{"id":"https://openalex.org/W1150141001","doi":"https://doi.org/10.1016/j.nrleng.2015.06.019","title":"The 6-hydroxydopamine model and parkinsonian pathophysiology: Novel findings in an older model","display_name":"The 6-hydroxydopamine model and parkinsonian pathophysiology: Novel findings in an older model","publication_year":2017,"publication_date":"2017-08-24","ids":{"openalex":"https://openalex.org/W1150141001","doi":"https://doi.org/10.1016/j.nrleng.2015.06.019","mag":"1150141001","pmid":"https://pubmed.ncbi.nlm.nih.gov/26304655"},"language":"en","primary_location":{"id":"doi:10.1016/j.nrleng.2015.06.019","doi":"https://doi.org/10.1016/j.nrleng.2015.06.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nrleng.2015.06.019","pdf_url":"https://www.sciencedirect.com/science/article/pii/S217358081730113X/pdf","source":{"id":"https://openalex.org/S4210230888","display_name":"Neurolog\u00eda (English Edition)","issn_l":"2173-5808","issn":["2173-5808"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurolog\u00eda (English Edition)","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S217358081730113X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063837274","display_name":"Daniel Hern\u00e1ndez-Baltazar","orcid":"https://orcid.org/0000-0002-3658-4808","observed_orcids":["https://orcid.org/0000-0002-3658-4808"]},"institutions":[{"id":"https://openalex.org/I147280213","display_name":"Universidad Veracruzana","ror":"https://ror.org/03efxn362","country_code":"MX","type":"education","lineage":["https://openalex.org/I147280213"]},{"id":"https://openalex.org/I4210163111","display_name":"Secretar\u00eda de Ciencia, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n","ror":"https://ror.org/059ex5q34","country_code":"MX","type":"government","lineage":["https://openalex.org/I4210163111"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"D. Hernandez-Baltazar","raw_affiliation_strings":["C\u00e1tedra CONACyT, Direcci\u00f3n Adjunta de Desarrollo Cient\u00edfico CONACyT, M\u00e9xico, D. F., Mexico","Instituto de Neuroetolog\u00eda, Universidad Veracruzana, Xalapa, Veracruz, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C\u00e1tedra CONACyT, Direcci\u00f3n Adjunta de Desarrollo Cient\u00edfico CONACyT, M\u00e9xico, D. F., Mexico","institution_ids":["https://openalex.org/I4210163111"]},{"raw_affiliation_string":"Instituto de Neuroetolog\u00eda, Universidad Veracruzana, Xalapa, Veracruz, Mexico","institution_ids":["https://openalex.org/I147280213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058239203","display_name":"Laura Mireya Zavala-Flores","orcid":"https://orcid.org/0000-0002-2456-6880","observed_orcids":["https://orcid.org/0000-0002-2456-6880"]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"L.M. Zavala-Flores","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica del Noreste, IMSS, Monterrey, Nuevo Le\u00f3n, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica del Noreste, IMSS, Monterrey, Nuevo Le\u00f3n, Mexico","institution_ids":["https://openalex.org/I164915025"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054260735","display_name":"Arnulfo Villanueva-Olivo","orcid":"https://orcid.org/0000-0003-3755-3437","observed_orcids":["https://orcid.org/0000-0003-3755-3437"]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"A. Villanueva-Olivo","raw_affiliation_strings":["Departamento de Histolog\u00eda, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, Nuevo Le\u00f3n, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Histolog\u00eda, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, Nuevo Le\u00f3n, Mexico","institution_ids":["https://openalex.org/I169046204"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5063837274"],"corresponding_institution_ids":["https://openalex.org/I147280213","https://openalex.org/I4210163111"],"apc_list":{"value":1800,"currency":"EUR","value_usd":2034},"apc_paid":{"value":1800,"currency":"EUR","value_usd":2034},"fwci":6.3164,"has_fulltext":true,"cited_by_count":138,"citation_normalized_percentile":{"value":0.97428359,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"32","issue":"8","first_page":"533","last_page":"539"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/6-hydroxydopamine","display_name":"6-hydroxydopamine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.777999997138977},{"id":"https://openalex.org/keywords/parkinson-s-disease-model","display_name":"Parkinson's disease