{"id":"https://openalex.org/W1149628126","doi":null,"title":"Exploration Into the Effects of Hypoxia in an In Vitro Canine Glioblastoma Model","display_name":"Exploration Into the Effects of Hypoxia in an In Vitro Canine Glioblastoma Model","publication_year":2013,"publication_date":"2013-04-23","ids":{"openalex":"https://openalex.org/W1149628126","mag":"1149628126"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1020.1808","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1020.1808","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://etd.auburn.edu/bitstream/handle/10415/3592/KOEHLER%20DISSERTATION%20FINAL%20PDF.pdf%3Bjsessionid%3DF4856BFA89077742C5A2E1CAB6F338B2?sequence%3D2","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082594969","display_name":"Jennifer Koehler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jennifer Koehler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5082594969"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.7621999979019165,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.7621999979019165,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.09139999747276306,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.08709999918937683,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9729999899864197},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.949999988079071},{"id":"https://openalex.org/keywords/cancer-stem-like-cells","display_name":"cancer stem-like cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7239999771118164},{"id":"https://openalex.org/keywords/cd133","display_name":"CD133","score":0.9279999732971191},{"id":"https://openalex.org/keywords/nestin","display_name":"nestin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hif-2alpha","display_name":"HIF-2\u03b1","score":0.9459999799728394},{"id":"https://openalex.org/keywords/stem-cell-markers","display_name":"stem cell markers","score":0.5979999899864197},{"id":"https://openalex.org/keywords/in-vitro-cancer-models","display_name":"in vitro tumor model","score":0.703000009059906},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.5149999856948853},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9369999766349792}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6557856202125549},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5697780847549438},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5181452035903931},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5157173275947571},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.47087037563323975},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.45675382018089294},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.45440974831581116},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.43073326349258423},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.4224183261394501},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3426355719566345},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.277376651763916},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2549625039100647},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16510286927223206},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15030190348625183},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.12641820311546326},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1020.1808","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1020.1808","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://etd.auburn.edu/bitstream/handle/10415/3592/KOEHLER%20DISSERTATION%20FINAL%20PDF.pdf%3Bjsessionid%3DF4856BFA89077742C5A2E1CAB6F338B2?sequence%3D2","raw_type":"text"},{"id":"mag:1149628126","doi":null,"is_oa":false,"landing_page_url":"https://etd.auburn.edu/bitstream/10415/3592/2/KOEHLER%20DISSERTATION%20FINAL%20PDF.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":217,"referenced_works":["https://openalex.org/W52324175","https://openalex.org/W101363752","https://openalex.org/W113639961","https://openalex.org/W116758555","https://openalex.org/W133253872","https://openalex.org/W1215934946","https://openalex.org/W1482045472","https://openalex.org/W1501926866","https://openalex.org/W1519412172","https://openalex.org/W1533600822","https://openalex.org/W1550975546","https://openalex.org/W1560814177","https://openalex.org/W1575973365","https://openalex.org/W1598408272","https://openalex.org/W1603509064","https://openalex.org/W1749022239","https://openalex.org/W1780308454","https://openalex.org/W1892956996","https://openalex.org/W1907982143","https://openalex.org/W1921143360","https://openalex.org/W1964037605","https://openalex.org/W1964971823","https://openalex.org