{"id":"https://openalex.org/W114869256","doi":null,"title":"HOMEOTIC MUTANTS AND THE ASSIMILATION OF DEVELOPMENTAL GENETICS INTO THE EVOLUTIONARY SYNTHESIS, 1915\u20151952","display_name":"HOMEOTIC MUTANTS AND THE ASSIMILATION OF DEVELOPMENTAL GENETICS INTO THE EVOLUTIONARY SYNTHESIS, 1915\u20151952","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W114869256","mag":"114869256"},"language":"en","primary_location":{"id":"mag:114869256","doi":null,"is_oa":false,"landing_page_url":"https://www.questia.com/library/journal/1P3-1697186511/chapter-7-homeotic-mutants-and-the-assimilation-of","pdf_url":null,"source":{"id":"https://openalex.org/S93118124","display_name":"Transactions of the American Philosophical Society","issn_l":"0065-9746","issn":["0065-9746","2325-9264"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Transactions of the American Philosophical Society","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103541683","display_name":"Gregory K. Davis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory K. Davis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090307601","display_name":"Michael R Dietrich","orcid":"https://orcid.org/0000-0001-6794-3618","observed_orcids":["https://orcid.org/0000-0001-6794-3618"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Dietrich","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6794-3618","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5058431722","display_name":"David K. Jacobs","orcid":"https://orcid.org/0000-0002-7252-1601","observed_orcids":["https://orcid.org/0000-0002-7252-1601"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David K. Jacobs","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7252-1601","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.5774,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.96512317,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"99","issue":"1","first_page":"133","last_page":"154"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10778","display_name":"Philosophy and History of Science","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10778","display_name":"Philosophy and History of Science","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homeotic-mutants","display_name":"homeotic mutants","score":0.9879999756813049},{"id":"https://openalex.org/keywords/homeosis","display_name":"homeosis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/homeotic-genes","display_name":"homeotic genes","score":0.8809999823570251},{"id":"https://openalex.org/keywords/homeobox","display_name":"homeobox","score":0.8690000176429749},{"id":"https://openalex.org/keywords/evolutionary-developmental-biology","display_name":"evolutionary developmental biology","score":0.765999972820282},{"id":"https://openalex.org/keywords/evolutionary-synthesis","display_name":"evolutionary synthesis","score":0.7020000219345093},{"id":"https://openalex.org/keywords/developmental-genetics","display_name":"developmental genetics","score":0.5400000214576721},{"id":"https://openalex.org/keywords/segmental-identity","display_name":"segmental identity","score":0.5680000185966492},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.7429999709129333},{"id":"https://openalex.org/keywords/hox-genes","display_name":"Hox genes","score":0.5649999976158142},{"id":"https://openalex.org/keywords/gene-expression-patterns","display_name":"gene expression patterns","score":0.3089999854564667},{"id":"https://openalex.org/keywords/discontinuous-variation","display_name":"discontinuous variation","score":0.5809999704360962},{"id":"https://openalex.org/keywords/william-bateson","display_name":"William Bateson","score":0.6010000109672546},{"id":"https://openalex.org/keywords/history-of-genetics","display_name":"history of genetics","score":0.5460000038146973},{"id":"https://openalex.org/keywords/comparative-genomics","display_name":"comparative genomics","score":0.3720000088214874},{"id":"https://openalex.org/keywords/comparative-embryology","display_name":"comparative embryology","score":0.39800000190734863},{"id":"https://openalex.org/keywords/comparative-anatomy","display_name":"comparative anatomy","score":0.328000009059906},{"id":"https://openalex.org/keywords/comparative-morphology","display_name":"comparative