{"id":"https://openalex.org/W114993171","doi":"https://doi.org/10.3967/bes2014.074","title":"Bioinformatics analysis raises candidate genes in blood for early screening of Parkinson's disease.","display_name":"Bioinformatics analysis raises candidate genes in blood for early screening of Parkinson's disease.","publication_year":2014,"publication_date":"2014-06-01","ids":{"openalex":"https://openalex.org/W114993171","doi":"https://doi.org/10.3967/bes2014.074","mag":"114993171","pmid":"https://pubmed.ncbi.nlm.nih.gov/24961856"},"language":"en","primary_location":{"id":"pmid:24961856","doi":"https://doi.org/10.3967/bes2014.074","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24961856","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical and environmental sciences : BES","raw_type":"Letter"},"volume":null,"type":"letter","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015666180","display_name":"Yi Zhang","orcid":"https://orcid.org/0000-0003-1642-5890","observed_orcids":["https://orcid.org/0000-0003-1642-5890"]},"institutions":[{"id":"https://openalex.org/I4391767982","display_name":"State Key Laboratory of Cancer Biology","ror":"https://ror.org/01b280561","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391767982","https://openalex.org/I9916479"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Zhang","raw_affiliation_strings":["Cell Engineering Research Center, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Engineering Research Center, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, China","institution_ids":["https://openalex.org/I4391767982","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034380614","display_name":"Yao Li","orcid":"https://orcid.org/0000-0002-7670-2194","observed_orcids":["https://orcid.org/0000-0002-7670-2194"]},"institutions":[{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Yao","raw_affiliation_strings":["Department of Pathology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, Shaanxi, China","institution_ids":["https://openalex.org/I4210154136","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100431996","display_name":"Wei Liu","orcid":"https://orcid.org/0000-0003-4199-5406","observed_orcids":["https://orcid.org/0000-0003-4199-5406"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Liu","raw_affiliation_strings":["The School of Acupuncture and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The School of Acupuncture and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802957242","display_name":"Beijing Jishuitan Hospital","ror":"https://ror.org/035t17984","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802957242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Department of laboratory medicine, Beijing Jishuitan Hospital, Beijing 100035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of laboratory medicine, Beijing Jishuitan Hospital, Beijing 100035, China","institution_ids":["https://openalex.org/I2802957242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101747128","display_name":"Chan Tian","orcid":"https://orcid.org/0000-0002-0488-9025","observed_orcids":["https://orcid.org/0000-0002-0488-9025"]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210140986","display_name":"National Institute for Viral Disease Control and Prevention","ror":"https://ror.org/04b1sh213","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210140986","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210146685","display_name":"National Institute for Communicable Disease Control and Prevention","ror":"https://ror.org/04f7g6845","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210146685","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4391768093","display_name":"State Key Laboratory of Infectious Disease Prevention and Control","ror":"https://ror.org/04bhsv505","country_code":"CN","type":"facility","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I4391768093"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chan Tian","raw_affiliation_strings":["State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (Hangzhou, China, 310003), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (Hangzhou, China, 310003), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986","https://openalex.org/I4210146685","https://openalex.org/I4391768093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100356525","display_name":"Zhaoyang Wang","orcid":"https://orcid.org/0000-0001-8309-6746","observed_orcids":["https://orcid.org/0000-0001-8309-6746"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhao Yang Wang","raw_affiliation_strings":["The School of Acupuncture and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The School of Acupuncture and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113356938","display_name":"Di Liu","orcid":"https://orcid.org/0000-0003-3693-2726","observed_orcids":["https://orcid.org/0000-0003-3693-2726","https://orcid.org/0009-0004-8842-5982"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210134982","display_name":"Institute of Microbiology","ror":"https://ror.org/047yhep71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Di Liu","raw_affiliation_strings":["Network Information Center, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Network Information Center, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"6","first_page":"462","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.8019999861717224},{"id":"https://openalex.org/keywords/blood-gene-expression","display_name":"blood gene expression","score":0.7519999742507935},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.9359999895095825},{"id":"https://openalex.org/keywords/candidate-genes","display_name":"candidate genes","score":0.7580000162124634},{"id":"https://openalex.org/keywords/genetic-markers","display_name":"genetic markers","score":0.8029999732971191},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6579999923706055},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.7289999723434448},{"id":"https://openalex.org/keywords/functional-enrichment-analysis","display_name":"functional enrichment","score":0.3319999873638153}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7294670939445496},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.6827683448791504},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6222066879272461},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4891071915626526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48431578278541565},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.46723538637161255},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.4541444778442383},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4479519724845886},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4327845573425293},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.346421480178833},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19728869199752808}],"mesh":[{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008403","descriptor_name":"Mass Screening","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24961856","doi":"https://doi.org/10.3967/bes2014.074","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24961856","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical and environmental sciences : BES","raw_type":"Letter"},{"id":"mag:114993171","doi":"https://doi.org/10.3967/bes2014.074","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24961856","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7400000095367432,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7097385041","https://openalex.org/W2971696794","https://openalex.org/W2187686753","https://openalex.org/W2157503003","https://openalex.org/W4405237322","https://openalex.org/W4312167726","https://openalex.org/W2951268836","https://openalex.org/W3094115129","https://openalex.org/W7097924800","https://openalex.org/W7131760512"],"abstract_inverted_index":{"Parkinson's":[0],"disease":[1,32],"(PD)":[2],"is":[3,9],"a":[4,105],"typical":[5],"degenerative":[6],"disease,":[7],"which":[8],"characterized":[10],"by":[11],"the":[12,50,58,74,81,88,138],"most":[13],"obvious":[14],"symptoms":[15],"of":[16,23,45,53,69,83,91,133,147],"movement":[17,24],"dysfunction,":[18],"including":[19,125],"shaking,":[20],"rigidity,":[21],"slowness":[22],"and":[25,29,77,112,130],"difficulty":[26],"in":[27,48,80,93,110,113,121,144],"walking":[28],"gait.":[30],"This":[31],"can":[33,141],"not":[34],"be":[35,142],"clearly":[36],"identified":[37],"through":[38],"laboratory":[39],"tests":[40],"at":[41],"present,":[42],"thus":[43],"application":[44],"high-throughput":[46],"technique":[47],"studying":[49],"expression":[51,67,89,107],"profiles":[52,68,90],"PD":[54,92],"helps":[55],"to":[56,128],"find":[57],"genetic":[59,139],"markers":[60,140],"for":[61],"its":[62],"early":[63,145],"diagnosis.":[64],"Studies":[65],"on":[66],"neurodegenerative":[70],"diseases":[71],"have":[72],"revealed":[73],"novel":[75],"genes":[76,102,117],"pathways":[78],"involved":[79],"progress":[82],"illness.":[84],"In":[85],"this":[86],"study,":[87],"blood":[94],"were":[95],"compared,":[96],"showing":[97],"that":[98,137],"181":[99],"differentially":[100],"expressed":[101],"(DEG)":[103],"exhibit":[104],"similar":[106],"trend":[108],"both":[109],"patients":[111],"normal":[114],"controls.":[115],"These":[116],"are":[118],"enriched":[119],"significantly":[120],"some":[122],"biological":[123],"processes,":[124],"development,":[126],"response":[127],"drugs,":[129],"DNA-dependent":[131],"regulation":[132],"transcription,":[134],"etc,":[135],"highlighting":[136],"used":[143],"diagnosis":[146],"PD.":[148]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
