{"id":"https://openalex.org/W114822334","doi":null,"title":"Disease modifying and immunomodulatory effects of high dose 1 alpha (OH) D3 in rheumatoid arthritis patients.","display_name":"Disease modifying and immunomodulatory effects of high dose 1 alpha (OH) D3 in rheumatoid arthritis patients.","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W114822334","mag":"114822334","pmid":"https://pubmed.ncbi.nlm.nih.gov/10464556"},"language":"en","primary_location":{"id":"pmid:10464556","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10464556","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056519835","display_name":"Zoran Andjelkovi\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1304155728","display_name":"Military Medical Academy","ror":"https://ror.org/04dt6a039","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I1304155728"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Z Andjelkovic","raw_affiliation_strings":["Department of Rheumatology, Military Medical Academy, Belgrade, Yugoslavia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Military Medical Academy, Belgrade, Yugoslavia","institution_ids":["https://openalex.org/I1304155728"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069508163","display_name":"Jelena Vojinovi\u0107","orcid":"https://orcid.org/0000-0002-6701-3370","observed_orcids":["https://orcid.org/0000-0002-6701-3370"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Vojinovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033016684","display_name":"Nada N. Pejnovic","orcid":"https://orcid.org/0000-0002-2279-9197","observed_orcids":["https://orcid.org/0000-0002-2279-9197"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Pejnovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110414301","display_name":"M Popovi\u0107","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Popovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021495650","display_name":"Aleksandar Duji\u0107","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Dujic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"D Mitrovic","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Mitrovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113759521","display_name":"Ljiljana Pavlica","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Pavlica","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110331441","display_name":"Dara Stefanovic","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Stefanovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8316,"has_fulltext":false,"cited_by_count":185,"citation_normalized_percentile":{"value":0.69658698,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"17","issue":"4","first_page":"453","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.07010000199079514,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1alpha-hydroxyvitamin-d3","display_name":"1\u03b1-hydroxyvitamin D3","score":0.8629999756813049},{"id":"https://openalex.org/keywords/vitamin-d-analogs","display_name":"vitamin D analogs","score":0.9120000004768372},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.8199999928474426},{"id":"https://openalex.org/keywords/lymphocyte-proliferation","display_name":"lymphocyte proliferation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/lymphocyte-apoptosis","display_name":"lymphocyte apoptosis","score":0.8640000224113464},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.8140000104904175},{"id":"https://openalex.org/keywords/hypercalcemia","display_name":"hypercalcemia","score":0.8939999938011169}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9665168523788452},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.8770875930786133},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6145410537719727},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.47279685735702515},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.4519290328025818},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.45008981227874756},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.44348132610321045},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.425961971282959},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.41993945837020874},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.41945821046829224},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3857811391353607},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32918593287467957},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2927044630050659}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002112","descriptor_name":"Calcifediol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010835","descriptor_name":"Phytohemagglutinins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10464556","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10464556","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Clinical Trial"},{"id":"mag:114822334","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10464556","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W123508740","https://openalex.org/W1967245452","https://openalex.org/W2002066790","https://openalex.org/W2068195632","https://openalex.org/W2125771292","https://openalex.org/W2135878618","https://openalex.org/W2152348310","https://openalex.org/W2161875278","https://openalex.org/W2164176723"],"related_works":["https://openalex.org/W3125769998","https://openalex.org/W2898156159","https://openalex.org/W7020000928","https://openalex.org/W2285122826","https://openalex.org/W2411364175","https://openalex.org/W2328419607","https://openalex.org/W2537651667","https://openalex.org/W2972868203","https://openalex.org/W1606461516","https://openalex.org/W2952584299"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Vitamin":[1],"D":[2],"analogues":[3],"such":[4],"as":[5,36,240],"1":[6],"alpha":[7],"(OH)":[8],"D3":[9],"(alphacalcidiol)":[10],"have":[11,33],"a":[12,48,146,170,197],"possible":[13],"physiological":[14],"paracrine":[15],"effect":[16,148],"on":[17,52,149,222],"cell":[18,231],"proliferation":[19,120,224],"and":[20,75,90,109,121,127,164,225],"differentiation.":[21],"Experimentally":[22],"established":[23],"possibilities":[24],"to":[25,228],"prevent":[26],"autoimmune":[27],"diseases":[28],"suggest":[29,193],"that":[30,194],"alphacalcidiol":[31,92,143,195],"may":[32],"therapeutic":[34],"value":[35],"an":[37,241],"immunomodulatory":[38,199],"agent":[39,200],"in":[40,124,128,130,152,246],"patients":[41,54,126,156,175,247],"with":[42,57,71,77,161,169,201,211,244,248],"rheumatoid":[43,249],"arthritis.":[44,250],"METHODS:":[45],"We":[46,218],"organized":[47],"3-month":[49],"open-label":[50],"trial":[51,89],"19":[53],"being":[55],"treated":[56],"standard":[58],"DMARD":[59],"therapy":[60,144,243],"for":[61],"acute":[62],"RA.":[63,80],"They":[64],"were":[65,99,115,188],"divided":[66],"into":[67],"2":[68,93],"subgroups,":[69],"those":[70,76],"highly":[72],"active":[73,79],"RA":[74],"moderately":[78],"Their":[81],"regular":[82],"drug":[83],"regimen":[84],"was":[85,95,208],"maintained":[86],"during":[87],"the":[88,106,110,125,155,212,229],"oral":[91,142],"micrograms/day":[94],"added.":[96],"Therapy":[97],"results":[98,192],"evaluated":[100],"by":[101,117],"ESR,":[102],"CRP,":[103],"morning":[104],"stiffness,":[105],"Richie":[107],"index,":[108],"Lee":[111],"index.":[112],"Immunomodulatory":[113],"effects":[114,187,221],"investigated":[116],"measuring":[118],"lymphocyte":[119,223],"apoptosis":[122,226],"both":[123],"vitro":[129],"10":[131],"nM":[132],"alphacalcidiol-supplemented":[133],"culture":[134],"medium.":[135],"RESULTS:":[136],"After":[137],"3":[138],"months,":[139],"high":[140],"dose":[141],"showed":[145,177],"positive":[147],"disease":[150],"activity":[151],"89%":[153],"of":[154,215],"(45%":[157],"or":[158,166],"9":[159],"pts.":[160,168],"complete":[162],"remission":[163],"44%":[165],"8":[167],"satisfactory":[171],"effect).":[172],"Only":[173],"two":[174],"(11%)":[176],"no":[178,181],"improvement,":[179],"but":[180],"new":[182],"symptoms":[183],"occurred.":[184],"No":[185],"side":[186],"observed.":[189],"CONCLUSION:":[190],"These":[191],"is":[196],"powerful":[198],"fairly":[202],"low":[203],"hypercalcemic":[204],"activity.":[205],"Clinical":[206],"improvement":[207],"strongly":[209],"correlated":[210],"immunomodulating":[213],"potential":[214],"this":[216],"agent.":[217],"noticed":[219],"dual":[220],"according":[227],"prior":[230],"activation":[232],"state.":[233],"Alphacalcidiol":[234],"could":[235],"therefore":[236],"possibly":[237],"be":[238],"used":[239],"adjunct":[242],"DMARDs":[245]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