morphology","score":0.4259999990463257},{"id":"https://openalex.org/keywords/comparative-cytology","display_name":"comparative cytology","score":0.40799999237060547},{"id":"https://openalex.org/keywords/comparative-cytogenetics","display_name":"comparative cytogenetics","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C46751350","wikidata":"https://www.wikidata.org/wiki/Q1939530","display_name":"Homeotic gene","level":4,"score":0.9672876596450806},{"id":"https://openalex.org/C111039654","wikidata":"https://www.wikidata.org/wiki/Q253149","display_name":"Hox gene","level":4,"score":0.7298359870910645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6441118717193604},{"id":"https://openalex.org/C121587040","wikidata":"https://www.wikidata.org/wiki/Q898769","display_name":"Homeobox","level":4,"score":0.5873198509216309},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5694252848625183},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5576505064964294},{"id":"https://openalex.org/C168601633","wikidata":"https://www.wikidata.org/wiki/Q1044484","display_name":"Evolutionary developmental biology","level":2,"score":0.44934356212615967},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32760003209114075},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.2875046133995056},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.1438259482383728}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:114869256","doi":null,"is_oa":false,"landing_page_url":"https://www.questia.com/library/journal/1P3-1697186511/chapter-7-homeotic-mutants-and-the-assimilation-of","pdf_url":null,"source":{"id":"https://openalex.org/S93118124","display_name":"Transactions of the American Philosophical Society","issn_l":"0065-9746","issn":["0065-9746","2325-9264"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Transactions of the American Philosophical Society","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.6600000262260437,"id":"https://metadata.un.org/sdg/15","display_name":"Life on land"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1893103237","https://openalex.org/W2092326131","https://openalex.org/W7163398237","https://openalex.org/W2045142460","https://openalex.org/W2741297513","https://openalex.org/W1528700601","https://openalex.org/W4211194786","https://openalex.org/W4239699717","https://openalex.org/W4404156006","https://openalex.org/W1655789513"],"abstract_inverted_index":{"INTRODUCTION":[0],"In":[1,350],"1894":[2],"William":[3],"Bateson":[4,54,104],"described":[5],"a":[6,29,38,42,45,48,95,138,220,233,437,580],"class":[7,235],"of":[8,21,28,31,34,37,68,111,118,130,150,181,206,217,223,232,236,302,316,319,335,339,376,405,450,461,473,503,533,540,543,550,563,583,592],"discontinuous":[9],"variation":[10,24,112],"that":[11,106,124,226,274,431,508,560,569],"he":[12],"considered":[13],"to":[14,56,98,127,209,214,328,383,407,414,427,435,486],"be":[15],"especially":[16],"valuable":[17],"for":[18,228,294,313],"the":[19,26,52,66,99,109,116,128,163,190,215,218,229,314,317,323,333,344,357,374,391,395,403,441,457,465,471,474,510,538,547,551,561,570,590],"study":[20],"evolution.":[22,388],"This":[23,447],"involved":[25],"repetition":[27],"set":[30],"features":[32],"typical":[33],"one":[35,60,93],"member":[36],"meristic":[39],"series":[40],"(e.g.,":[41,175,305,347],"vertebra":[43],"or":[44,79,171,410],"segment)":[46],"in":[47,51,147,158,187,195,276,343,356,365,399,440,509,519,526],"new":[49],"location":[50],"series.":[53],"referred":[55],"this":[57,534],"process,":[58,80],"whereby":[59],"body":[61,340],"part":[62,160],"is":[63],"transformed":[64],"into":[65],"likeness":[67],"another,":[69],"as":[70,88,167,468,470,490,523,525,557],"homeosis":[71,89,336,352],"(from":[72],"Greek":[73],"homoios=":[74],"same":[75],"and":[76,154,157,250,299,326,362,387,459,464,478,493,574,585],"-osis=":[77],"condition":[78],"Bateson,":[81],"1894,":[82,133],"pp.":[83,134],"84-85).":[84],"Because":[85],"phenomena":[86,380,433],"such":[87,432],"could":[90],"accomplish":[91],"at":[330,402],"step":[94],"change":[96],"similar":[97],"differences":[100],"observed":[101],"between":[102,476,572],"species,":[103],"held":[105],"it":[107],"was":[108,576],"discontinuity":[110,129],"itself,":[113],"rather":[114],"than":[115,137],"action":[117],"natural":[119],"selection":[120],"on":[121,184,500,565],"continuous":[122],