model","score":0.921999990940094},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.8610000014305115},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7770000100135803},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7889999747276306},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.8109999895095825},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.861274242401123},{"id":"https://openalex.org/C2911016594","wikidata":"https://www.wikidata.org/wiki/Q15946111","display_name":"Hydroxydopamine","level":4,"score":0.7273714542388916},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.5691053867340088},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5178914070129395},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5046888589859009},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4548710584640503},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.42663252353668213},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.4182153642177582},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.39235955476760864},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.3885740637779236},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.34969496726989746},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3250288963317871},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.289247989654541},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26777544617652893},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.26732635498046875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11537843942642212},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09462755918502808},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.060413241386413574}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016627","descriptor_name":"Oxidopamine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018663","descriptor_name":"Adrenergic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.nrleng.2015.06.019","doi":"https://doi.org/10.1016/j.nrleng.2015.06.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nrleng.2015.06.019","pdf_url":"https://www.sciencedirect.com/science/article/pii/S217358081730113X/pdf","source":{"id":"https://openalex.org/S4210230888","display_name":"Neurolog\u00eda (English Edition)","issn_l":"2173-5808","issn":["2173-5808"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurolog\u00eda (English Edition)","raw_type":"journal-article"},{"id":"pmid:26304655","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26304655","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurologia (Barcelona, Spain)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:daabde13629e4c19917387913bbdfe70","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/daabde13629e4c19917387913bbdfe70","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurolog\u00eda (English Edition), Vol 32, Iss 8, Pp 533-539 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.nrleng.2015.06.019","doi":"https://doi.org/10.1016/j.nrleng.2015.06.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nrleng.2015.06.019","pdf_url":"https://www.sciencedirect.com/science/article/pii/S217358081730113X/pdf","source":{"id":"https://openalex.org/S4210230888","display_name":"Neurolog\u00eda (English Edition)","issn_l":"2173-5808","issn":["2173-5808"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurolog\u00eda (English Edition)","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321739","display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","ror":"https://ror.org/059ex5q34"},{"id":"https://openalex.org/F4320322937","display_name":"Universidad Veracruzana","ror":"https://ror.org/03efxn362"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1150141001.pdf","grobid_xml":"https://content.openalex.org/works/W1150141001.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W220741418","https://openalex.org/W307046337","https://openalex.org/W1958274942","https://openalex.org/W1963526238","https://openalex.org/W1963585873","https://openalex.org/W1965628181","https://openalex.org/W1967018739","https://openalex.org/W1967282467","https://openalex.org/W1972937199","https://openalex.org/W1973376999","https://openalex.org/W1973385523","https://openalex.org/W1973409164","https://openalex.org/W1973722547","https://openalex.org/W1975268708","https://openalex.org/W1977252372","https://openalex.org/W1978926564","https://openalex.org/W1979480763","https://openalex.org/W1979767669","https://openalex.org/W1980142052","https://openalex.org/W1981756874","https://openalex.org/W1989411375","https://openalex.org/W1994246247","https://openalex.org/W1996241541","https://openalex.org/W1998461647","https://openalex.org/W1998778991","https://openalex.org/W2000767320","https://openalex.org/W2004991351","https://openalex.org/W2005799875","https://openalex.org/W2006256774","https://openalex.org/W2006878746","https://openalex.org/W2008513297","https://openalex.org/W2008624705","https://openalex.org/W2010162969","https://openalex.org/W2013826930","https://openalex.org/W2019125467","https://openalex.org/W2020171946","https://openalex.org/W2020593897","https://openalex.org/W2021897675","https://openalex.org/W2026965