{"id":"https://openalex.org/W115145477","doi":null,"title":"Soluble forms of the high-affinity fibroblast growth factor receptor in human vitreous fluid.","display_name":"Soluble forms of the high-affinity fibroblast growth factor receptor in human vitreous fluid.","publication_year":1995,"publication_date":"1995-05-01","ids":{"openalex":"https://openalex.org/W115145477","mag":"115145477","pmid":"https://pubmed.ncbi.nlm.nih.gov/7730030"},"language":"en","primary_location":{"id":"pmid:7730030","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7730030","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022215889","display_name":"Anne M. Hanneken","orcid":"https://orcid.org/0000-0002-7390-2596","observed_orcids":["https://orcid.org/0000-0002-7390-2596"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Hanneken","raw_affiliation_strings":["Whittier Institute for Diabetes and Endocrinology, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whittier Institute for Diabetes and Endocrinology, La Jolla, California, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001537127","display_name":"Andrew Baird","orcid":"https://orcid.org/0000-0003-0027-9905","observed_orcids":["https://orcid.org/0000-0003-0027-9905"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Baird","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7342,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.8451692,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"36","issue":"6","first_page":"1192","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13223","display_name":"Connective Tissue Growth Factor Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitreous-fluid","display_name":"vitreous fluid","score":0.8970000147819519},{"id":"https://openalex.org/keywords/fgf2","display_name":"FGF2","score":0.8730000257492065},{"id":"https://openalex.org/keywords/vitreoretinal-disorders","display_name":"vitreoretinal disease","score":0.8560000061988831},{"id":"https://openalex.org/keywords/vitreous-proteins","display_name":"vitreous proteins","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.6680680513381958},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6068600416183472},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6038351058959961},{"id":"https://openalex.org/C2779881004","wikidata":"https://www.wikidata.org/wiki/Q7451876","display_name":"Sepharose","level":3,"score":0.5131233334541321},{"id":"https://openalex.org/C82867764","wikidata":"https://www.wikidata.org/wiki/Q24780051","display_name":"Fibroblast growth factor receptor","level":4,"score":0.4532819390296936},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4485534131526947},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4441326856613159},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4336671233177185},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4229896366596222},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.4177970290184021},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3687843680381775},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09155148267745972}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002846","descriptor_name":"Chromatography, Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014822","descriptor_name":"Vitreous Body","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014909","descriptor_name":"Wheat Germ Agglutinins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017468","descriptor_name":"Receptors, Fibroblast Growth Factor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D017468","descriptor_name":"Receptors, Fibroblast Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7730030","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7730030","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:115145477","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7730030","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6929968331","display_name":"BRAIN PEPTIDES IN PITUITARY FUNCTIONS AND DIABETES","funder_award_id":"P01DK018811","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2034456113","https://openalex.org/W2013022765","https://openalex.org/W7099570490","https://openalex.org/W1972975078","https://openalex.org/W1986425703","https://openalex.org/W1966270411","https://openalex.org/W2141164706","https://openalex.org/W2089626468","https://openalex.org/W2115204154","https://openalex.org/W2008841329"],"abstract_inverted_index":{"PURPOSE:":[0],"Fibroblast":[1],"growth":[2],"factor-binding":[3],"proteins":[4,78,137,160,171],"(FGF-BPs)":[5],"have":[6,17,229],"been":[7,18],"identified":[8],"recently":[9],"in":[10,44,110,113,125,252,264],"blood":[11],"and":[12,16,62,134,225,231,256],"other":[13],"biologic":[14,260],"fluids":[15],"shown":[19],"to":[20,23,70,72,89,105,163,178,193,205,223,235],"be":[21,206],"identical":[22],"a":[24,67],"truncated":[25,207],"form":[26],"of":[27,94,100,115,127,157,182,197,209,213,239,262],"the":[28,37,91,97,111,116,128,131,135,150,155,170,179,183,194,198,210,214,236,240,253,259],"high-affinity":[29,73,184,215,241],"cell":[30],"surface":[31],"FGF":[32,74,85,185,199,216,242,251,263],"receptor.":[33,217,243],"The":[34,76,159],"authors":[35],"examined":[36],"hypothesis":[38],"that":[39,149,169,228],"FGF-BPs":[40,227,247],"also":[41],"are":[42,203],"present":[43],"human":[45],"vitreous":[46,112,254],"fluid.":[47],"METHODS:":[48],"Vitreous":[49,219],"fluid":[50,220],"obtained":[51],"from":[52],"12":[53,117],"patients":[54],"was":[55,108,123,152],"incubated":[56],"overnight":[57],"with":[58],"heparin-Sepharose,":[59,61],"FGF-2":[60,141],"wheat":[63],"germ":[64],"agglutinin":[65],"(WGA)-Sepharose,":[66],"lectin":[68],"known":[69],"bind":[71],"receptors.":[75],"precipitated":[77,139],"were":[79,138,172],"characterized":[80],"by":[81,140,145,174,189],"immunoblotting":[82],"using":[83],"two":[84],"receptor":[86,186],"antibodies":[87],"raised":[88,177,192],"either":[90],"extracellular":[92,180,211,237],"domain":[93,99,181,196,212,238],"FGFR-1":[95],"or":[96],"intracellular":[98,195],"FGFR-1.":[101],"RESULTS:":[102],"A":[103,120],"70-":[104,222],"85-kd":[106,224],"FGF-BP":[107,122],"detected":[109,124],"each":[114],"eyes":[118],"examined.":[119],"55-kd":[121,226],"six":[126],"samples.":[129],"Both":[130],"70-to":[132],"85-kDa":[133],"55-kDa":[136],"heparin-Sepharose":[142,146],"but":[143,187],"not":[144,188],"alone,":[147],"suggesting":[148],"interaction":[151],"dependent":[153],"on":[154],"presence":[156],"FGF-2.":[158],"bound":[161],"avidly":[162],"WGA-Sepharose.":[164],"Western":[165],"blot":[166],"analysis":[167],"revealed":[168],"recognized":[173],"an":[175,190],"antibody":[176,191],"receptor,":[200],"indicating":[201],"they":[202],"likely":[204],"portions":[208],"CONCLUSIONS:":[218],"contains":[221],"biochemical":[230],"immunologic":[232],"characteristics":[233],"similar":[234],"These":[244],"naturally":[245],"occurring":[246],"may":[248,257],"sequester":[249],"free":[250],"cavity":[255],"modulate":[258],"activity":[261],"vitreoretinal":[265],"diseases.":[266]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}