"variation,":[123],"gave":[125],"rise":[126],"species":[131],"(Bateson,":[132],"568-570).":[135],"More":[136],"century":[139,513],"later,":[140],"homeotic":[141,185,192,379,397,423,488,501,514,544,566,593],"mutants":[142,186,424,489,502,515,545,567],"play":[143,194,436],"an":[144,416],"important":[145],"role":[146,191,439],"contemporary":[148],"ideas":[149],"how":[151],"genetics,":[152,385],"development,":[153,386],"evolution":[155,342],"intersect,":[156],"large":[159,234],"have":[161,558],"inspired":[162],"research":[164,564,581],"program":[165,582],"known":[166],"evolutionary":[168,443,466,541,552],"developmental":[169,179,320,462,584],"biology,":[170,378],"more":[172,521],"popularly,":[173],"evo-devo":[174],"Stern,":[176],"2000).":[177],"The":[178,453,480,530],"genetics":[180,318,334,575,587],"Ed":[182],"Lewis":[183],"Drosophila":[188,400],"established":[189],"genes":[193,211],"specifying":[196],"segmental":[197],"identity":[198],"during":[199,390],"ontogeny":[200],"(Lewis,":[201],"1951,":[202],"1964,":[203],"1978).":[204],"Application":[205],"molecular":[207,377],"techniques":[208],"these":[210],"led":[212,327],"first":[213,454],"discovery":[216],"homeobox,":[219],"conserved":[221],"stretch":[222],"DNA":[224],"sequence":[225],"codes":[227],"DNA-binding":[230],"portion":[231],"transcription":[237],"factors":[238],"(McGinnis,":[239],"Levine,":[240,269],"Hafen,":[241],"Kuriowa,":[242],"&":[243,247,268,282,286,291,307],"Gehring,":[244],"1984;":[245],"Scott":[246],"Weiner,":[248],"1984),":[249],"later":[251],"revealed":[252,354],"gene":[253],"expression":[254],"patterns":[255,338],"consistent":[256],"with":[257,337],"mutant":[258],"phenotypes":[259],"(for":[260],"review,":[261],"see":[262,296],"Akam,":[263],"1987;":[264],"Harding,":[265],"Wedeen,":[266],"McGinnis,":[267,281,297],"1985).":[270],"These":[271],"studies,":[272],"those":[273,367,420],"followed":[275],"vertebrates":[277],"(Awgulewitsch,":[278],"Utset,":[279],"Hart,":[280],"Ruddle,":[283],"1986;":[284],"Duboule":[285],"Dolle,":[287],"1989;":[288,293],"Graham,":[289],"Paplopulu,":[290],"Krumlauf,":[292],"review":[295],"1994),":[298],"comparative":[300],"studies":[301],"other":[303],"arthropods":[304,520],"Averof":[306],"Patel,":[308],"1997)":[309],"provided":[310],"critical":[311],"evidence":[312],"commonality":[315],"programs":[321],"across":[322],"bilaterian":[324],"animals,":[325],"efforts":[329,406,485],"broadly":[331],"integrating":[332],"plan":[341],"fossil":[345],"record":[346],"Jacobs,":[348],"1990).":[349],"essence,":[351],"has":[353],"commonalities":[355],"way":[358],"animals":[359],"are":[360],"structured":[361],"suggested":[363],"ways":[364],"which":[366],"body-plan":[368],"organizations":[369],"evolve.":[370],"Yet,":[371],"even":[372],"before":[373],"advent":[375],"fueled":[381],"attempts":[382],"integrate":[384],"Indeed,":[389],"late":[392],"1920s":[393],"through":[394],"1950s,":[396],"mutations":[398],"were":[401,425,516],"center":[404],"achieve":[408],"conceptual":[409],"theoretical":[411],"integration":[412],"-":[413],"create":[415],"evolutionarydevelopmental":[417],"synthesis.":[418,444,553],"However,":[419],"who":[421],"researched":[422],"unable":[426],"convince":[428],"their":[429],"peers":[430],"ought":[434],"defining":[438],"emerging":[442],"Why":[445],"not?":[446],"chapter":[448,535],"consists":[449],"three":[451],"sections.":[452],"will":[455,482,498,536,555],"consider":[456,483,537],"history":[458,562],"historiography":[460],"biology":[463],"synthesis,":[467],"well":[469,524],"nature":[472],"split":[475,571],"embryology":[477,573],"genetics.":[479],"second":[481],"early":[484,511],"characterize":[487],"developmental,":[491],"evolutionary,":[492],"genetic":[494],"phenomena.":[495],"Although":[496],"we":[497,505],"focus":[499],"Drosophila,":[504],"should":[506],"note":[507],"twentieth":[512],"widely":[517],"recognized":[518],"generally,":[522],"plants":[527],"(Sattler,":[528],"1988).":[529],"third":[531],"section":[532],"reception":[539],"interpretations":[542],"by":[546],"primary":[548],"architects":[549],"We":[554],"argue,":[556],"others,":[559],"reveals":[568],"not":[577],"absolute.":[578],"Instead,":[579],"physiological":[586],"grew":[588],"around":[589],"analysis":[591],"mutants.":[594],"\u2026":[595]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}