{"id":"https://openalex.org/W115357665","doi":null,"title":"The regulation of mTORC2 kinase activity and complex integrity","display_name":"The regulation of mTORC2 kinase activity and complex integrity","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W115357665","mag":"115357665"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1296","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/280","pdf_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1296&context=utgsbs_dissertations","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1296&context=utgsbs_dissertations","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100721908","display_name":"Chien\u2010Hung Chen","orcid":"https://orcid.org/0000-0002-2056-0350","observed_orcids":["https://orcid.org/0000-0002-2056-0350"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Chien\u2010Hung Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2056-0350","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100721908"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtorc2","display_name":"mTORC2","score":0.9800000190734863},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.7860000133514404},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8849999904632568},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.671999990940094},{"id":"https://openalex.org/keywords/gsk-3beta","display_name":"GSK3\u03b2","score":0.8859999775886536},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.8420000076293945},{"id":"https://openalex.org/keywords/growth-factor-signaling","display_name":"growth factor signaling","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cellular-metabolism","display_name":"cellular metabolism","score":0.5049999952316284},{"id":"https://openalex.org/keywords/kinase-regulation","display_name":"kinase regulation","score":0.5080000162124634},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.39899998903274536},{"id":"https://openalex.org/keywords/substrate-affinity","display_name":"substrate affinity","score":0.45100000500679016},{"id":"https://openalex.org/keywords/cellular-stress-response","display_name":"cellular stress response","score":0.35600000619888306}],"concepts":[{"id":"https://openalex.org/C107846503","wikidata":"https://www.wikidata.org/wiki/Q14876061","display_name":"mTORC2","level":5,"score":0.5393211245536804},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3388781249523163},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.26877138018608093},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1824381947517395},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.17067500948905945},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1565382182598114}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1296","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/280","pdf_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1296&context=utgsbs_dissertations","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},{"id":"mag:115357665","doi":null,"is_oa":false,"landing_page_url":"http://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1296&context=utgsbs_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1296","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/280","pdf_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1296&context=utgsbs_dissertations","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W115357665.pdf","grobid_xml":"https://content.openalex.org/works/W115357665.grobid-xml"},"referenced_works_count":97,"referenced_works":["https://openalex.org/W1487234933","https://openalex.org/W1494495256","https://openalex.org/W1500729563","https://openalex.org/W1509669696","https://openalex.org/W1518972222","https://openalex.org/W1831189467","https://openalex.org/W1857109061","https://openalex.org/W1964631519","https://openalex.org/W1981517713","https://openalex.org/W1983698019","https://openalex.org/W1984736455","https://openalex.org/W1987656526","https://openalex.org/W1989294105","https://openalex.org/W1990841830","https://openalex.org/W1992170852","https://openalex.org/W1995117011","https://openalex.org/W1997465096","https://openalex.org/W2000731858","https://openalex.org/W2001803785","https://openalex.org/W2005303138","https://openalex.org/W2006559495","https://openalex.org/W2007078899","https://openalex.org/W2008294451","https://openalex.org/W2009886463","https://openalex.org/W2011282245","https://openalex.org/W2012297570","https://openalex.org/W2014222652","https://openalex.org/W2015714994","https://openalex.org/W2021012077","https://openalex.org/W2030573603","https://openalex.org/W2038874082","https://openalex.org/W2040942754","https://openalex.org/W2041058556","https://openalex.org/W2041308494","https://openalex.org/W2044195647","https://openalex.org/W2048498664","https://openalex.org/W2054427773","https://openalex.org/W2055716703","https://openalex.org/W2056909568","https://openalex.org/W2058138221","https://openalex.org/W2058793161","https://openalex.org/W2060905299","https://openalex.org/W2062934426","https://openalex.org/W2063223811","https://openalex.org/W2063620211","https://openalex.org/W2065887259","https://openalex.org/W2066659565","https://openalex.org/W2070732456","https://openalex.org/W2073304650","https://openalex.org/W2073368001","https://openalex.org/W2074851311","https://openalex.org/W2076891304","https://openalex.org/W2077