{"id":"https://openalex.org/W115455530","doi":null,"title":"Nifedipine serum concentrations following sublingual and oral doses.","display_name":"Nifedipine serum concentrations following sublingual and oral doses.","publication_year":1986,"publication_date":"1986-06-01","ids":{"openalex":"https://openalex.org/W115455530","mag":"115455530","pmid":"https://pubmed.ncbi.nlm.nih.gov/3733277"},"language":"en","primary_location":{"id":"pmid:3733277","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3733277","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical pharmacology, therapy, and toxicology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027602931","display_name":"Gill Brown","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G R Brown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103646539","display_name":"Donald G. Fraser","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D G Fraser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009312201","display_name":"J A Castile","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Castile","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081914245","display_name":"Pierre Gaudreault","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Gaudreault","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065717967","display_name":"David R. Platt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D R Platt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"P A Friedman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P A Friedman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6736,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.58688434,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"24","issue":"6","first_page":"283","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.6352999806404114,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.6352999806404114,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.07890000194311142,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.07360000163316727,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nifedipine","display_name":"nifedipine","score":1.0},{"id":"https://openalex.org/keywords/sublingual-administration","display_name":"sublingual administration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/serum-drug-levels","display_name":"serum drug concentration","score":0.8450000286102295},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8240000009536743},{"id":"https://openalex.org/keywords/time-to-maximum-concentration","display_name":"time to peak concentration","score":0.7950000166893005},{"id":"https://openalex.org/keywords/area-under-the-curve","display_name":"area under the curve","score":0.6290000081062317},{"id":"https://openalex.org/keywords/route-of-administration-comparison","display_name":"route of administration comparison","score":0.6660000085830688},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.953000009059906}],"concepts":[{"id":"https://openalex.org/C2779066535","wikidata":"https://www.wikidata.org/wiki/Q39111","display_name":"Nifedipine","level":3,"score":0.9881687164306641},{"id":"https://openalex.org/C2779350572","wikidata":"https://www.wikidata.org/wiki/Q784720","display_name":"Sublingual administration","level":2,"score":0.9652990102767944},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.7555689811706543},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6398395299911499},{"id":"https://openalex.org/C2776093070","wikidata":"https://www.wikidata.org/wiki/Q621636","display_name":"Route of administration","level":2,"score":0.5143698453903198},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.42094895243644714},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3192281126976013},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30560749769210815},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.07771596312522888}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009060","descriptor_name":"Mouth Floor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009543","descriptor_name":"Nifedipine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D009543","descriptor_name":"Nifedipine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3733277","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3733277","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical pharmacology, therapy, and toxicology","raw_type":"Journal Article"},{"id":"mag:115455530","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3733277","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2134489292","https://openalex.org/W2023839429","https://openalex.org/W1967120514","https://openalex.org/W15232820","https://openalex.org/W2044891661","https://openalex.org/W2102889157","https://openalex.org/W2413538162","https://openalex.org/W1985693751","https://openalex.org/W4379413448","https://openalex.org/W2069086975"],"abstract_inverted_index":{"Although":[0],"nifedipine":[1,44,49,63,70,98,146],"is":[2],"commonly":[3],"administered":[4],"sublingually":[5],"in":[6,33,145],"the":[7,13,109,128,131,136,155],"clinical":[8],"setting,":[9],"a":[10],"comparison":[11],"of":[12,42,135,139,157,159],"serum":[14,29,71,99,132],"concentrations":[15,30,50,64,72,147],"obtained":[16],"by":[17],"this":[18],"route":[19,156],"vs":[20,116],"oral":[21,40,67,84,110],"administration":[22,41,60,77,85,106,140,158],"has":[23],"not":[24],"been":[25],"previously":[26],"made.":[27],"Nifedipine":[28],"were":[31,51,73,141],"measured":[32,52],"6":[34],"healthy":[35],"subjects":[36],"following":[37,75,83,104],"sublingual":[38,59,76,105],"or":[39],"one":[43],"10":[45],"mg":[46],"capsule.":[47],"Serum":[48],"at":[53],"regular":[54],"intervals":[55],"and":[56],"demonstrated":[57],"that":[58],"produced":[61],"measurable":[62],"sooner":[65],"than":[66,82,92,107,123],"administration.":[68],"Peak":[69],"less":[74,91,122],"(41.9":[78],"+/-":[79,87,113,118],"24.9":[80],"ng/ml)":[81],"(99.6":[86],"49.8":[88],"ng/ml,":[89],"p":[90,121],"0.05).":[93,124],"The":[94],"time":[95],"to":[96],"peak":[97],"concentration":[100],"was":[101],"also":[102],"longer":[103],"with":[108],"dose":[111],"(74":[112],"24":[114],"minutes":[115],"40":[117],"14":[119],"minutes,":[120],"Despite":[125],"these":[126],"differences,":[127],"areas":[129],"under":[130],"concentration-time":[133],"curve":[134],"two":[137],"routes":[138],"similar.":[142],"These":[143],"differences":[144],"may":[148],"be":[149],"an":[150],"important":[151],"consideration":[152],"when":[153],"choosing":[154],"nifedipine.":[160]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}