/W1966008866","https://openalex.org/W1968329376","https://openalex.org/W1969326097","https://openalex.org/W1969854703","https://openalex.org/W1970530124","https://openalex.org/W1970572671","https://openalex.org/W1970744454","https://openalex.org/W1970792104","https://openalex.org/W1971681203","https://openalex.org/W1971886895","https://openalex.org/W1972022525","https://openalex.org/W1972700706","https://openalex.org/W1972764534","https://openalex.org/W1972783950","https://openalex.org/W1973092951","https://openalex.org/W1975183052","https://openalex.org/W1975545468","https://openalex.org/W1975957651","https://openalex.org/W1977116102","https://openalex.org/W1977304528","https://openalex.org/W1977394993","https://openalex.org/W1978747495","https://openalex.org/W1980026529","https://openalex.org/W1983274306","https://openalex.org/W1984637659","https://openalex.org/W1985712533","https://openalex.org/W1986076152","https://openalex.org/W1986926812","https://openalex.org/W1987085702","https://openalex.org/W1987145582","https://openalex.org/W1987278921","https://openalex.org/W1987999535","https://openalex.org/W1988377666","https://openalex.org/W1988986134","https://openalex.org/W1989249682","https://openalex.org/W1991421091","https://openalex.org/W1992069798","https://openalex.org/W1992867900","https://openalex.org/W1995078853","https://openalex.org/W1997226015","https://openalex.org/W1997422780","https://openalex.org/W1999356404","https://openalex.org/W1999670368","https://openalex.org/W2000292756","https://openalex.org/W2000400490","https://openalex.org/W2001544973","https://openalex.org/W2001573748","https://openalex.org/W2005609755","https://openalex.org/W2009886857","https://openalex.org/W2010057452","https://openalex.org/W2010317454","https://openalex.org/W2010386340","https://openalex.org/W2011076742","https://openalex.org/W2011376105","https://openalex.org/W2011704245","https://openalex.org/W2011767107","https://openalex.org/W2016851798","https://openalex.org/W2017577568","https://openalex.org/W2017736079","https://openalex.org/W2018607339","https://openalex.org/W2018671779","https://openalex.org/W2019768326","https://openalex.org/W2019950666","https://openalex.org/W2020590412","https://openalex.org/W2022451432","https://openalex.org/W2025109766","https://openalex.org/W2027048243","https://openalex.org/W2028342551","https://openalex.org/W2029452593","https://openalex.org/W2031945343","https://openalex.org/W2032039673","https://openalex.org/W2033314804","https://openalex.org/W2034528919","https://openalex.org/W2034739637","https://openalex.org/W2035396934","https://openalex.org/W2037286214","https://openalex.org/W2039075677","https://openalex.org/W2039767026","https://openalex.org/W2040352392","https://openalex.org/W2040385253","https://openalex.org/W2041617965","https://openalex.org/W2042702043","https://openalex.org/W2043703150","https://openalex.org/W2044682156","https://openalex.org/W2045115936","https://openalex.org/W2045507870","https://openalex.org/W2046628354","https://openalex.org/W2047922146","https://openalex.org/W2048160969","https://openalex.org/W2051588629","https://openalex.org/W2053375897","https://openalex.org/W2060551076","https://openalex.org/W2060583228","https://openalex.org/W2066503079","https://openalex.org/W2066623614","https://openalex.org/W2069002586","https://openalex.org/W2069845109","https://openalex.org/W2075306542","https://openalex.org/W2077067643","https://openalex.org/W2079121632","https://openalex.org/W2079356804","https://openalex.org/W2081258358","https://openalex.org/W2081460564","https://openalex.org/W2081758137","https://openalex.org/W2083098015","https://openalex.org/W2087823050","https://openalex.org/W2090982381","https://openalex.org/W2093578147","https://openalex.org/W2094360518","https://openalex.org/W2097607584","https://openalex.org/W2097713515","https://openalex.org/W2101190482","https://openalex.org/W2102476325","https://openalex.org/W2104761954","https://openalex.org/W2105236768","https://openalex.org/W2105689262","https://openalex.org/W2107030585","https://openalex.org/W2107277218","https://openalex.org/W2107880288","https://openalex.org/W2108186386","https://openalex.org/W2108573150","https://openalex.org/W2108712781","https://openalex.org/W2110362524","https://openalex.org/W2110711017","https://openalex.org/W2112703519","https://openalex.org/W2113001012","https://openalex.org/W2113942802","https://openalex.org/W2114098415","https://openalex.org/W2117767331","https://openalex.org/W2119593356","https://openalex.org/W2119793842","https://openalex.org/W2120608850","https://openalex.org/W2121909743","https