625075","https://openalex.org/W2080100938","https://openalex.org/W2082770517","https://openalex.org/W2083308747","https://openalex.org/W2084258581","https://openalex.org/W2094836461","https://openalex.org/W2094941511","https://openalex.org/W2097767970","https://openalex.org/W2098817749","https://openalex.org/W2098912234","https://openalex.org/W2099544753","https://openalex.org/W2101083009","https://openalex.org/W2101885674","https://openalex.org/W2103413641","https://openalex.org/W2105223251","https://openalex.org/W2108958930","https://openalex.org/W2109479865","https://openalex.org/W2111503158","https://openalex.org/W2114762453","https://openalex.org/W2117028091","https://openalex.org/W2117793740","https://openalex.org/W2119584760","https://openalex.org/W2120138780","https://openalex.org/W2121009129","https://openalex.org/W2125904354","https://openalex.org/W2128282944","https://openalex.org/W2136676465","https://openalex.org/W2136860804","https://openalex.org/W2137035181","https://openalex.org/W2143912677","https://openalex.org/W2144059623","https://openalex.org/W2144323242","https://openalex.org/W2145808065","https://openalex.org/W2146157811","https://openalex.org/W2150595264","https://openalex.org/W2152289580","https://openalex.org/W2152589884","https://openalex.org/W2155453789","https://openalex.org/W2156370464","https://openalex.org/W2158368342","https://openalex.org/W2166551984","https://openalex.org/W2166979725","https://openalex.org/W2505157809","https://openalex.org/W3005428319","https://openalex.org/W7096186325"],"related_works":["https://openalex.org/W2063223811","https://openalex.org/W2155453789","https://openalex.org/W1994033171","https://openalex.org/W2143912677","https://openalex.org/W2065322400","https://openalex.org/W2137103342","https://openalex.org/W2073368001","https://openalex.org/W2314701251","https://openalex.org/W2152589884","https://openalex.org/W1523756085"],"abstract_inverted_index":{"Growth":[0],"factor":[1,83],"signaling":[2,103,162,183],"promotes":[3],"anabolic":[4],"processes":[5],"via":[6,279],"activation":[7],"of":[8,14,51,76,100,111,139,158,197,236,255,304,320],"the":[9,15,48,59,73,93,98,101,109,121,137,155,190,195,198,242,318],"PI3K-Akt":[10,18],"kinase":[11,30,141,187,206,222,247],"cascade.":[12],"Deregulation":[13],"growth":[16,82],"factor-dependent":[17],"pathway":[19],"was":[20,56],"implicated":[21],"in":[22,79,136,175,291],"tumorigenesis.":[23],"Akt":[24,61,70,145,182],"is":[25,67,88,126,213,223,232,239,257],"an":[26,233],"essential":[27,122],"serine/threonine":[28],"protein":[29,227],"that":[31,170,203,252],"controls":[32],"multiple":[33],"physiological":[34],"functions":[35],"such":[36],"as":[37,58],"cell":[38,217],"growth,":[39],"proliferation,":[40],"and":[41,64,163,229,238,245,283],"survival":[42],"to":[43,81,147,177],"maintain":[44],"cellular":[45,86],"homeostasis.":[46],"Recently,":[47],"mammalian":[49],"Target":[50],"Rapamycin":[52],"Complex":[53],"2":[54],"(mTORC2)":[55],"identified":[57,108],"main":[60],"Ser-473":[62,65],"kinase,":[63],"phosphorylation":[66,133,152,174,228,254,289,303],"required":[68,224,240],"for":[69,225,241,259],"hyperactivation.":[71],"However,":[72],"detailed":[74],"mechanism":[75],"mTORC2":[77,112,123,140,186,199,237,246,276,292],"regulation":[78,99,196,319],"response":[80,176],"stimulation":[84],"or":[85],"stresses":[87],"not":[89],"well":[90],"understood.":[91],"In":[92,189,269],"first":[94],"project,":[95,192],"we":[96],"studied":[97],"mTORC2-Akt":[102],"under":[104],"ER":[105,119,178],"stress.":[106],"We":[107,201],"inactivation":[110,293],"by":[113,128,143,184,216,263,294],"glycogen":[114],"synthase":[115],"kinase-3\u03b2":[116],"(GSK-3\u03b2).":[117],"Under":[118],"stress,":[120],"component,":[124],"rictor,":[125],"phosphorylated":[127],"GSK-3\u03b2":[129,159],"at":[130],"Ser-1235.":[131],"This":[132],"event":[134],"results":[135,290],"inhibition":[138],"activity":[142,207],"interrupting":[144],"binding":[146,298],"mTORC2.":[148,321],"Blocking":[149],"rictor":[150,172,282,287],"Ser-1235":[151,173,288],"can":[153],"attenuate":[154],"negative":[156],"impacts":[157],"on":[160,209],"mTORC2/Akt":[161],"tumor":[164],"growth.":[165],"Thus,":[166,310],"our":[167,271],"work":[168],"demonstrated":[169],"GSK-3\u03b2-mediated":[171,286],"stress":[179],"interferes":[180],"with":[181],"inhibiting":[185],"activity.":[188,248],"second":[191],"I":[193],"investigated":[194],"integrity.":[200,309],"found":[202],"basal":[204],"mTOR":[205,221],"depends":[208],"ATP":[210],"level,":[211],"which":[212],"tightly":[214],"regulated":[215],"metabolism.":[218],"The":[219],"ATP-sensitive":[220],"SIN1":[226,231,256,265,305],"stabilization.":[230],"indispensable":[234],"subunit":[235],"complex":[243,261,308],"assembly":[244],"Our":[249],"findings":[250,272],"reveal":[251],"mTOR-mediated":[253,301],"critical":[258],"maintaining":[260],"integrity":[262],"preventing":[264],"from":[266],"lysosomal":[267],"degradation.":[268],"sum,":[270],"verify":[273],"two":[274,312],"distinct":[275],"regulatory":[277],"mechanisms":[278],"its":[280,296,307],"components":[281],"SIN1.":[284],"First,":[285],"interfering":[295],"substrate":[297],"ability.":[299],"Second,":[300],"Ser-260":[302],"preserves":[306],"these":[311],"projects":[313],"provide":[314],"novel":[315],"insights":[316],"into":[317]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}