{"id":"https://openalex.org/W1152765663","doi":"https://doi.org/10.1021/acs.langmuir.5b02511","title":"Slope-Dependent Cell Motility Enhancements at the Walls of PEG-Hydrogel Microgroove Structures","display_name":"Slope-Dependent Cell Motility Enhancements at the Walls of PEG-Hydrogel Microgroove Structures","publication_year":2015,"publication_date":"2015-08-19","ids":{"openalex":"https://openalex.org/W1152765663","doi":"https://doi.org/10.1021/acs.langmuir.5b02511","mag":"1152765663","pmid":"https://pubmed.ncbi.nlm.nih.gov/26287573"},"language":"en","primary_location":{"id":"doi:10.1021/acs.langmuir.5b02511","doi":"https://doi.org/10.1021/acs.langmuir.5b02511","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.langmuir.5b02511","pdf_url":null,"source":{"id":"https://openalex.org/S75741262","display_name":"Langmuir","issn_l":"0743-7463","issn":["0743-7463","1520-5827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Langmuir","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020911946","display_name":"Keiichiro Kushiro","orcid":"https://orcid.org/0000-0002-0612-4667","observed_orcids":["https://orcid.org/0000-0002-0612-4667"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Keiichiro Kushiro","raw_affiliation_strings":["Department of Bioengineering,\rSchool of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering,\rSchool of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011556710","display_name":"Takamasa Sakai","orcid":"https://orcid.org/0000-0001-5052-0512","observed_orcids":["https://orcid.org/0000-0001-5052-0512"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takamasa Sakai","raw_affiliation_strings":["Department of Bioengineering,\rSchool of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering,\rSchool of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001297025","display_name":"Madoka Takai","orcid":"https://orcid.org/0000-0002-6238-6717","observed_orcids":["https://orcid.org/0000-0002-6238-6717"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Madoka Takai","raw_affiliation_strings":["Department of Bioengineering,\rSchool of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering,\rSchool of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001297025","https://openalex.org/A5020911946"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.243,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.75814503,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"31","issue":"37","first_page":"10215","last_page":"10222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11737","display_name":"Advanced Materials and Mechanics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-motility","display_name":"cell motility","score":0.9860000014305115},{"id":"https://openalex.org/keywords/surface-microtopography","display_name":"surface microtopography","score":0.7350000143051147},{"id":"https://openalex.org/keywords/actin-filament-alignment","display_name":"actin filament alignment","score":0.7509999871253967},{"id":"https://openalex.org/keywords/actin-aggregation","display_name":"actin aggregation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.8840000033378601},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8479999899864197},{"id":"https://openalex.org/keywords/cell-sorting","display_name":"cell sorting","score":0.9399999976158142}],"concepts":[{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.8754954934120178},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5276212692260742},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5205974578857422},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5194203853607178},{"id":"https://openalex.org/C499950583","wikidata":"https://www.wikidata.org/wiki/Q183252","display_name":"Morphology (biology)","level":2,"score":0.5150477886199951},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.49512043595314026},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.4685457944869995},{"id":"https://openalex.org/C2776964284","wikidata":"https://www.wikidata.org/wiki/Q410083","display_name":"Polyethylene glycol","level":2,"score":0.46185624599456787},{"id":"https://openalex.org/C54400483","wikidata":"https://www.wikidata.org/wiki/Q1793202","display_name":"PEG ratio","level":2,"score":0.4507068991661072},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43024274706840515},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.4182896018028259},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.4179230034351349},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35648322105407715},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3065483570098877},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15565654635429382},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.09474948048591614},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08644372224807739},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.langmuir.5b02511","doi":"https://doi.org/10.1021/acs.langmuir.5b02511","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.langmuir.5b02511","pdf_url":null,"source":{"id":"https://openalex.org/S75741262","display_name":"Langmuir","issn_l":"0743-7463","issn":["0743-7463","1520-5827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Langmuir","raw_type":"journal-article"},{"id":"pmid:26287573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26287573","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Langmuir : the ACS journal of surfaces and colloids","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3327533801","display_name":"Using Structural Patterns of Microchannel Systems for Directional Control of Cell Migration","funder_award_id":"24810002","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6118457147","display_name":"Establishing the Design Principles to Control the Directional Cell Motility on Material Surface Topographies","funder_award_id":"26870166","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G873917775","display_name":"Function of cell adhesion on protein-adsorbed well-defined nanostructured interface","funder_award_id":"24241042","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320325276","display_name":"Iketani Science and Technology Foundation","ror":"https://ror.org/0382jhd52"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320335759","display_name":"Noguchi Memorial Institute for Medical Research, University of Ghana","ror":"https://ror.org/00f1qr933"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1459987971","https://openalex.org/W1910382375","https://openalex.org/W1948887717","https://openalex.org/W1966501485","https://openalex.org/W1967880112","https://openalex.org/W1970963094","https://openalex.org/W1972081276","https://openalex.org/W1974163433","https://openalex.org/W1979712769","https://openalex.org/W1983744704","https://openalex.org/W1989021197","https://openalex.org/W1998067465","https://openalex.org/W2010660319","https://openalex.org/W2018295362","https://openalex.org/W2030582971","https://openalex.org/W2035235278","https://openalex.org/W2036716507","https://openalex.org/W2040794674","https://openalex.org/W2041779667","https://openalex.org/W2042898787","https://openalex.org/W2047253804","https://openalex.org/W2055798867","https://openalex.org/W2056830833","https://openalex.org/W2061334803","https://openalex.org/W2066098137","https://openalex.org/W2083914261","https://openalex.org/W2084936639","https://openalex.org/W2095108228","https://openalex.org/W2148328620","https://openalex.org/W2170271633"],"related_works":["https://openalex.org/W4396827100","https://openalex.org/W1989168904","https://openalex.org/W1980039509","https://openalex.org/W2085150946","https://openalex.org/W2638279019","https://openalex.org/W2074607580","https://openalex.org/W4402703874","https://openalex.org/W2711245422","https://openalex.org/W3087396515","https://openalex.org/W2028279702"],"abstract_inverted_index":{"In":[0,50,129],"recent":[1],"years,":[2],"research":[3,201],"utilizing":[4],"micro-":[5],"and":[6,9,22,65,97,123,167,174,230],"nanoscale":[7],"geometries":[8],"structures":[10,90],"on":[11,100,144,164],"biomaterials":[12],"to":[13,131],"manipulate":[14],"cellular":[15],"behaviors,":[16],"such":[17,36,226],"as":[18,37,227],"differentiation,":[19],"proliferation,":[20],"survival,":[21],"motility,":[23],"have":[24],"gained":[25],"much":[26],"popularity;":[27],"however,":[28],"how":[29,55],"the":[30,56,63,66,109,117,120,124,136,145,150,154,165,168,171,177,180],"surface":[31],"microtopography":[32],"of":[33,58,68,83,119,126,170,179,208,221],"3D":[34],"objects,":[35],"implantable":[38],"devices,":[39],"can":[40,61],"affect":[41],"these":[42,101],"various":[43],"cell":[44,98,194,222,231],"behaviors":[45,115],"still":[46],"remains":[47],"largely":[48],"unknown.":[49],"this":[51,160,193,200],"study,":[52],"we":[53],"discuss":[54],"walls":[57,125,189],"microgroove":[59,89,127,146,181],"topography":[60],"influence":[62],"morphology":[64,195],"motility":[67,99,140,223],"unrestrained":[69],"cells,":[70],"in":[71,199],"a":[72,133],"different":[73,113],"fashion":[74],"from":[75],"2D":[76,92,121,151],"line":[77,93],"micropatterns.":[78],"Here":[79],"adhesive":[80],"substrates":[81,102],"made":[82],"tetra(polyethylene":[84],"glycol)":[85],"(tetra-PEG)":[86],"hydrogels":[87],"with":[88,149],"or":[91,153],"micropatterns":[94,122],"were":[95],"fabricated,":[96],"was":[103,162,184],"evaluated.":[104],"Interestingly,":[105],"despite":[106],"being":[107],"unconstrained,":[108],"cells":[110,137],"exhibited":[111],"drastically":[112],"migration":[114],"at":[116],"edges":[118],"structures.":[128],"addition":[130],"acquiring":[132],"unilamellar":[134],"morphology,":[135],"increased":[138],"their":[139],"by":[141,175],"roughly":[142],"3-fold":[143],"structures,":[147],"compared":[148],"counterpart":[152],"nonpatterned":[155],"surface.":[156],"Immunostaining":[157],"revealed":[158],"that":[159,186],"behavior":[161],"dependent":[163],"alignment":[166],"aggregation":[169],"actin":[172],"filaments,":[173],"varying":[176],"slope":[178],"walls,":[182],"it":[183],"found":[185],"relatively":[187],"upright":[188],"are":[190],"necessary":[191],"for":[192,224],"alterations.":[196],"Further":[197],"progress":[198],"will":[202],"not":[203],"only":[204],"deepen":[205],"our":[206],"understanding":[207],"topography-assisted":[209],"biological":[210],"phenomena":[211],"like":[212],"cancer":[213,228],"metastasis":[214],"but":[215],"also":[216],"enable":[217],"precise,":[218],"topography-guided":[219],"manipulation":[220],"applications":[225],"diagnosis":[229],"sorting.":[232]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2016-06-24T00:00:00"}