747","https://openalex.org/W2030481310","https://openalex.org/W2033721300","https://openalex.org/W2036533672","https://openalex.org/W2044699444","https://openalex.org/W2050865611","https://openalex.org/W2052299360","https://openalex.org/W2056894898","https://openalex.org/W2057451803","https://openalex.org/W2058074769","https://openalex.org/W2063030523","https://openalex.org/W2065000444","https://openalex.org/W2069515205","https://openalex.org/W2071871730","https://openalex.org/W2074354488","https://openalex.org/W2075093116","https://openalex.org/W2075688817","https://openalex.org/W2079231229","https://openalex.org/W2082033259","https://openalex.org/W2082893764","https://openalex.org/W2086208850","https://openalex.org/W2086483799","https://openalex.org/W2090140489","https://openalex.org/W2092808670","https://openalex.org/W2093248461","https://openalex.org/W2093956035","https://openalex.org/W2097830904","https://openalex.org/W2098109126","https://openalex.org/W2104281624","https://openalex.org/W2107073592","https://openalex.org/W2111372299","https://openalex.org/W2111697227","https://openalex.org/W2113513651","https://openalex.org/W2113979027","https://openalex.org/W2123812707","https://openalex.org/W2130440901","https://openalex.org/W2138381240","https://openalex.org/W2139312815","https://openalex.org/W2140283306","https://openalex.org/W2141677575","https://openalex.org/W2148214085","https://openalex.org/W2161325655","https://openalex.org/W2164546175","https://openalex.org/W2165713986","https://openalex.org/W2169661258","https://openalex.org/W2284628150","https://openalex.org/W2398382217","https://openalex.org/W2441519221"],"related_works":["https://openalex.org/W2804098348","https://openalex.org/W2761174062","https://openalex.org/W3049486795","https://openalex.org/W2139086927","https://openalex.org/W7213284602","https://openalex.org/W2755218244","https://openalex.org/W2079231229","https://openalex.org/W126359368","https://openalex.org/W2998118331","https://openalex.org/W7096088294"],"abstract_inverted_index":{"The":[0],"neurotoxin":[1],"6-hydroxydopamine":[2],"(6-OHDA)":[3,105],"is":[4,92],"widely":[5],"used":[6],"to":[7,95],"induce":[8],"models":[9],"of":[10,61,80],"Parkinson's":[11],"disease":[12],"(PD).":[13],"We":[14],"now":[15],"know":[16],"that":[17],"the":[18,33,56,59,67,76,81,93],"model":[19,91],"induced":[20],"by":[21,49],"6-OHDA":[22,77,133],"does":[23,31],"not":[24],"include":[25],"all":[26],"PD":[27],"symptoms,":[28],"although":[29],"it":[30],"reproduce":[32,135],"main":[34],"cellular":[35],"processes":[36],"involved":[37,83],"in":[38,75,84,89],"PD,":[39],"such":[40],"as":[41,64,66],"oxidative":[42],"stress,":[43],"neurodegeneration,":[44,72],"neuroinflammation,":[45,71],"and":[46,73,86],"neuronal":[47,159],"death":[48,88],"apoptosis.":[50,161],"In":[51],"this":[52,90],"review":[53],"we":[54],"analyse":[55],"factors":[57],"affecting":[58],"vulnerability":[60],"dopaminergic":[62],"neurons":[63],"well":[65],"close":[68],"relationships":[69],"between":[70],"apoptosis":[74,194],"model.":[78],"Knowledge":[79],"mechanisms":[82],"neurodegeneration":[85],"cell":[87],"key":[94],"identifying":[96],"potential":[97],"therapeutic":[98],"targets":[99],"for":[100],"PD.":[101],"El":[102,199],"neurot\u00f3xico":[103],"6-hidroxidopamina":[104],"ha":[106,122],"sido":[107],"utilizado":[108],"para":[109,217,222],"generar":[110],"modelos":[111],"de":[112,115,138,140,169,177,201],"la":[113,119,132,136,141,152,154,157,175,183,193,197,206,209],"enfermedad":[114],"Parkinson":[116],"(EP).":[117],"A":[118],"fecha":[120],"se":[121,165],"establecido":[123],"que":[124,172],"si":[125],"bien":[126],"el":[127,149,167,187,190],"modelo":[128,214],"neurodegenerativo":[129],"inducido":[130],"por":[131,160,196],"no":[134],"totalidad":[137],"s\u00edntomas":[139],"enfermedad,":[142],"s\u00ed":[143],"replica":[144],"procesos":[145],"celulares":[146],"tales":[147],"como":[148,182],"estr\u00e9s":[150],"oxidativo,":[151],"neurodegeneraci\u00f3n,":[153],"neuroinflamaci\u00f3n":[155],"y":[156,192,208],"muerte":[158,210],"En":[162],"esta":[163],"revisi\u00f3n":[164],"contempla":[166],"an\u00e1lisis":[168],"los":[170,202],"factores":[171],"influyen":[173],"en":[174,205,212],"vulnerabilidad":[176],"las":[178],"neuronas":[179],"dopamin\u00e9rgicas,":[180],"as\u00ed":[181],"estrecha":[184],"relaci\u00f3n":[185],"entre":[186],"proceso":[188],"neurodegenerativo,":[189],"neuroinflamatorio":[191],"ocasionada":[195],"6-OHDA.":[198],"conocimiento":[200],"mecanismos":[203],"involucrados":[204],"neurodegeneraci\u00f3n":[207],"celular":[211],"este":[213],"es":[215],"relevante":[216],"definir":[218],"posibles":[219],"blancos":[220],"terap\u00e9uticos":[221],"EP.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":24},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}