://openalex.org/W2124053736","https://openalex.org/W2125668457","https://openalex.org/W2126932298","https://openalex.org/W2127863564","https://openalex.org/W2129375080","https://openalex.org/W2129966883","https://openalex.org/W2130485280","https://openalex.org/W2130976070","https://openalex.org/W2131702292","https://openalex.org/W2131872235","https://openalex.org/W2132023472","https://openalex.org/W2133486230","https://openalex.org/W2134812217","https://openalex.org/W2134959033","https://openalex.org/W2139181014","https://openalex.org/W2140375000","https://openalex.org/W2140744545","https://openalex.org/W2140763084","https://openalex.org/W2140960450","https://openalex.org/W2141405250","https://openalex.org/W2141573080","https://openalex.org/W2142534649","https://openalex.org/W2143372016","https://openalex.org/W2143754133","https://openalex.org/W2145000920","https://openalex.org/W2145755327","https://openalex.org/W2146680438","https://openalex.org/W2146953551","https://openalex.org/W2150479858","https://openalex.org/W2150485214","https://openalex.org/W2151089290","https://openalex.org/W2152112132","https://openalex.org/W2153584576","https://openalex.org/W2154899683","https://openalex.org/W2155105887","https://openalex.org/W2155170455","https://openalex.org/W2155228504","https://openalex.org/W2155415917","https://openalex.org/W2156338513","https://openalex.org/W2158804607","https://openalex.org/W2159406166","https://openalex.org/W2161071327","https://openalex.org/W2162017151","https://openalex.org/W2162450040","https://openalex.org/W2164036826","https://openalex.org/W2164076826","https://openalex.org/W2165582566","https://openalex.org/W2166637572","https://openalex.org/W2167414381","https://openalex.org/W2167650288","https://openalex.org/W2169798272","https://openalex.org/W2169940012","https://openalex.org/W2170563276","https://openalex.org/W2172266256","https://openalex.org/W2177184392","https://openalex.org/W2178005554","https://openalex.org/W2187591034","https://openalex.org/W2221025169","https://openalex.org/W2327673986","https://openalex.org/W2400033278","https://openalex.org/W2489862608","https://openalex.org/W2606600470"],"related_works":["https://openalex.org/W2605175195","https://openalex.org/W2938308452","https://openalex.org/W4400764115","https://openalex.org/W2133460396","https://openalex.org/W2040113269","https://openalex.org/W2119793842","https://openalex.org/W7124840484","https://openalex.org/W2802266385","https://openalex.org/W7052609934","https://openalex.org/W2624969848"],"abstract_inverted_index":{"ii":[0],"Glioblastomas":[1],"are":[2,95],"aggressive,":[3],"lethal":[4],"primary":[5],"brain":[6],"tumors":[7],"that":[8,148],"affect":[9],"human":[10,88],"and":[11,42,64,66,78,93,106,130,156,167],"canine":[12,170],"patients.":[13],"A":[14],"subpopulation":[15],"representing":[16],"a":[17,102,151],"variably":[18],"large":[19],"percentage":[20],"of":[21,24,38,73,82,84,108,125,132,165],"the":[22,71,126,133,163],"bulk":[23,72],"tumor":[25,74,99],"cells":[26],"has":[27,55,136],"been":[28,56,116,138],"identified":[29],"to":[30,58,62,69,146,161],"have":[31,59,115],"stem":[32],"cell-like":[33],"properties":[34,44],"based":[35],"on":[36],"expression":[37],"certain":[39],"molecular":[40],"markers":[41,86,119],"growth":[43],"in":[45,87,112,128,157],"specialized":[46],"culture":[47],"conditions.":[48],"This":[49],"cancer":[50],"stem-like":[51,134],"cell":[52],"(CSLC)":[53],"population":[54],"demonstrated":[57],"increased":[60],"resistance":[61],"radiation":[63],"chemotherapy,":[65],"is":[67,143],"postulated":[68],"drive":[70],"growth,":[75],"invasion,":[76],"regrowth,":[77],"treatment":[79],"failure.":[80],"Expression":[81],"several":[83],"these":[85],"tumors,":[89],"including":[90],"CD133,":[91],"nestin,":[92],"HIF2\u03b1,":[94],"associated":[96],"with":[97,172],"increasing":[98],"grade":[100],"and/or":[101],"negative":[103],"prognostic":[104],"outcome,":[105],"because":[107],"their":[109],"known":[110],"roles":[111],"developmental":[113],"biology":[114,164],"utilized":[117],"as":[118],"for":[120],"identifying":[121],"CSLC.":[122],"The":[123],"role":[124],"microenvironment":[127],"acquisition":[129],"maintenance":[131],"state":[135],"not":[137],"fully":[139],"elucidated;":[140],"however,":[141],"there":[142],"mounting":[144],"evidence":[145],"indicate":[147],"hypoxia":[149],"plays":[150],"crucial":[152],"role.":[153],"Although":[154],"rodent":[155],"vitro":[158],"models":[159],"exist":[160],"study":[162],"glioblastoma":[166],"potential":[168],"therapeutics,":[169],"patients":[171],"naturally-":[173]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
