-mer":[52],"phosphorothioate":[55],"oligodeoxynucleotide":[56],"(S-ODN)":[57],"on":[58,140],"OF":[59,83,186,235,254],"monolayers":[60,84],"derived":[61,187],"from":[62,188],"connective":[64],"tissue":[65,263],"patients":[67,189],"with":[68,87,190],"severe":[69],"GO":[70,191],"(n":[71,77],"=":[72,78],"6)":[73],"healthy":[75,193],"individuals":[76],"3)":[79],"were":[80,85,92,147,203,215],"investigated.":[81],"Quiescent":[82],"treated":[86],"serum":[88,238],"or":[89,213,239],"cytokines":[90,240],"exposed":[93,236],"increasing":[95],"concentrations":[96],"S-ODN":[101,136,139,173,209],"several":[103],"control":[104,138],"S-ODN.":[105],"Cell":[106,211],"was":[108,124],"quantitated":[109],"by":[110,115,126,169],"direct":[111],"counting":[113],"immunocytochemistry":[116],"for":[117,205],"nuclear":[119],"Ki-67":[120],"antigen.":[121],"Glycosaminoglycan":[122],"examined":[125],"[3H]":[127],"GAG":[128,183],"analysis.":[129],"mRNA":[142,163],"protein":[144,167,224],"product":[145,168,225],"levels":[146],"analyzed":[148],"reverse-transcriptase":[150],"polymerase":[151],"chain":[152],"reaction,":[153],"immunocytochemistry,":[154],"immunoblotting,":[156],"respectively.":[157],"RESULTS:":[158],"Transient":[159],"suppression":[160],"(2":[174],"8":[176],"microM)":[177],"strongly":[178],"inhibited":[179],"individuals.":[194],"These":[195],"occurred":[197],"dose-dependent":[200],"manner":[201],"specific":[204],"used.":[210],"morphology":[212],"viability":[214],"not":[216],"affected.":[217],"CONCLUSIONS:":[218],"its":[223],"are":[226],"proliferative":[230],"metabolic":[232],"activities":[233,256],"vitro.":[242],"C-myc":[243],"appears":[244],"be":[246],"an":[247],"essential":[248],"component":[249],"at":[251],"least":[252],"two":[253],"cellular":[255],"likely":[257],"contribute":[259],"alterations":[264],"GO.":[266]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}